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Volumn 56, Issue 4, 2013, Pages 560-566

Hepatitis C therapy: Highlights from the 2012 annual meeting of the european association for the study of the liver

Author keywords

DAA; directly acting antivirals; drug resistance; hepatitis C; HIV

Indexed keywords

ABT 072; ABT 333; ABT 450; ANTIVIRUS AGENT; ASUNAPREVIR; BOCEPREVIR; DACLATASVIR; DANOPREVIR; FALDAPREVIR; GS 5885; GS 9451; INTERLEUKIN 28B; LOMIBUVIR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; NONSTRUCTURAL PROTEIN 5A; PEGINTERFERON ALPHA2A PLUS RIBAVIRIN; PROTEINASE INHIBITOR; RITONAVIR; SIMEPREVIR; SOFOSBUVIR; TEGOBUVIR; TELAPREVIR; UNCLASSIFIED DRUG;

EID: 84873027142     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cis915     Document Type: Article
Times cited : (16)

References (54)
  • 1
    • 84857170853 scopus 로고    scopus 로고
    • Hepatitis C: The end of the beginning and possibly the beginning of the end
    • Alter H. Hepatitis C: the end of the beginning and possibly the beginning of the end. Ann Intern Med 2012; 156:317-9.
    • (2012) Ann Intern Med , vol.156 , pp. 317-319
    • Alter, H.1
  • 3
    • 84873054623 scopus 로고    scopus 로고
    • Safety of telaprevir and boceprevir in combination with peginterferon alfa/ribavirin in cirrhotic nonresponders. First results of the French early access program (ANRS CO20-CUPIC)
    • 18-22 April Abstract 8
    • Hezode C, Dorival C, Zoulim F, et al. Safety of telaprevir and boceprevir in combination with peginterferon alfa/ribavirin in cirrhotic nonresponders. First results of the French early access program (ANRS CO20-CUPIC). In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 8.
    • (2012) 47th EASL Barcelona
    • Hezode, C.1    Dorival, C.2    Zoulim, F.3
  • 4
    • 84891488872 scopus 로고    scopus 로고
    • Sustained virologic response (SVR) in prior peginterferon/ribavirin (PR) treatment failures after retreatment with boceprevir (BOC) + PR: The PROVIDE study interim results
    • 18-22 April Abstract 11
    • Bronowicki J, Davis M, Flamm S, et al. Sustained virologic response (SVR) in prior peginterferon/ribavirin (PR) treatment failures after retreatment with boceprevir (BOC) + PR: the PROVIDE study interim results. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 11.
    • (2012) 47th EASL Barcelona
    • Bronowicki, J.1    Davis, M.2    Flamm, S.3
  • 5
    • 84881475330 scopus 로고    scopus 로고
    • Boceprevir plus peginterferon/ribavirin for the treatment of HCV/HIV co-infected patients: End of treatment (week 48) interim results
    • 18-22 April Abstract 50
    • Mallolas J, Pol S, Rivero A, et al. Boceprevir plus peginterferon/ ribavirin for the treatment of HCV/HIV co-infected patients: end of treatment (week 48) interim results. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 50.
    • (2012) 47th EASL Barcelona
    • Mallolas, J.1    Pol, S.2    Rivero, A.3
  • 6
    • 80855137985 scopus 로고    scopus 로고
    • Challenges and opportunities for hepatitis C drug development in HIV-hepatitis C viruscoinfected patients
    • Soriano V, Sherman K, Rockstroh J, et al. Challenges and opportunities for hepatitis C drug development in HIV-hepatitis C viruscoinfected patients. AIDS 2011; 25:2197-208.
    • (2011) AIDS , vol.25 , pp. 2197-2208
    • Soriano, V.1    Sherman, K.2    Rockstroh, J.3
  • 7
    • 84873035162 scopus 로고    scopus 로고
    • Ritonavir substantially reduces reactive metabolite formation of the HCV protease inhibitor danoprevir both in vitro and in vivo
    • 18-22 April Abstract 1180
    • Goelzer P, Morcos P, Tran J, et al. Ritonavir substantially reduces reactive metabolite formation of the HCV protease inhibitor danoprevir both in vitro and in vivo. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1180.
