메뉴 건너뛰기




Volumn 103, Issue 2-3, 2013, Pages 135-152

The intrahippocampal kainate model of temporal lobe epilepsy revisited: Epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats

Author keywords

Antiepileptic drugs; Hippocampus; Learning and memory; Phenobarbital; Seizures

Indexed keywords

KAINIC ACID; PHENOBARBITAL;

EID: 84873084581     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2012.09.015     Document Type: Article
Times cited : (81)

References (78)
  • 1
    • 19344368157 scopus 로고    scopus 로고
    • Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus
    • Arabadzisz D., Antal K., Parpan F., Emri Z., Fritschy J.M. Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus. Exp. Neurol. 2005, 194:76-90.
    • (2005) Exp. Neurol. , vol.194 , pp. 76-90
    • Arabadzisz, D.1    Antal, K.2    Parpan, F.3    Emri, Z.4    Fritschy, J.M.5
  • 2
    • 0029020815 scopus 로고
    • Kainic acid induced hippocampal seizures in rats: comparisons of acute and chronic seizures using intrahippocampal versus systemic injections
    • Babb T.L., Pereira-Leite J., Mathern G.W., Pretorius J.K. Kainic acid induced hippocampal seizures in rats: comparisons of acute and chronic seizures using intrahippocampal versus systemic injections. Ital. J. Neurol. Sci. 1995, 16:39-44.
    • (1995) Ital. J. Neurol. Sci. , vol.16 , pp. 39-44
    • Babb, T.L.1    Pereira-Leite, J.2    Mathern, G.W.3    Pretorius, J.K.4
  • 3
    • 0026058891 scopus 로고
    • Seizure frequency in intractable partial epilepsy: a statistical analysis
    • Balish M., Albert P.S., Theodore W.H. Seizure frequency in intractable partial epilepsy: a statistical analysis. Epilepsia 1991, 32:642-649.
    • (1991) Epilepsia , vol.32 , pp. 642-649
    • Balish, M.1    Albert, P.S.2    Theodore, W.H.3
  • 4
    • 41949126379 scopus 로고    scopus 로고
    • Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain
    • Bankstahl J.P., Hoffmann K., Bethmann K., Löscher W. Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. Neuropharmacology 2008, 54:1006-1016.
    • (2008) Neuropharmacology , vol.54 , pp. 1006-1016
    • Bankstahl, J.P.1    Hoffmann, K.2    Bethmann, K.3    Löscher, W.4
  • 5
    • 0034922506 scopus 로고    scopus 로고
    • Course of chronic focal epilepsy resistant to anticonvulsant treatment
    • Bauer J., Burr W. Course of chronic focal epilepsy resistant to anticonvulsant treatment. Seizure 2001, 10:239-246.
    • (2001) Seizure , vol.10 , pp. 239-246
    • Bauer, J.1    Burr, W.2
  • 6
    • 8344264314 scopus 로고    scopus 로고
    • Phenobarbital and other barbiturates: clinical efficacy and use in epilepsy
    • Lippincott Williams & Wilkins, Philadelphia, R.H. Levy, R.H. Mattson, B.S. Meldrum, E. Perucca (Eds.)
    • Baulac M. Phenobarbital and other barbiturates: clinical efficacy and use in epilepsy. Antiepileptic Drugs 2002, 514-521. Lippincott Williams & Wilkins, Philadelphia. 5th ed. R.H. Levy, R.H. Mattson, B.S. Meldrum, E. Perucca (Eds.).
    • (2002) Antiepileptic Drugs , pp. 514-521
    • Baulac, M.1
  • 7
    • 0034333266 scopus 로고    scopus 로고
    • Kainate, a double agent that generates seizures: two decades of progress
    • Ben Ari Y., Cossart R. Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci. 2000, 23:580-587.
    • (2000) Trends Neurosci. , vol.23 , pp. 580-587
    • Ben Ari, Y.1    Cossart, R.2
  • 8
    • 0018381552 scopus 로고
    • Evidence suggesting secondary epileptogenic lesion after kainic acid: pre treatment with diazepam reduces distant but not local brain damage
    • Ben Ari Y., Tremblay E., Ottersen O.P., Naquet R. Evidence suggesting secondary epileptogenic lesion after kainic acid: pre treatment with diazepam reduces distant but not local brain damage. Brain Res. 1979, 165:362-365.
