Increased expression of Interleukin-18 receptor in blood cells of subjects with Mild Cognitive Impairment and Alzheimer's disease

Cytokine

Volumn 61, Issue 2, 2013, Pages 360-363

  Salani, Francesca ^a   Ciaramella, Antonio ^a   Bizzoni, Federica ^a   Assogna, Francesca ^a   Caltagirone, Carlo ^a   Spalletta, Gianfranco ^a   Bossù, Paola ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Alzheimer's disease; IL 18 receptor chains; Mild Cognitive Impairment; Monocytes; T lymphocytes

Indexed keywords

CD14 ANTIGEN; CD3 ANTIGEN; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 18 RECEPTOR BETA; LIPOPOLYSACCHARIDE;

AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD CELL; CD3+ T LYMPHOCYTE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIGH RISK POPULATION; HUMAN; IN VITRO STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MONOCYTE; PATHOPHYSIOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AGED; ALZHEIMER DISEASE; BLOOD CELLS; CASE-CONTROL STUDIES; FEMALE; HUMANS; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-18 RECEPTOR BETA SUBUNIT; MALE; MILD COGNITIVE IMPAIRMENT;

EID: 84873148889     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.11.001     Document Type: Article

References (17)

1. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G.M., et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000, 21:383-421.
2. Eikelenboom P., van Exel E., Hoozemans J.J., Veerhuis R., Rozemuller A.J., van Gool W.A. Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease. Neurodegener Dis 2010, 7:38S-41S.
3. Perry V.H., Cunningham C., Holmes C. Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol 2007, 7:161-167.
4. Holmes C., Cunningham C., Zotova E., Woolford J., Dean C., Kerr S., et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology 2009, 73:768R-774R.
5. Bossù P., Ciaramella A., Salani F., Vanni D., Palladino I., Caltagirone C., et al. Interleukin-18, from neuroinflammation to Alzheimer's disease. Curr Pharm Des 2010, 16:4213-4224.
6. Born T., Thomassen E., Bird T.A., Sims J.E. Cloning a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem 1998, 273:29445-29450.
7. Petersen R.C., Parisi J.E., Dickson D.W., Johnson K.A., Knopman D.S., Boeve B.F., et al. Neuropathologic features of amnestic mild cognitive impairment. Arch Neurol 2006, 63:665-672.
8. Bossù P., Ciaramella A., Salani F., Bizzoni F., Varsi E., Di Iulio F., et al. Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment. Brain Behav Immun 2008, 22:487-492.
9. Alboni S., Cervia D., Sugama S., Conti B. Interleukin 18 in the CNS. J Neuroinflammation 2010, 7:9.
10. Andre R., Wheeler R.D., Collins P.D., Luheshi G.N., Pickering-Brown S., Kimber I., et al. Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain. J Neuroimmunol 2003, 145:40-45.
11. Neumann D., Del Giudice E., Ciaramella A., Boraschi D., Bossù P. Lymphocytes from autoimmune MRL lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain. J Immunol 2001, 166:3757-3762.
12. Feng Y., Li L., Sun X.H. Monocytes and Alzheimer's disease. Neurosci Bull 2011, 27:115-122.
13. Ruth J.H., Park C.C., Amin M.A., Lesch C., Marotte H., Shahrara S., et al. Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis. Arthritis Res Ther 2010, 12:R118.
14. Ciaramella A., Bizzoni F., Salani F., Vanni D., Spalletta G., Sanarico N., et al. Increased pro-inflammatory response by dendritic cells from patients with Alzheimer's disease. J Alzheimer Dis 2010, 19:559-572.
15. Town T., Tan J., Flavell R.A., Mullan M. T-cells in Alzheimer disease. Neuromolecular Med 2005, 7:255-264.
16. Monsonego A., Imitola J., Petrovic S., Zota V., Nemirovsky A., Baron R., et al. Abeta-induced meningoencephalitis is IFN-{gamma}-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2006, 103:5048-5053.
17. Tan Z.S., Beiser A.S., Vasan R.S., Roubenoff R., Dinarello C.A., Harris T.B., et al. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology 2007, 68:1902-1908.