Expression of cholera toxin B-lumbrokinase fusion protein in Pichia pastoris - The use of transmucosal carriers in the delivery of therapeutic proteins to protect rats against thrombosis

Applied Biochemistry and Biotechnology

Volumn 169, Issue 2, 2013, Pages 636-650

  Chunfeng, Guan ^a   Xiaozhou, Li ^b   Gang, Wang ^a   Jing, Ji ^a   Chao, Jin ^a   Josine, Tchouopou Lontchi ^a  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Cholera toxin B subunit; Lumbrokinase; Thrombosis; Transmucosal carriers

Indexed keywords

ANTI-THROMBOTIC EFFECT; ANTIGEN DELIVERY; CHOLERA TOXIN; CHOLERA TOXIN B SUBUNIT; CLEAVAGE SITES; FIBRINOLYTIC ENZYMES; FUSION PROTEINS; LUMBROKINASE; MUCOSAL CARRIER; ORAL ADMINISTRATION; ORAL DELIVERY; PICHIA PASTORIS; PLATE ASSAY; THERAPEUTIC PROTEIN; THROMBOSIS; WESTERN-BLOT ANALYSIS;

BLOOD VESSELS; RATS; RECOMBINANT PROTEINS; VACCINES; YEAST;

DISEASES;

CHOLERA TOXIN B SUBUNIT; FURIN; GANGLIOSIDE GM1; HYBRID PROTEIN; LUMBROKINASE; PLASMIN; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EARTHWORM; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FIBRINOLYSIS; FIBRINOLYTIC THERAPY; FUNGAL STRAIN; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PICHIA PASTORIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FOLDING; RAT; THROMBOSIS; VEIN THROMBOSIS; WESTERN BLOTTING;

ADMINISTRATION, MUCOSAL; ADMINISTRATION, ORAL; ANIMALS; CHOLERA TOXIN; ENDOPEPTIDASES; FIBRINOLYTIC AGENTS; MALE; MICE; MICE, INBRED BALB C; MOUTH MUCOSA; PICHIA; PROTEIN ENGINEERING; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; THROMBOSIS; TREATMENT OUTCOME;

ANIMALIA; MUS; PICHIA PASTORIS; RATTUS;

EID: 84873083685     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-012-0004-2     Document Type: Article

References (37)