    • (1979) Brain Res. , vol.165 , pp. 362-365
    • Ben Ari, Y.1    Tremblay, E.2    Ottersen, O.P.3    Naquet, R.4
  • 9
    • 0021921141 scopus 로고
    • Limbic seizures and brain damage produced by kainic acid: mechanisms and relevance in human temporal lobe epilepsy
    • Ben-Ari Y. Limbic seizures and brain damage produced by kainic acid: mechanisms and relevance in human temporal lobe epilepsy. Neuroscience 1985, 14:375-403.
    • (1985) Neuroscience , vol.14 , pp. 375-403
    • Ben-Ari, Y.1
  • 10
    • 55749103870 scopus 로고    scopus 로고
    • Temporal lobe epilepsy: where do the seizures really begin?
    • Bertram E.H. Temporal lobe epilepsy: where do the seizures really begin?. Epilepsy Behav. 2009, 14(Suppl. 1):32-37.
    • (2009) Epilepsy Behav. , vol.14 , Issue.SUPPL. 1 , pp. 32-37
    • Bertram, E.H.1
  • 11
    • 34247132191 scopus 로고    scopus 로고
    • Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy
    • Bethmann K., Brandt C., Löscher W. Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy. Epilepsia 2007, 48:816-826.
    • (2007) Epilepsia , vol.48 , pp. 816-826
    • Bethmann, K.1    Brandt, C.2    Löscher, W.3
  • 12
    • 33744815213 scopus 로고    scopus 로고
    • Place learning in the Morris water task: making the memory stick
    • Bolding K., Rudy J.W. Place learning in the Morris water task: making the memory stick. Learn. Mem. 2006, 13:278-286.
    • (2006) Learn. Mem. , vol.13 , pp. 278-286
    • Bolding, K.1    Rudy, J.W.2
  • 13
    • 0032940256 scopus 로고    scopus 로고
    • Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy
    • Bouilleret V., Ridoux V., Depaulis A., Marescaux C., Nehlig A., Lasalle G.L. Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy. Neuroscience 1999, 89:717-729.
    • (1999) Neuroscience , vol.89 , pp. 717-729
    • Bouilleret, V.1    Ridoux, V.2    Depaulis, A.3    Marescaux, C.4    Nehlig, A.5    Lasalle, G.L.6
  • 14
    • 0032879314 scopus 로고    scopus 로고
    • Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection
    • Bragin A., Engel J., Wilson C.L., Vizentin E., Mathern G.W. Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection. Epilepsia 1999, 40:1210-1221.
    • (1999) Epilepsia , vol.40 , pp. 1210-1221
    • Bragin, A.1    Engel, J.2    Wilson, C.L.3    Vizentin, E.4    Mathern, G.W.5
  • 15
    • 4544271982 scopus 로고    scopus 로고
    • High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis
    • Bragin A., Wilson C.L., Almajano J., Mody I., Engel J. High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis. Epilepsia 2004, 45:1017-1023.
    • (2004) Epilepsia , vol.45 , pp. 1017-1023
    • Bragin, A.1    Wilson, C.L.2    Almajano, J.3    Mody, I.4    Engel, J.5
  • 16
    • 27244437742 scopus 로고    scopus 로고
    • Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats
    • Bragin A., Azizyan A., Almajano J., Wilson C.L., Engel J. Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats. Epilepsia 2005, 46:1592-1598.
    • (2005) Epilepsia , vol.46 , pp. 1592-1598
    • Bragin, A.1    Azizyan, A.2    Almajano, J.3    Wilson, C.L.4    Engel, J.5
  • 17
    • 63849122971 scopus 로고    scopus 로고
    • The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset
    • Bragin A., Azizyan A., Almajano J., Engel J. The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset. J. Neurosci. 2009, 29:3660-3671.
