Extracellular vesicles in the circulation: Are erythrocyte microvesicles a confounder in the plasma haemoglobin assay?

Biochemical Society Transactions

Volumn 41, Issue 1, 2013, Pages 288-292

  De Vooght, Karen M K ^a   Lau, Cedric ^a   De Laat, Pim P M ^a   Wijk, Richard Van ^a   Van Solinge, Wouter W ^a   Schiffelers, Raymond M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Blood; Differential ultracentrifugation; Extracellular vesicle; Haemoglobin; Microvesicle; Spectrophotometry

Indexed keywords

CELL FREE SYSTEM; CELL TYPE; CELL VACUOLE; CONFERENCE PAPER; CONFOUNDING VARIABLE; ENDOTHELIUM CELL; ERYTHROCYTE; ERYTHROCYTE MICROVESICLE; EXOSOME; EXTRACELLULAR VESICLE; FREEZE THAWING; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HEMOLYSIS; HUMAN; LEUKOCYTE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; THROMBOCYTE;

ERYTHROCYTES; HEMOGLOBINS; HEMOLYSIS; HUMANS;

EID: 84873134192     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120254     Document Type: Conference Paper

References (33)

1. Kooijmans, S. A., Vader, P., van Dommelen, S. M., van Solinge, W. W. and Schiffelers, R. M. (2012) Exosome mimetics: a novel class of drug delivery systems. Int. J. Nanomed. 7, 1525-1541
2. Lotvall, J. and Valadi, H. (2007) Cell to cell signalling via exosomes through esRNA. Cell Adhes. Migr. 1, 156-158
3. Thery, C., Ostrowski, M. and Segura, E. (2009) Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 9, 581-593
4. György, B., Szabó, T. G., Pásztói, M., Pál, Z., Misják, P., Aradi, B., László, V., Pállinger, E., Pap, E., Kittel, A. et al. (2012) Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell. Mol. Life Sci. 68, 2667-2688
5. Duijvesz, D., Luider, T., Bangma, C. H. and Jenster, G. (2012) Exosomes as biomarker treasure chests for prostate cancer. Eur. Urol. 59, 823-831
6. Vlassov, A. V., Magdaleno, S., Setterquist, R. and Conrad, R. (2012) Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta 1820, 940-948
7. Berckmans, R. J., Nieuwland, R., Böing, A. N., Romijn, F. P., Hack, C. E. and Sturk, A. (2001) Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb. Haemostasis 85, 639-646 (Pubitemid 32293699)
8. van Beers, E. J., Schaap, M. C., Berckmans, R. J., Nieuwland, R., Sturk, A., van Doormaal, F. F., Meijers, J. C. and Biemond, B. J. (2009) Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease. Haematologica 94, 1513-1519
9. Pelletier, F., Garnache-Ottou, F., Angelot, F., Biichle, S., Vidal, C., Humbert, P., Saas, P., Seilles, E. and Aubin, F. (2011) Increased levels of circulating endothelial-derived microparticles and small-size platelet-derived microparticles in psoriasis. J. Invest. Dermatol. 131, 1573-1576
10. Kang, P., Shen, B., Yang, J. and Pei, F. (2008) Circulating platelet-derived microparticles and endothelium-derived microparticles may be a potential cause of microthrombosis in patients with osteonecrosis of the femoral head. Thromb. Res. 123, 367-373
11. Trappenburg, M. C., van Schilfgaarde, M., Marchetti, M., Spronk, H. M., ten Cate, H., Leyte, A., Terpstra, W. E. and Falanga, A. (2009) Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia. Haematologica 94, 911-918
12. Wolf, P. (1967) The nature and significance of platelet products in human plasma. Br. J. Haematol. 13, 269-288
13. van de Waart, P., Bruls, H., Hemker, H. C. and Lindhout, T. (1983) Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles. Biochemistry 22, 2427-2432 (Pubitemid 13093550)
14. Aatonen, M., Gronholm, M. and Siljander, P. R. (2012) Platelet-derived microvesicles: multitalented participants in intercellular communication. Semin. Thromb. Hemostasis 38, 102-113
