Sudden cardiac arrest in a patient on chronic methadone after the addition of azithromycin

American Journal of the Medical Sciences

Volumn 345, Issue 2, 2013, Pages 160-162

  Winton, John C ^a,b   Twilla, Jennifer D ^a,b  

^a METHODIST UNIVERSITY HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Arrhythmia; Azithromycin; Methadone

Indexed keywords

AZITHROMYCIN; BENZONATATE; HYDROCHLOROTHIAZIDE PLUS LISINOPRIL; METHADONE; NON PRESCRIPTION DRUG;

ADULT; ANTIBIOTIC THERAPY; ANTIHYPERTENSIVE THERAPY; ARTICLE; CASE REPORT; CHRONIC DRUG ADMINISTRATION; CLINICAL FEATURE; COMMON COLD; ELECTROCARDIOGRAPHY; EMERGENCY WARD; HUMAN; HYPERTENSION; MALE; METHADONE TREATMENT; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OPIATE ADDICTION; PRESCRIPTION; QT INTERVAL; QT PROLONGATION; RESUSCITATION; SIDE EFFECT; SINUS TACHYCARDIA; SUDDEN DEATH; SYSTOLIC HEART MURMUR; UPPER RESPIRATORY TRACT INFECTION;

EID: 84873180501     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e318266e7af     Document Type: Article

References (16)

1. Krantz MJ, Martin J, Stimmel B, et al. QTc interval screening in methadone treatment. Ann Intern Med 2009;150:387-95
2. The DASIS Report. Facilities operating opioid treatment programs: 2005. Rockville (MD): Substance Abuse and Mental Health Services Administration, Office of Applied Studies; 2006. http://oas.samhsa. gov/2k6/OTP/OTP.pdf. Accessed June 22, 2011
3. Lipski J, Stimmel B, Donoso E. The effect of heroin and multiple drug abuse on the electrocardiogram. Am Heart J 1973;86:663-8
4. Krantz MJ, Kutinsky IB, Roberston AD, et al. Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. Pharmacotherapy 2003;23:802-5
5. Stringer J, Welsh C, Tommasello A. Methadone-associated Q-T interval prolongation and torsades de pointes. Am J Health Syst Pharm 2009;66:825-33
6. Robson N, HabilMH. Erythromycin induced torsade de pointes in a methadone maintenance patient: Case report. Asean J Psychiatry 2010;11:1-5
7. Abramson DW, Quinn DK, Stern TA. Methadone-associated QTc prolongation: A case report and review of the literature. J Clin Psychiatry 2008;10:470-6
8. Pearson EC, Woosley RL. QT prolongation and torsades de pointes among methadone users: Reports to the FDA spontaneous reporting system. Pharmacoepidemiol Drug Saf 2005;14:747-53
9. Girolamo G. Drug-induced QT interval prolongation: Clinical, safety and regulatory update. Curr Drug Saf 2010;5:41-3
10. Kezerashvili A, Khattak H, Barsky A, et al. Azithromycin as a cause of QT-interval prolongation and torsade de pointes in the absence of other known precipitating factors. J Interv Card Electrophysiol 2007;18:243-6
11. Huang B, Wu C, Hsia C, et al. Azithromycin-induced torsades de pointes. Pacing Clin Electrophysiol 2007;30:1579-82
12. Russo V, Puzio G, Siniscalchi N. Azithromycin-induced QT prolongation in elderly patient. Acta Biomed 2006;77:30-2
13. Ray WA, Murray KT, Hall K, et al. Azithromycin and the risk of cardiovascular death. N Eng J Med 2012;366:1881-90
14. Milberg P, Eckardt L, Bruns H, et al. Divergent proarrhythmic potential of macrolide antibiotics similar QT prolongation: Fast phase 3 repolarization prevents early after depolarizations and torsades de pointes. J Pharmacol Exp Ther 2002;303:218-25
15. Gonzales R, Bartlett JG, Besser RE, et al. Principles of appropriate antibiotic use for treatment of nonspecific upper respiratory tract infections in adults: Background. Ann Intern Med 2001;134:490-4
16. Gill JM, Flischut P, Hass S, et al. Use of antibiotics for adult upper respiratory infections in outpatient settings: A national ambulatory network study. Fam Med 2006;38:349-54.