메뉴 건너뛰기




Volumn 62, Issue 2, 2013, Pages 572-580

Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE; INSULIN; VASCULOTROPIN;

EID: 84873032159     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0354     Document Type: Article
Times cited : (77)

References (56)
  • 1
    • 0026021161 scopus 로고
    • Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991;14:173-194
    • (1991) Diabetes Care , vol.14 , pp. 173-194
    • Defronzo, R.A.1    Ferrannini, E.2
  • 3
    • 13844266843 scopus 로고    scopus 로고
    • Control of muscle glucose uptake: Test of the rate-limiting step paradigm in conscious, unrestrained mice
    • Fueger PT, Shearer J, Bracy DP, et al. Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice. J Physiol 2005;562:925-935
    • (2005) J Physiol , vol.562 , pp. 925-935
    • Fueger, P.T.1    Shearer, J.2    Bracy, D.P.3
  • 4
    • 0033667852 scopus 로고    scopus 로고
    • Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat
    • Halseth AE, Bracy DP, Wasserman DH. Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat. Am J Physiol Endocrinol Metab 2000;279:E1064-E1071
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Halseth, A.E.1    Bracy, D.P.2    Wasserman, D.H.3
  • 5
    • 42449107752 scopus 로고    scopus 로고
    • Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal
    • Chiu JD, Richey JM, Harrison LN, et al. Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal. Diabetes 2008;57:828-835
    • (2008) Diabetes , vol.57 , pp. 828-835
    • Chiu, J.D.1    Richey, J.M.2    Harrison, L.N.3
  • 6
    • 33748295591 scopus 로고    scopus 로고
    • Reduced access to insulinsensitive tissues in dogs with obesity secondary to increased fat intake
    • Ellmerer M, Hamilton-Wessler M, Kim SP, et al. Reduced access to insulinsensitive tissues in dogs with obesity secondary to increased fat intake. Diabetes 2006;55:1769-1775
    • (2006) Diabetes , vol.55 , pp. 1769-1775
    • Ellmerer, M.1    Hamilton-Wessler, M.2    Kim, S.P.3
  • 7
    • 79551595824 scopus 로고    scopus 로고
    • Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice
    • Kang L, Ayala JE, Lee-Young RS, et al. Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes 2011;60:416-426
    • (2011) Diabetes , vol.60 , pp. 416-426
    • Kang, L.1    Ayala, J.E.2    Lee-Young, R.S.3
  • 8
    • 23744440521 scopus 로고    scopus 로고
    • Hypertension-independent microvascular rarefaction in the obese Zucker rat model of the metabolic syndrome
    • Frisbee JC. Hypertension-independent microvascular rarefaction in the obese Zucker rat model of the metabolic syndrome. Microcirculation 2005; 12:383-392
    • (2005) Microcirculation , vol.12 , pp. 383-392
    • Frisbee, J.C.1
  • 9
    • 84855426289 scopus 로고    scopus 로고
    • Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats
    • Guo Q, Mori T, Jiang Y, et al. Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats. Hypertens Res 2012;35:48-54
    • (2012) Hypertens Res , vol.35 , pp. 48-54
    • Guo, Q.1    Mori, T.2    Jiang, Y.3
  • 11
    • 79955653370 scopus 로고    scopus 로고
    • Progressive hyperglycemia across the glucose tolerance continuum in older obese adults is related to skeletal muscle capillarization and nitric oxide bioavailability
    • Solomon TP, Haus JM, Li Y, Kirwan JP. Progressive hyperglycemia across the glucose tolerance continuum in older obese adults is related to skeletal muscle capillarization and nitric oxide bioavailability. J Clin Endocrinol Metab 2011;96:1377-1384
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1377-1384
    • Solomon, T.P.1    Haus, J.M.2    Li, Y.3    Kirwan, J.P.4
  • 12
    • 2542539954 scopus 로고    scopus 로고
    • Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo
    • Vincent MA, Clerk LH, Lindner JR, et al. Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo. Diabetes 2004;53:1418-1423
    • (2004) Diabetes , vol.53 , pp. 1418-1423
    • Vincent, M.A.1    Clerk, L.H.2    Lindner, J.R.3
  • 13
    • 0025954408 scopus 로고
    • Mechanism of insulin resistance in insulin-dependent diabetes mellitus: A major role for reduced skeletal muscle blood flow
    • Baron AD, Laakso M, Brechtel G, Edelman SV. Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J Clin Endocrinol Metab 1991;73:637-643
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 637-643
    • Baron, A.D.1    Laakso, M.2    Brechtel, G.3    Edelman, S.V.4
  • 14
    • 0034037949 scopus 로고    scopus 로고
    • Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: Evidence for capillary recruitment