15. Mezentsev, A., Merks, R. M., O'Riordan, E., Chen, J., Mendelev, N., Goligorsky, M. S. and Brodsky, S. V. (2005) Endothelial microparticles affect angiogenesis in vitro: role of oxidative stress. Am. J. Physiol. Heart Circ. Physiol. 289, H1106-H1114 (Pubitemid 41208953)
16. Hergenreider, E., Heydt, S., Treguer, K., Boettger, T., Horrevoets, A. J., Zeiher, A. M., Scheffer, M. P., Frangakis, A. S., Yin, X., Mayr, M. et al. (2012) Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat. Cell Biol. 14, 249-256
17. de Jong, O. G., Verhaar, M. C., Chen, Y., Vader, P., Gremmels, H., Posthuma, G., Schiffelers, R. M., Gucek, M. and van Balkom, B. W. M. (2012) Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. J. Extracell. Vesicles 1, 18396
18. Leroyer, A. S., Anfosso, F., Lacroix, R., Sabatier, F., Simoncini, S., Njock, S. M., Jourde, N., Brunet, P., Camoin-Jau, L., Sampol, J. and Dignat-George, F. (2010) Endothelial-derived microparticles: biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis. Thromb. Haemostasis 104, 456-463
19. Burger, D. and Touyz, R. M. (2012) Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. J. Am. Soc. Hypertens. 6, 85-99
20. Yong, P. J., Koh, C. H. and Shim, W. (2012) Endothelial microparticles: missing link in endothelial dysfunction? Eur. J. Prev. Cardiol., doi:10.1177/2047487312445001
21. Gasser, O., Hess, C., Miot, S., Deon, C., Sanchez, J. C. and Schifferli, J. A. (2003) Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils. Exp. Cell Res. 285, 243-257 (Pubitemid 36432112)
22. Gasser, O. and Schifferli, J. A. (2004) Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood 104, 2543-2548 (Pubitemid 39331859)
23. Yang, C. and Robbins, P. D. (2012) Immunosuppressive exosomes: a new approach for treating arthritis. Int. J. Rheumatol. 2012, 573528
24. Morse, M. A., Garst, J., Osada, T., Khan, S., Hobeika, A., Clay, T. M., Valente, N., Shreeniwas, R., Sutton, M. A., Delcayre, A. et al. (2005) A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J. Transl. Med. 3, 9
25. Angelillo-Scherrer, A. (2012) Leukocyte-derived microparticles in vascular homeostasis. Circ. Res. 110, 356-369
26. Delcayre, A., Shu, H. and Le Pecq, J. B. (2005) Dendritic cell-derived exosomes in cancer immunotherapy: exploiting nature's antigen delivery pathway. Expert Rev. Anticancer Ther. 5, 537-547 (Pubitemid 40894984)
27. Spinella, P. C., Sparrow, R. L., Hess, J. R. and Norris, P. J. (2011) Properties of stored red blood cells: understanding immune and vascular reactivity. Transfusion 51, 894-900
28. Willekens, F. L., Werre, J. M., Groenen-Dopp, Y. A., Roerdinkholder- Stoelwinder, B., de Pauw, B. and Bosman, G. J. (2008) Erythrocyte vesiculation: a self-protective mechanism? Br. J. Haematol. 141, 549-556 (Pubitemid 351550554)
29. Piccard, H., Van den Steen, P. E. and Opdenakker, G. (2007) Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins. J. Leukocyte Biol. 81, 870-892 (Pubitemid 46495636)
30. Hvidberg, V., Maniecki, M. B., Jacobsen, C., Hojrup, P., Moller, H. J. and Moestrup, S. K. (2005) Identification of the receptor scavenging hemopexin-heme complexes. Blood 106, 2572-2579 (Pubitemid 41510836)
31. Sears, D. A. (1968) Plasma heme-binding in patients with hemolytic disorders. J. Lab. Clin. Med. 71, 484-494
32. Rother, R. P., Bell, L., Hillmen, P. and Gladwin, M. T. (2005) The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA, J. Am. Med. Assoc. 293, 1653-1662 (Pubitemid 40471796)
33. Kahn, S. E., Watkins, B. F. and Bermes, Jr, E. W. (1981) An evaluation of a spectrophotometric scanning technique for measurement of plasma hemoglobin. Ann. Clin. Lab. Sci. 11, 126-131 (Pubitemid 11138303)