    • (2012) 47th EASL Barcelona
    • Goelzer, P.1    Morcos, P.2    Tran, J.3
  • 8
    • 84873047847 scopus 로고    scopus 로고
    • Rapid and sustained achievement of undetectable HCV RNA during treatment with ritonavirboosted danoprevir/peg-IFNa-2a/RBV in HCV genotype 1 or 4 patients: DAUPHINE week 12 interim analysis
    • 18-22 April Abstract 1177
    • Everson G, Cooper C, Hézode C, et al. Rapid and sustained achievement of undetectable HCV RNA during treatment with ritonavirboosted danoprevir/peg-IFNa-2a/RBV in HCV genotype 1 or 4 patients: DAUPHINE week 12 interim analysis. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1177.
    • (2012) 47th EASL Barcelona
    • Everson, G.1    Cooper, C.2    Hézode, C.3
  • 9
    • 84873021741 scopus 로고    scopus 로고
    • TMC435 in HCV genotype 1 patients who have failed previous pegylated interferon/ribavirin treatment: Final SVR24 results of the ASPIRE trial
    • 18-22 April Abstract 2
    • Zeuzem S, Berg T, Gane E, et al. TMC435 in HCV genotype 1 patients who have failed previous pegylated interferon/ribavirin treatment: final SVR24 results of the ASPIRE trial. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 2.
    • (2012) 47th EASL, Barcelona
    • Zeuzem, S.1    Berg, T.2    Gane, E.3
  • 10
    • 84873022487 scopus 로고    scopus 로고
    • ABT-450/ritonavir (ABT-450/r) combined with pegylated interferon alpha-2a/ribavirin after 3-day monotherapy in genotype 1 (GT1) HCV-infected treatmentnaive subjects: 12-week sustained virologic response
    • 18-22 April Abstract 1187
    • Lawitz E, Poordad F, De Jesus E, et al. ABT-450/ritonavir (ABT-450/r) combined with pegylated interferon alpha-2a/ribavirin after 3-day monotherapy in genotype 1 (GT1) HCV-infected treatmentnaive subjects: 12-week sustained virologic response. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1187.
    • (2012) 47th EASL Barcelona
    • Lawitz, E.1    Poordad, F.2    De Jesus, E.3
  • 11
    • 78049527728 scopus 로고    scopus 로고
    • Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
    • Gane E, Roberts S, Stedman C, et al. Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 2010; 376:1467-75.
    • (2010) Lancet , vol.376 , pp. 1467-1475
    • Gane, E.1    Roberts, S.2    Stedman, C.3
  • 12
    • 84873031427 scopus 로고    scopus 로고
    • Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype 1-infected patients
    • 18-22 April Abstract 1412
    • Gane E, Pockros P, Zeuzem S, et al. Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype 1-infected patients. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1412.
    • (2012) 47th EASL Barcelona
    • Gane, E.1    Pockros, P.2    Zeuzem, S.3
  • 13
    • 84873049899 scopus 로고    scopus 로고
    • ATOMIC: 97% RVR for PSI-7977 + PEG/RBV x 12 week regimen in HCV GT1: An end to response-guided therapy?
    • Barcelona 18-22 April Abstract 1
    • Kowdley K, Lawitz E, Crespo I, et al. ATOMIC: 97% RVR for PSI-7977 + PEG/RBV x 12 week regimen in HCV GT1: an end to response-guided therapy? In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1.
    • (2012) 47th EASL
    • Kowdley, K.1    Lawitz, E.2    Crespo, I.3
  • 14
    • 84873044907 scopus 로고    scopus 로고
    • PSI-7977 PROTON and ELECTRON: 100% concordance of SVR4 with SVR24 in HCV GT1, GT2 & GT3
    • 18-22 April Abstract 7
    • Lawitz E, Gane E, Stedman C, et al. PSI-7977 PROTON and ELECTRON: 100% concordance of SVR4 with SVR24 in HCV GT1, GT2 & GT3. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 7.
    • (2012) 47th EASL, Barcelona
    • Lawitz, E.1    Gane, E.2    Stedman, C.3
  • 15
    • 84855248040 scopus 로고    scopus 로고
    • Once daily PSI-7977 plus RBV: Pegylated interferon-α not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3
    • San Francisco, CA 4-8 November Abstract 34
    • Gane E, Stedman C, Hyland R, et al. Once daily PSI-7977 plus RBV: pegylated interferon-α not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3. In: 62nd AASLD, San Francisco, CA, 4-8 November 2011. Abstract 34.