    • (2009) J. Neurosci. , vol.29 , pp. 3660-3671
    • Bragin, A.1    Azizyan, A.2    Almajano, J.3    Engel, J.4
  • 18
    • 0041429359 scopus 로고    scopus 로고
    • Epileptogenesis and neuropathology after different types of status epilepticus induced by prolonged electrical stimulation of the basolateral amygdala in rats
    • Brandt C., Glien M., Potschka H., Volk H., Löscher W. Epileptogenesis and neuropathology after different types of status epilepticus induced by prolonged electrical stimulation of the basolateral amygdala in rats. Epilepsy Res. 2003, 55:83-103.
    • (2003) Epilepsy Res. , vol.55 , pp. 83-103
    • Brandt, C.1    Glien, M.2    Potschka, H.3    Volk, H.4    Löscher, W.5
  • 19
    • 9644283802 scopus 로고    scopus 로고
    • Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus
    • Brandt C., Volk H.A., Löscher W. Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus. Epilepsia 2004, 45:1488-1497.
    • (2004) Epilepsia , vol.45 , pp. 1488-1497
    • Brandt, C.1    Volk, H.A.2    Löscher, W.3
  • 20
    • 33747828519 scopus 로고    scopus 로고
    • Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats
    • Brandt C., Gastens A.M., Sun M.Z., Hausknecht M., Löscher W. Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats. Neuropharmacology 2006, 51:789-804.
    • (2006) Neuropharmacology , vol.51 , pp. 789-804
    • Brandt, C.1    Gastens, A.M.2    Sun, M.Z.3    Hausknecht, M.4    Löscher, W.5
  • 21
    • 34547534763 scopus 로고    scopus 로고
    • Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats
    • Brandt C., Glien M., Gastens A.M., Fedrowitz M., Bethmann K., Volk H.A., Potschka H., Löscher W. Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats. Neuropharmacology 2007, 53:207-221.
    • (2007) Neuropharmacology , vol.53 , pp. 207-221
    • Brandt, C.1    Glien, M.2    Gastens, A.M.3    Fedrowitz, M.4    Bethmann, K.5    Volk, H.A.6    Potschka, H.7    Löscher, W.8
  • 22
    • 77954120760 scopus 로고    scopus 로고
    • Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy
    • Brandt C., Nozadze M., Heuchert N., Rattka M., Löscher W. Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. J. Neurosci. 2010, 30:8602-8612.
    • (2010) J. Neurosci. , vol.30 , pp. 8602-8612
    • Brandt, C.1    Nozadze, M.2    Heuchert, N.3    Rattka, M.4    Löscher, W.5
  • 23
    • 34548248103 scopus 로고    scopus 로고
    • Temporal lobe epilepsy: more than hippocampal pathology
    • Cascino G.D. Temporal lobe epilepsy: more than hippocampal pathology. Epilepsy Curr. 2005, 5:187-189.
    • (2005) Epilepsy Curr. , vol.5 , pp. 187-189
    • Cascino, G.D.1
  • 24
    • 0019952583 scopus 로고
    • Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures
    • Cavalheiro E.A., Riche D.A., Le Gal L.S. Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures. Electroencephalogr. Clin. Neurophysiol. 1982, 53:581-589.
    • (1982) Electroencephalogr. Clin. Neurophysiol. , vol.53 , pp. 581-589
    • Cavalheiro, E.A.1    Riche, D.A.2    Le Gal, L.S.3
  • 28
    • 0025117514 scopus 로고
    • GABAergic neurons are spared after intrahippocampal kainate in the rat
    • Davenport C.J., Brown W.J., Babb T.L. GABAergic neurons are spared after intrahippocampal kainate in the rat. Epilepsy Res. 1990, 5:28-42.
    • (1990) Epilepsy Res. , vol.5 , pp. 28-42
    • Davenport, C.J.1    Brown, W.J.2    Babb, T.L.3
  • 29
    • 0034888287 scopus 로고    scopus 로고
    • Applications of the Morris water maze in the study of learning and memory
    • D'Hooge R., De Deyn P.P. Applications of the Morris water maze in the study of learning and memory. Brain Res. Brain Res. Rev. 2001, 36:60-90.
