Impact of omega-3 fatty acids and/or plant sterol supplementation on non-HDL cholesterol levels of dyslipidemic Indian adults

Journal of Functional Foods

Volumn 5, Issue 1, 2013, Pages 36-43

  Khandelwal, Shweta ^a,b   Shidhaye, Rahul ^b   Demonty, Isabelle ^c   Lakshmy, Ramakrishnan ^d   Gupta, Ruby ^d   Prabhakaran, Dorairaj ^a   Reddy, Srinath ^b  

^a Centre for Chronic Disease Control (CCDC)   (India)

^b PUBLIC HEALTH FOUNDATION OF INDIA   (India)

^c UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^d ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Dyslipidemia; Fish oil; Interaction; Non HDL C; Omega 3 fatty acids; Plant sterols

Indexed keywords

EID: 84873245151     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2012.08.001     Document Type: Article

References (42)

1. Aalbers J. Omega-3 intake in patients with coronary artery disease: Focus on recent studies. Cardiovascular Journal of Africa 2010, 21(1):50.
2. Abeywardena M.Y., Patten G.S. Role of omega3 longchain polyunsaturated fatty acids in reducing cardio-metabolic risk factors. Endocrine Metabolic & Immune Disorders - Drug Targets 2011, 11(3):232-246.
3. Abumweis S.S., Barake R., Jones P.J. Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. Food & Nutrition Research 2008, 52. 10.3402/fnr.v52i0.1811.
4. Arnesen H., Seljeflot I. Studies on very long chain marine n-3 fatty acids in patients with atherosclerotic heart disease with special focus on mechanisms, dosage and formulas of supplementation. Cellular & Molecular Biology (Noisy-le-grand) 2010, 56(1):18-27.
5. Baber N. International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use (ICH). British Journal of Clinical Pharmacology 1994, 37(5):401-404.
6. Balk E.M., Lichtenstein A.H., Chung M., Kupelnick B., Chew P., Lau J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 2006, 189(1):19-30.
7. Baumgartner S., Mensink R.P., Plat J. Plant sterols and stanols in the treatment of dyslipidemia: New insights into targets and mechanisms related to cardiovascular risk. Current Pharmaceutical Design 2011, 17(9):922-932.
8. Bays H.E., McKenney J., Maki K.C., Doyle R.T., Carter R.N., Stein E. Effects of prescription omega-3-acid ethyl esters on non-high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin. Mayo Clinic Proceedings 2010, 85(2):22-128.
9. Brunzell J.D., Davidson M., Furberg C.D., Goldberg R.B., Howard B.V., Stein J.H., Witztum J.L. Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care 2008, 31(4):811-822.
10. Brunzell J.D., Davidson M., Furberg C.D., Goldberg R.B., Howard B.V., Stein J.H., Witztum J.L. Lipoprotein management in patients with cardiometabolic risk: Consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation. Journal of the American College of Cardiology 2008, 51(15):1512-1524.
11. Cui Y., Blumenthal R.S., Flaws J.A., Whiteman M.K., Langenberg P., Bachorik P.S., Bush T.L. Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality. Archives of Internal Medicine 2001, 161(11):1413-1419.
12. Davidson M.H., Stein E.A., Bays H.E., Maki K.C., Doyle R.T., Shalwitz R.A., Ballantyne C.M., Ginsberg H.N. Combination of prescription Omega-3 with Simvastatin (COMBOS) Investigators. Efficacy and tolerability of adding prescription omega-3 fatty acids 4g/d to simvastatin 40mg/d in hypertriglyceridemic patients: An 8-week, randomized, double-blind, placebo-controlled study. Clinical Therapeutics 2007, 29(7):1354-1367.
13. de Goede J., Geleijnse J.M., Boer J.M., Kromhout D., Verschuren W.M. Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake. Journal of Nutrition 2010, 140(5):1023-1028.
14. Demonty I., Chan Y.M., Pelled D., Jones P.J. Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols. American Journal of Clinical Nutrition 2006, 84(6):1534-1542.
15. Demonty I., Ras R.T., van der Knaap H.C., Duchateau G.S., Meijer L., Zock P.L., Geleijnse J.M., Trautwein E.A. Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake. Journal of Nutrition 2009, 139(2):271-284.
16. Devaraj S., Jialal I. The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease. Nutrition Reviews 2006, 64(7 Pt. 1):348-354.
17. Heritier S.R., Gebski V.J., Keech A.C. Inclusion of patients in clinical trial analysis: The intention-to-treat principle. Medical Journal of Australia 2003, 179(8):438-440.
18. Hirsch G.A., Vaid N., Blumenthal R.S. Perspectives: The significance of measuring non-HDL-cholesterol. Preventive Cardiology 2002, 5(3):156-159.
19. Jacobson T.A. Beyond lipids: The role of omega-3 fatty acids from fish oil in the prevention of coronary heart disease. Current Atherosclerosis Reports 2007, 9(2):145-153.
