Low-dose vaporized cannabis significantly improves neuropathic pain

Journal of Pain

Volumn 14, Issue 2, 2013, Pages 136-148

  Wilsey, Barth ^a   Marcotte, Thomas ^b   Deutsch, Reena ^b   Gouaux, Ben ^b   Sakai, Staci ^a   Donaghe, Haylee ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

analgesia; cannabis; clinical trial; Neuropathic pain; neuropsychological testing

Indexed keywords

ANTICONVULSIVE AGENT; CANNABIS; DRONABINOL; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PLACEBO; UNCLASSIFIED DRUG; VAPORIZED CANNABIS;

ADULT; ALLODYNIA; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; INFANT; LOW DRUG DOSE; MALE; NEUROPATHIC PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; VISUAL ANALOG SCALE;

ADMINISTRATION, INHALATION; ADULT; AFFECT; CANNABIS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERALGESIA; LINEAR MODELS; MALE; MIDDLE AGED; NEURALGIA; NEUROPSYCHOLOGICAL TESTS; PAIN MEASUREMENT; PAIN THRESHOLD; PATIENT SELECTION; PHYTOTHERAPY; SOCIOECONOMIC FACTORS; TETRAHYDROCANNABINOL; TREATMENT OUTCOME; VOLATILIZATION;

EID: 84873287705     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2012.10.009     Document Type: Article

References (58)

