Individual and combined roles of the master regulators apha and luxr in control of the Vibrio harveyi quorum-sensing regulon

Journal of Bacteriology

Volumn 195, Issue 3, 2013, Pages 436-443

  Van Kessel, Julia C ^a   Rutherford, Steven T ^a   Shao, Yi ^a   Utria, Alan F ^a   Bassler, Bonnie L ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR APHA; TRANSCRIPTION FACTOR LUXR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BACTERIAL GENE; CELL DENSITY; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCUS; GENE REPRESSION; GENE TARGETING; GENETIC CODE; LIFESTYLE; NONHUMAN; PRIORITY JOURNAL; QUORUM SENSING; REGULATOR GENE; REGULON; TYPE III SECRETION SYSTEM; VIBRIO HARVEYI;

CELL PROLIFERATION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; MUTATION; PROTEIN ARRAY ANALYSIS; QUORUM SENSING; REAL-TIME POLYMERASE CHAIN REACTION; REGULON; REPRESSOR PROTEINS; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; VIBRIO;

EID: 84873046241     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.01998-12     Document Type: Article

References (29)

1. Ng WL, Bassler BL. 2009. Bacterial quorum-sensing network architectures. Annu. Rev. Genet. 43:197-222.
2. Henke JM, Bassler BL. 2004. Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi. J. Bacteriol. 186:6902-6914.
3. Bassler BL, Wright M, Silverman MR. 1994. Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway. Mol. Microbiol. 13:273-286.
4. Bassler BL, Wright M, Showalter RE, Silverman MR. 1993. Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Mol. Microbiol. 9:773-786.
5. Bassler BL, Wright M, Silverman MR. 1994. Sequence and function of LuxO, a negative regulator of luminescence in Vibrio harveyi. Mol. Microbiol. 12:403-412.
6. Freeman JA, Bassler BL. 1999. A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi. Mol. Microbiol. 31:665-677.
7. Lenz DH, Mok KC, Lilley BN, Kulkarni RV, Wingreen NS, Bassler BL. 2004. The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell 118:69-82.
8. Lilley BN, Bassler BL. 2000. Regulation of quorum sensing in Vibrio harveyi by LuxO and sigma-54. Mol. Microbiol. 36:940-954.
9. Tu KC, Bassler BL. 2007. Multiple small RNAs act additively to integrate sensory information and control quorum sensing in Vibrio harveyi. Genes Dev. 21:221-233.
10. Rutherford ST, van Kessel JC, Shao Y, Bassler BL. 2011. AphA and LuxR/HapR reciprocally control quorum sensing in vibrios. Genes Dev. 25:397-408.
11. Shao Y, Bassler BL. 2012. Quorum-sensing non-coding small RNAs use unique pairing regions to differentially control mRNA targets. Mol. Microbiol. 83:599-611.
12. Pompeani AJ, Irgon JJ, Berger MF, Bulyk ML, Wingreen NS, Bassler BL. 2008. The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters. Mol. Microbiol. 70:76-88.
13. Waters CM, Bassler BL. 2006. The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers. Genes Dev. 20:2754-2767.
14. Swartzman E, Silverman M, Meighen EA. 1992. The luxR gene product of Vibrio harveyi is a transcriptional activator of the lux promoter. J. Bacteriol. 174:7490-7493.
15. Miyamoto CM, Smith EE, Swartzman E, Cao JG, Graham AF, Meighen EA. 1994. Proximal and distal sites bind LuxR independently and activate expression of the Vibrio harveyi lux operon. Mol. Microbiol. 14:255-262.
16. Tu KC, Waters CM, Svenningsen SL, Bassler BL. 2008. A small-RNAmediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi. Mol. Microbiol. 70:896-907.
17. Henke JM, Bassler BL. 2004. Quorum sensing regulates type III secretion in Vibrio harveyi and Vibrio parahaemolyticus. J. Bacteriol. 186:3794-3805.
18. Skorupski K, Taylor RK. 1999. A new level in the Vibrio cholerae ToxR virulence cascade: AphA is required for transcriptional activation of the tcpPH operon. Mol. Microbiol. 31:763-771.
19. De Silva RS, Kovacikova G, Lin W, Taylor RK, Skorupski K, Kull FJ. 2005. Crystal structure of the virulence gene activator AphA from Vibrio cholerae reveals it is a novel member of the winged helix transcription factor superfamily. J. Biol. Chem. 280:13779-13783.
20. Rickard AH, Palmer RJ, Jr, Blehert DS, Campagna SR, Semmelhack MF, Egland PG, Bassler BL, Kolenbrander PE. 2006. Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth. Mol. Microbiol. 60:1446-1456.
21. Lynch SA, Gallivan JP. 2009. A flow cytometry-based screen for synthetic riboswitches. Nucleic Acids Res. 37:184-192.
22. Tu KC, Long T, Svenningsen SL, Wingreen NS, Bassler BL. 2010. Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response. Mol. Cell 37:567-579.
23. Kovacikova G, Lin W, Skorupski K. 2003. The virulence activator AphA links quorum sensing to pathogenesis and physiology in Vibrio cholerae by repressing the expression of a penicillin amidase gene on the small chromosome. J. Bacteriol. 185:4825-4836.
24. Kovacikova G, Lin W, Skorupski K. 2005. Dual regulation of genes involved in acetoin biosynthesis and motility/biofilm formation by the virulence activator AphA and the acetate-responsive LysR-type regulator AlsR in Vibrio cholerae. Mol. Microbiol. 57:420-433.
25. Waters CM, Wu JT, Ramsey ME, Harris RC, Bassler BL. 2010. Control of the type 3 secretion system in Vibrio harveyi by quorum sensing through repression of ExsA. Appl. Environ. Microbiol. 76:4996-5004.
26. Teng SW, Schaffer JN, Tu KC, Mehta P, Lu W, Ong NP, Bassler BL, Wingreen NS. 2011. Active regulation of receptor ratios controls integration of quorum-sensing signals in Vibrio harveyi. Mol. Syst. Biol. 7:491. doi:10.1038/msb.2011.30.
27. Hammer BK, Bassler BL. 2007. Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae. Proc. Natl. Acad. Sci. U. S. A. 104:11145-11149.
28. Yahr TL, Wolfgang MC. 2006. Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system. Mol. Microbiol. 62:631-640.
29. Angot A, Vergunst A, Genin S, Peeters N. 2007. Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems. PLoS Pathog. 3:e3. doi:10.1371 /journal.ppat.0030003.