Chronic Free-Choice Drinking in Crossed High Alcohol Preferring Mice Leads to Sustained Blood Ethanol Levels and Metabolic Tolerance Without Evidence of Liver Damage

Alcoholism: Clinical and Experimental Research

Volumn 37, Issue 2, 2013, Pages 194-201

  Matson, Liana ^a   Liangpunsakul, Suthat ^a   Crabb, David ^a   Buckingham, Amy ^a   Ross, Ruth Ann ^a   Halcomb, Meredith ^a   Grahame, Nicholas ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol Metabolism; Rodent Model; Selective Breeding; Self Administration

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; LIVER ENZYME; WATER;

ALCOHOL BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD SAMPLING; CONTROLLED STUDY; DRUG INDUCED DISEASE; FATTY LIVER; FEMALE; HISTOPATHOLOGY; LIGHT DARK CYCLE; LIVER INJURY; MALE; METABOLISM; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL;

ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ANIMALS; CHOICE BEHAVIOR; CYTOCHROME P-450 CYP2E1; DISEASE MODELS, ANIMAL; DRUG TOLERANCE; ETHANOL; FATTY LIVER; FEMALE; GENE EXPRESSION; HYBRIDIZATION, GENETIC; MALE; MICE; MICE, INBRED STRAINS; PHOTOPERIOD;

MUS; RODENTIA;

EID: 84873262611     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01873.x     Document Type: Article

References (39)