    • (2001) Brain Res. Brain Res. Rev. , vol.36 , pp. 60-90
    • D'Hooge, R.1    De Deyn, P.P.2
  • 30
    • 65249131854 scopus 로고    scopus 로고
    • Emerging concepts in the pathogenesis of epilepsy and epileptogenesis
    • Dichter M.A. Emerging concepts in the pathogenesis of epilepsy and epileptogenesis. Arch. Neurol. 2009, 66:443-447.
    • (2009) Arch. Neurol. , vol.66 , pp. 443-447
    • Dichter, M.A.1
  • 31
    • 79957814303 scopus 로고    scopus 로고
    • The time course of acquired epilepsy: implications for therapeutic intervention to suppress epileptogenesis
    • Dudek F.E., Staley K.J. The time course of acquired epilepsy: implications for therapeutic intervention to suppress epileptogenesis. Neurosci. Lett. 2011, 497:240-246.
    • (2011) Neurosci. Lett. , vol.497 , pp. 240-246
    • Dudek, F.E.1    Staley, K.J.2
  • 32
    • 33845536723 scopus 로고    scopus 로고
    • Kainate-induced status epilepticus: a chronic model of acquired epilepsy
    • Elsevier, Amsterdam, A. Pitkänen, P.A. Schwartzkroin, S.L. Moshé (Eds.)
    • Dudek F.E., Clark S., Williams P.A., Grabenstatter H.L. Kainate-induced status epilepticus: a chronic model of acquired epilepsy. Models of Seizures and Epilepsy 2006, 415-432. Elsevier, Amsterdam. A. Pitkänen, P.A. Schwartzkroin, S.L. Moshé (Eds.).
    • (2006) Models of Seizures and Epilepsy , pp. 415-432
    • Dudek, F.E.1    Clark, S.2    Williams, P.A.3    Grabenstatter, H.L.4
  • 33
    • 0033898768 scopus 로고    scopus 로고
    • Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy
    • Fujikawa D.G., Itabashi H.H., Wu A., Shinmei S.S. Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy. Epilepsia 2000, 41:981-991.
    • (2000) Epilepsia , vol.41 , pp. 981-991
    • Fujikawa, D.G.1    Itabashi, H.H.2    Wu, A.3    Shinmei, S.S.4
  • 34
    • 79951676950 scopus 로고    scopus 로고
    • Study of spontaneous recurrent seizures and morphological alterations after status epilepticus induced by intrahippocampal injection of pilocarpine
    • Furtado M.A., Castro O.W., Del Vecchio F., de Oliveira J.A., Garcia-Cairasco N. Study of spontaneous recurrent seizures and morphological alterations after status epilepticus induced by intrahippocampal injection of pilocarpine. Epilepsy Behav. 2011, 20:257-266.
    • (2011) Epilepsy Behav. , vol.20 , pp. 257-266
    • Furtado, M.A.1    Castro, O.W.2    Del Vecchio, F.3    de Oliveira, J.A.4    Garcia-Cairasco, N.5
  • 35
    • 0035976866 scopus 로고    scopus 로고
    • Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats
    • Gernert M., Löscher W. Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats. Eur. J. Pharmacol. 2001, 432:35-41.
    • (2001) Eur. J. Pharmacol. , vol.432 , pp. 35-41
    • Gernert, M.1    Löscher, W.2
  • 36
    • 0036221629 scopus 로고    scopus 로고
    • Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy
    • Glien M., Brandt C., Potschka H., Löscher W. Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy. Epilepsia 2002, 43:350-357.
    • (2002) Epilepsia , vol.43 , pp. 350-357
    • Glien, M.1    Brandt, C.2    Potschka, H.3    Löscher, W.4
  • 37
    • 34248581590 scopus 로고    scopus 로고
    • Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat
    • Goffin K., Nissinen J., Van Laere K., Pitkänen A. Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. Exp. Neurol. 2007, 205:501-505.
    • (2007) Exp. Neurol. , vol.205 , pp. 501-505
    • Goffin, K.1    Nissinen, J.2    Van Laere, K.3    Pitkänen, A.4
  • 38
    • 0001939761 scopus 로고    scopus 로고
    • Experimental models of status epilepticus
    • CRC Press, Boca Raton, S.L. Peterson, T.E. Albertson (Eds.)
