Effects of topical ocular administration of high doses of human recombinant interferon alpha-2b and feline recombinant interferon omega on naturally occurring viral keratoconjunctivitis in cats

American Journal of Veterinary Research

Volumn 74, Issue 2, 2013, Pages 281-289

  Slack, Jessica M ^a,c   Stiles, Jean ^a   Leutenegger, Christian M ^b   Moore, George E ^a   Pogranichniy, Roman M ^a  

^a PURDUE UNIVERSITY   (United States)

^b IDEXX LABORATORIES   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; FLUORESCEIN; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT INTERFERON; RECOMBINANT OMEGA INTERFERON; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIUM DETECTION; BORDETELLA BRONCHISEPTICA; CALICIVIRUS INFECTION; CAT; CLINICAL ASSESSMENT; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; FELINE PANLEUKOPENIA; FEMALE; HERPES SIMPLEX VIRUS 1; KERATOCONJUNCTIVITIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; RHINOTRACHEITIS; SCORING SYSTEM; SLIT LAMP; SYSTEMIC DISEASE; VESIVIRUS; VIRAL EYE INFECTION; VIRUS DETECTION; VIRUS ISOLATION;

ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTIVIRAL AGENTS; CALICIVIRUS, FELINE; CAT DISEASES; CATS; FEMALE; HUMANS; INTERFERON TYPE I; INTERFERON-ALPHA; KERATOCONJUNCTIVITIS, INFECTIOUS; MALE; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; VARICELLOVIRUS;

EID: 84873331748     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.74.2.281     Document Type: Article

References (47)