1. Aalto J (1986) Circadian drinking rhythms and blood alcohol levels in two rat lines developed for their alcohol consumption. Alcohol 3:73-75.
2. Agabio R, Cortis G, Fadda F, Gessa GL, Lobina C, Reali R, Colombo G (1996) Circadian drinking pattern of Sardinian alcohol-preferring rats. Alcohol Alcohol 31:385-388.
3. American Psychological Association (2000) Diagnostic and Statistical Manual of Mental Disorders. Text Revision, 4th ed. American Psychiatric Press, Washington, DC.
4. Anji A, Kumari M (2008) Supplementing the liquid alcohol diet with chow enhances alcohol intake in C57 BL/6 mice. Drug Alcohol Depend 97:86-93.
5. Badger TM, Hoog JO, Svensson S, McGehee RE Jr, Fang C, Ronis MJ, Ingelman-Sundberg M (2000) Cyclic expression of class I alcohol dehydrogenase in male rats treated with ethanol. Biochem Biophys Res Commun 274:684-688.
6. Badger TM, Huang J, Ronis M, Lumpkin CK (1993) Induction of cytochrome P450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high. Biochem Biophys Res Commun 190:780-785.
7. Crabbe JC (2010) Consilience of rodent and human phenotypes relevant for alcohol dependence. Addict Biol 15:103-108.
8. Cunningham CL, Fidler TL, Hill KG (2000) Animal models of alcohol's motivational effects. Alcohol Res Health 24:85-92.
9. DeCarli LM, Lieber CS (1967) Fatty liver in the rat after prolonged intake of ethanol with a nutritionally adequate new liquid diet. J Nutr 91:331-336.
10. Denucci SM, Tong M, Longato L, Lawton M, Setshedi M, Carlson RI, Wands JR, de la Monte SM (in press) Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance. Gastroenterol Res Pract [Epub ahead of print].
11. Dole VP, Gentry RT (1984) Toward an analogue of alcoholism in mice: scale factors in the model. Proc Natl Acad Sci U S A 81:3543-3546.
12. D'Souza El-Guindy NB, Kovacs EJ, De Witte P, Spies C, Littleton JM, de Villiers WJ, Lott AJ, Plackett TP, Lanzke N, Meadows GG (2010) Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model. Alcohol Clin Exp Res 34:1489-1511.
13. Fisher H, Halladay A, Ramasubramaniam N, Petrucci JC, Dagounis D, Sekowski A, Martin JV, Wagner GC (2002) Liver fat and plasma ethanol are sharply lower in rats fed ethanol in conjunction with high carbohydrate compared with high fat diets. J Nutr 132:2732-2736.
14. Grahame NJ, Li TK, Lumeng L (1999) Selective breeding for high and low alcohol preference in mice. Behav Genet 29:47-57.
15. Green AS, Grahame NJ (2008) Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol? Alcohol 42:1-11.
16. Leeman RF, Heilig M, Cunningham CL, Stephens DN, Duka T, O'Malley SS (2010) Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. Addict Biol 15:109-124.
17. Liangpunsakul S, Rahmini Y, Ross RA, Zhao Z, Xu Y, Crabb DW (2012) Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice. Am J Physiol Gastrointest Liver Physiol 302:G515-G523.
18. Lieber CS (1997) Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 77:517-544.
19. Lieber CS (2004) The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. Drug Metab Rev 36:511-529.
20. Lieber CS, DeCarli LM (1968) Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding. Science 162:917-918.
21. Lieber CS, DeCarli LM (1970) Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo. J Biol Chem 245:2505-2512.
22. Lieber CS, DeCarli LM (1972) The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo. J Pharmacol Exp Ther 181:279-287.
23. Lieber CS, DeCarli LM (1989) Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcohol 24:197-211.
24. Lieber CS, Jones DP, Mendelson JH, DeCarli LM (1963) Fatty liver, hyperlipemia, and hyperuricemia produced by prolonged alcohol consumption, despite adequate dietary intake. Trans Assoc Am Physicians 76:289-300.
25. Lumeng L, Li TK (1986) The development of metabolic tolerance in the alcohol-preferring P rats: comparison of forced and free-choice drinking of ethanol. Pharmacol Biochem Behav 25:1013-1020.
26. Lumeng L, Waller MB, McBride WJ, Li TK (1982) Different sensitivities to ethanol in alcohol-preferring and -nonpreferring rats. Pharmacol Biochem Behav 16:125-130.
27. de la M Hall P, Lieber CS, DeCarli LM, French SW, Lindros KO, Jarvelainen H, Bode C, Parlesak A, Bode JC (2001) Models of alcoholic liver disease in rodents: a critical evaluation. Alcohol Clin Exp Res 25:254S-261S.
28. Matson L, Grahame N (in press) Pharmacologically relevant intake during chronic, free-choice drinking rhythms in selectively bred high alcohol preferring mice. Addict Biol doi: 10.1111/j.1369-1600.2011.00412.x [Epub ahead of print].
29. McBride WJ, Li TK (1998) Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol 12:339-369.
30. Mello NK, Mendelson JH (1970) Experimentally induced intoxication in alcoholics: a comparison between programed and spontaneous drinking. J Pharmacol Exp Ther 173:101-116.
31. Morse RM, Flavin DK (1992) The definition of alcoholism. The Joint Committee of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism. JAMA 268:1012-1014.
32. Murphy JM, Gatto GJ, Waller MB, McBride WJ, Lumeng L, Li TK (1986) Effects of scheduled access on ethanol intake by the alcohol-preferring (P) line of rats. Alcohol 3:331-336.
33. Oberlin B, Best C, Matson L, Henderson A, Grahame N (2010) Derivation and characterization of replicate high- and low-alcohol preferring lines of mice and a high-drinking crossed HAP line. Behav Genet 41:288-302.
34. Ohnishi K, Lieber CS (1977) Reconstitution of the microsomal ethanol-oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption. J Biol Chem 252:7124-7131.
35. Rachamin G, MacDonald JA, Wahid S, Clapp JJ, Khanna JM, Israel Y (1980) Modulation of alcohol dehydrogenase and ethanol metabolism by sex hormones in the spontaneously hypertensive rat. Effect of chronic ethanol administration. Biochem J 186:483-490.
36. Rodgers DA, McClearn G, Bennett EL, Hebert M (1963) Alcohol preference as a function of its caloric utility in mice. J Comp Physiol 56:666-672.
37. Ronis MJ, Huang J, Crouch J, Mercado C, Irby D, Valentine CR, Lumpkin CK, Ingelman-Sundberg M, Badger TM (1993) Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats. J Pharmacol Exp Ther 264:944-950.
38. Takahashi T, Lasker JM, Rosman AS, Lieber CS (1993) Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 17:236-245.
39. You M, Considine RV, Leone TC, Kelly DP, Crabb DW (2005) Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42:568-577.