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Volumn 23, Issue 2, 2013, Pages 84-93

Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: A CYP2B6 gene resequencing study

Author keywords

CYP2B6; DNA sequencing; methadone; pharmacogenetics; polymorphism

Indexed keywords

CYTOCHROME P450 2B6; METHADONE;

EID: 84873096248     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32835cb2e2     Document Type: Article
Times cited : (40)

References (37)
  • 1
    • 0029018372 scopus 로고
    • Methadone maintenance treatment: An update
    • Bertschy G. Methadone maintenance treatment: an update. Eur Arch Psychiatry Clin Neurosci 1995; 245:114-124.
    • (1995) Eur Arch Psychiatry Clin Neurosci , vol.245 , pp. 114-124
    • Bertschy, G.1
  • 2
    • 0028970418 scopus 로고
    • The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine
    • Kristensen K, Christensen CB, Christrup LL. The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine. Life Sci 1995; 56:L45-L50.
    • (1995) Life Sci , vol.56
    • Kristensen, K.1    Christensen, C.B.2    Christrup, L.L.3
  • 3
    • 78651012481 scopus 로고
    • Pharmacological comparison of the optical isomers of methadone
    • Scott CC, Robbins EB, Chen KK. Pharmacological comparison of the optical isomers of methadone. J Pharmacol Exp Ther 1948; 92:282-286.
    • (1948) J Pharmacol Exp Ther , vol.92 , pp. 282-286
    • Scott, C.C.1    Robbins, E.B.2    Chen, K.K.3
  • 4
    • 34247210196 scopus 로고    scopus 로고
    • Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers
    • Eap CB, Crettol S, Rougier JS, Schlapfer J, Sintra GL, Deglon JJ, et al. Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers. Clin Pharmacol Ther 2007; 81:719-728.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 719-728
    • Eap, C.B.1    Crettol, S.2    Rougier, J.S.3    Schlapfer, J.4    Sintra, G.L.5    Deglon, J.J.6
  • 5
    • 55149102596 scopus 로고    scopus 로고
    • The effects of chiral isolates of methadone on the cardiac potassium channel IKr
    • Lin C, Somberg T, Molnar J, Somberg J. The effects of chiral isolates of methadone on the cardiac potassium channel IKr. Cardiology 2009; 113:59-65.
    • (2009) Cardiology , vol.113 , pp. 59-65
    • Lin, C.1    Somberg, T.2    Molnar, J.3    Somberg, J.4
  • 6
    • 66149165776 scopus 로고    scopus 로고
    • Methadone-associated Q-T interval prolongation and torsades de pointes
    • Stringer J, Welsh C, Tommasello A. Methadone-associated Q-T interval prolongation and torsades de pointes. Am J Health Syst Pharm 2009; 66:825-833.
    • (2009) Am J Health Syst Pharm , vol.66 , pp. 825-833
    • Stringer, J.1    Welsh, C.2    Tommasello, A.3
  • 8
    • 0036439851 scopus 로고    scopus 로고
    • Interindividual variability of the clinical pharmacokinetics of methadone: Implications for the treatment of opioid dependence
    • Eap CB, Buclin T, Baumann P. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet 2002; 41:1153-1193.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 1153-1193
    • Eap, C.B.1    Buclin, T.2    Baumann, P.3
  • 9
    • 0347383736 scopus 로고    scopus 로고
    • Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19
    • Gerber JG, Rhodes RJ, Gal J. Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19. Chirality 2004; 16:36-44.
    • (2004) Chirality , vol.16 , pp. 36-44
    • Gerber, J.G.1    Rhodes, R.J.2    Gal, J.3
  • 11
    • 33845533592 scopus 로고    scopus 로고
    • ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment
    • Crettol S, Déglon JJ, Besson J, Croquette-Krokkar M, Hämmig R, Gothuey I, et al. ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Clin Pharmacol Ther 2006; 80:668-681.
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 668-681
    • Crettol, S.1    Déglon, J.J.2    Besson, J.3    Croquette-Krokkar, M.4    Hämmig, R.5    Gothuey, I.6
  • 13
    • 34248529829 scopus 로고    scopus 로고
    • Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients
    • Uehlinger C, Crettol S, Chassot P, Brocard M, Koeb L, Brawand-Amey M, et al. Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients. J Clin Psychopharmacol 2007; 27:273-278.
    • (2007) J Clin Psychopharmacol , vol.27 , pp. 273-278
    • Uehlinger, C.1    Crettol, S.2    Chassot, P.3    Brocard, M.4    Koeb, L.5    Brawand-Amey, M.6
  • 15
    • 67650488215 scopus 로고    scopus 로고