    • Goodman J.H. Experimental models of status epilepticus. Neuropharmacology Methods in Epilepsy Research 1998, 95-125. CRC Press, Boca Raton. S.L. Peterson, T.E. Albertson (Eds.).
    • (1998) Neuropharmacology Methods in Epilepsy Research , pp. 95-125
    • Goodman, J.H.1
  • 39
    • 0037478606 scopus 로고    scopus 로고
    • Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy
    • Gouder N., Fritschy J.M., Boison D. Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia 2003, 44:877-885.
    • (2003) Epilepsia , vol.44 , pp. 877-885
    • Gouder, N.1    Fritschy, J.M.2    Boison, D.3
  • 40
    • 49349087280 scopus 로고    scopus 로고
    • Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate
    • Gröticke I., Hoffmann K., Löscher W. Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate. Exp. Neurol. 2008, 213:71-83.
    • (2008) Exp. Neurol. , vol.213 , pp. 71-83
    • Gröticke, I.1    Hoffmann, K.2    Löscher, W.3
  • 41
    • 0019450078 scopus 로고
    • Spatial memory following damage to hippocampal CA3 pyramidal cells with kainic acid: impairment and recovery with preoperative training
    • Handelmann G.E., Olton D.S. Spatial memory following damage to hippocampal CA3 pyramidal cells with kainic acid: impairment and recovery with preoperative training. Brain Res. 1981, 217:41-58.
    • (1981) Brain Res. , vol.217 , pp. 41-58
    • Handelmann, G.E.1    Olton, D.S.2
  • 42
    • 30844436580 scopus 로고    scopus 로고
    • Seizure clustering
    • Haut S.R. Seizure clustering. Epilepsy Behav. 2006, 8:50-55.
    • (2006) Epilepsy Behav. , vol.8 , pp. 50-55
    • Haut, S.R.1
  • 43
    • 0036062268 scopus 로고    scopus 로고
    • Seizure clustering during epilepsy monitoring
    • Haut S.R., Swick C., Freeman K., Spencer S. Seizure clustering during epilepsy monitoring. Epilepsia 2002, 43:711-715.
    • (2002) Epilepsia , vol.43 , pp. 711-715
    • Haut, S.R.1    Swick, C.2    Freeman, K.3    Spencer, S.4
  • 44
    • 0035986214 scopus 로고    scopus 로고
    • Use of excitotoxins to lesion the hippocampus: update
    • Jarrard L.E. Use of excitotoxins to lesion the hippocampus: update. Hippocampus 2002, 12:405-414.
    • (2002) Hippocampus , vol.12 , pp. 405-414
    • Jarrard, L.E.1
  • 45
    • 75949120331 scopus 로고    scopus 로고
    • Kindling as a model of temporal lobe epilepsy induces bilateral changes in spontaneous striatal activity
    • Kücker S., Töllner K., Piechotta M., Gernert M. Kindling as a model of temporal lobe epilepsy induces bilateral changes in spontaneous striatal activity. Neurobiol. Dis. 2010, 37:661-672.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 661-672
    • Kücker, S.1    Töllner, K.2    Piechotta, M.3    Gernert, M.4
  • 46
    • 80053920088 scopus 로고    scopus 로고
    • Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats
    • Langer M., Brandt C., Löscher W. Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats. Epilepsy Res. 2011, 96:207-224.
    • (2011) Epilepsy Res. , vol.96 , pp. 207-224
    • Langer, M.1    Brandt, C.2    Löscher, W.3
  • 47
    • 0030550268 scopus 로고    scopus 로고
    • Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats
    • Leite J.P., Babb T.L., Pretorius J.K., Kuhlman P.A., Yeoman K.M., Mathern G.W. Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats. Epilepsy Res. 1996, 26:219-231.