1. D.I. Abrams, C.A. Jay, S.B. Shade, H. Vizoso, H. Reda, S. Press, M.E. Kelly, M.C. Rowbotham, and K.L. Petersen Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial Neurology 68 2007 515 521
2. D.I. Abrams, H.P. Vizoso, S.B. Shade, C. Jay, M.E. Kelly, and N.L. Benowitz Vaporization as a smokeless cannabis delivery system: A pilot study Clin Pharmacol Ther 82 2007 572 578
3. M.M. Backonja Use of anticonvulsants for treatment of neuropathic pain Neurology 59 2002 S14 S17
4. M.P. Barnes Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain Expert Opin Pharmacother 7 2006 607 615
5. W.T. Beaver, J. Buring, A. Goldstein, K. Johnson, and R. Jones Workshop on the Medical Utility of Marijuana Ad Hoc Group of Experts, Report to the Director 1997 National Institutes of Health p. 19 of 36
6. L.J. Beglinger, B. Gaydos, O. Tangphao-Daniels, K. Duff, D.A. Kareken, J. Crawford, P.S. Fastenau, and E.R. Siemers Practice effects and the use of alternate forms in serial neuropsychological testing Arch Clin Neuropsychol 20 2005 517 529
7. R. Benedict, D. Schretlen, L. Groninger, and J. Brandt Hopkins Verbal Learning Test-Revised: Normative data and analysis of inter-form and test-retest reliability Clin Neuropsycholt 12 1998 43 55
8. R.H. Benedict, and D.J. Zgaljardic Practice effects during repeated administrations of memory tests with and without alternate forms J Clin Exp Neuropsychol 20 1998 339 352
9. S. Bruehl, R.N. Harden, B.S. Galer, S. Saltz, M. Bertram, M. Backonja, R. Gayles, N. Rudin, M.K. Bhugra, and M. Stanton-Hicks External validation of IASP diagnostic criteria for Complex Regional Pain Syndrome and proposed research diagnostic criteria. International Association for the Study of Pain Pain 81 1999 147 154
10. F.A. Campbell, M.R. Tramer, D. Carroll, D.J. Reynolds, R.A. Moore, and H.J. McQuay Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review BMJ 323 2001 13 16
11. Cannabis and the Regulatory Void: Background Paper and Recommendations. California Medical Association, Marijuana Technical Advisory Committee, 2011
12. G.T. Carter, P. Weydt, M. Kyashna-Tocha, and D.I. Abrams Medicinal cannabis: Rational guidelines for dosing IDrugs 7 2004 464 470
13. H. Chabrol, and M. Choquet Relationship between depressive symptoms, hopelessness and suicidal ideation among 1547 high school students Encephale 35 2008 443 447
14. L.D. Chait, R.L. Corwin, and C.E. Johanson A cumulative dosing procedure for administering marijuana smoke to humans Pharmacol Biochem Behav 29 1988 553 557
15. M. Costigan, J. Scholz, and C.J. Woolf Neuropathic pain: A maladaptive response of the nervous system to damage Annu Rev Neurosci 32 2009 1 32
16. R.H. Dworkin, J. Katz, and M.J. Gitlin Placebo response in clinical trials of depression and its implications for research on chronic neuropathic pain Neurology 65 2005 S7 19
17. R.H. Dworkin, D.C. Turk, G.A. Walco, C.D. Wells, A.B. O'Connor, J. Audette, R. Baron, G.K. Gourlay, M.L. Haanpaa, R. Baron, M.L. Haanpää, J.L. Kent, E.J. Krane, A.A. Lebel, R.M. Levy, S.C. Mackey, J. Mayer, C. Miaskowski, S.N. Raja, A.S. Rice, K.E. Schmader, B. Stacey, S. Stanos, and R.D. Treede Recommendations for the pharmacological management of neuropathic pain: An overview and literature update Mayo Clin Proc 85 2010 S3 14
18. R.J. Ellis, W. Toperoff, F. Vaida, G. van den Brande, J. Gonzales, B. Gouaux, H. Bentley, and J.H. Atkinson Smoked medicinal cannabis for neuropathic pain in HIV: A randomized, crossover clinical trial Neuropsychopharmacology 34 2009 672 680
19. J.T. Farrar, J.P. Young Jr., L. LaMoreaux, J.L. Werth, and R.M. Poole Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale Pain 94 2010 149 158
20. Federal Guidelines Announcement of the Department of Health And Human Services' Guidance On Procedures for The Provision of Marijuana for Medical Research Release. National Institutes of Health, Date: May 21, 1999
21. B.S. Galer, S. Bruehl, and R.N. Harden IASP diagnostic criteria for complex regional pain syndrome: A preliminary empirical validation study. International Association for the Study of Pain Clin J Pain 14 2000 48 54
22. B.S. Galer, and M.P. Jensen Development and preliminary validation of a pain measure specific to neuropathic pain: The Neuropathic Pain Scale Neurology 48 2007 332 338
23. C.Z. Garrison, C.L. Addy, K.L. Jackson, R.E. McKeown, and J.L. Waller A longitudinal study of suicidal ideation in young adolescents J Am Acad Child Adolesc Psychiatry 30 1991 597 603
24. C.Z. Garrison, K.L. Jackson, C.L. Addy, R.E. McKeown, and J.L. Waller Suicidal behaviors in young adolescents Am J Epidemiol 133 1990 1005 1014
25. D. Gieringer, J. St. Laurent, and S. Goodrich Cannabis Vaporizer Combines Efficient Delivery of THC with Effective Suppression of Pyrolytic Compounds J Cannabis Ther 4 2004 2 27
26. D. Gieringer Marijuana research: Waterpipe study Multidisciplinary Association for Psychedelic Studies Bulletin 6 1996 59 66
27. M.K. Greenwald, and M.L. Stitzer Antinociceptive, subjective and behavioral effects of smoked marijuana in humans Drug Alcohol Depend 59 2000 261 275
28. F. Grotenhermen Pharmacokinetics and pharmacodynamics of cannabinoids Clin Pharmacokinet 42 2003 327 360
29. M. Haney, A.S. Ward, S.D. Comer, R.W. Foltin, and M.W. Fischman Abstinence symptoms following oral THC administration to humans Psychopharmacology 141 1999 385 394
