Autologous point-of-care cellular therapies variably induce equine mesenchymal stem cell migration, proliferation and cytokine expression

Equine Veterinary Journal

Volumn 45, Issue 2, 2013, Pages 193-198

  Kol, A ^a   Walker, N J ^a   Galuppo, L D ^a   Clark, K C ^a   Buerchler, S ^a   Bernanke, A ^a   Borjesson, D L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone marrow mononuclear cells; Chemotaxis; Cord blood mononuclear cells; Cytokines; Horse; Mesenchymal stem cells; Platelet lysate; Stromal vascular fraction

Indexed keywords

CYTOKINE;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; CHEMOTAXIS; CULTURE TECHNIQUE; CYTOLOGY; FETUS BLOOD; GENE EXPRESSION REGULATION; GENETICS; HOSPITAL INFORMATION SYSTEM; MESENCHYMAL STROMA CELL; METABOLISM; METHODOLOGY; PHYSIOLOGY; THROMBOCYTE;

ADIPOSE TISSUE; ANIMALS; BLOOD PLATELETS; BONE MARROW TRANSPLANTATION; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CHEMOTAXIS; CYTOKINES; FETAL BLOOD; GENE EXPRESSION REGULATION; MESENCHYMAL STROMAL CELLS; POINT-OF-CARE SYSTEMS;

EQUIDAE;

EID: 84873164688     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2012.00600.x     Document Type: Article

References (45)