    • (1996) Epilepsy Res. , vol.26 , pp. 219-231
    • Leite, J.P.1    Babb, T.L.2    Pretorius, J.K.3    Kuhlman, P.A.4    Yeoman, K.M.5    Mathern, G.W.6
  • 48
    • 0036348280 scopus 로고    scopus 로고
    • New insights from the use of pilocarpine and kainate models
    • Leite J.P., Garcia-Cairasco N., Cavalheiro E.A. New insights from the use of pilocarpine and kainate models. Epilepsy Res. 2002, 50:93-103.
    • (2002) Epilepsy Res. , vol.50 , pp. 93-103
    • Leite, J.P.1    Garcia-Cairasco, N.2    Cavalheiro, E.A.3
  • 49
    • 0002991799 scopus 로고    scopus 로고
    • Animal models of epilepsy and epileptic seizures
    • Springer, Berlin, M.J. Eadie, F. Vajda (Eds.)
    • Löscher W. Animal models of epilepsy and epileptic seizures. Antiepileptic Drugs. Handbook of Experimental Pharmacology 1999, 19-62. Springer, Berlin. M.J. Eadie, F. Vajda (Eds.).
    • (1999) Antiepileptic Drugs. Handbook of Experimental Pharmacology , pp. 19-62
    • Löscher, W.1
  • 50
    • 79955677603 scopus 로고    scopus 로고
    • Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    • Löscher W. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure 2011, 20:359-368.
    • (2011) Seizure , vol.20 , pp. 359-368
    • Löscher, W.1
  • 51
    • 78650118698 scopus 로고    scopus 로고
    • Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research
    • Löscher W., Brandt C. Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research. Pharmacol. Rev. 2010, 62:668-700.
    • (2010) Pharmacol. Rev. , vol.62 , pp. 668-700
    • Löscher, W.1    Brandt, C.2
  • 52
    • 77957337142 scopus 로고    scopus 로고
    • Functional, metabolic, and synaptic changes after seizures as potential targets for antiepileptic therapy
    • Löscher W., Köhling R. Functional, metabolic, and synaptic changes after seizures as potential targets for antiepileptic therapy. Epilepsy Behav. 2010, 19:105-113.
    • (2010) Epilepsy Behav. , vol.19 , pp. 105-113
    • Löscher, W.1    Köhling, R.2
  • 53
    • 79955053045 scopus 로고    scopus 로고
    • Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice
    • Maroso M., Balosso S., Ravizza T., Iori V., Wright C.I., French J., Vezzani A. Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice. Neurotherapeutics 2011, 8:304-315.
    • (2011) Neurotherapeutics , vol.8 , pp. 304-315
    • Maroso, M.1    Balosso, S.2    Ravizza, T.3    Iori, V.4    Wright, C.I.5    French, J.6    Vezzani, A.7
  • 54
    • 0028049969 scopus 로고
    • Automated EEG monitoring in defining a chronic epilepsy model
    • Mascott C.R., Gotman J., Beaudet A. Automated EEG monitoring in defining a chronic epilepsy model. Epilepsia 1994, 35:895-902.
    • (1994) Epilepsia , vol.35 , pp. 895-902
    • Mascott, C.R.1    Gotman, J.2    Beaudet, A.3
  • 56
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 1984, 11:47-60.
    • (1984) J. Neurosci. Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 57
    • 0023791416 scopus 로고
    • Comparison of chlordimeform and carbaryl using a functional observational battery
    • Moser V.C., McCormick J.P., Creason J.P., MacPhail R.C. Comparison of chlordimeform and carbaryl using a functional observational battery. Fundam. Appl. Toxicol. 1988, 11:189-206.
    • (1988) Fundam. Appl. Toxicol. , vol.11 , pp. 189-206
    • Moser, V.C.1    McCormick, J.P.2    Creason, J.P.3    MacPhail, R.C.4
  • 58
    • 68549083382 scopus 로고    scopus 로고
    • Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice
    • Müller C.J., Gröticke I., Bankstahl M., Löscher W. Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. Exp. Neurol. 2009, 219:284-297.