    • (2011) 62nd AASLD
    • Gane, E.1    Stedman, C.2    Hyland, R.3
  • 16
    • 84873041620 scopus 로고    scopus 로고
    • ELECTRON: Once daily PSI-7977 plus RBV in HCV GT1/2/3
    • 18-22 April Abstract 1113
    • Gane E, Stedman C, Hyland R, et al. ELECTRON: once daily PSI-7977 plus RBV in HCV GT1/2/3. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1113.
    • (2012) 47th EASL Barcelona
    • Gane, E.1    Stedman, C.2    Hyland, R.3
  • 17
    • 84872614959 scopus 로고    scopus 로고
    • 100% rapid virologic response for PSI-7977 + ribavirin in genotype 1 null responders (ELECTRON): Early viral decline similar to that observed in genotype 1 and genotypes 2/3 treatment-naive patients
    • Seattle, WA 5-8 March Abstract 54LB
    • Gane E, Stedman C, Anderson J, et al. 100% rapid virologic response for PSI-7977 + ribavirin in genotype 1 null responders (ELECTRON): early viral decline similar to that observed in genotype 1 and genotypes 2/3 treatment-naive patients. In: 19th CROI, Seattle, WA, 5-8 March 2012. Abstract 54LB.
    • (2012) 19th CROI
    • Gane, E.1    Stedman, C.2    Anderson, J.3
  • 18
    • 84873035108 scopus 로고    scopus 로고
    • PSI-7977 400 mg QD safety and tolerability in the first 450 patients treated for 12 weeks
    • 18-22 April Abstract 1120
    • Jacobson I, Lawitz E, Lalezari J, et al. PSI-7977 400 mg QD safety and tolerability in the first 450 patients treated for 12 weeks. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1120.
    • (2012) 47th EASL Barcelona
    • Jacobson, I.1    Lawitz, E.2    Lalezari, J.3
  • 19
    • 84873024272 scopus 로고    scopus 로고
    • The effect of hepatic impairment on the pharmacokinetics and antiviral activity of PSI-7977 in hepatitis C infected subjects treated for seven days
    • 18-22 April Abstract 1130
    • Lawitz E, Rodriguez-Torres M, Cornpropst M, et al. The effect of hepatic impairment on the pharmacokinetics and antiviral activity of PSI-7977 in hepatitis C infected subjects treated for seven days. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1130.
    • (2012) 47th EASL Barcelona
    • Lawitz, E.1    Rodriguez-Torres, M.2    Cornpropst, M.3
  • 20
    • 84873021592 scopus 로고    scopus 로고
    • Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), +/-ribavirin, in treatment-naive patients with chronic HCV GT1,2, or 3
    • Barcelona 18-22 April Abstract 1422
    • Sulkowski M, Gardiner D, Lawitz E, et al. Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), +/-ribavirin, in treatment-naive patients with chronic HCV GT1, 2, or 3. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1422.
    • (2012) 47th EASL
    • Sulkowski, M.1    Gardiner, D.2    Lawitz, E.3
  • 21
    • 84873040430 scopus 로고    scopus 로고
    • SVR4 and SVR12 with an interferon-free regimen of BI-201335 and BI-207127 ± ribavirin in treatment-naïve patients with genotype 1 HCV infection: Interim results of SOUND-C2
    • 18-22 April Abstract 101
    • Zuzem S, Soriano V, Asselah T, et al. SVR4 and SVR12 with an interferon-free regimen of BI-201335 and BI-207127 ± ribavirin in treatment-naïve patients with genotype 1 HCV infection: interim results of SOUND-C2. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 101.
    • (2012) 47th EASL Barcelona
    • Zuzem, S.1    Soriano, V.2    Asselah, T.3
  • 22
    • 84873052818 scopus 로고    scopus 로고
    • The efficacy and safety of the interferon-free combination of BI-201335 and BI-207127 in genotype 1 HCV patients with cirrhosis-interim analysis from SOUND-C2
    • 18-22 April Abstract 1420
    • Soriano V, Gane E, Angus P, et al. The efficacy and safety of the interferon-free combination of BI-201335 and BI-207127 in genotype 1 HCV patients with cirrhosis-interim analysis from SOUND-C2. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1420.