    • Validation and long-term evaluation of a modified on-line chiral analytical method for therapeutic drug monitoring of (R, S)-methadone in clinical samples
    • Ansermot N, Rudaz S, Brawand-Amey M, Fleury-Souverain S, Veuthey JL, Eap CB. Validation and long-term evaluation of a modified on-line chiral analytical method for therapeutic drug monitoring of (R, S)-methadone in clinical samples. J Chromatogr B 2009; 877:2301-2307.
    • (2009) J Chromatogr B , vol.877 , pp. 2301-2307
    • Ansermot, N.1    Rudaz, S.2    Brawand-Amey, M.3    Fleury-Souverain, S.4    Veuthey, J.L.5    Eap, C.B.6
  • 16
    • 0346728533 scopus 로고    scopus 로고
    • Automated LC-MS method for the fast stereoselective determination of methadone in plasma
    • Souverain S, Eap CB, Veuthey JL, Rudaz S. Automated LC-MS method for the fast stereoselective determination of methadone in plasma. Clin Chem Lab Med 2003; 41:1615-1621.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1615-1621
    • Souverain, S.1    Eap, C.B.2    Veuthey, J.L.3    Rudaz, S.4
  • 18
    • 4644349582 scopus 로고    scopus 로고
    • Multiple novel nonsynonymous CYP2B6 gene polymorphisms in caucasians: Demonstration of phenotypic null alleles
    • Lang T, Klein K, Richter T, Zibat A, Kerb R, Eichelbaum M, et al. Multiple novel nonsynonymous CYP2B6 gene polymorphisms in caucasians: demonstration of phenotypic null alleles. J Pharmacol Exp Ther 2004; 311:34-43.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 34-43
    • Lang, T.1    Klein, K.2    Richter, T.3    Zibat, A.4    Kerb, R.5    Eichelbaum, M.6
  • 19
    • 84873087035 scopus 로고    scopus 로고
    • National Center For Biotechnology Information-dbSNP. Build 137 For Human [Accessed 20 February 2012]
    • National Center for Biotechnology Information-dbSNP. Build 137 for human. Available at: http://www.ncbi.nlm.nih.gov/snp [Accessed 20 February 2012].
  • 20
    • 84873089843 scopus 로고    scopus 로고
    • Home Page Of The Human Cytochrome P450 (CYP) Allele Nomenclature Committee [Accessed 20 February 2012]
    • Home page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee; 2009. Available at: https://www.cypalleles.ki.se [Accessed 20 February 2012].
    • (2009)
  • 23
    • 33947382259 scopus 로고    scopus 로고
    • Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals
    • Rotger M, Tegude H, Colombo S, Cavassini M, Furrer H, Decosterd L, et al. Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals. Clin Pharmacol Ther 2007; 81:557-566.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 557-566
    • Rotger, M.1    Tegude, H.2    Colombo, S.3    Cavassini, M.4    Furrer, H.5    Decosterd, L.6
  • 24
    • 0034948077 scopus 로고    scopus 로고
    • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver
    • Lang T, Klein K, Fischer J, Nussler AK, Neuhaus P, Hofmann U, et al. Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 2001; 11:399-415.
    • (2001) Pharmacogenetics , vol.11 , pp. 399-415
    • Lang, T.1    Klein, K.2    Fischer, J.3    Nussler, A.K.4    Neuhaus, P.5    Hofmann, U.6
  • 25
    • 77949539805 scopus 로고    scopus 로고
    • Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide
    • Bray J, Sludden J, Griffin MJ, Cole M, Verrill M, Jamieson D, et al. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. Br J Cancer 2010; 102:1003-1009.
    • (2010) Br J Cancer , vol.102 , pp. 1003-1009
    • Bray, J.1    Sludden, J.2    Griffin, M.J.3    Cole, M.4    Verrill, M.5    Jamieson, D.6
  • 26
    • 58149117630 scopus 로고    scopus 로고
    • Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa
    • Ekhart C, Doodeman VD, Rodenhuis S, Smits PH, Beijnen JH, Huitema AD. Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Br J Clin Pharmacol 2009; 67:50-60.
    • (2009) Br J Clin Pharmacol , vol.67 , pp. 50-60
    • Ekhart, C.1    Doodeman, V.D.2    Rodenhuis, S.3    Smits, P.H.4    Beijnen, J.H.5    Huitema, A.D.6
  • 27
    • 41149132905 scopus 로고    scopus 로고
    • Aberrant splicing caused by single nucleotide polymorphism c.516G > T [Q172H], a marker of CYP2B66, is responsible for decreased expression and activity of CYP2B6 in liver
    • Hofmann MH, Blievernicht JK, Klein K, Saussele T, Schaeffeler E, Schwab M, et al. Aberrant splicing caused by single nucleotide polymorphism c.516G > T [Q172H], a marker of CYP2B66, is responsible for decreased expression and activity of CYP2B6 in liver. J Pharmacol Exp Ther 2008; 325:284-292.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 284-292
