Phosphorylation of the Streptococcus pneumoniae cell wall biosynthesis enzyme MurC by a eukaryotic-like Ser/Thr kinase

FEMS Microbiology Letters

Volumn 340, Issue 1, 2013, Pages 19-23

  Falk, Shaun P ^a   Weisblum, Bernard ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Kinase; MurC; Phosphatase; PhpP; StkP; Streptococcus pneumoniae

Indexed keywords

ASPARTIC ACID; BACTERIAL ENZYME; CYSTEINE; GLUTAMIC ACID; GLYCINE; PROTEIN SERINE THREONINE KINASE; SERINE; THREONINE; TYROSINE; UDP N ACETYLMURAMOYL ALANINE LIGASE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL CELL WALL; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; METABOLIC REGULATION; MOLECULAR INTERACTION; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE;

BACTERIAL PROTEINS; BINDING SITES; CELL SURFACE DISPLAY TECHNIQUES; ENZYME-LINKED IMMUNOSORBENT ASSAY; PEPTIDE SYNTHASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; STREPTOCOCCUS PNEUMONIAE;

EUKARYOTA; STREPTOCOCCUS PNEUMONIAE;

EID: 84873258925     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/1574-6968.12067     Document Type: Article

References (28)

1. Agarwal S, Agarwal S, Pancholi P & Pancholi V (2012) Strain-specific regulatory role of eukaryote-like serine/threonine phosphatase in pneumococcal adherence. Infect Immun 80: 1361-1372.
2. Altschul SF, Gish W, Miller W, Myers EW & Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
3. Beilharz K, Nováková L, Fadda D, Branny P, Massidda O & Veening JW (2012) Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP. P Natl Acad Sci USA 109: E905-E913.
4. Corpet F (1988) Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res 16: 10881-10890.
5. Deutscher J & Saier MH Jr (2005) Ser/Thr/Tyr protein phosphorylation in bacteria - for long time neglected, now well established. J Mol Microbiol Biotechnol 9: 125-131.
6. Echenique J, Kadioglu A, Romao S, Andrew PW & Trombe MC (2004) Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae. Infect Immun 72: 2434-2437.
7. El Zoeiby A, Sanschagrin F & Levesque RC (2003) Structure and function of the Mur enzymes: development of novel inhibitors. Mol Microbiol 47: 1-12.
8. Fiuza M, Canova MJ, Patin D, Letek M, Zanella-Cléon I, Becchi M, Mateos LM, Mengin-Lecreulx D, Molle V & Gil JA (2008) The MurC ligase essential for peptidoglycan biosynthesis is regulated by the serine/threonine protein kinase PknA in Corynebacterium glutamicum. J Biol Chem 283: 36553-36563.
9. Gee SH, Sekely SA, Lombardo C, Kurakin A, Froehner SC & Kay BK (1998) Cyclic peptides as non-carboxyl-terminal ligands of syntrophin PDZ domains. J Biol Chem 273: 21980-21987.
10. Giefing C, Jelencsics KE, Gelbmann D, Senn BM & Nagy E (2010) The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro. Microbiology 156: 1697-1707.
11. Gordon E, Mouz N, Duée E & Dideberg O (2000) The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance. J Mol Biol 299: 477-485.
12. Jones G & Dyson P (2006) Evolution of transmembrane protein kinases implicated in coordinating remodeling of gram-positive peptidoglycan: inside versus outside. J Bacteriol 188: 7470-7476.
13. Kennelly PJ (2002) Protein kinases and protein phosphatases in prokaryotes: a genomic perspective. FEMS Microbiol Lett 206: 1-8.
14. Maestro B, Novaková L, Hesek D, Lee M, Leyva E, Mobashery S, Sanz JM & Branny P (2011) Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae. FEBS Lett 585: 357-363.
15. Nováková L, Sasková L, Pallová P, Janecek J, Novotná J, Ulrych A, Echenique J, Trombe MC & Branny P (2005) Characterization of a eukaryotic type serine/threonine protein kinase and protein phosphatase of Streptococcus pneumoniae and identification of kinase substrates. FEBS J 272: 1243-1254.
16. Nováková L, Bezousková S, Pompach P, Spidlová P, Sasková L, Weiser J & Branny P (2010) Identification of multiple substrates of the StkP Ser/Thr protein kinase in Streptococcus pneumoniae. J Bacteriol 192: 3629-3638.
17. Osaki M, Arcondéguy T, Bastide A, Touriol C, Prats H & Trombe MC (2009) The StkP/PhpP signaling couple in Streptococcus pneumoniae: cellular organization and physiological characterization. J Bacteriol 191: 4943-4950.
18. Rajagopal L, Clancy A & Rubens CE (2003) A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence. J Biol Chem 278: 14429-14441.
19. Rajagopal L, Vo A, Silvestroni A & Rubens CE (2006) Regulation of cytotoxin expression by converging eukaryotic-type and two-component signaling mechanisms in Streptococcus agalactiae. Mol Microbiol 62: 941-957.
20. Sasková L, Nováková L, Basler M & Branny P (2007) Eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae. J Bacteriol 189: 4168-4179.
21. Smith CA (2006) Structure, function and dynamics in the mur family of bacterial cell wall ligases. J Mol Biol 362: 640-655.
22. Sparks A, Adey N, Cwirla S & Kay BK (1996) Screening phage-displayed random peptide libraries. Phage Display of Peptides and Proteins: A Laboratory Manual (Kay BK, Winter J & McCafferty J, eds), pp. 227-253. Academic Press, San Diego, CA.
23. Standish AJ, Stroeher UH & Paton JC (2007) The pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms. J Bacteriol 189: 5591-6000.
24. Sun X, Ge F, Xiao CL, Yin XF, Ge R, Zhang LH & He QY (2010) Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae. J Proteome Res 9: 275-282.
25. Thakur M & Chakraborti PK (2008) Ability of PknA, a mycobacterial eukaryotic-type serine/threonine kinase, to transphosphorylate MurD, a ligase involved in the process of peptidoglycan biosynthesis. Biochem J 415: 27-33.
26. Ulijasz AT, Falk SP & Weisblum B (2009) Phosphorylation of the RitR DNA-binding domain by a Ser-Thr phosphokinase: implications for global gene regulation in the streptococci. Mol Microbiol 71: 382-390.
27. van Heijenoort J (2001) Recent advances in the formation of the bacterial peptidoglycan monomer unit. Nat Prod Rep 18: 503-519.
28. Yeats C, Finn RD & Bateman A (2002) The PASTA domain: a beta-lactam-binding domain. Trends Biochem Sci 27: 438-440.