Sympathoinhibitory signals from the gut and obesity-related hypertension

Clinical Autonomic Research

Volumn 23, Issue 1, 2013, Pages 33-39

  Sartor, Daniela M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cardiovascular; Cholecystokinin; Hypertension; Leptin; Obesity; Sympathetic nervous system

Indexed keywords

ANGIOTENSIN II; CHOLECYSTOKININ A RECEPTOR; GHRELIN; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; OREXIN; SEROTONIN 3 RECEPTOR;

APPETITE; AUTONOMIC DENERVATION; AUTONOMIC NERVOUS SYSTEM; ENTEROENDOCRINE CELL; FAT INTAKE; FOOD INTAKE; GASTROINTESTINAL TRACT; HEART OUTPUT; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HYPERTENSION; INFLAMMATION; KIDNEY BLOOD FLOW; KIDNEY BLOOD VESSEL; KIDNEY NERVE; LIPID DIET; NONHUMAN; OBESITY; PRESSORECEPTOR REFLEX; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SATIETY; SIGNAL TRANSDUCTION; SPLANCHNIC NERVE; SYMPATHETIC NERVE; SYMPATHETIC REFLEX; SYMPATHETIC TONE; THERMOGENESIS; VAGUS NERVE; VASCULAR RESISTANCE; VASODILATATION; VASOMOTOR REFLEX; VON BEZOLDRECENTLY REFLEX; WEIGHT GAIN;

ANIMALS; BAROREFLEX; GASTROINTESTINAL HORMONES; HUMANS; HYPERTENSION; OBESITY; SYMPATHETIC NERVOUS SYSTEM;

EID: 84873081526     PISSN: 09599851     EISSN: 16191560     Source Type: Journal    
DOI: 10.1007/s10286-012-0171-9     Document Type: Review

References (49)