    • (2012) 47th EASL Barcelona
    • Soriano, V.1    Gane, E.2    Angus, P.3
  • 23
    • 84873027228 scopus 로고    scopus 로고
    • Characterization of HCV variants in genotype 1 treatment-naive patients administered the combination of TVR and VX-222 in DUAL arms of ZENITH study
    • 18-22 April Abstract 1184
    • Zhang E, Tigges A, Jiang M, et al. Characterization of HCV variants in genotype 1 treatment-naive patients administered the combination of TVR and VX-222 in DUAL arms of ZENITH study. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1184.
    • (2012) 47th EASL Barcelona
    • Zhang, E.1    Tigges, A.2    Jiang, M.3
  • 24
    • 84873035089 scopus 로고    scopus 로고
    • ABT-072 or ABT-333 combined with pegylated interferon/ribavirin after 3-day monotherapy in HCV genotype 1 (GT1)-infected treatment-naive subjects: 12-week sustained virologic response (SVR12)
    • Barcelona 18-22 April Abstract 1206
    • Poordad F, Lawitz E, De Jesus E, et al. ABT-072 or ABT-333 combined with pegylated interferon/ribavirin after 3-day monotherapy in HCV genotype 1 (GT1)-infected treatment-naive subjects: 12-week sustained virologic response (SVR12). In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1206.
    • (2012) 47th EASL
    • Poordad, F.1    Lawitz, E.2    De Jesus, E.3
  • 25
    • 84873032562 scopus 로고    scopus 로고
    • 1. A 12-week interferon-free regimen of ABT-450/r, ABT-072, and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects
    • Barcelona 18-22 April Abstract 13
    • Lawitz E, Poordad F, Kowdley K, et al. 1. A 12-week interferon-free regimen of ABT-450/r, ABT-072, and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 13.
    • (2012) 47th EASL
    • Lawitz, E.1    Poordad, F.2    Kowdley, K.3
  • 26
    • 84873019512 scopus 로고    scopus 로고
    • 12-week interferon-free regimen of ABT-450/r + ABT-333 + ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders
    • 18-22 April Abstract 21
    • Poordad F, Lawitz E, Kowdley K, et al. 12-week interferon-free regimen of ABT-450/r + ABT-333 + ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 21.
    • (2012) 47th EASL Barcelona
    • Poordad, F.1    Lawitz, E.2    Kowdley, K.3
  • 27
    • 84873045160 scopus 로고    scopus 로고
    • Dual oral therapy with the NS5A inhibitor daclatasvir (BMS-790052) and NS3 protease inhibitor asunaprevir (BMS-650032) in HCV genotype 1b-infected null responders or ineligible/intolerant to peginterferon
    • 18-22 April Abstract 14
    • Suzuki F, Ikeda K, Toyota J, et al. Dual oral therapy with the NS5A inhibitor daclatasvir (BMS-790052) and NS3 protease inhibitor asunaprevir (BMS-650032) in HCV genotype 1b-infected null responders or ineligible/ intolerant to peginterferon. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 14.
    • (2012) 47th EASL Barcelona
    • Suzuki, F.1    Ikeda, K.2    Toyota, J.3
  • 28
    • 84873047572 scopus 로고    scopus 로고
    • High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: Interim results
    • 18-22 April Abstract 1421
    • Sulkowski M, Rodriguez-Torres M, Lawitz E, et al. High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: interim results. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1421.
    • (2012) 47th EASL Barcelona
    • Sulkowski, M.1    Rodriguez-Torres, M.2    Lawitz, E.3
  • 29
    • 84873027365 scopus 로고    scopus 로고
    • 100% SVR in IL28B SNP rs12979860 C/C patients treated with 12 weeks of telaprevir, peginterferon and ribavirin in the PROVE2 trial
    • Barcelona 18-22 April Abstract 1094
    • Bronowicki J, Hezode C, Bergtsoon L, et al. 100% SVR in IL28B SNP rs12979860 C/C patients treated with 12 weeks of telaprevir, peginterferon and ribavirin in the PROVE2 trial. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1094.