1. Borjesson, D.L. and Peroni, J.F. (2011) The regenerative medicine laboratory: facilitating stem cell therapy for equine disease. Clin. Lab. Med. 31, 109-123.
2. Christensen, M.E., Turner, B.E., Sinfield, L.J., Kollar, K., Cullup, H., Waterhouse, N.J., Hart, D.N., Atkinson, K. and Rice, A.M. (2010) Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versus-host disease. Haematologica 95, 2102-2110.
3. Crop, M.J., Korevaar, S.S., de Kuiper, R., Ijzermans, J.N., van Besouw, N.M., Baan, C.C., Weimar, W. and Hoogduijn, M.J. (2011) Human mesenchymal stem cells are susceptible to lysis by CD8+ T-cells and NK cells. Cell Transplant. 3, 1547-1559.
4. Torricelli, P., Fini, M., Filardo, G., Tschon, M., Pischedda, M., Pacorini, A., Kon, E. and Giardino, R. (2011) Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses. Int. Orthop. 35, 1569-1576.
5. Black, L.L., Gaynor, J., Adams, C., Dhupa, S., Sams, A.E., Taylor, R., Harman, S., Gingerich, D.A. and Harman, R. (2008) Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet. Ther. 9, 192-200.
6. Black, L.L., Gaynor, J., Gahring, D., Adams, C., Aron, D., Harman, S., Gingerich, D.A. and Harman, R. (2007) Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet. Ther. 8, 272-284.
7. Frisbie, D.D., Kisiday, J.D., Kawcak, C.E., Werpy, N.M. and McIlwraith, C.W. (2009) Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis. J. Orthop. Res. 27, 1675-1680.
8. Kasten, P., Vogel, J., Geiger, F., Niemeyer, P., Luginbuhl, R. and Szalay, K. (2008) The effect of platelet-rich plasma on healing in critical-size long-bone defects. Biomaterials 29, 3983-3992.
9. Crovace, A., Lacitignola, L., De Siena, R., Rossi, G. and Francioso, E. (2007) Cell therapy for tendon repair in horses: an experimental study. Vet. Res. Commun. 31, Suppl 1, 281-283.
10. Lacitignola, L., Crovace, A., Rossi, G. and Francioso, E. (2008) Cell therapy for tendinitis, experimental and clinical report. Vet. Res. Commun. 32, Suppl 1, S33-S38.
11. Schnabel, L.V., Mohammed, H.O., Miller, B.J., McDermott, W.G., Jacobson, M.S., Santangelo, K.S. and Fortier, L.A. (2007) Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J. Orthop. Res. 25, 230-240.
12. Brandau, S., Jakob, M., Hemeda, H., Bruderek, K., Janeschik, S., Bootz, F. and Lang, S. (2010) Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge. J. Leukoc. Biol. 88, 1005-1015.
13. Jakob, M., Hemeda, H., Janeschik, S., Bootz, F., Rotter, N., Lang, S. and Brandau, S. (2010) Human nasal mucosa contains tissue-resident immunologically responsive mesenchymal stromal cells. Stem Cells Dev. 19, 635-644.
14. Crisan, M., Yap, S., Casteilla, L., Chen, C.W., Corselli, M., Park, T.S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., Norotte, C., Teng, P.N., Traas, J., Schugar, R., Deasy, B.M., Badylak, S., Buhring, H.J., Giacobino, J.P., Lazzari, L., Huard, J. and Peault, B. (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3, 301-313.
15. Kode, J.A., Mukherjee, S., Joglekar, M.V. and Hardikar, A.A. (2009) Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy 11, 377-391.
16. Renner, P., Eggenhofer, E., Rosenauer, A., Popp, F.C., Steinmann, J.F., Slowik, P., Geissler, E.K., Piso, P., Schlitt, H.J. and Dahlke, M.H. (2009) Mesenchymal stem cells require a sufficient, ongoing immune response to exert their immunosuppressive function. Transplant. Proc. 41, 2607-2611.
17. Prasanna, S.J., Gopalakrishnan, D., Shankar, S.R. and Vasandan, A.B. (2010) Pro-inflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS ONE 5, e9016.
18. Hemeda, H., Jakob, M., Ludwig, A.K., Giebel, B., Lang, S. and Brandau, S. (2010) Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells. Stem Cells Dev. 19, 693-706.
19. Carrade, D.D., Lame, M.W., Kent, M.S., Clark, K.C., Walker, N.J. and Borjesson, D.L. (2012) Comparative analysis of the immunomodulatory properties of equine adult-derived mesenchymal stem cells. Cell Medicine Epub ahead of print; doi: 10.3727/215517912X647217
20. Bartholemew, S., Owens, S.D., Ferraro, G.L., Carrade, D.D., Lara, D.J., Librach, F., Borjeson, D.L. and Gallupo, L.D. (2009) Collection of equine cord blood and placental tissues in forty thoroughbred mares. Equine Vet. J. 41, 724-728.
21. Toupadakis, C.A., Wong, A., Genetos, D.C., Cheung, W.K., Borjesson, D.L., Ferraro, G.L., Galuppo, L.D., Leach, J.K., Owens, S.D. and Yellowley, C.E. (2010) Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue. Am. J. Vet. Res. 71, 1237-1245.
22. Schuh, E.M., Friedman, M.S., Carrade, D.D., Li, J., Heeke, D., Oyserman, S.M., Galuppo, L.D., Lara, D.J., Walker, N.J., Ferraro, G.L., Owens, S.D. and Borjesson, D.L. (2009) Identification of variables that optimize isolation and culture of multipotent mesenchymal stem cells from equine umbilical-cord blood. Am. J. Vet. Res. 70, 1526-1535.
