Lack of haptoglobin results in unbalanced VEGFα/angiopoietin-1 expression, Intramural hemorrhage and impaired wound healing after myocardial infarction

Journal of Molecular and Cellular Cardiology

Volumn 56, Issue 1, 2013, Pages 116-128

  Arslan, Fatih ^a,b   Smeets, Mirjam B ^b   Buttari, Brigitta ^c   Profumo, Elisabetta ^c   Riganò, Rachele ^c   Akeroyd, Lars ^a   Kara, Emrah ^a   Timmers, Leo ^a   Sluijter, Joost P ^a,b   van Middelaar, Ben ^a   den Ouden, Krista ^a   Pasterkamp, Gerard ^a   Lim, Sai Kiang ^d   de Kleijn, Dominique P V ^a,b,e  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^e NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

Author keywords

Heart failure; Myocardial infarction; Remodeling

Indexed keywords

ANGIOPOIETIN 1; HAPTOGLOBIN; HEMOGLOBIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ENDOTHELIUM CELL; FOLLOW UP; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART PERFORMANCE; HEART RUPTURE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTRAMURAL HEMORRHAGE; LYMPHOCYTIC INFILTRATION; MALE; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCAR FORMATION; SURVIVAL; TISSUE REPAIR; TRANSCRIPTION REGULATION; WILD TYPE; WOUND HEALING IMPAIRMENT;

ANGIOPOIETIN-1; ANIMALS; CAPILLARY PERMEABILITY; CORONARY VESSELS; GENE EXPRESSION; HAPTOGLOBINS; HEART RUPTURE; HEMORRHAGE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIUM; NEUTROPHIL INFILTRATION; OXIDATION-REDUCTION; OXIDATIVE STRESS; SERPIN E2; STROKE VOLUME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENTRICULAR REMODELING; WOUND HEALING;

ANIMALIA; MUS;

EID: 84873187499     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.12.012     Document Type: Article

References (34)