20. Jacobson T.A. Role of n-3 fatty acids in the treatment of hypertriglyceridemia and cardiovascular disease. American Journal of Clinical Nutrition 2008, 87(6):1981S-1990S.
21. Katan M.B., Grundy S.M., Jones P., Law M., Miettinen T., Paoletti R., Stresa Workshop Participants Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clinic Proceedings 2003, 78(8):965-978.
22. Khandelwal S., Demonty I., Jeemon P., Lakshmy R., Mukherjee R., Gupta R., Snehi U., Niveditha D., Singh Y., van der Knaap H.C., Passi S.J., Prabhakaran D., Reddy K.S. Independent and interactive effects of plant sterols and fish oil n-3 long-chain polyunsaturated fatty acids on the plasma lipid profile of mildly hyperlipidaemic Indian adults. British Journal of Nutrition 2009, 102(5):722-732.
23. Kris-Etherton P.M., Harris W.S., Appel L.J. Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arteriosclerosis, Thrombosis and Vascular Biology 2003, 23(2):151-152.
24. Kromhout D., Giltay E.J., Geleijnse J.M. N-3 fatty acids and cardiovascular events after myocardial infarction. New England Journal of Medicine 2010, 363(21):2015-2026.
25. Lau V.W., Journoud M., Jones P.J. Plant sterols are efficacious in lowering plasma LDL and non-HDL cholesterol in hypercholesterolemic type 2 diabetic and nondiabetic persons. American Journal of Clinical Nutrition 2005, 81(6):1351-1358.
26. Lee K.W., Lip G.Y. The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease. QJM: Monthly Journal of the Association of Physicians 2003, 96(7):465-480.
27. Lichtenstein A.H., Appel L.J., Brands M., Carnethon M., Daniels S., Franch H.A., Franklin B., Kris-Etherton P., Harris W.S., Howard B., Karanja N., Lefevre M., Rudel L., Sacks F., Van Horn L., Winston M., Wylie-Rosett J. Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006. Arteriosclerosis, Thrombosis and Vascular Biology 2006, 26(10):2186-2191.
28. Micallef M.A., Garg M.L. The lipid-lowering effects of phytosterols and (n-3) polyunsaturated fatty acids are synergistic and complementary in hyperlipidemic men and women. Journal of Nutrition 2008, 138(6):1086-1090.
29. Micallef M.A., Garg M.L. Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals. Atherosclerosis 2009, 204(2):476-482.
30. Moreau R.A., Whitaker B.D., Hicks K.B. Phytosterols, phytostanols, and their conjugates in foods: Structural diversity, quantitative analysis, and health-promoting uses. Progress in Lipid Research 2002, 41:457-500.
31. Mozaffarian D., Wu J.H. Omega-3 fatty acids and cardiovascular disease: Effects on risk factors, molecular pathways, and clinical events. Journal of the American College of Cardiology 2011, 58(20):2047-2067.
32. Murphy K.J., Meyer B.J., Mori T.A., Burke V., Mansour J., Patch C.S., Tapsell L.C., Noakes M., Clifton P.A., Barden A., Puddey I.B., Beilin L.J., Howe P.R. Impact of foods enriched with n-3 long-chain polyunsaturated fatty acids on erythrocyte n-3 levels and cardiovascular risk factors. British Journal of Nutrition 2007, 97(4):749-757.
33. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (2002). Final report (pp. 3143-4321).
34. Plat J., Brufau G., Dallinga-Thie G.M., Dasselaar M., Mensink R.P. A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients. Journal of Nutrition 2009, 139(6):1143-1149.
35. Pocock S.J., Assmann S.E., Enos L.E., Kasten L.E. Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: Current practice and problems. Statistics in Medicine 2002, 21(19):2917-2930.
36. Reiner E., Tedeschi-Reiner E., Stajminger G. The role of omega-3 fatty acids from fish in prevention of cardiovascular diseases. Lijec Vjesn 2007, 129(10-11):350-355.
37. Robinson J.G., Wang S., Smith B.J., Jacobson T.A. Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk. Journal of the American College of Cardiology 2009, 53(4):316-322.
38. Sawant A.M., Shetty D., Mankeshwar R., Ashavaid T.F. Prevalence of dyslipidemia in young adult Indian population. Journal of the Association of the Physicians of India 2008, 56:99-102.
39. Srinath R.K., Katan M.B. Diet, nutrition and the prevention of hypertension and cardiovascular diseases. Public Health Nutrition 2004, 7(1A):167-186.
40. St-Onge M.P., Jones P.J. Phytosterols and human lipid metabolism: Efficacy, safety, and novel foods. Lipids 2003, 38(4):367-375.
41. Wang C.Y., Chang T.C. Non-HDL cholesterol level is reliable to be an early predictor for vascular inflammation in type 2 diabetes mellitus. Journal of Clinical Endocrinology & Metabolism 2004, 89(9):4762-4767.
42. Weidner C., Krempf M., Bard J.M., Cazaubiel M., Bell D. Cholesterol lowering effect of a soy drink enriched with plant sterols in a French population with moderate hypercholesterolemia. Lipids in Health and Disease 2008, 7:35.