1. Alisky, J. M.; van de Wetering, C. I.; & Davidson, B. L. (2002). Experimental Neurology, 178, 139-146.
2. Arêas, A. P. M.; Oliveira, M. L. S.; Miyaji, E. N.; Leite, L. C. C.; Araújo Aires, K.; Dias, W. O.; et al. (2004). Biochemical and Biophysical Research Communications, 321, 192-196.
3. Arakawa, T.; Yu, J.; Chong, D. K. X.; Hough, J.; Engen, P. C.; & Langridge, W. H. R. (1998). Nature Biotechnology, 16, 934-938.
4. Befus, N.; & Langridge, W. H. R. (2000). Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 43, 116-120.
5. Bekemeier, H.; Hirschelmann, R.; & Giessler, A. J. (1984). Biomedica Biochimica Acta, 43, S347-S350.
6. Bergerot, I.; Ploix, C.; Petersen, J.; Moulin, V.; Rask, C.; Fabien, N.; et al. (1997). Proceedings of the National Academy of Sciences, 94, 4610-4614.
7. Bertelli, A.; Bertelli, A. A.; Galmozzi, G.; Giovannini, L.; & Mian, M. (1993). Drugs under Experimental and Clinical Research, 19, 75-78.
8. Bradford, M. M. (1976). Analytical Biochemistry, 72, 248-254.
9. Fan, Q.; Wu, C.; Li, L.; Fan, R.; Wu, C.; Hou, Q.; et al. (2001). Biochimica et Biophysica Acta (BBA) - General Subjects, 1526, 286-292.
10. Gong, Z.; Jin, Y.; & Zhang, Y. (2007). Vaccine, 25, 1444-1451.
11. Gresele, P.; Momi, S.; Berrettini, M.; Nenci, G. G.; Schwarz, H. P.; Semeraro, N.; et al. (1998). The Journal of Clinical Investigation, 101, 667-676.
12. Guan, C.; Wang, G.; Ji, J.; Wang, J.; Wang, H.; & Tan, M. (2008). Journal of Sol-Gel Science and Technology, 48, 369-377.
13. Hamman, J. H.; Enslin, G. M.; & Kotzé, F. A. (2005). BioDrugs, 19, 165-177.
14. Heath, J. P. (1996). Cell Biology International, 20, 139-146.
15. Holmgren, J.; Harandi, A. M.; & Czerkinsky, C. (2003). Expert Review of Vaccines, 2, 205-217.
16. Huston, J. S.; Levinson, D.; Mudgett-Hunter, M.; Tai, M. S.; Novotny, J.; Margolies, M. N.; et al. (1988). Proceedings of the National Academy of Sciences of the United States of America, 85, 5879-5883.
17. Jin, L.; Jin, H.; Zhang, G.; & Xu, G. (2000). Clinical Hemorheology and Microcirculation, 23, 213-218.
18. Kim, T. G.; & Langridge, W. H. R. (2003). Plant Cell Reports, 21, 884-890.
19. Kipnes, M.; Dandona, P.; Tripathy, D.; Still, J. G.; & Kosutic, G. (2003). Diabetes Care, 26, 421-426.
20. Kod'ousek, R.; Jezdinsky, J.; & Krajci, D. (2007). Medical Principles and Practice, 16, 360-366.
21. Kumada, T.; Ishihara, M.; Ogawa, H.; & Abiko, Y. (1980). Thrombosis Research, 18, 189-203.
22. Laemmli, U. K. (1970). Nature, 227, 680-685.
23. Lee, C. K.; Shin, J. S.; Kim, B. S.; Cho, I. H.; Kim, Y. S.; & Lee, E. B. (2007). Archives of Pharmacal Research, 30, 475-480.
24. Lencer, W. I. (2001). American Journal of Physiology - Gastrointestinal and Liver Physiology, 280, G781-G786.
25. Li, D.; O'Leary, J.; Huang, Y.; Huner, N.; Jevnikar, A.; & Ma, S. (2006). Plant Cell Reports, 25, 417-424.
26. Limaye, A.; Koya, V.; Samsam, M.; & Daniell, H. (2006). The FASEB Journal, 20, 959-961.
27. Ling, H.; Boodhoo, A.; Hazes, B.; Cummings, M. D.; Armstrong, G. D.; Brunton, J. L.; et al. (1998). Biochemistry, 37, 1777-1788.
28. McKenzie, S. J.; & Halsey, J. F. (1984). The Journal of Immunology, 133, 1818-1824.
29. Mihara, H. (1983). Thrombosis and Haemostasis, 50, 258.
30. Mustata, G.; & Dinh, S. M. (2006). Critical Reviews in Therapeutic Drug Carrier Systems, 23, 111-135.
31. Nakajima, N.; Ishihara, K.; Sugimoto, M.; Sumi, H.; Mikuni, K.; & Hamada, H. (1996). Bioscience, Biotechnology, and Biochemistry, 60, 293-300.
32. Nakajima, N.; Mihara, H.; & Sumi, H. (1993). Bioscience, Biotechnology, and Biochemistry, 57, 1726-1730.
33. Philipose, S.; Konya, V.; Sreckovic, I.; Marsche, G.; Lippe, I. T.; Peskar, B. A.; et al. (2010). Arteriosclerosis, Thrombosis, and Vascular Biology, 30, 2416-2423.
34. Riewald, M.; & Ruf, W. (2003). Critical Care, 7, 123-129.
35. Shah, R. B.; Ahsan, F.; & Khan, M. A. (2002). Critical Reviews in Therapeutic Drug Carrier Systems, 19, 135-169.
36. Tomoko, N.; Fumio, T.; Naotoshi, T.; Takashi, Y.; Takeshi, A.; Yoshihiro, H.; et al. (2009). Journal of Veterinary Medical Science, 71, 995-1000.
37. Van Der Lubben, I. M.; Konings, F. A. J.; Borchard, G.; Verhoef, J. C.; & Junginger, H. E. (2001). Journal of Drug Targeting, 9, 39-47.