Chromothripsis in a case of TP53-deficient chronic lymphocytic leukemia

Leukemia Research Reports

Volumn 1, Issue 1, 2012, Pages 4-6

  Pei, Jianming ^a   Jhanwar, Suresh C ^b   Testa, Joseph R ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Chromosome microarray analysis; Chromothripsis; Chronic lymphocytic leukemia; Genomic imbalances; P53

Indexed keywords

PROTEIN P53;

ANALYTIC METHOD; ARTICLE; CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; CHROMOTHRIPSIS; CHRONIC LYMPHATIC LEUKEMIA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE DOSAGE; HETEROZYGOSITY; HUMAN; KARYOTYPE; MALIGNANT TRANSFORMATION; MICROARRAY ANALYSIS; OSCILLATION; PROGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84873315458     PISSN: 22130489     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lrr.2012.09.001     Document Type: Article

References (10)

1. Bazargan A., Tam C.S., Keating M.J. Predicting survival in chronic lymphocytic leukemia. Expert Reviews of Anticancer Therapy 2012, 12:393-403.
2. Dohner H., Stilgenbauer S., Benner A., Leupolt E., Kröber A., Bullinger L., et al. Genomic aberrations and survival in chronic lymphocytic leukemia. New England Journal of Medicine 2000, 343:1911-1916.
3. Zenz T., Mertens D., Döhner H., Stilgenbauer S. Molecular diagnostics in chronic lymphocytic leukemia-pathogenetic and clinical implications. Leukemia & Lymphoma 2008, 49:864-873.
4. Patel A., Kang S.H., Lennon P.A., Li Y.F., Rao P.N., Abruzzo L., et al. Validation of a targeted DNA microarray for the clinical evaluation of recurrent abnormalities in chronic lymphocytic leukemia. American Journal of Hematology 2008, 83:540-546.
5. Stephens P.J., Greenman C.D., Fu B., Yang F., Bignell G.R., Mudie L.J., et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 2011, 144:27-40.
6. Roberts J.L., Buckley R.H., Luo B., Pei J., Lapidus A., Peri S., et al. CD45-deficient severe combined immunodeficiency caused by uniparental disomy. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:10456-10461.
7. Tam C.S., Shanafelt T.D., Wierda W.G., Abruzzo L.V., Van Dyke D.L., O'Brien S., et al. De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience. Blood 2009, 114:957-964.
8. Stilgenbauer S., Sander S., Bullinger L., Benner A., Leupolt E., Winkler D., et al. Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival. Haematologica 2007, 92:1242-1245.
9. Cavazzini F., Rizzotto L., Sofritti O., Daghia G., Cibien F., Martinelli S., et al. Clonal evolution including 14q32/IGH translocations in chronic lymphocytic leukemia: analysis of clinicobiologic correlations in 105 patients. Leukemia & Lymphoma 2012, 53:83-88.
10. Reindl L., Bacher U., Dicker F., Alpermann T., Kern W., Schnittger S., et al. Biological and clinical characterization of recurrent 14q deletions in CLL and other mature B-cell neoplasms. British Journal of Haematology 2010, 151:25-36.