Perampanel: Newly approved, novel antiepileptic medication for partial-onset seizures

Expert Review of Neurotherapeutics

Volumn 13, Issue 2, 2013, Pages 131-134

  Shvarts, Vladimir ^a   Chung, Steve ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Fycompa ; Glutamate; a amino 3 hydroxy 5 methyl 4 isoxazole propionic acid; Novel antiepileptic drug; Partial seizures; Perampanel; Refractory epilepsy

Indexed keywords

CARBAMAZEPINE; ETIRACETAM; LAMOTRIGINE; ORAL CONTRACEPTIVE AGENT; OXCARBAZEPINE; PERAMPANEL; PHENYTOIN; PLACEBO; TOPIRAMATE; VALPROIC ACID; ANTICONVULSIVE AGENT; PYRIDONE DERIVATIVE;

ARTICLE; CLINICAL PRACTICE; DIZZINESS; DRUG DOSE ESCALATION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EPILEPTIC STATE; FALLING; FATIGUE; FOCAL EPILEPSY; HEADACHE; HUMAN; IN VITRO STUDY; IRRITABILITY; MULTICENTER STUDY (TOPIC); NAUSEA; NEUROTRANSMISSION; NONHUMAN; PHASE 3 CLINICAL TRIAL (TOPIC); QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RASH; SIDE EFFECT; SOMNOLENCE; SUDDEN DEATH; TREATMENT DURATION; WEIGHT GAIN; ADOLESCENT; ADULT; CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; INTERNATIONAL COOPERATION; LONGITUDINAL STUDY; MALE; MULTICENTER STUDY; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SEIZURES; YOUNG ADULT;

ADOLESCENT; ADULT; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERNATIONAL COOPERATION; LONGITUDINAL STUDIES; MALE; PYRIDONES; SEIZURES; YOUNG ADULT;

EID: 84873164987     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.12.154     Document Type: Article

References (16)

1. Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia 32(4), 429-445 (1991).
2. Chung S, Wang N, Hank N. Comparative retention rates and long-term tolerability of new antiepileptic drugs. Seizure 16(4), 296-304 (2007). (Pubitemid 46614649)
3. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N. Engl. J. Med. 342(5), 314-319 (2000). (Pubitemid 30075244)
4. Perucca E, French J, Bialer M. Development of new antiepileptic drugs: challenges, incentives, and recent advances. Lancet Neurol. 6(9), 793-804 (2007). (Pubitemid 47243712)
5. Rogawski MA. Revisiting AMPA receptors as an antiepileptic drug target. Epilepsy Curr. 11(2), 56-63 (2011).
6. Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X). Epilepsy Res. 92(2-3), 89-124 (2010).
7. Hanada T, Hashizume Y, Tokuhara N et al. Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia 52(7), 1331-1340 (2011).
8. Krauss GL, Bar M, Biton V et al. Tolerability and safety of perampanel: two randomized dose-escalation studies. Acta Neurol. Scand. 125(1), 8-15 (2012).
9. Rektor I, Krauss GL, Bar M et al. Perampanel Study 207: long-term open-label evaluation in patients with epilepsy. Acta Neurol. Scand. 126(4), 263-269 (2012).
10. French JA, Krauss GL, Biton V et al. Adjunctive perampanel for refractorypartial-onset seizures: randomized Phase III study 304. Neurology 79(6), 589-596 (2012).
11. French JA, Krauss GL, Steinhoff BJ et al. Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: results of randomized global Phase III study 305. Epilepsia doi:10.1111/j.1528-1167.2012. 03638.x (2012) (Epub ahead of print).
12. Krauss GL, Perucca E, Ben-Menachem E et al. Perampanel, a selective, noncompetitive a-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial-onset seizures: interim results from Phase III, extension study 307. Epilepsia doi:10.1111/j.1528-1167. 2012. 03648.x (2012) (Epub ahead of print).
13. Kew JN, Kemp JA. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl.) 179(1), 4-29 (2005). (Pubitemid 40576690)
14. Sutula T, He XX, Cavazos J, Scott G. Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science 239(4844), 1147-1150 (1988). (Pubitemid 18084325)
15. Mazarati AM, Wasterlain CG. N-methyld- asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat. Neurosci. Lett. 265(3), 187-190 (1999). (Pubitemid 29207397)
16. Mikati MA, Werner S, Gatt A et al. Consequences of 〈-amino-3- hydroxy-5- methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain. Brain Res. Dev. Brain Res. 113(1-2), 139-142 (1999). (Pubitemid 29125280)