30. M. Haney, A.S. Ward, S.D. Comer, R.W. Foltin, and M.W. Fischman Abstinence symptoms following smoked marijuana in humans Psychopharmacology 141 1999 395 404
31. P. Hansson, and U. Lindblom Hyperalgesia assessed with quantitative sensory testing in patients with neurogenic pain Hyperalgesia and Allodynia 1992 Raven Press New York, NY 335 343
32. R.N. Harden, S. Bruehl, B.S. Galer, S. Saltz, M. Bertram, M. Backonja, R. Gayles, N. Rudin, M.K. Bhugra, and M. Stanton-Hicks Complex regional pain syndrome: Are the IASP diagnostic criteria valid and sufficiently comprehensive? Pain 83 1999 211 219
33. C.L. Hart, W. van Gorp, M. Haney, R.W. Foltin, and M.W. Fischman Effects of acute smoked marijuana on complex cognitive performance Neuropsychopharmacology 25 2001 757 765
34. R. Heaton, and T. Marcotte Clinical neuropsychological tests and assessment techniques F. Boller, J. Grafman, Handbook of Neuropsychology 2000 Elsevier Science Amsterdam, NE
35. S.J. Heishman, K. Arasteh, and M.L. Stitzer Comparative effects of alcohol and marijuana on mood, memory, and performance Pharmacol Biochem Behav 58 1997 93 101
36. A. Khan, S.R. Khan, G. Walens, R. Kolts, and E.L. Giller Frequency of positive studies among fixed and flexible dose antidepressant clinical trials: An analysis of the food and drug administration summary basis of approval reports Neuropsychopharmacology 28 2003 552 557
37. K. Kieburtz, D. Simpson, C. Yiannoutsos, M.B. Max, C.D. Hall, R.J. Ellis, C.M. Marra, R. McKendall, E. Singer, G.J. Dal Pan, D.B. Clifford, T. Tucker, and B. Cohen A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team Neurology 51 2008 1682 1688
38. H. Klove Clinical neuropsychology F.E. Forster, Medical Clinics of North America 1963 Saunders New York, NY
39. K. Kroenke, R.L. Spitzer, and J.B. Williams The PHQ-9: validity of a brief depression severity measure JGIM 16 2001 606 613
40. Marijuana and Medicine; Assessing the Science Base 1999 National Academy Press Washington, D.C.
41. J.M. McPartland, and P.L. Pruitt Medical marijuana and its use by the immunocompromised Altern Ther Health Med 3 1997 39 45
42. Medical marijuana and the mind. More is known about the psychiatric risks than the benefits Harv Ment Health Lett 26 2010 1 3
43. N. Mello, and J. Mendelson Cocaine and Other Commonly Abused Drugs: Introduction, Cocaine, Marijuana and Cannabis Compounds, Methamphetamine, Lysergic Acid Diethylamide (LSD), Phencyclidine (PCP), Other Drugs of Abuse, Polydrug Abuse A. Fauci, E. Braunwald, D. Kasper, S. Hauser, D. Longo, J. Jameson, J. Loscalzo, Harrison's Principles of Internal Medicine 2012 The McGraw-Hill Companies, Inc New York, N.Y.
44. R.A. Moore, S. Straube, P.J. Wiffen, S. Derry, and H.J. McQuay Pregabalin for acute and chronic pain in adults Cochrane Database of Systematic Reviews (Online) 2010 CD007076
45. D. Naleschinski, and R. Baron Complex regional pain syndrome type I: Neuropathic or not? Curr Pain Headache Rep 14 2010 196 202
46. B.R. Nordstrom, and C.L. Hart Assessing cognitive functioning in cannabis users: Cannabis use history an important consideration Neuropsychopharmacology 31 2006 2798 2799 author reply 800-1
47. E.J. Rahn, and A.G. Hohmann Cannabinoids as pharmacotherapies for neuropathic pain: From the bench to the bedside Neurotherapeutics 6 2009 713 737
48. J.G. Ramaekers, G. Kauert, E.L. Theunissen, S.W. Toennes, and M.R. Moeller Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users J Psychopharmacol 23 2011 266 277
49. J.G. Ramaekers, E.L. Theunissen, M. de Brouwer, S.W. Toennes, M.R. Moeller, and G. Kauert Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users Psychopharmacology (Berl) 214 2011 391 401
50. C. Reinarman, H. Nunberg, F. Lanthier, and T. Heddleston Who are medical marijuana patients? Population characteristics from nine California assessment clinics J Psychoactive Drugs 43 2011 128 135
51. J.C. Shlay, K. Chaloner, M.B. Max, B. Flaws, P. Reichelderfer, D. Wentworth, S. Hillman, B. Brizz, and D.L. Cohn Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: A randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS JAMA 280 1998 1590 1595
52. J.H. Vranken, M.G. Dijkgraaf, M.R. Kruis, M.H. van der Vegt, M.W. Hollmann, and M. Heesen Pregabalin in patients with central neuropathic pain: A randomized, double-blind, placebo-controlled trial of a flexible-dose regimen Pain 136 2010 150 157
53. M. Wallace, G. Schulteis, J.H. Atkinson, T. Wolfson, D. Lazzaretto, H. Bentley, B. Gouaux, and I. Abramson Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers Anesthesiology 107 2007 785 796
54. A.S. Ward, S.D. Comer, M. Haney, R.W. Foltin, and M.W. Fischman The effects of a monetary alternative on marijuana self-administration Behav Pharmacol 8 1997 275 286
55. M.A. Ware, C.R. Doyle, R. Woods, M.E. Lynch, and A.J. Clark Cannabis use for chronic non-cancer pain: Results of a prospective survey Pain 102 2003 211 216
56. M.A. Ware, T. Wang, S. Shapiro, A. Robinson, T. Ducruet, T. Huynh, A. Gamsa, G.J. Bennett, and J.P. Collet Smoked cannabis for chronic neuropathic pain: A randomized controlled trial CMAJ 182 2010 E694 E701
57. D. Wechsler Wechsler Adult Intelligence Scale, Third Edition, Administration and Scoring Manual 1997 The Psychological Corporation, Harcourt Brace & Co San Antonio, TX
58. B. Wilsey, T. Marcotte, A. Tsodikov, J. Millman, H. Bentley, B. Gouaux, and S. Fishman A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain J Pain 9 2008 506 521