Involvement of KLF14 and egr-1 in the TGF-beta1 action on Leydig cell proliferation

Cytokine

Volumn 61, Issue 2, 2013, Pages 670-675

  Gonzalez, C R ^a   Vallcaneras, S S ^b   Calandra, R S ^c   Gonzalez Calvar, S I ^c,d  

^a DEPARTAMENTO DE CIENCIAS NATURALES Y ANTROPOLOGÍA   (Argentina)

^b UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

KLF14; Leydig cells; Proliferation; TGF 1

Indexed keywords

CYCLINE; EARLY GROWTH RESPONSE FACTOR 1; ENDOGLIN; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 14; MIFEPRISTONE; PROGESTERONE; PROTEIN P15; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION; LEYDIG CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; CELL LINE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DNA, COMPLEMENTARY; EARLY GROWTH RESPONSE PROTEIN 1; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LEYDIG CELLS; MALE; MICE; MICE, INBRED BALB C; PROGESTERONE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84873143096     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.12.009     Document Type: Article

References (32)

1. Ingman W.V., Robertson S.A. The essential roles of TGFB1 in reproduction. Cytokine Growth Factor Rev 2009, 20:233-239.
2. Ingman W.V., Robertson S.A. Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology 2007, 148:4032-4043.
3. Fan Y.S., Hu Y.J., Yang W.X. TGF-superfamily: how does it regulate testis development. Mol Biol Rep 2012, 39:4727-4741.
4. Gautier C., Levacher C., Saez J.M., Habert R. Transforming growth factor beta1 inhibits steroidogenesis in dispersed fetal testicular cells in culture. Mol Cell Endocrinol 1997, 131:21-30.
5. Goddard L., Bouras M., Keramidas M., Hendrick J.C., Feige J.J., Benahmed M. Transforming growth factor-beta receptor types I and II in cultured porcine Leydig cells: expression and hormonal regulation. Endocrinology 2000, 141:2068-2074.
6. Teerds K.J., Dorrington J.H. Localization of transforming growth factor β1 and β2 during testicular development in the rat. Biol Reprod 1993, 48:40-45.
7. Konrad L., Keilani M.M., Laible L., Nottelmann U., Hofmann R. Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Apoptosis 2006, 11:739-748.
8. Dickson C., Webster D.R., Johnson H., Cecilia Millena A., Khan S.A. Transforming growth factor-beta effects on morphology of immature rat Leydig cells. Mol Cell Endocrinol 2002, 195:65-77.
9. Lebrin F., Deckers M., Bertolino P., Ten Dijke P. TGF-β receptor functions in the endothelium. Cardiov Res 2005, 65:599-608.
10. Feng X.-H., Derynck R. Specificity and versatility in TGF-β signaling through Smads. Annu Rev Cell Dev Biol 2005, 21:659-693.
11. Moustakas, Heldin C.H. Non-Smad TGF-beta signals. J Cell Sci 2005, 118(Pt16):3573-3584.
12. Goumans M.J., Valdimarsdottir G., Itoh S., Lebrin F., Larsson J., Mummery C., et al. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell 2003, 12:817-828.
13. Xu P., Liu J., Derynck R. Post-translational regulation of TGF-b receptor and Smad signalling. FEBS Lett 2012, 586:1871-1884.
14. Hou X., Arvisais E.W., Jiang C., Chen D., Roy S.K., Pate J.L., et al. Prostaglandin F2α stimulates the expression and secretion of transforming growth factor B1 via induction of the early growth response 1 gene (EGR1) in the bovine corpus luteum. Mol Endocrinol 2008, 22:403-414.
15. Truty M.J., Lomberk G., Fernandez-Zapico M.E., Urrutia R. Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Krüppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signalling. J Biol Chem 2009, 284:6291-6300.
16. Gonzalez C.R., Gonzalez B., Rulli S.B., Dos Santos M.L., Mattos Jardim Costa G., França L.R., et al. TGF-β1 system in Leydig cells. Part II: TGF-β1 and progesterone, through Smad1/5, are involved in the hyperplasia/hypertrophy of Leydig cells. J Reprod Dev 2010, 56:400-404.
17. Gonzalez C.R., Matzkin M.E., Frungieri M.B., Terradas C., Ponzio R., Puigdomenech E., et al. Expression of the TGF-β1 system in human testicular pathologies. Reprod Biol Endocrinol 2010, 8:148-159.
18. Gonzalez C.R., Calandra R.S., Gonzalez-Calvar S.I. Influence of the photoperiod on TGF-β1 and p15 expression in hamster Leydig cells. Reprod Biol 2012, 12:201-208.
19. Mather J.P. Establishment and characterization of two distinct mouse testicular epithelial cell lines. Biol Reprod 1980, 23:243-252.
20. Pfaffl M.W. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001, 29:e45.
21. Quandt K., Frech K., Karas H., Wingender E., Werner T. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 1995, 23:4878-4884.
22. Wagener, Fickel J., Schön J., Fritzenkötter A., Göritz F., Blottner S. Seasonal variation in expression and localization of testicular transforming growth factors TGF-β1 and TGF-β3 corresponds with spermatogenic activity in roe deer. J Endocrinol 2005, 187:205-215.
23. Gonzalez R., Gonzalez B., Rulli S.B., Huhtaniemi I., Calandra R.S., Gonzalez-Calvar S.I. TGF-β1 system in Leydig cells. Part I: Effect of hCG and progesterone. J Reprod Dev 2010, 56:389-395.
24. Lebrin F., Goumans M.J., Jonker L., Carvalho R.L., Valdimarsdottir G., Thorikay M., et al. Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J 2004, 23:4018-4028.
25. Ink4B transcription in response to TGF-β. EMBO J 2000, 19:5178-5193.
26. Li X., Zhang Y.Y., Wang Q., Fu S.B. Association between endogenous gene expression and growth regulation induced by TGF-beta1 in human gastric cancer cells. World J Gastroenterol 2005, 11:61-68.
27. Li Z., Chen Y., Cao D., Wang Y., Chen G., Zhang S., et al. Glucocorticoid up-regulates transforming growth factor-beta (TGF-beta) type II receptor and enhances TGF-beta signaling in human prostate cancer PC-3 cell. Endocrinology 2006, 147:5259-5267.
28. Naryzhny S.N. Proliferating cell nuclear antigen: a proteomics view. Cell Mol Life Sci 2008, 65:3789-3808.
29. Simmen R.C., Simmen F.A. Progesterone receptors and Sp/Krüppel-like family members in the uterine endometrium. Front Biosci 2002, 7:d1556-d1565.
30. Owen G.I., Richer J.K., Tung L., Takimoto G., Horwitz K.B. Progesterone regulates transcription of the p21WAF1 Cyclin dependent kinase inhibitor gene through Sp1 and CBP/p300. J Biol Chem 1998, 273:10696-10701.
31. Rius C., Smith J.D., Almendro N., Langa C., Botella L.M., Marchuk D.A., et al. Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. Blood 1998, 92:4677-4690.
32. Pagel J.I., Deindl E. Early growth response 1 - a transcription factor in the crossfire of signal transduction cascades. Indian J Biochem Biophys 2011, 48:226-235.