23. Carrade, D.D., Owens, S.D., Galuppo, L.D., Vidal, M.A., Ferraro, G.L., Librach, F., Buerchler, S., Friedman, M.S., Walker, N.J. and Borjesson, D.L. (2011) Clinicopathologic findings following intra-articular injection of autologous and allogeneic placentally derived equine mesenchymal stem cells in horses. Cytotherapy 13, 419-430.
24. Goodwin, C.J., Holt, S.J., Downes, S. and Marshall, N.J. (1995) Microculture tetrazolium assays: a comparison between two new tetrazolium salts, XTT and MTS. J. Immunol. Methods 179, 95-103.
25. McCarrel, T. and Fortier, L. (2009) Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J. Orthop. Res. 27, 1033-1042.
26. Burton, A.B., Wagner, B., Erb, H.N. and Ainsworth, D.M. (2009) Serum interleukin-6 (IL-6) and IL-10 concentrations in normal and septic neonatal foals. Vet. Immunol. Immunopathol. 132, 122-128.
27. Frisbie, D.D., Al-Sobayil, F., Billinghurst, R.C., Kawcak, C.E. and McIlwraith, C.W. (2008) Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses. Osteoarthr. Cartil. 16, 1196-1204.
28. McFarlane, D. and Holbrook, T.C. (2008) Cytokine dysregulation in aged horses and horses with pituitary pars intermedia dysfunction. J. Vet. Intern. Med. 22, 436-442.
29. Osman, F. and Rowhani, A. (2008) Real-time RT-PCR (TaqMan) assays for the detection of viruses associated with Rugose wood complex of grapevine. J. Virol. Methods 154, 69-75.
30. Cipriani, P., Guiducci, S., Miniati, I., Cinelli, M., Urbani, S., Marrelli, A., Dolo, V., Pavan, A., Saccardi, R., Tyndall, A., Giacomelli, R. and Cerinic, M.M. (2007) Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis. Arthritis Rheum. 56, 1994-2004.
31. Fiedler, J., Leucht, F., Waltenberger, J., Dehio, C. and Brenner, R.E. (2005) VEGF-A and PlGF-1 stimulate chemotactic migration of human mesenchymal progenitor cells. Biochem. Biophys. Res. Commun. 334, 561-568.
32. Fiedler, J., Etzel, N. and Brenner, R.E. (2004) To go or not to go: migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF. J. Cell. Biochem. 93, 990-998.
33. Wynn, R.F., Hart, C.A., Corradi-Perini, C., O'Neill, L., Evans, C.A., Wraith, J.E., Fairbairn, L.J. and Bellantuono, I. (2004) A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood 104, 2643-2645.
34. Sundaravaradan, V., Mehta, R., Harris, D.T., Zack, J.A. and Ahmad, N. (2010) Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells. Virology 400, 32-43.
35. Bernardo, M.E., Avanzini, M.A., Perotti, C., Cometa, A.M., Moretta, A., Lenta, E., Del Fante, C., Novara, F., de Silvestri, A., Amendola, G., Zuffardi, O., Maccario, R. and Locatelli, F. (2007) Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute. J. Cell. Physiol. 211, 121-130.
36. Castegnaro, S., Chieregato, K., Maddalena, M., Albiero, E., Visco, C., Madeo, D., Pegoraro, M. and Rodeghiero, F. (2011) Effect of platelet lysate on the functional and molecular characteristics of mesenchymal stem cells isolated from adipose tissue. Curr. Stem Cell Res. Ther. 6, 105-114.
37. Doucet, C., Ernou, I., Zhang, Y., Llense, J.R., Begot, L., Holy, X. and Lataillade, J.J. (2005) Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J. Cell. Physiol. 205, 228-236.
38. Mishra, A., Tummala, P., King, A., Lee, B., Kraus, M., Tse, V. and Jacobs, C.R. (2009) Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Eng. Part C Methods 15, 431-435.
39. Vogel, J.P., Szalay, K., Geiger, F., Kramer, M., Richter, W. and Kasten, P. (2006) Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics. Platelets 17, 462-469.
40. Monteiro, S.O., Lepage, O.M. and Theoret, C.L. (2009) Effects of platelet-rich plasma on the repair of wounds on the distal aspect of the forelimb in horses. Am. J. Vet. Res. 70, 277-282.
41. Drengk, A., Zapf, A., Sturmer, E.K., Sturmer, K.M. and Frosch, K.H. (2009) Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells. Cells Tissues Organs 189, 317-326.
42. Huang, Q., Wang, Y.D., Wu, T., Jiang, S., Hu, Y.L. and Pei, G.X. (2009) Preliminary separation of the growth factors in platelet-rich plasma: effects on the proliferation of human marrow-derived mesenchymal stem cells. Chin. Med. J. (Engl) 122, 83-87.
43. Tablin, F., Walker, N.J., Hogle, S.E., Pratt, S.M. and Norris, J.W. (2008) Assessment of platelet growth factors in supernatants from rehydrated freeze-dried equine platelets and their effects on fibroblasts in vitro. Am. J. Vet. Res. 69, 1512-1519.
44. Schnabel, L.V., Sonea, H.O., Jacobson, M.S. and Fortier, L.A. (2008) Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explant cultures. Equine Vet. J. 40, 260-265.
45. Smith, J.J., Ross, M.W. and Smith, R.K. (2006) Anabolic effects of acellular bone marrow, platelet rich plasma, and serum on equine suspensory ligament fibroblasts in vitro. Vet. Comp. Orthop. Traumatol. 19, 43-47.