MARTX of Vibrio vulnificus biotype 2 is a virulence and survival factor

Environmental Microbiology

Volumn 15, Issue 2, 2013, Pages 419-432

  Lee, Chung Te ^c   Pajuelo, David ^a   Llorens, Amparo ^a   Chen, Yi Hsuan ^c   Leiro, José M ^d   Padrós, Francesc ^e   Hor, Lien I ^b,c   Amaro, Carmen ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; RTXA PROTEIN, VIBRIO CHOLERAE; VIRULENCE FACTOR;

AMOEBA (LIFE CYCLE STAGE); ANIMAL; ANIMAL DISEASE; ARTICLE; CELL LINE; EEL; EPITHELIUM CELL; FISH DISEASE; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; METABOLISM; MICROBIOLOGY; MOUSE; PATHOGENICITY; PHAGOCYTE; PHAGOCYTOSIS; PLASMID; VIBRIO VULNIFICUS; VIBRIOSIS;

AMOEBA; ANIMALS; BACTERIAL TOXINS; CELL LINE; EELS; EPITHELIAL CELLS; FISH DISEASES; GENE EXPRESSION REGULATION, BACTERIAL; HOST-PATHOGEN INTERACTIONS; HUMANS; MICE; PHAGOCYTES; PHAGOCYTOSIS; PLASMIDS; VIBRIO INFECTIONS; VIBRIO VULNIFICUS; VIRULENCE FACTORS;

AMOEBA (GENUS); BACTERIA (MICROORGANISMS); EUKARYOTA; MURINAE; MUS; VIBRIO VULNIFICUS;

EID: 84873192379     PISSN: 14622912     EISSN: 14622920     Source Type: Journal    
DOI: 10.1111/j.1462-2920.2012.02854.x     Document Type: Article

References (39)

