Increasing local blood flow by warming the application site: Beneficial effects on postprandial glycemic excursions

Journal of Diabetes Science and Technology

Volumn 6, Issue 4, 2012, Pages 780-785

  Freckmann, Guido ^a   Pleus, Stefan ^a   Haug, Cornelia ^a   Bitton, Gabriel ^b   Nagar, Ron ^b  

^a Institute for Diabetes Technology   (Germany)

^b Insuline Medical   (Israel)

Author keywords

Continuous subcutaneous insulin infusion; Insulin absorption; Postprandial excursion; Prandial insulin; Skin heating; Skin temperature

Indexed keywords

PIG INSULIN; SHORT ACTING INSULIN; ANTIDIABETIC AGENT;

BLOOD FLOW; CIRCULATION; CONFERENCE PAPER; DIABETES MELLITUS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; GLUCOSE BLOOD LEVEL; HEAT; HUMAN; HYPERGLYCEMIA; INSULIN PUMP; JET INJECTOR; MASSAGE; NEEDLE; POSTPRANDIAL STATE; SKIN; TISSUE PERFUSION; WARMING; ABSORPTION; BIOLOGICAL MODEL; BLOOD; DRUG EFFECT; EVALUATION; INSTRUMENTATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN INFUSION; METABOLISM; METHODOLOGY; PHYSIOLOGY; REVIEW; SKIN ABSORPTION; SKIN TEMPERATURE; SUBCUTANEOUS DRUG ADMINISTRATION; VASCULARIZATION;

ABSORPTION; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; HOT TEMPERATURE; HUMANS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN INFUSION SYSTEMS; INSULIN, SHORT-ACTING; MODELS, BIOLOGICAL; POSTPRANDIAL PERIOD; REGIONAL BLOOD FLOW; SKIN; SKIN ABSORPTION; SKIN TEMPERATURE;

EID: 84873168033     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229681200600407     Document Type: Conference Paper

References (26)