    • (2009) Exp. Neurol. , vol.219 , pp. 284-297
    • Müller, C.J.1    Gröticke, I.2    Bankstahl, M.3    Löscher, W.4
  • 59
    • 0019126681 scopus 로고
    • Some behavioral effects of selective neuronal depletion by kainic acid in the dorsal hippocampus of rats
    • Munoz C., Grossman S.P. Some behavioral effects of selective neuronal depletion by kainic acid in the dorsal hippocampus of rats. Physiol. Behav. 1980, 25:581-587.
    • (1980) Physiol. Behav. , vol.25 , pp. 581-587
    • Munoz, C.1    Grossman, S.P.2
  • 60
    • 33847278982 scopus 로고    scopus 로고
    • Effect of antiepileptic drugs on spontaneous seizures in epileptic rats
    • Nissinen J., Pitkänen A. Effect of antiepileptic drugs on spontaneous seizures in epileptic rats. Epilepsy Res. 2007, 73:181-191.
    • (2007) Epilepsy Res. , vol.73 , pp. 181-191
    • Nissinen, J.1    Pitkänen, A.2
  • 62
    • 77953707753 scopus 로고    scopus 로고
    • The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy
    • Polascheck N., Bankstahl M., Löscher W. The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. Exp. Neurol. 2010, 224:219-233.
    • (2010) Exp. Neurol. , vol.224 , pp. 219-233
    • Polascheck, N.1    Bankstahl, M.2    Löscher, W.3
  • 63
    • 0037178642 scopus 로고    scopus 로고
    • P-glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats
    • Potschka H., Fedrowitz M., Löscher W. P-glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats. Neurosci. Lett. 2002, 327:173-176.
    • (2002) Neurosci. Lett. , vol.327 , pp. 173-176
    • Potschka, H.1    Fedrowitz, M.2    Löscher, W.3
  • 64
    • 0015309163 scopus 로고
    • Modification of seizure activity by electrical stimulation: II. Motor seizure
    • Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972, 32:281-294.
    • (1972) Electroencephalogr. Clin. Neurophysiol. , vol.32 , pp. 281-294
    • Racine, R.J.1
  • 66
    • 70449622815 scopus 로고    scopus 로고
    • Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus
    • Raedt R., Van Dycke A., Waeytens A., Wyckhuys T., Vonck K., Wadman W., Boon P. Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus. Epilepsy Res. 2009, 87:148-159.
    • (2009) Epilepsy Res. , vol.87 , pp. 148-159
    • Raedt, R.1    Van Dycke, A.2    Waeytens, A.3    Wyckhuys, T.4    Vonck, K.5    Wadman, W.6    Boon, P.7
  • 67
    • 78650846816 scopus 로고    scopus 로고
    • Enhanced susceptibility to the GABA antagonist pentylenetetrazole during the latent period following a pilocarpine-induced status epilepticus in rats
    • Rattka M., Brandt C., Bankstahl M., Bröer S., Löscher W. Enhanced susceptibility to the GABA antagonist pentylenetetrazole during the latent period following a pilocarpine-induced status epilepticus in rats. Neuropharmacology 2011, 60:505-512.
    • (2011) Neuropharmacology , vol.60 , pp. 505-512
    • Rattka, M.1    Brandt, C.2    Bankstahl, M.3    Bröer, S.4    Löscher, W.5
  • 68
    • 84865315539 scopus 로고    scopus 로고
    • Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy
    • Rattka M., Brandt C., Löscher W. Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy. Eur. J. Neurosci. 2012, 36:2505-2520.
    • (2012) Eur. J. Neurosci. , vol.36 , pp. 2505-2520
    • Rattka, M.1    Brandt, C.2    Löscher, W.3
  • 69
    • 0037067050 scopus 로고    scopus 로고
    • Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy
    • Riban V., Bouilleret V., Pham L., Fritschy J.M., Marescaux C., Depaulis A. Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy. Neuroscience 2002, 112:101-111.
    • (2002) Neuroscience , vol.112 , pp. 101-111
    • Riban, V.1    Bouilleret, V.2    Pham, L.3    Fritschy, J.M.4    Marescaux, C.5    Depaulis, A.6
  • 70
    • 0031738370 scopus 로고    scopus 로고
    • Status epilepticus causes long-term NMDA receptor-dependent behavioral changes and cognitive deficits
    • Rice A.C., Floyd C.L., Lyeth B.G., Hamm R.J., DeLorenzo R.J. Status epilepticus causes long-term NMDA receptor-dependent behavioral changes and cognitive deficits. Epilepsia 1998, 39:1148-1157.