1. Morita H., Seidman J., Seidman C.E. Genetic causes of human heart failure. J Clin Invest 2005, 115:518-526.
2. Chapelle J.P., Albert A., Smeets J.P., Heusghem C., Kulbertus H.E. Effect of the haptoglobin phenotype on the size of a myocardial infarct. N Engl J Med 1982, 307:457-463.
3. Buehler P.W., Abraham B., Vallelian F., Linnemayr C., Pereira C.P., Cipollo J.F., et al. Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood 2009, 113:2578-2586.
4. Roguin A., Koch W., Kastrati A., Aronson D., Schomig A., Levy A.P. Haptoglobin genotype is predictive of major adverse cardiac events in the 1-year period after percutaneous transluminal coronary angioplasty in individuals with diabetes. Diabetes Care 2003, 26:2628-2631.
5. Levy A.P., Asleh R., Blum S., Levy N.S., Miller-Lotan R., Kalet-Litman S., et al. Haptoglobin: basic and clinical aspects. Antioxid Redox Signal 2010, 12:293-304.
6. Moreno P.R., Purushothaman K.R., Purushothaman M., Muntner P., Levy N.S., Fuster V., et al. Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque. J Am Coll Cardiol 2008, 52:1049-1051.
7. Boyle J.J., Harrington H.A., Piper E., Elderfield K., Stark J., Landis R.C., et al. Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. Am J Pathol 2009, 174:1097-1108.
8. Moreno P.R., Purushothaman M., Purushothaman K.R. Plaque neovascularization: defense mechanisms, betrayal, or a war in progress. Ann N Y Acad Sci 2012, 1254:7-17.
9. Blum S., Asaf R., Guetta J., Miller-Lotan R., Asleh R., Kremer R., et al. Haptoglobin genotype determines myocardial infarct size in diabetic mice. J Am Coll Cardiol 2007, 49:82-87.
10. Asaf R., Blum S., Roguin A., Kalet-Litman S., Kheir J., Frisch A., et al. Haptoglobin genotype is a determinant of survival and cardiac remodeling after myocardial infarction in diabetic mice. Cardiovasc Diabetol 2009, 8:29.
11. Suleiman M., Aronson D., Asleh R., Kapeliovich M.R., Roguin A., Meisel S.R., et al. Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction. Diabetes 2005, 54:2802-2806.
12. Lim S.K., Kim H., Lim S.K., bin A.A., Lim Y.K., Wang Y., et al. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood 1998, 92:1870-1877.
13. van Lammeren G.W., Pasterkamp G., de Vries J.P., Bosch L., de Haan J.J., de Kleijn D.P., et al. Platelets enter atherosclerotic plaque via intraplaque microvascular leakage and intraplaque hemorrhage: a histopathological study in carotid plaques. Atherosclerosis 2012, 222:355-359.
14. Levy A.P., Moreno P.R. Intraplaque hemorrhage. Curr Mol Med 2006, 6:479-488.
15. Xu Z., Castellino F.J., Ploplis V.A. Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood 2010, 115:2038-2047.
16. Thurston G., Suri C., Smith K., McClain J., Sato T.N., Yancopoulos G.D., et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 1999, 286:2511-2514.
17. Kellouche S., Mourah S., Bonnefoy A., Schoevaert D., Podgorniak M.P., Calvo F., et al. Platelets, thrombospondin-1 and human dermal fibroblasts cooperate for stimulation of endothelial cell tubulogenesis through VEGF and PAI-1 regulation. Exp Cell Res 2007, 313:486-499.
18. Blum S., Vardi M., Brown J.B., Russell A., Milman U., Shapira C., et al. Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. Pharmacogenomics 2010, 11:675-684.
19. Ushio-Fukai M., Alexander R.W. Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase. Mol Cell Biochem 2004, 264:85-97.
20. Kalet-Litman S., Moreno P.R., Levy A.P. The haptoglobin 2-2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaque. Atherosclerosis 2010, 209:28-31.
21. de Kleijn D.P., Smeets M.B., Kemmeren P.P., Lim S.K., Van Middelaar B.J., Velema E., et al. Acute-phase protein haptoglobin is a cell migration factor involved in arterial restructuring. FASEB J 2002, 16:1123-1125.
22. Gaffney M.M., Hynes S.O., Barry F., O'Brien T. Cardiovascular gene therapy: current status and therapeutic potential. Br J Pharmacol 2007, 152:175-188.
23. Askari A.T., Brennan M.L., Zhou X., Drinko J., Morehead A., Thomas J.D., et al. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med 2003, 197:615-624.
24. Heymans S., Luttun A., Nuyens D., Theilmeier G., Creemers E., Moons L., et al. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med 1999, 5:1135-1142.
25. Zaman A.K., Fujii S., Schneider D.J., Taatjes D.J., Lijnen H.R., Sobel B.E. Deleterious effects of lack of cardiac PAI-1 after coronary occlusion in mice and their pathophysiologic determinants. Histochem Cell Biol 2007, 128:135-145.
26. Mehta R., Shapiro A.D. Plasminogen activator inhibitor type 1 deficiency. Haemophilia 2008, 14:1255-1260.
27. Inoue M., Sawada T., Uchima Y., Kimura K., Nishihara T., Tanaka H., et al. Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis. Oncol Rep 2005, 14:1445-1451.
28. Reeder B.J., Wilson M.T. Hemoglobin and myoglobin associated oxidative stress: from molecular mechanisms to disease states. Curr Med Chem 2005, 12:2741-2751.
29. Lim Y.K., Jenner A., Ali A.B., Wang Y., Hsu S.I., Chong S.M., et al. Haptoglobin reduces renal oxidative DNA and tissue damage during phenylhydrazine-induced hemolysis. Kidney Int 2000, 58:1033-1044.
30. Asleh R., Guetta J., Kalet-Litman S., Miller-Lotan R., Levy A.P. Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo. Circ Res 2005, 96:435-441.
31. Buttari B., Profumo E., Di C.C., Pietraforte D., Lionetti V., Capoano R., et al. Haemoglobin triggers chemotaxis of human monocyte-derived dendritic cells: possible role in atherosclerotic lesion instability. Atherosclerosis 2011, 215:316-322.
32. Gao X.M., White D.A., Dart A.M., Du X.J. Post-infarct cardiac rupture: recent insights on pathogenesis and therapeutic interventions. Pharmacol Ther 2012, 134:156-179.
33. Arslan F., de Kleijn D.P., Pasterkamp G. Innate immune signaling in cardiac ischemia. Nat Rev Cardiol 2011, 8:292-300.
34. Ganame J., Messalli G., Dymarkowski S., Rademakers F.E., Desmet W., Van de W.F., et al. Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction. Eur Heart J 2009, 30:1440-1449.