    • Baron AD, Tarshoby M, Hook G, et al. Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Diabetes 2000;49:768-774
    • (2000) Diabetes , vol.49 , pp. 768-774
    • Baron, A.D.1    Tarshoby, M.2    Hook, G.3
  • 16
    • 79952142784 scopus 로고    scopus 로고
    • Impaired insulin signaling in en-dothelial cells reduces insulin-induced glucose uptake by skeletal muscle
    • Kubota T, Kubota N, Kumagai H, et al. Impaired insulin signaling in en-dothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab 2011;13:294-307
    • (2011) Cell Metab , vol.13 , pp. 294-307
    • Kubota, T.1    Kubota, N.2    Kumagai, H.3
  • 17
    • 0025292440 scopus 로고
    • Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
    • Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest 1990;85:1844-1852
    • (1990) J Clin Invest , vol.85 , pp. 1844-1852
    • Laakso, M.1    Edelman, S.V.2    Brechtel, G.3    Baron, A.D.4
  • 18
    • 11144327215 scopus 로고    scopus 로고
    • Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans
    • Gavin TP, Stallings HW 3rd, Zwetsloot KA, et al. Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans. J Appl Physiol 2005;98:315-321
    • (2005) J Appl Physiol , vol.98 , pp. 315-321
    • Gavin, T.P.1    Stallings Iii., H.W.2    Zwetsloot, K.A.3
  • 19
    • 0023392223 scopus 로고
    • Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man
    • Lillioja S, Young AA, Culter CL, et al. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest 1987;80:415-424
    • (1987) J Clin Invest , vol.80 , pp. 415-424
    • Lillioja, S.1    Young, A.A.2    Culter, C.L.3
  • 20
    • 0028353239 scopus 로고
    • Muscle fiber composition and capillary density in women and men with NIDDM
    • Mårin P, Andersson B, Krotkiewski M, Björntorp P. Muscle fiber composition and capillary density in women and men with NIDDM. Diabetes Care 1994;17:382-386
    • (1994) Diabetes Care , vol.17 , pp. 382-386
    • Mårin, P.1    Andersson, B.2    Krotkiewski, M.3    Björntorp, P.4
  • 21
    • 33747611521 scopus 로고    scopus 로고
    • Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and-9 in human type 2 diabetic arterial vasculature
    • Chung AW, Hsiang YN, Matzke LA, McManus BM, van Breemen C, Okon EB. Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and-9 in human type 2 diabetic arterial vasculature. Circ Res 2006;99:140-148
    • (2006) Circ Res , vol.99 , pp. 140-148
    • Chung, A.W.1    Hsiang, Y.N.2    Matzke, L.A.3    McManus, B.M.4    Van Breemen, C.5    Okon, E.B.6
  • 22
    • 34047094881 scopus 로고    scopus 로고
    • Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice
    • Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 2007;56:1025-1033
    • (2007) Diabetes , vol.56 , pp. 1025-1033
    • Ayala, J.E.1    Bracy, D.P.2    Julien, B.M.3    Rottman, J.N.4    Fueger, P.T.5    Wasserman, D.H.6
  • 23
    • 80755168880 scopus 로고    scopus 로고
    • Angiotensin ii receptors modulate muscle microvascular and metabolic responses to insulin in vivo
    • Chai W, Wang W, Dong Z, Cao W, Liu Z. Angiotensin II receptors modulate muscle microvascular and metabolic responses to insulin in vivo. Diabetes 2011;60:2939-2946
    • (2011) Diabetes , vol.60 , pp. 2939-2946
    • Chai, W.1    Wang, W.2    Dong, Z.3    Cao, W.4    Liu, Z.5
  • 25
    • 0037154304 scopus 로고    scopus 로고
    • Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: A possible explanation for impaired collateral formation in cardiac tissue
    • Chou E, Suzuma I, Way KJ, et al. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation 2002;105:373-379
    • (2002) Circulation , vol.105 , pp. 373-379
    • Chou, E.1    Suzuma, I.2    Way, K.J.3
  • 26
    • 24044517938 scopus 로고    scopus 로고
    • Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease
    • Sasso FC, Torella D, Carbonara O, et al. Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease. J Am Coll Cardiol 2005;46:827-834
    • (2005) J Am Coll Cardiol , vol.46 , pp. 827-834
    • Sasso, F.C.1    Torella, D.2    Carbonara, O.3
  • 27
    • 37349118333 scopus 로고    scopus 로고
    • Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: Differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1
    • Hazarika S, Dokun AO, Li Y, Popel AS, Kontos CD, Annex BH. Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. Circ Res 2007;101: 948-956
    • (2007) Circ Res , vol.101 , pp. 948-956
    • Hazarika, S.1    Dokun, A.O.2    Li, Y.3    Popel, A.S.4    Kontos, C.D.5    Annex, B.H.6