    • (2012) 47th EASL
    • Bronowicki, J.1    Hezode, C.2    Bergtsoon, L.3
  • 30
    • 84873022900 scopus 로고    scopus 로고
    • Pre-treatment IP-10 levels and IL28B genotype in prediction of SVR in prior treatment-experienced genotype 1 HCV patients treated with telaprevir/peginterferon/ribavirin in the REALIZE study
    • 18-22 April Abstract 1167
    • Vijgen L, Talloen W, Scholliers A, et al. Pre-treatment IP-10 levels and IL28B genotype in prediction of SVR in prior treatment-experienced genotype 1 HCV patients treated with telaprevir/peginterferon/ribavirin in the REALIZE study. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1167.
    • (2012) 47th EASL Barcelona
    • Vijgen, L.1    Talloen, W.2    Scholliers, A.3
  • 31
    • 84873027096 scopus 로고    scopus 로고
    • A comprehensive review of patterns of viral load decline in patients treated with telaprevir plus peginterferon and ribavirin
    • 18-22 April Abstract 1150
    • Picchio G, De Meyer S, Dierynk I, et al. A comprehensive review of patterns of viral load decline in patients treated with telaprevir plus peginterferon and ribavirin. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1150.
    • (2012) 47th EASL Barcelona
    • Picchio, G.1    De Meyer, S.2    Dierynk, I.3
  • 32
    • 84873035565 scopus 로고    scopus 로고
    • Dynamics of HCV quasiespecies during telaprevir treatment dissected using ultra-deep pyrosequencing: Treatment failure in 100% of genotype 1a patients
    • 18-22 April Abstract 56
    • Pinson P, Trimoulet P, Papuchon J, et al. Dynamics of HCV quasiespecies during telaprevir treatment dissected using ultra-deep pyrosequencing: treatment failure in 100% of genotype 1a patients. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 56.
    • (2012) 47th EASL Barcelona
    • Pinson, P.1    Trimoulet, P.2    Papuchon, J.3
  • 33
    • 84873041815 scopus 로고    scopus 로고
    • Futility rules in telaprevir combination therapy
    • 18-22 April Abstract 55
    • Jacobson I, Bartels D, Gritz L, et al. Futility rules in telaprevir combination therapy. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 55.
    • (2012) 47th EASL Barcelona
    • Jacobson, I.1    Bartels, D.2    Gritz, L.3
  • 34
    • 84865753312 scopus 로고    scopus 로고
    • Comparison of high ribavirin induction versus standard ribavirin dosing, plus peginterferon-α for the treatment of chronic hepatitis C in HIV-infected patients: The PERICO trial
    • Labarga P, Barreiro P, da Silva A, et al. Comparison of high ribavirin induction versus standard ribavirin dosing, plus peginterferon-α for the treatment of chronic hepatitis C in HIV-infected patients: the PERICO trial. J Infect Dis 2012; 206:961-8.
    • (2012) J Infect Dis , vol.206 , pp. 961-968
    • Labarga, P.1    Barreiro, P.2    Da Silva, A.3
  • 35
    • 84873022733 scopus 로고    scopus 로고
    • Ribavirin dose modification in treatment-naive and previously treated patients who received telaprevir combination treatment: No impact on sustained virologic response in phase 3 studies
    • 18-22 April Abstract 1162
    • Sulkowski M, Roberts S, Afdhal N, et al. Ribavirin dose modification in treatment-naive and previously treated patients who received telaprevir combination treatment: no impact on sustained virologic response in phase 3 studies. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1162.
    • (2012) 47th EASL Barcelona
    • Sulkowski, M.1    Roberts, S.2    Afdhal, N.3
  • 36
    • 84873032679 scopus 로고    scopus 로고
    • A randomized trial comparing ribavirin dose reduction versus erythropoietin for anemia management in previously untreated patients with chronic hepatitis C receiving boceprevir plus peginterferon/ribavirin
    • 18-22 April Abstract 1419
    • Poordad F, Lawitz E, Reddy K, et al. A randomized trial comparing ribavirin dose reduction versus erythropoietin for anemia management in previously untreated patients with chronic hepatitis C receiving boceprevir plus peginterferon/ribavirin. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1419.
    • (2012) 47th EASL Barcelona
    • Poordad, F.1    Lawitz, E.2    Reddy, K.3
  • 37
    • 45749088957 scopus 로고    scopus 로고
    • Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?
