Microbiological and biochemical origins of human axillary odour

FEMS Microbiology Ecology

Volumn 83, Issue 3, 2013, Pages 527-540

  James, A Gordon ^a   Austin, Corrine J ^a,b   Cox, Diana S ^a   Taylor, David ^a   Calvert, Ralph ^a  

^a UNILEVER RESEARCH   (United Kingdom)

^b Austin Davis Biologics Ltd   (United Kingdom)

Author keywords

16 androstene; Axilla; C S lyase; Corynebacterium; Thioalcohol; Volatile fatty acid

Indexed keywords

16-ANDROSTENE; ALCOHOL DERIVATIVE; ANDROST 16 ENE; ANDROSTANE DERIVATIVE; VOLATILE FATTY ACID;

BIOTRANSFORMATION; DATA PROCESSING; ENZYME ACTIVITY; METABOLISM; MICROBIAL COMMUNITY; MICROBIOLOGY; ODOR; SECRETION; SKIN;

APOCRINE GLAND; AXILLA; CHEMISTRY; CORYNEBACTERIUM; HUMAN; METABOLISM; MICROBIOLOGY; MICROCOCCUS; ODOR; PROPIONIBACTERIUM; SEBACEOUS GLAND; SHORT SURVEY; SKIN; STAPHYLOCOCCUS; SWEAT GLAND;

ALCOHOLS; ANDROSTENES; APOCRINE GLANDS; AXILLA; CORYNEBACTERIUM; ECCRINE GLANDS; FATTY ACIDS, VOLATILE; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MICROCOCCUS; ODORS; PROPIONIBACTERIUM; SEBACEOUS GLANDS; SKIN; STAPHYLOCOCCUS;

CORYNEBACTERIUM; MICROCOCCUS; POSIBACTERIA; PROPIONIBACTERIUM; STAPHYLOCOCCUS;

EID: 84873204477     PISSN: 01686496     EISSN: 15746941     Source Type: Journal    
DOI: 10.1111/1574-6941.12054     Document Type: Short Survey

References (45)

