Assessment of NMDA receptor genes (GRIN2A, GRIN2B and GRIN2C) as candidate genes in the development of degenerative lumbar scoliosis

Experimental and Therapeutic Medicine

Volumn 5, Issue 3, 2013, Pages 977-981

  Kim, Ki Tack ^a   Kim, Jinsung ^b   Han, Yoo Jin ^b   Kim, Jun Ho ^b   Lee, Jong Seok ^b   Chung, Joo Ho ^b  

^a Kyung Hee University College of Medicine   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

Degenerative lumbar scoliosis; GRIN2; Korean; Single nucleotide polymorphism

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DEGENERATIVE LUMBAR SCOLIOSIS; FEMALE; GENOTYPING TECHNIQUE; HUMAN; MAJOR CLINICAL STUDY; MALE; SCOLIOSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84873137129     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.910     Document Type: Article

References (27)

1. Aebi M: The adult scoliosis. Eur Spine J 14: 925-948, 2005.
2. Ploumis A, Transfledt EE and Denis F: Degenerative lumbar scoliosis associated with spinal stenosis. Spine J 7: 428-436, 2007.
3. Oskouian RJ Jr and Shaffrey CI: Degenerative lumbar scoliosis. Neurosurg Clin N Am 17: 299-315, vii, 2006.
4. Daffner SD and Vaccaro AR: Adult degenerative lumbar scoliosis. Am J Orthop (Belle Mead NJ) 32: 77-82, 2003.
5. Skerry TM: The role of glutamate in the regulation of bone mass and architecture. J Musculoskelet Neuronal Interact 8: 166-173, 2008.
6. Spencer GJ, McGrath CJ and Genever PG: Current perspectives on NMDA-type glutamate signalling in bone. Int J Biochem Cell Biol 39: 1089-1104, 2007.
7. Weinberg RJ: Glutamate: an excitatory neurotransmitter in the mammalian CNS. Brain Res Bull 50: 353-354, 1999.
8. Merle B, Itzstein C, Delmas PD and Chenu C: NMDA glutamate receptors are expressed by osteoclast precursors and involved in the regulation of osteoclastogenesis. J Cell Biochem 90: 424-436, 2003.
9. Hinoi E, Takarada T and Yoneda Y: Glutamate signaling system in bone. J Pharmacol Sci 94: 215-220, 2004.
10. Mason DJ: Glutamate signalling and its potential application to tissue engineering of bone. Eur Cell Mater 7: 12-26, 2004.
11. Lin TH, Yang RS, Tang CH, Wu MY and Fu WM: Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamate. Eur J Pharmacol 589: 37-44, 2008.
12. Solé X, Guinó E, Valls J, Iniesta R and Moreno V: SNPStats: a web tool for the analysis of association studies. Bioinformatics22: 1928-1929, 2006.
13. Gabriel SB, Schaffner SF, Nguyen H, et al: The structure of haplotype blocks in the human genome. Science 296: 2225-2229, 2002.
14. Liao JC, Chen WJ, Chen LH and Niu CC: Outcome of the L5-S1 segment after posterior instrumented spinal surgery in degenerative lumbar diseases. Chang Gung Med J 32: 81-88, 2009.
15. Schlenk RP, Kowalski RJ and Benzel EC: Biomechanics of spinal deformity. Neurosurg Focus 14: e2, 2003.
16. Arbit E and Pannullo S: Lumbar stenosis: a clinical review. Clin Orthop Relat Res 137-143, 2001.
17. Fisher M: Characterizing the target of acute stroke therapy. Stroke 28: 866-872, 1997.
18. Moult PR: Neuronal glutamate and GABAA receptor function in health and disease. Biochem Soc Trans 37: 1317-1322, 2009.
19. Tanabe Y, Masu M, Ishii T, Shigemoto R and Nakanishi S: A family of metabotropic glutamate receptors. Neuron 8: 169-179, 1992.
20. Hollmann M and Heinemann S: Cloned glutamate receptors. Annu Rev Neurosci 17: 31-108, 1994.
21. Yoneda Y, Kuramoto N, Kitayama T and Hinoi E: Consolidation of transient ionotropic glutamate signals through nuclear transcription factors in the brain. Prog Neurobiol 63: 697-719, 2001.
22. Arning L, Saft C, Wieczorek S, et al: NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner. Hum Genet 122: 175-182, 2007.
23. Tang, J, Chen X, Xu X, et al: Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene (GRIN2A) and schizophrenia. Neurosci Lett 409: 80-82, 2006.
24. Szczepankiewicz A, Skibinska M, Rybakowski J, et al: Lack of association of three GRIN2B polymorphisms with bipolar disorder. World J Biol Psychiatry 10: 469-473, 2009.
25. Seripa D, Matera MG, Franceschi M, et al: Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease. Dement Geriatr Cogn Disord25: 287-292, 2008.
26. Kim JH, Park M, Yang SY, et al: Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism. Neurosci Res 56: 220-223, 2006.
27. Tadic A, Dahmen N, Szegedi A, et al: Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens. Eur Arch Psychiatry Clin Neurosci 255: 129-135, 2005.