    • Hofmann, M.H.1    Blievernicht, J.K.2    Klein, K.3    Saussele, T.4    Schaeffeler, E.5    Schwab, M.6
  • 29
    • 79960598589 scopus 로고    scopus 로고
    • CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer
    • Wang SC, Ho IK, Tsou HH, Tian JN, Hsiao CF, Chen CH, et al. CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer. J Clin Psychopharmacol 2011; 31:463-469.
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 463-469
    • Wang, S.C.1    Ho, I.K.2    Tsou, H.H.3    Tian, J.N.4    Hsiao, C.F.5    Chen, C.H.6
  • 30
    • 84879462963 scopus 로고    scopus 로고
    • CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction
    • doi: 10.1111/j.1369-1600.2011.00349.x
    • Levran O, Peles E, Hamon S, Randesi M, Adelson M, Kreek MJ. CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction. Addict Biol 2011. doi: 10.1111/j.1369-1600.2011.00349.x.
    • (2011) Addict Biol
    • Levran, O.1    Peles, E.2    Hamon, S.3    Randesi, M.4    Adelson, M.5    Kreek, M.J.6
  • 31
    • 77955674979 scopus 로고    scopus 로고
    • Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort
    • Carr DF, la Porte CJ, Pirmohamed M, Owen A, Cortes CP. Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. J Antimicrob Chemother 2010; 65:1889-1893.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1889-1893
    • Carr, D.F.1    La Porte, C.J.2    Pirmohamed, M.3    Owen, A.4    Cortes, C.P.5
  • 32
    • 10744221053 scopus 로고    scopus 로고
    • Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression
    • Lamba V, Lamba J, Yasuda K, Strom S, Davila J, Hancock ML, et al. Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 2003; 307:906-922.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 906-922
    • Lamba, V.1    Lamba, J.2    Yasuda, K.3    Strom, S.4    Davila, J.5    Hancock, M.L.6
  • 33
    • 17844375918 scopus 로고    scopus 로고
    • A natural CYP2B6 TATA box polymorphism (-82T-C) leading to enhanced transcription and relocation of the transcriptional start site
    • Zukunft J, Lang T, Richter T, Hirsch-Ernst KI, Nussler AK, Klein K, et al. A natural CYP2B6 TATA box polymorphism (-82T-C) leading to enhanced transcription and relocation of the transcriptional start site. Mol Pharmacol 2005; 67:1772-1782.
    • (2005) Mol Pharmacol , vol.67 , pp. 1772-1782
    • Zukunft, J.1    Lang, T.2    Richter, T.3    Hirsch-Ernst, K.I.4    Nussler, A.K.5    Klein, K.6
  • 34
    • 27944492382 scopus 로고    scopus 로고
    • Genetic variability of CYP2B6 in populations of African and Asian origin: Allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz
    • Klein K, Lang T, Saussele T, Barbosa-Sicard E, Schunck WH, Eichelbaum M, et al. Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz. Pharmacogenet Genomics 2005; 15:861-873.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 861-873
    • Klein, K.1    Lang, T.2    Saussele, T.3    Barbosa-Sicard, E.4    Schunck, W.H.5    Eichelbaum, M.6
  • 35
    • 33644588715 scopus 로고    scopus 로고
    • Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz
    • Wang J, Sonnerborg A, Rane A, Josephson F, Lundgren S, Stahle L, et al. Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz. Pharmacogenet Genomics 2006; 16:191-198.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 191-198
    • Wang, J.1    Sonnerborg, A.2    Rane, A.3    Josephson, F.4    Lundgren, S.5    Stahle, L.6
  • 36
    • 35348923463 scopus 로고    scopus 로고
    • Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6&z.ast;6 and &z.ast;26
    • Gatanaga H, Hayashida T, Tsuchiya K, Yoshino M, Kuwahara T, Tsukada H, et al. Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6&z.ast;6 and &z.ast;26. Clin Infect Dis 2007; 45: 1230-1237.
    • (2007) Clin Infect Dis , vol.45 , pp. 1230-1237
    • Gatanaga, H.1    Hayashida, T.2    Tsuchiya, K.3    Yoshino, M.4    Kuwahara, T.5    Tsukada, H.6
  • 37
    • 0142188754 scopus 로고    scopus 로고
    • Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6
    • Kirchheiner J, Klein C, Meineke I, Sasse J, Zanger UM, Murdter TE, et al. Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics 2003; 13:619-626.
    • (2003) Pharmacogenetics , vol.13 , pp. 619-626
    • Kirchheiner, J.1    Klein, C.2    Meineke, I.3    Sasse, J.4    Zanger, U.M.5    Murdter, T.E.6


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