    • Soriano V, Zeuzem S, Zoulim F. Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses? J Antimicrob Chemother 2008; 62:1-4.
    • (2008) J Antimicrob Chemother , vol.62 , pp. 1-4
    • Soriano, V.1    Zeuzem, S.2    Zoulim, F.3
  • 38
    • 84873041815 scopus 로고    scopus 로고
    • Futility rules in telaprevir combination treatment
    • 18-22 April Abstract 55
    • Jacobson I, Bartels D, Gritz L, et al. Futility rules in telaprevir combination treatment. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 55.
    • (2012) 47th EASL Barcelona
    • Jacobson, I.1    Bartels, D.2    Gritz, L.3
  • 40
    • 77950203857 scopus 로고    scopus 로고
    • Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs)
    • Kieffer T, Kwong A, Picchio G. Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs). J Antimicrob Chemother. 2010; 65:202-12.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 202-212
    • Kieffer, T.1    Kwong, A.2    Picchio, G.3
  • 41
    • 84862117053 scopus 로고    scopus 로고
    • Differences in virological response to peginterferon-α plus ribavirin in HIV-positive patients coinfected with HCV subtypes 1a or 1b
    • Rallón N, Pineda JA, Soriano V, et al. Differences in virological response to peginterferon-α plus ribavirin in HIV-positive patients coinfected with HCV subtypes 1a or 1b. J Acquir Immune Defic Syndr 2012; 60:117-23.
    • (2012) J Acquir Immune Defic Syndr , vol.60 , pp. 117-123
    • Rallón, N.1    Pineda, J.A.2    Soriano, V.3
  • 42
    • 84865195864 scopus 로고    scopus 로고
    • Different impact of IL28B polymorphisms on response to peginterferon plus ribavirin in HIVpositive patients infected with HCV subtypes 1a or 1b
    • Vispo E, Rallon N, Labarga P, et al. Different impact of IL28B polymorphisms on response to peginterferon plus ribavirin in HIVpositive patients infected with HCV subtypes 1a or 1b. J Clin Virol 2012; 55:58-61.
    • (2012) J Clin Virol , vol.55 , pp. 58-61
    • Vispo, E.1    Rallon, N.2    Labarga, P.3
  • 43
    • 51749123143 scopus 로고    scopus 로고
    • Natural prevalence of HCV variants with decreased sensitivity to NS3-4A protease inhibitors in treatmentnaive subjects
    • Bartels D, Zhou Y, Zhang E, et al. Natural prevalence of HCV variants with decreased sensitivity to NS3-4A protease inhibitors in treatmentnaive subjects. J Infect Dis 2008; 198:800-7.
    • (2008) J Infect Dis , vol.198 , pp. 800-807
    • Bartels, D.1    Zhou, Y.2    Zhang, E.3
  • 44
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to HCV protease and polymerase inhibitors in treatment-naive patients
    • Kuntzen T, Timm J, Berical A, et al. Naturally occurring dominant resistance mutations to HCV protease and polymerase inhibitors in treatment-naive patients. Hepatology 2008; 48:1769-78.
    • (2008) Hepatology , vol.48 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3
  • 45
    • 81855199759 scopus 로고    scopus 로고
    • Impact of antiretroviral therapy on the variability of the HCV NS5B polymerase in HIV/HCV co-infected patients
    • Plaza Z, Soriano V, Gonzalez MM, et al. Impact of antiretroviral therapy on the variability of the HCV NS5B polymerase in HIV/HCV co-infected patients. J Antimicrob Chemother 2011; 66:2838-42.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2838-2842
    • Plaza, Z.1    Soriano, V.2    Gonzalez, M.M.3
  • 46
    • 78649644443 scopus 로고    scopus 로고
    • Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors
    • Bae A, Sun S, Qi X, et al. Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors. Antimicrob Agents Chemother 2010; 54:5288-97.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 5288-5297
    • Bae, A.1    Sun, S.2    Qi, X.3
  • 47
    • 79959401302 scopus 로고    scopus 로고
    • Natural polymorphisms associated with resistance to new antivirals against HCV in newly diagnosed HIV-HCV-coinfected patients
    • Treviño A, de Mendoza C, Parra P, et al. Natural polymorphisms associated with resistance to new antivirals against HCV in newly diagnosed HIV-HCV-coinfected patients. Antivir Ther 2011; 16:413-6.