1. World Health Organization (2011) Obesity and Overweight, Fact Sheet N 311, http://www.who.int/mediacentre/factsheets/fs311/en/
2. Lambert E, Sari CI, Dawood T, Nguyen J, McGrane M, Eikelis N, Chopra R, Wong C, Chatzivlastou K, Head G, Straznicky N, Esler M, Schlaich M, Lambert G (2010) Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults. Hypertension 56:351-358
3. Grassi G, Seravalle G, Dell'oro R (2010) Sympathetic activation in obesity: a non innocent bystander. Hypertension 56:338-340
4. Stapleton PA, James ME, Goodwill AG, Frisbee JC (2008) Obesity and vascular dysfunction. Pathophysiology 15:79-89
5. Schreihofer AM, Mandel DA, Mobley SC, Stepp DW (2007) Impairment of sympathetic baroreceptor reflexes in obese Zucker rats. Am J Physiol 293:H2543-H2549
6. Huber DA, Schreihofer AM (2010) Attenuated baroreflex control of sympathetic nerve activity in obese Zucker rats by central mechanisms. J Physiol 588:1515-1525
7. Gordon FJ, Mark AL (1984) Mechanism of impaired baroreflex control in pre hypertensive Dahl salt-sensitive rats. Circ Res 54:378-387
8. Fink GD (2010) Does our fat tell our brain what to do? A sympathetic' appraisal. J Physiol 588:1389-1390
9. Davy KP, Hall JE (2004) Obesity and hypertension: two epidemics or one? Am J Physiol 286:R803-R813
10. Haynes WG (2005) Role of leptin in obesity-related hypertension. Exp Physiol 90:683-688
11. Rahmouni K (2010) Obesity, sympathetic overdrive, and hypertension: the leptin connection. Hypertension 55:844-845
12. Anubhuti Arora S (2008) Leptin and its metabolic interactions: an update. Diabetes Obes Metab 10:973-993
13. Beltowski J (2006) Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens 24:789-801
14. Esler M, Straznicky N, Eikelis N, Masuo K, Lambert G, Lambert E (2006) Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 48:787-796
15. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ (1998) The stomach is a source of leptin. Nature 394:790-793
16. Sartor DM, Verberne AJ (2010) Gastric leptin: a novel role in cardiovascular regulation. Am J Physiol 298:H406-H414
17. Peters JH, McKay BM, Simasko SM, Ritter RC (2005) Leptin-induced satiation mediated by abdominal vagal afferents. Am J Physiol 288:R879-R884
18. Sartor DM, Verberne AJ (2008) Abdominal vagal signalling: a novel role for cholecystokinin in circulatory control? Br Res Rev 59:140-154
19. Guilmeau S, Buyse M, Bado A (2004) Gastric leptin: a new manager of gastrointestinal function. Curr Opin Pharmacol 4:561-566
20. Sartor DM, Verberne AJM (2002) Cholecystokinin selectively affects pre sympathetic vasomotor neurons and sympathetic vasomotor outflow. Am J Physiol 282:R1174-R1184
21. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y (1997) Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Nat Acad Sci USA 94:10455-10460
22. Wang YH, Tache Y, Sheibel AB, Go VL, Wei JY (1997) Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. Am J Physiol 273:R833-R837
23. Sartor DM, Shulkes A, Verberne AJ (2006) An enteric signal regulates putative gastrointestinal presympathetic vasomotor neurons in rats. Am J Physiol 290:R625-R633
24. Sartor DM, Verberne AJ (2006) The sympathoinhibitory effects of systemic cholecystokinin are dependent on neurons in the caudal ventrolateral medulla in the rat. Am J Physiol 291:R1390-R1398
25. Sartor DM, Verberne AJ (2007) The role of NMDA and non-NMDA receptors in the NTS in mediating three distinct sympathoinhibitory reflexes. N-S Arch Pharmacol 376:241-252
26. Sartor DM, Verberne AJM (2003) Phenotypic identification of rat rostroventrolateral medullary presympathetic vasomotor neurons inhibited by exogenous cholecystokinin. J Comp Neurol 465:467-479
27. Verberne AJM, Sartor DM (2004) Cholecystokinin-induced inhibition of presympathetic vasomotor neurons: dependence on sub-diaphragmatic vagal afferents and central NMDA receptors in the rat. Am J Physiol 287:R809-R816
28. Sartor DM, Pumpa T, How JMY (2011) Obesity-induced hypertension is associated with blunted renal sympathoinhibitory responses to gastric peptides. FASEB J 25(1078):4
29. Yagi K, Kim S, Wanibuchi H, Yamashita T, Yamamura Y, Iwao H (1997) Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats. Hypertension 29:728-735
30. Granger DN, Kvietys PR, Korthuis RJ, Premen AJ (1989) Microcirculation of the intestinal mucosa. In: Schultz SC, Wood JD, Rauner BB (eds) Handbook of physiology. Oxford University Press, New York
31. Premen AJ (1988) Potential mechanisms mediating postprandial renal hyperemia and hyperfiltration. FASEB J 2:131-137
32. Echtenkamp SF, Davis JO, Freeman RH, Dietz JR, Villarreal D (1983) Splanchnic and renal contributions to circulatory homeostasis in sodium depletion. Am J Physiol 245:H573-H579
33. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376:1903-1909
34. Smithwick RH, Thompson JE (1953) Splanchnicectomy for essential hypertension; results in 1,266 cases. J Am Med Assoc 152:1501-1504
35. Osborn JW, Fink GD, Kuroki MT (2011) Neural mechanisms of angiotensin II-salt hypertension: implications for therapies targeting neural control of the splanchnic circulation. Curr Hypertens Rep 13:221-228
36. Conway J (1984) Hemodynamic aspects of essential hypertension in humans. Physiol Rev 64:617-660
37. Hall JE, Hildebrandt DA, Kuo J (2001) Obesity hypertension: role of leptin and sympathetic nervous system. Am J Hypertens 14:103S-115S
38. Bell CG, Walley AJ, Froguel P (2005) The genetics of human obesity. Nat Rev Genet 6:221-234
39. Levin BE, Triscari J, Sullivan AC (1983) Altered sympathetic activity during development of diet-induced obesity in rat. Am J Physiol 244:R347-R355
40. Boustany-Kari CM, Gong M, Akers WS, Guo Z, Cassis LA (2007) Enhanced vascular contractility and diminished coronary artery flow in rats made hypertensive from diet-induced obesity. Int J Obes 31:1652-1659
41. How JM, Fam BC, Verberne AJ, Sartor DM (2011) High fat diet is associated with blunted splanchnic sympathoinhibitory responses to gastric leptin and cholecystokinin: implications for circulatory control. Am J Physiol 300:H961-H967
42. Stocker SD, Meador R, Adams JM (2007) Neurons of the rostral ventrolateral medulla contribute to obesity-induced hypertension in rats. Hypertension 49:640-646
43. Burdyga G, Spiller D, Morris R, Lal S, Thompson DG, Saeed S, Dimaline R, Varro A, Dockray GJ (2002) Expression of the leptin receptor in rat and human nodose ganglion neurones. Neurosci 109:339-347
44. Nefti W, Chaumontet C, Fromentin G, Tome D, Darcel N (2009) A high-fat diet attenuates the central response to within-meal satiation signals and modifies the receptor expression of vagal afferents in mice. Am J Physiol 296:R1681-R1686
45. Dockray G (2012) Cholecystokinin. Curr Op Endocrin Diab Obes 19:8-12
46. de Lartigue G, de La Serre CB, Raybould HE (2011) Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin. Physiol Behav 105:100-105
47. How JMY, Pumpa TJ, Sartor DM (2011) Attenuated regional vasodilatory effects of gastrointestinal hormones in obesity prone animals: implications for obesity-related hypertension. FASEB J 25:lb607
48. Takahashi T, Owyang C (1999) Mechanism of cholecystokinin-induced relaxation of the rat stomach. J Auton Nerv Syst 75:123-130
49. Prentice AM, Jebb SA (2003) Fast foods, energy density and obesity: a possible mechanistic link. Obes Rev 4:187-194