  • 28
    • 65249181467 scopus 로고    scopus 로고
    • Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice
    • Olfert IM, Howlett RA, Tang K, et al. Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol 2009;587:1755-1767
    • (2009) J Physiol , vol.587 , pp. 1755-1767
    • Olfert, I.M.1    Howlett, R.A.2    Tang, K.3
  • 29
    • 4844228637 scopus 로고    scopus 로고
    • Capillary regression in vascular endothelial growth factor-deficient skeletal muscle
    • Tang K, Breen EC, Gerber HP, Ferrara NMA, Wagner PD. Capillary regression in vascular endothelial growth factor-deficient skeletal muscle. Physiol Genomics 2004;18:63-69
    • (2004) Physiol Genomics , vol.18 , pp. 63-69
    • Tang, K.1    Breen, E.C.2    Gerber, H.P.3    Ferrara, N.M.A.4    Wagner, P.D.5
  • 30
    • 0032931234 scopus 로고    scopus 로고
    • VEGF is required for growth and survival in neonatal mice
    • Gerber HP, Hillan KJ, Ryan AM, et al. VEGF is required for growth and survival in neonatal mice. Development 1999;126:1149-1159
    • (1999) Development , vol.126 , pp. 1149-1159
    • Gerber, H.P.1    Hillan, K.J.2    Ryan, A.M.3
  • 31
    • 48249100979 scopus 로고    scopus 로고
    • Glucose metabolism in vivo in four commonly used inbred mouse strains
    • Berglund ED, Li CY, Poffenberger G, et al. Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes 2008;57:1790-1799
    • (2008) Diabetes , vol.57 , pp. 1790-1799
    • Berglund, E.D.1    Li, C.Y.2    Poffenberger, G.3
  • 32
    • 33644778829 scopus 로고    scopus 로고
    • Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse
    • Ayala JE, Bracy DP, McGuinness OP, Wasserman DH. Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes 2006;55:390-397
    • (2006) Diabetes , vol.55 , pp. 390-397
    • Ayala, J.E.1    Bracy, D.P.2    McGuinness, O.P.3    Wasserman, D.H.4
  • 33
    • 79954996869 scopus 로고    scopus 로고
    • Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
    • Jornayvaz FR, Birkenfeld AL, Jurczak MJ, et al. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc Natl Acad Sci U S A 2011;108:5748-5752
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5748-5752
    • Jornayvaz, F.R.1    Birkenfeld, A.L.2    Jurczak, M.J.3
  • 34
    • 12144290761 scopus 로고    scopus 로고
    • Differential effects of interleukin-6 and-10 on skeletal muscle and liver insulin action in vivo
    • Kim HJ, Higashimori T, Park SY, et al. Differential effects of interleukin-6 and-10 on skeletal muscle and liver insulin action in vivo. Diabetes 2004; 53:1060-1067
    • (2004) Diabetes , vol.53 , pp. 1060-1067
    • Kim, H.J.1    Higashimori, T.2    Park, S.Y.3
  • 35
    • 77049274176 scopus 로고
    • Measurement of size and turnover rate of body glucose pool by the isotope dilution method
    • Steele R, Wall JS, De Bodo RC, Altszuler N. Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 1956;187:15-24
    • (1956) Am J Physiol , vol.187 , pp. 15-24
    • Steele, R.1    Wall, J.S.2    De Bodo, R.C.3    Altszuler, N.4
  • 36
    • 0017159024 scopus 로고
    • A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hep-atocytes
    • Chan TM, Exton JH. A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hep-atocytes. Anal Biochem 1976;71:96-105
    • (1976) Anal Biochem , vol.71 , pp. 96-105
    • Chan, T.M.1    Exton, J.H.2
  • 37
    • 0017344721 scopus 로고
    • An improved procedure for the assay of gly-cogen synthase and phosphorylase in rat liver homogenates
    • Golden S, Wals PA, Katz J. An improved procedure for the assay of gly-cogen synthase and phosphorylase in rat liver homogenates. Anal Biochem 1977;77:436-445
    • (1977) Anal Biochem , vol.77 , pp. 436-445
    • Golden, S.1    Wals, P.A.2    Katz, J.3
  • 38
    • 0345832116 scopus 로고    scopus 로고
    • Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    • Jørgensen SB, Viollet B, Andreelli F, et al. Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. J Biol Chem 2004;279:1070-1079
    • (2004) J Biol Chem , vol.279 , pp. 1070-1079
    • Jørgensen, S.B.1    Viollet, B.2    Andreelli, F.3
  • 39
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in realtime RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001;29:e45
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 40
    • 7044235846 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates skeletal muscle regeneration in vivo
    • Arsic N, Zacchigna S, Zentilin L, et al. Vascular endothelial growth factor stimulates skeletal muscle regeneration in vivo. Mol Ther 2004;10:844-854