1. Akiba S, Arai N, Kusuoku H, Takagi Y, Hagura T, Takeuchi K & Fuji A (2011) The N-terminal amino acid of apolipoprotein D is putatively covalently bound to 3-hydroxy-3-methyl hexanoic acid, a key odour compound in axillary sweat. Int J Cosmet Sci 33: 283-286.
2. Amoore JE (1977) Specific anosmia and the concept of primary odors. Chem Senses 2: 267-281.
3. Austin C & Ellis J (2003) Microbial pathways leading to steroidal malodour in the axilla. J Steroid Biochem Mol Biol 87: 105-110.
4. Barzantny H, Brune I & Tauch A (2012a) Molecular basis of human body odor formation: insights deduced from corynebacterial genome sequences. Int J Cosmet Sci 34: 2-11.
5. Barzantny H, Schroder J, Strotmeier J, Fredrrich E, Brune I & Tauch A (2012b) The transcriptional regulatory network of Corynebacterium jeikeium K411 and its interaction with metabolic routes contributing to human body odor formation. J Biotechnol 159: 235-248.
6. Bennett S (2004) Solexa Ltd. Pharmacogenomics 5: 433-438.
7. Brune I, Barzantny H, Klotzel M, Jones J, James G & Tauch A (2010) Identification of McbR as a transcription regulator of aecD and genes involved in methionine biosynthesis in Corynebacterium jeikeium K411. J Biotechnol 151: 22-29.
8. 2U-globulins and aphrodisin. Biochim Biophys Acta 1482: 218-228.
9. Claus R & Alsing W (1976) Occurrence of 5α-androst-16-en-3-one, a boar pheromone, in man and its relationship to testosterone. J Endrocrinol 68: 483-484.
10. Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI & Knight R (2009) Bacterial community variation in human body habitats across space and time. Science 326: 1694-1697.
11. Egert M, Schmidt I, Hohne HM, Lachnit T, Schmitz RA & Breves R (2011) rRNA-based profiling of bacteria in the axilla of healthy males suggests right-left asymmetry in bacterial activity. FEMS Microbiol Ecol 77: 146-153.
12. Emter R & Natsch A (2008) The sequential action of a dipeptidase and a beta-lyase is required for the release of the human body odorant 3-methyl-3-sulfanylhexan-1-ol from a secreted Cys-Gly-(S) conjugate by Corynebacteria. J Biol Chem 283: 20645-20652.
13. Gower DB, Holland KT, Mallet AI, Rennie PJ & Watkins WJ (1994) Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions: interconversions of 16-androstenes by the axillary microflora - a mechanism for axillary odour production in man? J Steroid Biochem Mol Biol 48: 409-418.
14. Grice EA, Kong HH, Conlan S et al. (2009) Topographical and temporal diversity of the human skin microbiome. Science 324: 1190-1192.
15. Hasegawa Y, Yabuki M & Matsukane M (2004) Identification of new odoriferous compounds in human axillary sweat. Chem Biodivers 1: 2042-2050.
16. Holland KT (1993) Nutrition of cutaneous resident microorganisms. The Skin Microflora and Microbial Skin Disease (Noble WC, ed), pp. 33-72. University Press, Cambridge, UK.
17. James AG, Casey J, Hyliands D & Mycock G (2004a) Fatty acid metabolism by cutaneous bacteria and its role in axillary malodour. World J Microbiol Biotechnol 20: 787-793.
18. James AG, Hyliands D & Johnston H (2004b) Generation of volatile fatty acids by axillary bacteria. Int J Cosmet Sci 26: 149-156.
19. Kanlayavattanakul M & Lourith N (2011) Body malodours and their topical treatment agents. Int J Cosmet Sci 33: 298-311.
20. Kuhn F & Natsch A (2009) Body odour of monozygotic human twins: a common pattern of of odorant carboxylic acids released by a bacterial aminoacylase from axilla secretions contributing to an inherited body odour type. J R Soc Interface 6: 377-392.
21. Leyden JJ, McGinley KJ, Holzle E, Labows JN & Kligman AM (1981) The microbiology of the human axilla and its relationship to axillary odor. J Invest Dermatol 77: 413-416.
22. Margulies M, Egholm M, Altman WE et al. (2005) Genome sequencing in microfabricated high-density picolitre reactors. Nature 437: 376-380.
23. Martin A, Saathoff M, Kuhn F, Max H, Terstegen L & Natsch A (2010) A functional ABCC11 allele is essential in the biochemical formation of human axillary odor. J Invest Dermatol 130: 529-540.
24. Natsch A, Gfeller H, Gygax P, Schmid J & Acuna G (2003) A specific bacterial aminoacylase cleaves odorant precursors secreted in the human axilla. J Biol Chem 278: 5718-5727.
25. Natsch A, Schmid J & Flachsmann F (2004) Identification of odoriferous sulfanylalkanols in human axilla secretions and their formation through cleavage of cysteine precursors by a C-S lyase isolated from axilla bacteria. Chem Biodivers 1: 1058-1072.
26. Natsch A, Derrer S, Flachsmann F & Schmid J (2006) A broad diversity of volatile carboxylic acids, released by a bacterial aminoacylase from axilla secretions, as candidate molecules for the determination of human-body odor type. Chem Biodivers 3: 1-20.
27. Natsch A, Kuhn F & Tiercy J-M (2010) Lack of evidence for HLA-linked patterns of odorous carboxylic acids released from glutamine conjugates secreted in the human axilla. J Chem Ecol 36: 837-846.
28. Nelson KE & White BA (2010) Metagenomics and its applications to the study of the human microbiome. Metagenomics: Theory, Methods and Applications (Marco D, ed), pp. 171-182. Caister Academic Press, Norfolk, UK.
29. Nicolaides N (1974) Skin lipids: their biochemical uniqueness. Science 186: 19-26.
30. Rothberg JM, Hinz W, Rearick TM et al. (2011) An integrated semiconductor device enabling non-optical genome sequencing. Nature 475: 348-352.
31. Shelley WB, Hurley HJ Jr & Nichols AC (1953) Axillary odor - experimental study of the role of bacteria, apocrine sweat, and deodorants. AMA Arch Derm Syphilol 68: 430-446.
32. Song Y, Liu C & Finegold SM (2007) Development of a flow chart for identification of Gram-positive anaerobic cocci in the clinical laboratory. J Clin Microbiol 45: 512-516.
33. Spielman AI, Zeng X-N, Leyden JJ & Preti G (1995) Proteinaceous precursors of human axillary odor: isolation of two novel odor-binding proteins. Experientia 51: 40-47.
34. Starkenmann C, Niclass Y, Troccaz M & Clark AJ (2005) Identification of the precursor of (S)-3-methyl-3-sulfanylhexan-1-ol, the sulfury malodour of human axilla sweat. Chem Biodivers 2: 705-716.
35. Tauch A, Kaiser O, Hain T et al. (2005) Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. J Bacteriol 187: 4671-4682.
36. Taylor D, Daulby A, Grimshaw S, James G, Mercer J & Vaziri S (2003) Characterization of the microflora of the human axilla. Int J Cosmet Sci 25: 137-145.
37. Tominaga T, Peyrot des Gachons C & Dubourdieu D (1998) A new type of flavour precursors in Vitis vinifera L. cv. Sauvignon Blanc: S-cysteine conjugates. J Agric Food Chem 46: 5215-5219.
38. Troccaz M, Starkenmann C, Niclass Y, van de Waal M & Clark AJ (2004) 3-methyl-3-sulfanylhaxan-1-ol as a major descriptor for the human axilla-sweat odour profile. Chem Biodivers 1: 1022-1035.
39. Troccaz M, Benattia F, Borchard G & Clark AJ (2008) Properties of recombinant Staphylococcus haemolyticus cystathionine β-lyase (metC) and its potential role in the generation of volatile thiols in axillary malodour. Chem Biodivers 5: 2372-2385.
40. Troccaz M, Borchard G, Vuilleumier C, Raviot-Derrien S, Niclass Y, Beccucci S & Starkenmann C (2009) Gender-specific differences between the concentrations of nonvolatile (R)/(S)-3-methyl-3-sulfanylhexan-1-ol and (R)/(S)-3-hydroxy-3-methyl-hexanoic acid odor precursors in axillary secretions. Chem Senses 34: 203-210.
41. Williamson P & Kligman AM (1965) A new method for the quantitative investigation of cutaneous bacteria. J Invest Dermatol 45: 498-503.
42. Yoshiura K, Kinoshita A, Ishida T et al. (2006) A SNP in the ABCC11 gene is the determinant of human earwax type. Nat Genet 38: 324-330.
43. Zdych E, Peist R, Reidl J & Boos W (1995) MalY of Escherichia coli is an enzyme with the activity of a beta C-S lyase (cystathionase). J Bacteriol 177: 5035-5039.
44. Zeng X-N, Leyden JJ, Lawley HJ, Sawano K, Nohara I & Preti G (1991) Analysis of characteristic odors from human male axillae. J Chem Ecol 17: 1469-1492.
45. Zeng C, Spielman AI, Vowels BR, Leyden JJ, Biemann K & Preti G (1996) A human axillary odorant is carried by apolipoprotein D. P Natl Acad Sci USA 93: 6626-6630.