1. Amaro, C., and Biosca, E.G. (1996) Vibrio vulnificus biotype 2, pathogenic for eels, is also an opportunistic pathogen for humans. Appl Environ Microbiol 62: 1454-1457.
2. Amaro, C., Biosca, E.G., Fouz, B., Toranzo, A.E., and Garay, E. (1994) Role of iron, capsule, and toxins in the pathogenicity of Vibrio vulnificus biotype 2 for mice. Infect Immun 62: 759-763.
3. Amaro, C., Biosca, E.G., Fouz, B., Alcaide, E., and Esteve, C. (1995) Evidence that water transmits Vibrio vulnificus biotype 2 infections to eels. Appl Environ Microbiol 61: 1133-1137.
4. Biosca, E.G., and Amaro, C. (1996) Toxic and enzymatic activities of Vibrio vulnificus biotype 2 with respect to host specificity. Appl Environ Microbiol 62: 2331-2337.
5. Biosca, E.G., Llorens, H., Garay, E., and Amaro, C. (1993) Presence of a capsule in Vibrio vulnificus biotype 2 and its relationship to virulence for eels. Infect Immun 61: 1611-1618.
6. Biosca, E.G., Fouz, B., Alcaide, E., and Amaro, C. (1996) Siderophore-mediated iron acquisition mechanisms in Vibrio vulnificus biotype 2. Appl Environ Microbiol 62: 928-935.
7. Bisharat, N., Agmon, V., Finkelstein, R., Raz, R., Ben-Dror, G., Lerner, L., etal. (1999) Clinical, epidemiological, and microbiological features of Vibrio vulnificus biogroup 3 causing outbreaks of wound infection and bacteraemia in Israel. Israel Vibrio Study Group. Lancet 354: 1421-1424.
8. Callol, A., Amaro, C., Goetz, F.W., and Mackenzie, S.A. (2011) Deep sequencing of the European eel immunome. Abstr. Genomics in Aquaculture International Symposium GIA Heraklion, Crete (Greece).
9. Cohen, A.L., Oliver, J.D., DePaola, A., Feil, E.J., and Boyd, E.F. (2007) Emergence of a virulent clade of Vibrio vulnificus and correlation with the presence of a 33-kilobase genomic island. Appl Environ Microbiol 73: 5553-5565.
10. Donnenberg, M.S., and Kaper, J.B. (1991) Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect Immun 59: 4310-4317.
11. Esteve-Gasent, M.D., and Amaro, C. (2004) Immunogenic antigens of the eel pathogen Vibrio vulnificus serovar E. Fish Shellfish Immunol 17: 277-291.
12. Huang, C.Y., Lee, C.T., and Hor., L.I. (2010) Can the eel-nonvirulent biotype 1 Vibrio vulnificus strains be converted into eel-virulent ones by acquiring the virulence plasmid via conjugation between the two biotypes? Abstr. Vibrios in the Environment. Biloxi (USA).
13. Iliev, D.V., Roach, J.C., Mackenzie, S., Planas, J.V., and Goetz, F.W. (2005) Endotoxin recognition: in fish or not in fish. FEBS Lett 579: 6519-6528.
14. Jones, M.K., and Oliver, J.D. (2009) Vibrio vulnificus: disease and pathogenesis. Infect Immun 77: 1723-1733.
15. Kim, Y.R., Lee, S.E., Kook, H., Yeom, J.A., Na, H.S., Kim, S.Y., etal. (2008) Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells. Cell Microbiol 10: 848-862.
16. Kou, G.H., Wang, C.H., Hung, H.W., Jang, Y.S., Chou, C.M., and Lo, C.F. (1995) A cell line (EP-1 cell line) derived from 'Beko disease' affected Japanese eel elver (Anguilla japonica) persistently infected with Pleistophora anguillarum. Aquaculture 132: 161-173.
17. Kwak, J.S., Jeong, H.G., and Satchell, K.J. (2011) Vibrio vulnificus rtxA gene recombination generates toxin variants with altered potency during intestinal infection. Proc Natl Acad Sci USA 108: 1645-1650.
18. Lamas, J., Santos, Y., Bruno, D., Toranzo, A.E., and Anadón, R. (1994) A comparison of pathological changes caused by Vibrio anguillarum and its extracellular products in rainbow trout (Oncorhynchus mykiss). Fish Pathol 29: 79-89.
19. Lee, C.T., Amaro, C., Wu, K.M., Valiente, E., Chang, Y.F., Tsai, S.F., etal. (2008) A common virulence plasmid inbiotype 2 Vibrio vulnificus and its dissemination aided by a conjugal plasmid. J Bacteriol 190: 1638-1648.
20. Lee, J.H., Kim, M.W., Kim, B.S., Kim, S.M., Lee, B.C., Kim, T.S., and Choi, S.H. (2007) Identification and characterization of the Vibrio vulnificus rtxA essential for cytotoxicity in vitro and virulence in mice. J Microbiol 45: 146-152.
21. Leiro, J., Paniagua, E., Ortega, M., Paramá, A., Fernández, J., and Sanmartín, M.L. (1998) An amoeba associated with gill disease in turbot, Scophthalmus maximus. J Fish Dis 21: 281-288.
22. Liu, M., Alice, A.F., Naka, H., and Crosa, J.H. (2007) The HlyU protein is a positive regulator of rtxA1, a gene responsible for cytotoxicity and virulence in the human pathogen Vibrio vulnificus. Infect Immun 75: 3282-3289.
23. Lo, H.R., Lin, J.H., Chen, Y.H., Chen, C.L., Shao, C.P., Lai, Y.C., and Hor, L.I. (2011) RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis. J Infect Dis 203: 1866-1874.
24. Marco-Noales, E., Milán, M., Fouz, B., Sanjuán, E., and Amaro, C. (2001) Transmission to eels, portals of entry, and putative reservoirs of Vibrio vulnificus serovar E (biotype 2). Appl Environ Microbiol 67: 4717-4725.
25. Miyazaki, T., and Kurata, K. (1987) Phagocytic response of exudate peritoneal cells of the japanese eel against Vibrio vulnificus. Bull Fac Fish 14: 33-40.
26. Morera, D., Roher, N., Ribas, L., Balasch, J.C., Doñate, C., Callol, A., etal. (2011) RNA-seq reveals an integrated immune response in nucleated erythrocytes. PLoS ONE 6: e26998.
27. Paniagua, E., Paramá, A., Iglesias, R., Sanmartín, M.L., and Leiro, J. (2001) Effects of bacteria on the growth of an amoeba infecting the gills of turbot. Dis Aquat Organ 45: 73-76.
28. Reed, M.J., and Münch, M. (1938) A simple method for estimating fifty percent endpoints. Am J Hyg 27: 493-497.
29. Roig, F.J., and Amaro, C. (2009) Plasmid diversity in Vibrio vulnificus biotypes. Microbiology 155: 489-497.
30. Roig, F.J., González-Candelas, F., and Amaro, C. (2011) Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus. Appl Environ Microbiol 77: 657-668.
31. Sambrook, J., and Russell, D.W. (2001) Molecular Cloning: A Laboratory Manual Cold, 3rd edn. New York, USA: Spring Harbor Laboratory Press.
32. Sanjuán, E., González-Candelas, F., and Amaro, C. (2011) Polyphyletic origin of Vibrio vulnificus biotype 2 as revealed by sequence-based analysis. Appl Environ Microbiol 77: 688-695.
33. Satchel, K. (2011) Structure and function of MARTX toxins and other large repetitive RTX proteins. Annu Rev Microbiol 65: 71-90.
34. Shao, C.P., and Hor, L.I. (2000) Metalloprotease is not essential for Vibrio vulnificus virulence in mice. Infect Immun 68: 3569-3573.
35. Shinoda, S., Miyoshi, S., Yamanaka, H., and Miyoshi-Nakahara, N. (1985) Some properties of Vibrio vulnificus hemolysin. Microbiol Immunol 29: 583-590.
36. Tison, D.L., Nishibuchi, M., Greenwood, J.D., and Seidler, R.J. (1982) Vibrio vulnificus biogroup 2: new biogroup pathogenic for eels. Appl Environ Microbiol 44: 640-646.
37. Valiente, E., and Amaro, C. (2006) A method to diagnose the carrier state of Vibrio vulnificus serovar E in eels: Development and field studies. Aquaculture 258: 173-179.
38. Valiente, E., Lee, C.T., Lamas, J., Hor, L.I., and Amaro, C. (2008) Role of the virulence plasmid pR99 and the metalloprotease Vvp in resistance of Vibrio vulnificus serovar E to eel innate immunity. Fish Shellfish Immunol 24: 134-141.
39. Zhang, Z., Schwartz, S., Wagner, L., and Miller, W. (2000) A greedy algorithm for aligning DNA sequences. J Comput Biol 7: 203-214.