Interrelations between blood-brain barrier permeability and matrix metalloproteinases are differently affected by tissue plasminogen activator and hyperoxia in a rat model of embolic stroke

Medical Gas Research

Volumn 2, Issue 1, 2012, Pages

  Michalski, Dominik ^a   Hobohm, Carsten ^a   Weise, Christopher ^a   Pelz, Johann ^a   Heindl, Marita ^a   Kamprad, Manja ^a   Kacza, Johannes ^a   Härtig, Wolfgang ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

blood brain barrier; Experimental stroke; FITC albumin; HBO; MMP; NBO; TIMP; tissue plasminogen activator

Indexed keywords

ALBUMIN; ALTEPLASE; GELATINASE A; GELATINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPERBARIC OXYGEN; HYPEROXIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT;

EID: 84873197356     PISSN: None     EISSN: 20459912     Source Type: Journal    
DOI: 10.1186/2045-9912-2-2     Document Type: Article

References (25)

1. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D, ECASS Investigators, N Engl J Med 2008 359 1317 1329 10.1056/NEJMoa0804656 18815396
2. Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis. Kelly MA, Shuaib A, Todd KG, Exp Neurol 2006 200 38 49 10.1016/j.expneurol.2006.01.032 16624294 (Pubitemid 44080746)
3. Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. Adibhatla RM, Hatcher JF, CNS Neurol Disord Drug Targets 2008 7 243 253 10.2174/187152708784936608 18673209
4. Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Jin R, Yang G, Li G, Neurobiol Dis 2010 38 376 385 10.1016/j.nbd.2010.03.008 20302940
5. Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes. Ergul A, Elgebaly MM, Middlemore ML, Li W, Elewa H, Switzer JA, Hall C, Kozak A, Fagan SC, BMC Neurol 2007 7 33 10.1186/1471-2377-7-33 17937795 (Pubitemid 350193885)
6. Improved prediction of poor outcome after thrombolysis using conservative definitions of symptomatic hemorrhage. Gumbinger C, Gruschka P, Böttinger M, Heerlein K, Barrows R, Hacke W, Ringleb P, Stroke 2012 43 240 242 10.1161/STROKEAHA.111.623033 21998049
7. Multiple roles for MMPs and TIMPs in cerebral ischemia. Cunningham LA, Wetzel M, Rosenberg GA, Glia 2005 50 329 339 10.1002/glia.20169 15846802 (Pubitemid 40780839)
8. Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Candelario-Jalil E, Yang Y, Rosenberg GA, Neuroscience 2009 158 983 994 10.1016/j.neuroscience. 2008.06.025 18621108
9. Multiphasic roles for matrix metalloproteinases after stroke. Rosell A, Lo EH, Curr Opin Pharmacol 2008 8 82 89 10.1016/j.coph.2007.12.001 18226583
10. rt-PA causes a dose-dependent increase in the extravasation of cellular and non-cellular blood elements after focal cerebral ischemia. Burggraf D, Martens HK, Dichgans M, Hamann GF, Brain Res 2007 1164 55 62 17644075 (Pubitemid 47198222)
11. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Aoki T, Sumii T, Mori T, Wang X, Lo EH, Stroke 2002 33 2711 2717 10.1161/01.STR.0000033932.34467.97 12411666 (Pubitemid 35266446)
12. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J, Lo EH, Stroke 2005 36 1954 1959 10.1161/01.STR.0000177517.01203.eb 16051896 (Pubitemid 41266533)
13. Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment? Morancho A, Rosell A, García-Bonilla L, Montaner J, Ann N Y Acad Sci 2010 1207 123 133 10.1111/j.1749-6632.2010.05734.x 20955435
14. Improving outcome after stroke: overcoming the translational roadblock. Endres M, Engelhardt B, Koistinaho J, Lindvall O, Meairs S, Mohr JP, Planas A, Rothwell N, Schwaninger M, Schwab ME, Vivien D, Wieloch T, Dirnagl U, Cerebrovasc Dis 2008 25 268 278 10.1159/000118039 18292653 (Pubitemid 351450431)
15. Jain KK, Textbook of Hyperbaric Medicine Göttingen: Hogrefe & Huber 5 2009
16. A review of oxygen therapy in ischemic stroke. Singhal AB, Neurol Res 2007 29 173 183 10.1179/016164107X181815 17439702 (Pubitemid 46685270)
17. Hyperbaric oxygen reduces basal lamina degradation after transient focal cerebral ischemia in rats. Veltkamp R, Bieber K, Wagner S, Beynon C, Siebing DA, Veltkamp C, Schwaninger M, Marti HH, Brain Res 2006 1076 231 237 10.1016/j.brainres.2006.01.013 16480689 (Pubitemid 43376043)
18. Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia. Sun L, Zhou W, Mueller C, Sommer C, Heiland S, Bauer AT, Marti HH, Veltkamp R, J Cereb Blood Flow Metab 2010 30 1651 1660 10.1038/jcbfm.2010.50 20424638
19. Normobaric hyperoxia reduces the neurovascular complications associated with delayed tissue plasminogen activator treatment in a rat model of focal cerebral ischemia. Liu W, Hendren J, Qin XJ, Liu KJ, Stroke 2009 40 2526 2531 10.1161/STROKEAHA.108.545483 19478225
20. Early outcome and blood-brain barrier integrity after co-administered thrombolysis and hyperbaric oxygenation in experimental stroke. Michalski D, Pelz J, Weise C, Kacza J, Boltze J, Grosche J, Kamprad M, Schneider D, Hobohm C, Härtig W, Exp Transl Stroke Med 2011 3 5 10.1186/2040-7378-3-5 21679435
21. A rat model of focal embolic cerebral ischemia. Zhang RL, Chopp M, Zhang ZG, Jiang Q, Ewing JR, Brain Res 1997 766 83 92 10.1016/S0006-8993(97)00580-5 9359590 (Pubitemid 27431437)
22. A novel quantification of blood-brain barrier damage and histochemical typing after embolic stroke in rats. Michalski D, Grosche J, Pelz J, Schneider D, Weise C, Bauer U, Kacza J, Gärtner U, Hobohm C, Härtig W, Brain Res 2010 1359 186 200 20732314
23. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH, BMC Neurosci 2009 10 79 10.1186/1471-2202-10-79 19604385
24. Neuroprotection and stroke: time for a compromise. Young AR, Ali C, Duretête A, Vivien D, J Neurochem 2007 103 1302 1309 10.1111/j.1471-4159. 2007.04866.x 17727635 (Pubitemid 47631819)
25. Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH, Stroke 2009 40 2836 2842 10.1161/STROKEAHA.109.554824 19556529