    • (1998) Epilepsia , vol.39 , pp. 1148-1157
    • Rice, A.C.1    Floyd, C.L.2    Lyeth, B.G.3    Hamm, R.J.4    DeLorenzo, R.J.5
  • 71
    • 84885951336 scopus 로고    scopus 로고
    • Resistance to classical antiepileptic drugs in the MTLE mouse: a model of Mesial Temporal Lobe Epilepsy to explore new mechanisms of actions?
    • Roucard C., Bressand K., Depaulis A. Resistance to classical antiepileptic drugs in the MTLE mouse: a model of Mesial Temporal Lobe Epilepsy to explore new mechanisms of actions?. American Epilepsy Society, Annual Meeting, Abstract No. 2.387 2010, http://www.aesnet.org/.
    • (2010) American Epilepsy Society, Annual Meeting, Abstract No. 2.387
    • Roucard, C.1    Bressand, K.2    Depaulis, A.3
  • 72
    • 0018240145 scopus 로고
    • Microinjection of kainic acid into the rat hippocampus
    • Schwarcz R., Zaczek R., Coyle J.T. Microinjection of kainic acid into the rat hippocampus. Eur. J. Pharmacol. 1978, 50:209-220.
    • (1978) Eur. J. Pharmacol. , vol.50 , pp. 209-220
    • Schwarcz, R.1    Zaczek, R.2    Coyle, J.T.3
  • 73
    • 0030474749 scopus 로고    scopus 로고
    • Hippocampal pathology and pathophysiology in temporal lobe epilepsy
    • Sloviter R.S. Hippocampal pathology and pathophysiology in temporal lobe epilepsy. Neurologia 1996, 11(Suppl. 4):29-32.
    • (1996) Neurologia , vol.11 , Issue.SUPPL. 4 , pp. 29-32
    • Sloviter, R.S.1
  • 74
    • 0028057773 scopus 로고
    • Kainic acid seizures in the rat
    • Sperk G. Kainic acid seizures in the rat. Prog. Neurobiol. 1994, 42:1-32.
    • (1994) Prog. Neurobiol. , vol.42 , pp. 1-32
    • Sperk, G.1
  • 75
    • 0023727440 scopus 로고
    • Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid
    • Tanaka S., Kondo S., Tanaka T., Yonemasu Y. Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid. Brain Res. 1988, 463:163-167.
    • (1988) Brain Res. , vol.463 , pp. 163-167
    • Tanaka, S.1    Kondo, S.2    Tanaka, T.3    Yonemasu, Y.4
  • 76
    • 0024510191 scopus 로고
    • Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel model of intractable epilepsy
    • Turski L., Ikonomidou C., Turski W.A., Bortolotto Z.A., Cavalheiro E.A. Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel model of intractable epilepsy. Synapse 1989, 3:154-171.
    • (1989) Synapse , vol.3 , pp. 154-171
    • Turski, L.1    Ikonomidou, C.2    Turski, W.A.3    Bortolotto, Z.A.4    Cavalheiro, E.A.5
  • 77
    • 3042685585 scopus 로고    scopus 로고
    • ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis
    • Wieser H.G. ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 2004, 45:695-714.
    • (2004) Epilepsia , vol.45 , pp. 695-714
    • Wieser, H.G.1
  • 78
    • 84885960125 scopus 로고    scopus 로고
    • Microinjection of kainic acid into the amygdala of the rat as a model of limbic epilepsy with recurrent spontaneous seizures
    • Wlaz P., Ebert U., Löscher W. Microinjection of kainic acid into the amygdala of the rat as a model of limbic epilepsy with recurrent spontaneous seizures. Naunyn-Schmiedeberg's Arch. Pharmacol. 2000, 362(Suppl.):R49.
    • (2000) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.362 , Issue.SUPPL.
    • Wlaz, P.1    Ebert, U.2    Löscher, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.