    • (2011) Antivir Ther , vol.16 , pp. 413-416
    • Treviño, A.1    De Mendoza, C.2    Parra, P.3
  • 48
    • 84858415895 scopus 로고    scopus 로고
    • Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor
    • Plaza Z, Soriano V, Vispo E, et al. Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor. Antivir Ther 2012; 17:921-6.
    • (2012) Antivir Ther , vol.17 , pp. 921-926
    • Plaza, Z.1    Soriano, V.2    Vispo, E.3
  • 49
    • 84873054740 scopus 로고    scopus 로고
    • TMC-435 in patients infected with HCV genotype 1 who have failed previous pegylated interferon/ribavirin treatment: Virological analyses of the ASPIRE trial
    • 18-22 April Abstract 9
    • Lenz O, Fevery B, Vijgen L, et al. TMC-435 in patients infected with HCV genotype 1 who have failed previous pegylated interferon/ribavirin treatment: virological analyses of the ASPIRE trial. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 9.
    • (2012) 47th EASL Barcelona
    • Lenz, O.1    Fevery, B.2    Vijgen, L.3
  • 50
    • 84873029991 scopus 로고    scopus 로고
    • Characterization of HCV NS3 protease variants from patients enrolled in a 28-day phase 2a trial of ACH-1625 daily dosing plus pegIFN-alpha 2a/RBV
    • 18-22 April Abstract 1182
    • Fabrycki J, Patel D, Yang G, et al. Characterization of HCV NS3 protease variants from patients enrolled in a 28-day phase 2a trial of ACH-1625 daily dosing plus pegIFN-alpha 2a/RBV. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1182.
    • (2012) 47th EASL Barcelona
    • Fabrycki, J.1    Patel, D.2    Yang, G.3
  • 51
    • 1642328395 scopus 로고    scopus 로고
    • A 48-week duration of therapy with pegylated interferon alpha 2b plus ribavirin may be too short to maximize longterm response among patients infected with genotype 1 hepatitis C virus
    • Drusano G, Preston S. A 48-week duration of therapy with pegylated interferon alpha 2b plus ribavirin may be too short to maximize longterm response among patients infected with genotype 1 hepatitis C virus. J Infect Dis 2004; 189:964-70.
    • (2004) J Infect Dis , vol.189 , pp. 964-970
    • Drusano, G.1    Preston, S.2
  • 52
    • 84873021514 scopus 로고    scopus 로고
    • Consideration of new endpoints for regulatory approval and dose selection of hepatitis C therapies
    • San Francisco, CA 4-8 November Abstract LB-28
    • Florian J, Chen J, Jadav P, et al. Consideration of new endpoints for regulatory approval and dose selection of hepatitis C therapies. In: 62nd AASLD, San Francisco, CA, 4-8 November 2011. Abstract LB-28.
    • (2011) 62nd AASLD
    • Florian, J.1    Chen, J.2    Jadav, P.3
  • 53
    • 84873040430 scopus 로고    scopus 로고
    • SVR4 and SVR12 with an interferon-free regimen of BI-201335 and BI-207127 +/-ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: Interim results of SOUND-C2
    • Barcelona 18-22 April Abstract 21
    • Zeuzem S, Soriano V, Asselah T, et al. SVR4 and SVR12 with an interferon-free regimen of BI-201335 and BI-207127 +/-ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: Interim results of SOUND-C2. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 21.
    • (2012) 47th EASL
    • Zeuzem, S.1    Soriano, V.2    Asselah, T.3
  • 54
    • 84873034873 scopus 로고    scopus 로고
    • High concordance between SVR12 and SVR24 in patients receiving telaprevir plus peginterferon and ribavirin in three phase III clinical trials: ADVANCE, ILLUMINATE and REALIZE
    • Barcelona 18-22 April Abstract 1132
    • Luo D, Zeuzem S, Jacobson I, et al. High concordance between SVR12 and SVR24 in patients receiving telaprevir plus peginterferon and ribavirin in three phase III clinical trials: ADVANCE, ILLUMINATE and REALIZE. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1132.
    • (2012) 47th EASL
    • Luo, D.1    Zeuzem, S.2    Jacobson, I.3


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