    • (2004) Mol Ther , vol.10 , pp. 844-854
    • Arsic, N.1    Zacchigna, S.2    Zentilin, L.3
  • 41
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 1999;104:733-741
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 42
    • 79960768692 scopus 로고    scopus 로고
    • Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature
    • Barrett EJ, Wang H, Upchurch CT, Liu Z. Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature. Am J Physiol Endocrinol Metab 2011;301:E252-E263
    • (2011) Am J Physiol Endocrinol Metab , vol.301
    • Barrett, E.J.1    Wang, H.2    Upchurch, C.T.3    Liu, Z.4
  • 43
    • 33745295339 scopus 로고    scopus 로고
    • Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle
    • Clerk LH, Vincent MA, Jahn LA, Liu Z, Lindner JR, Barrett EJ. Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes 2006;55:1436-1442
    • (2006) Diabetes , vol.55 , pp. 1436-1442
    • Clerk, L.H.1    Vincent, M.A.2    Jahn, L.A.3    Liu, Z.4    Lindner, J.R.5    Barrett, E.J.6
  • 45
    • 0021006463 scopus 로고
    • Microvascular blood flow distribution in skeletal muscle. An intravital microscopic study in the rabbit
    • Lindbom L. Microvascular blood flow distribution in skeletal muscle. An intravital microscopic study in the rabbit. Acta Physiol Scand Suppl 1983; 525:1-40
    • (1983) Acta Physiol Scand Suppl , vol.525 , pp. 1-40
    • Lindbom, L.1
  • 46
    • 0020174263 scopus 로고
    • Active and passive capillary control in red muscle at rest and in exercise
    • Honig CR, Odoroff CL, Frierson JL. Active and passive capillary control in red muscle at rest and in exercise. Am J Physiol 1982;243:H196-H206
    • (1982) Am J Physiol , vol.243
    • Honig, C.R.1    Odoroff, C.L.2    Frierson, J.L.3
  • 47
    • 3142677991 scopus 로고    scopus 로고
    • Physiological hyperinsulinaemia increases intramuscular microvas-cular reactive hyperaemia and vasomotion in healthy volunteers
    • de Jongh RT, Clark AD, IJzerman RG, Serné EH, de Vries G, Stehouwer CD. Physiological hyperinsulinaemia increases intramuscular microvas-cular reactive hyperaemia and vasomotion in healthy volunteers. Dia-betologia 2004;47:978-986.
    • (2004) Dia-betologia , vol.47 , pp. 978-986
    • De Jongh, R.T.1    Clark, A.D.2    Ijzerman, R.G.3    Serné, E.H.4    De Vries, G.5    Stehouwer, C.D.6
  • 48
    • 0025297082 scopus 로고
    • Tissue-specific distribution and developmental regulation of M and B creatine kinase mRNAs
    • Trask RV, Billadello JJ. Tissue-specific distribution and developmental regulation of M and B creatine kinase mRNAs. Biochim Biophys Acta 1990; 1049:182-188
    • (1990) Biochim Biophys Acta , vol.1049 , pp. 182-188
    • Trask, R.V.1    Billadello, J.J.2
  • 49
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996;380:435-439
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3
  • 50
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380:439-442
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1    Carver-Moore, K.2    Chen, H.3
  • 51
    • 34547941252 scopus 로고    scopus 로고
    • Autocrine VEGF signaling is required for vascular homeostasis
    • Lee S, Chen TT, Barber CL, et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell 2007;130:691-703
    • (2007) Cell , vol.130 , pp. 691-703
    • Lee, S.1    Chen, T.T.2    Barber, C.L.3
  • 52
    • 0037108152 scopus 로고    scopus 로고
    • Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    • Ruhrberg C, Gerhardt H, Golding M, et al. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev 2002;16:2684-2698
    • (2002) Genes Dev , vol.16 , pp. 2684-2698
    • Ruhrberg, C.1    Gerhardt, H.2    Golding, M.3
  • 53
    • 14344279280 scopus 로고    scopus 로고
    • A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function
    • Giordano FJ, Gerber HP, Williams SP, et al. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A 2001;98:5780-5785
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5780-5785
    • Giordano, F.J.1    Gerber, H.P.2    Williams, S.P.3
  • 54
    • 20244378531 scopus 로고    scopus 로고
    • Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: Restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor
    • Yoon YS, Uchida S, Masuo O, et al. Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation 2005;111:2073-2085
    • (2005) Circulation , vol.111 , pp. 2073-2085
    • Yoon, Y.S.1    Uchida, S.2    Masuo, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.