1. Garg SK. New insulin analogues. Diabetes Technol Ther. 2005;7(5):813-7. (Pubitemid 41572090)
2. Boland E, Monsod T, Delucia M, Brandt CA, Fernando S, Tamborlane WV. Limitations of conventional methods of self-monitoring of blood glucose: lessons learned from 3 days of continuous glucose sensing in pediatric patients with type 1 diabetes. Diabetes Care. 2001;24(11):1858-62. (Pubitemid 33716491)
3. Heptulla RA, Allen HF, Gross TM, Reiter EO. Continuous glucose monitoring in children with type 1 diabetes: before and after insulin pump therapy. Pediatr Diabetes. 2004;5(1):10-5. (Pubitemid 38489439)
4. Garg S, Zisser H, Schwartz S, Bailey T, Kaplan R, Ellis S, Jovanovic L. Improvement in glycemic excursions with a transcutaneous, real-time continuous glucose sensor: a randomized controlled trial. Diabetes Care. 2006;29(1):44-50. (Pubitemid 44033429)
5. Cobry E, McFann K, Messer L, Gage V, VanderWel B, Horton L, Chase HP. Timing of meal insulin boluses to achieve optimal postprandial glycemic control in patients with type 1 diabetes. Diabetes Technol Ther. 2010;12(3):173-7.
6. Heinemann L. Variability of insulin absorption and insulin action. Diabetes Technol Ther. 2002;4(5):673-82. (Pubitemid 35283332)
7. Bookbinder LH, Hofer A, Haller MF, Zepeda ML, Keller GA, Lim JE, Edgington TS, Shepard HM, Patton JS, Frost GI. A recombinant human enzyme for enhanced interstitial transport of therapeutics. J Control Release. 2006;114(2):230-41. (Pubitemid 44291844)
8. Steiner S, Hompesch M, Pohl R, Simms P, Flacke F, Mohr T, Pfutzner A, Heinemann L. A novel insulin formulation with a more rapid onset of action. Diabetologia. 2008;51(9):1602-6.
9. Ciccone CD. Basic pharmacokinetics and the potential effect of physical therapy interventions on pharmacokinetic variables. Phys Ther. 1995;75(5):343-51.
10. Dillon RS. Improved serum insulin profiles in diabetic individuals who massaged their insulin injection sites. Diabetes Care. 1983;6(4):399-401. (Pubitemid 13078724)
11. Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol. 2001;91(4):1619-26. (Pubitemid 32900352)
12. Kellogg DL Jr. In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges. J Appl Physiol. 2006;100(5):1709-18.
13. Magerl W, Treede RD. Heat-evoked vasodilatation in human hairy skin: axon reflexes due to low-level activity of nociceptive afferents. J Physiol. 1996;497(Pt 3):837-48. (Pubitemid 27032919)
14. Koivisto VA. Sauna-induced acceleration in insulin absorption from subcutaneous injection site. Br Med J. 1980;280(6229):1411-3. (Pubitemid 10123127)
15. Danon A, Ben-Shimon S, Ben-Zvi Z. Effect of exercise and heat exposure on percutaneous absorption of methyl salicylate. Eur J Clin Pharmacol. 1986;31(1):49-52. (Pubitemid 16017451)
16. Ashburn MA, Ogden LL, Zhang J, Love G, Basta SV. The pharmacokinetics of transdermal fentanyl delivered with and without controlled heat. J Pain. 2003;4(6):291-7. (Pubitemid 37013019)
17. Sindelka G, Heinemann L, Berger M, Frenck W, Chantelau E. Effect of insulin concentration, subcutaneous fat thickness and skin temperature on subcutaneous insulin absorption in healthy subjects. Diabetologia. 1994;37(4):377-80. (Pubitemid 24113569)
18. Raz I, Weiss R, Yegorchikov Y, Bitton G, Nagar R, Pesach B. Effect of a local heating device on insulin and glucose pharmacokinetic profiles in an open-label, randomized, two-period, one-way crossover study in patients with type 1 diabetes using continuous subcutaneous insulin infusion. Clin Ther. 2009;31(5):980-7.
19. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):E214-23. (Pubitemid 9249478)
20. Raz I, Yegorchikov Y, Bitton G, Pesach B, Nagar R, Weiss R. Improving pharmacokinetic and pharmacodynamic profiles of rapid-acting insulin analogs using the InsuPatch device. J Diabetes Sci Technol. 2009;3(2):384,A138.
21. Cengiz E, Tamborlane W, Sherr J, Martin M, Carria L, Sikes K, Urban A, Bitton G, Weinzimer S. O-11 Effect of a novel warming device on pharmacodynamics (PD) of rapid acting insulin in youth with type 1 diabetes (T1D). Abstracts. Diabetes Technol Ther. 2011;13(2):173-293.
22. Freckmann G, Pleus S, Westhoff A, Krinelke LG, Buhr A, Jendrike N, Haug C. Clinical performance of a device that applies local heat to the insulin infusion site: a crossover study. J Diabetes Sci Technol. 2012;6(2):320-7.
23. Peters AL, Davidson MB. Protein and fat effects on glucose responses and insulin requirements in subjects with insulin-dependent diabetes mellitus. Am J Clin Nutr. 1993;58(4):555-60. (Pubitemid 23307416)
24. Service FJ, Rizza RA, Hall LD, Westland RE, O'Brien PC, Clemens AH, Haymond MW, Gerich JE. Prandial insulin requirements in insulin-dependent diabetics: effects of size, time of day, and sequence of meals. J Clin Endocrinol Metab. 1983;57(5):931-6. (Pubitemid 14204289)
25. Becker RH, Frick AD, Nosek L, Heinemann L, Rave K. Dose-response relationship of insulin glulisine in subjects with type 1 diabetes. Diabetes Care. 2007;30(10):2506-7. (Pubitemid 47547782)
26. Petrofsky J, Paluso D, Anderson D, Swan K, Alshammari F, Katrak V, Murugesan V, Hudlikar AN, Chindam T, Trivedi M, Lee H, Goraksh N, Yim JE. The ability of different areas of the skin to absorb heat from a locally applied heat source: the impact of diabetes. Diabetes Technol Ther. 2011;13(3):365-72.