1. Stiles J. Feline herpesvirus. Vet Clin North Am Small Anim Pract 2000;30:1001-1014
2. Sykes JE. Feline upper respiratory tract pathogens: herpesvirus- 1 and calicivirus. Compend Contin Educ Pract Vet 2001;23:166-176
3. Malik R, Lessels NS, Webb S, et al. Treatment of feline herpesvirus- 1 associated disease in cats with famciclovir and related drugs. J Feline Med Surg 2009;11:40-48
4. Stiles J, Townsend WM, Rogers QR, et al. Effect of oral administration of L-lysine on conjunctivitis caused by feline herpesvirus in cats. Am J Vet Res 2002;63:99-103
5. Fontenelle JP, Powell CC, Veir JK, et al. Effect of topical ophthalmic application of cidofovir on experimentally induced primary ocular feline herpesvirus-1 infection in cats. Am J Vet Res 2008;69:289-293
6. Nasisse MP, Guy JS, Davidson MG, et al. In vitro susceptibility of feline herpesvirus-1 to virabidine, idoxuridine, trifluridine, acyclovir or bromovinyldeoxyuridine. Am J Vet Res 1989;50:158-160
7. Stiles J. Feline herpesvirus. Clin Tech Small Anim Pract 2003;18:178-185
8. Goodbuourn S, Didcock L, Randell RE. Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures. J Gen Virol 2000;81:2341-2364
9. Vögtlin C, Fraefel S, Leutenegger CM, et al. Quantification of feline herpesvirus-1 DNA in ocular samples of clinically diseased cats by real time TaqMan PCR. J Clin Microbiol 2002;40:519-523
10. Mapes S, Leutenegger CM, Pusterla N. Nucleic acid extraction methods for detection of EHV-1 from blood and nasopharyngeal secretions. Vet Rec 2008;162:857-859
11. Pusterla N, Wilson WD, Mapes S, et al. Evaluation of nasopharyngeal swabs and feces as potentially useful diagnostic specimens for Rhodococcus equi pneumonia in foals using real-time TaqMan PCR. Vet Rec 2007;161:272-274
12. Isaacs A, Lindenmann J. Virus interference. I. The interferon. Proc R Soc Lond (Biol) 1957;147:258-267
13. Jonasch E, Haluska FG. Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities. Oncologist 2001;6:34-55
14. Loma I, Heyman R. Multiple sclerosis: pathogenesis and treatment. Curr Neuropharmacol 2011;9:409-416
15. Feld JJ, Hoofnagle JH. Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature 2005;436:967-972
16. Sundmacher R, Neumann-Haefelin D, Cantell K, et al. Successful treatment of dendritic keratitis with human leukocytic interferon. Graef Arch Ophthalmol 1976;201:39-45
17. Sundmacher R, Neumann-Haefelin D, Manthey K, et al. Interferon in treatment of dendritic keratitis in humans: a preliminary report. J Infect Dis 1976;133:160-164
18. Sundmacher R, Cantell K, Haug P, et al. Role of debridement and interferon in the treatment of dendritic keratitis. Graef Arch Ophthalmol 1978;207:77-82
19. Sundmacher R, Cantell K, Mattes A. Combination therapy for dendritic keratitis. Arch Ophthalmol 1984;102:554-555
20. Levin M, Leary P. Inhibition of human herpesviruses by combinations of acyclovir and human leukocytic interferon. Infect Immun 1981;32:995-999
21. Fulton R, Burge L. Susceptibility of feline herpesvirus-1 and a feline calicivirus to feline interferon and recombinant human leukocytic interferons. Antimicrob Agents Chemother 1985;28:698-699
22. Siebeck N, Hurley DJ, Garcia M, et al. Effects of human recombinant alpha-2b interferon and feline recombinant omega interferon on in vitro replication of feline herpesvirus-1. Am J Vet Res 2006;67:1406-1411
23. Sandmeyer LS, Keller CB, Bienzle D. Effects of interferon-alpha on cytopathic changes and titers for feline herpesvirus-1 in primary cultures of feline corneal epithelial cells. Am J Vet Res 2005;66:210-216
24. Weiss RC. Synergistic antiviral activities of acyclovir and recombinant human leukocyte (alpha) interferon on feline herpesvirus replication. Am J Vet Res 1989;50:1672-1677
25. Haid C, Kaps S, Gonezi E, et al. Pretreatment with feline interferon omega and the course of subsequent infection with feline herpesvirus in cats. Vet Ophthalmol 2007;10:278-284
26. Marsilio F, Martino B, Decaro N, et al. A novel nested PCR for the diagnosis of caliciviruses in the cat. Vet Microbiol 2005;105:1-7
27. Gaskell R, Dawson S. Viral-induced upper respiratory tract disease. In: Chandler EA, Gaskell CJ, Gaskell RM, eds. Feline medicine and therapeutics. 3rd ed. Oxford, England: Blackwell Scientific Publications, 1994;453-472
28. Sykes J, Studdert V, Browning G. Detection and strain differentiation of feline calicivirus in conjunctival swabs by RT-PCR of the hypervariable region of the capsid protein gene. Arch Virol 1998;143:1321-1334
29. Maggs D, Lappin MR, Reif JS, et al. Evaluation of serological and viral detection methods for diagnosing feline herpesvirus-1 infection in cats with acute respiratory tract or chronic ocular disease. J Am Vet Med Assoc 1999;214:502-507
30. Burgesser K, Hotaling S, Schiebel A, et al. Comparison of PCR, virus isolation, and indirect fluorescent antibody staining in the detection of naturally occurring feline herpesvirus infections. J Vet Diagn Invest 1999;11:122-126
31. Stiles J, McDermott M, Willis M, et al. Comparison of nested polymerase chain reaction, virus isolation, and florescent antibody testing for identifying feline herpesvirus in cats with conjunctivitis. Am J Vet Res 1997;58:804-807
32. Thiry E, Addie D, Belak S, et al. Feline herpesvirus infection: ABCD guidelines on prevention and management. J Feline Med Surg 2009;11:547-555
33. Townsend WM, Stiles J, Guptill-Yoran L, et al. Development of a reverse transcriptase-polymerase chain reaction assay to detect feline herpesvirus-1 latency-associated transcripts in the trigeminal ganglia and corneas of cats that did not have clinical signs of ocular disease. Am J Vet Res 2004;65:314-319
34. Zicola A, Saegerman C, Quatpers D, et al. Feline herpesvirus-1 and feline calicivirus infections in a heterologous cat population of a rescue shelter. J Feline Med Surg 2009;11:1023-1027
35. Low HC, Powell CC, Veir JK, et al. Prevalence of feline herpesvirus 1, Chlamydophila felis, and Mycoplasma spp DNA in conjunctival cells collected from cats with and without conjunctivitis. Am J Vet Res 2007;68:643-648
36. Stiles J, McDermott M, Bigsby D, et al. Use of nested polymerase chain reaction to identify feline herpesvirus in ocular tissue from clinically normal cats and cats with corneal sequestra or conjunctivitis. Am J Vet Res 1997;58:338-342
37. Sykes JE, Anderson GA, Studdert VP, et al. Prevalence of feline Chlamydia psittaci and feline herpesvirus 1 in cats with upper respiratory tract disease. J Vet Intern Med 1999;13:153-162
38. Sykes JE, Allen JL, Studdert VP, et al. Detection of feline calicivirus, feline herpesvirus 1 and Chlamydia psittaci mucosal swabs by multiplex RT-PCR/PCR. Vet Microbiol 2001;81:95-108
39. Rampazzo A, Appino S, Pregel P, et al. Prevalence of Chlamydophila felis and feline herpesvirus 1 in cats with conjunctivitis in northern Italy. J Vet Intern Med 2003;17:799-807
40. Volopich S, Benetka V, Schwendenwein I, et al. Cytologic findings, and feline herpesvirus DNA and Chlamydophila felis antigen detection rates in normal cats and cats with conjunctival and corneal lesions. Vet Ophthalmol 2005;8:25-32
41. Cai Y, Fukushi H, Koyasu S, et al. An etiological investigation of domestic cats with conjunctivitis and upper respiratory tract disease in Japan. J Vet Med Sci 2002;64:215-219
42. Binns SH, Dawson S, Speakman AJ, et al. Prevalence and risk factors for feline Bordetella bronchiseptica infection. Vet Rec 1999;144:575-580
43. Helps CR, Lait P, Damhuis A, et al. Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: experience from 218 European catteries. Vet Rec 2005;156:669-673
44. Haesebrouck F, Devriese LA, van Rijssen B, et al. Incidence and significance of isolation of Mycoplasma felis from conjunctival swabs of cats. Vet Microbiol 1991;26:95-101
45. Ruch-Gallie R, Veir J, Hawley J, et al. Results of molecular diagnostic assays targeting feline herpesvirus-1 and feline calicivirus in adult cats administered modified live vaccines. J Feline Med Surg 2011;13:541-545
46. Ruiz L, Reyes N, Aroche K, et al. Influence of packaging material on the liquid stability of interferon-α2b. J Pharm Pharmaceut Sci 2005;8:207-216
47. Ruiz L, Rodriguez I, Baez R, et al. Stability of extemporaneously prepared recombinant human interferon alfa-2b eye drop formulation. Am J Health Syst Pharm 2007;64:1716-1719.