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1
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84857170853
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Hepatitis C: The end of the beginning and possibly the beginning of the end
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Alter H. Hepatitis C: the end of the beginning and possibly the beginning of the end. Ann Intern Med 2012; 156:317-9.
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(2012)
Ann Intern Med
, vol.156
, pp. 317-319
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Alter, H.1
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2
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84856952240
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Pharmacogenetics of hepatitis C
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Soriano V, Poveda E, Vispo E, Labarga P, Rallón N, Barreiro P. Pharmacogenetics of hepatitis C. J Antimicrob Chemother 2012; 67:523-9.
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(2012)
J Antimicrob Chemother
, vol.67
, pp. 523-529
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Soriano, V.1
Poveda, E.2
Vispo, E.3
Labarga, P.4
Rallón, N.5
Barreiro, P.6
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3
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84873054623
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Safety of telaprevir and boceprevir in combination with peginterferon alfa/ribavirin in cirrhotic nonresponders. First results of the French early access program (ANRS CO20-CUPIC)
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18-22 April Abstract 8
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Hezode C, Dorival C, Zoulim F, et al. Safety of telaprevir and boceprevir in combination with peginterferon alfa/ribavirin in cirrhotic nonresponders. First results of the French early access program (ANRS CO20-CUPIC). In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 8.
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(2012)
47th EASL Barcelona
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Hezode, C.1
Dorival, C.2
Zoulim, F.3
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4
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84891488872
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Sustained virologic response (SVR) in prior peginterferon/ribavirin (PR) treatment failures after retreatment with boceprevir (BOC) + PR: The PROVIDE study interim results
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18-22 April Abstract 11
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Bronowicki J, Davis M, Flamm S, et al. Sustained virologic response (SVR) in prior peginterferon/ribavirin (PR) treatment failures after retreatment with boceprevir (BOC) + PR: the PROVIDE study interim results. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 11.
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(2012)
47th EASL Barcelona
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Bronowicki, J.1
Davis, M.2
Flamm, S.3
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5
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84881475330
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Boceprevir plus peginterferon/ribavirin for the treatment of HCV/HIV co-infected patients: End of treatment (week 48) interim results
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18-22 April Abstract 50
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Mallolas J, Pol S, Rivero A, et al. Boceprevir plus peginterferon/ ribavirin for the treatment of HCV/HIV co-infected patients: end of treatment (week 48) interim results. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 50.
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(2012)
47th EASL Barcelona
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Mallolas, J.1
Pol, S.2
Rivero, A.3
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6
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80855137985
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Challenges and opportunities for hepatitis C drug development in HIV-hepatitis C viruscoinfected patients
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Soriano V, Sherman K, Rockstroh J, et al. Challenges and opportunities for hepatitis C drug development in HIV-hepatitis C viruscoinfected patients. AIDS 2011; 25:2197-208.
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(2011)
AIDS
, vol.25
, pp. 2197-2208
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Soriano, V.1
Sherman, K.2
Rockstroh, J.3
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7
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84873035162
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Ritonavir substantially reduces reactive metabolite formation of the HCV protease inhibitor danoprevir both in vitro and in vivo
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18-22 April Abstract 1180
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Goelzer P, Morcos P, Tran J, et al. Ritonavir substantially reduces reactive metabolite formation of the HCV protease inhibitor danoprevir both in vitro and in vivo. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1180.
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(2012)
47th EASL Barcelona
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Goelzer, P.1
Morcos, P.2
Tran, J.3
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8
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84873047847
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Rapid and sustained achievement of undetectable HCV RNA during treatment with ritonavirboosted danoprevir/peg-IFNa-2a/RBV in HCV genotype 1 or 4 patients: DAUPHINE week 12 interim analysis
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18-22 April Abstract 1177
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Everson G, Cooper C, Hézode C, et al. Rapid and sustained achievement of undetectable HCV RNA during treatment with ritonavirboosted danoprevir/peg-IFNa-2a/RBV in HCV genotype 1 or 4 patients: DAUPHINE week 12 interim analysis. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1177.
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(2012)
47th EASL Barcelona
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Everson, G.1
Cooper, C.2
Hézode, C.3
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9
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84873021741
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TMC435 in HCV genotype 1 patients who have failed previous pegylated interferon/ribavirin treatment: Final SVR24 results of the ASPIRE trial
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18-22 April Abstract 2
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Zeuzem S, Berg T, Gane E, et al. TMC435 in HCV genotype 1 patients who have failed previous pegylated interferon/ribavirin treatment: final SVR24 results of the ASPIRE trial. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 2.
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(2012)
47th EASL, Barcelona
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Zeuzem, S.1
Berg, T.2
Gane, E.3
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10
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84873022487
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ABT-450/ritonavir (ABT-450/r) combined with pegylated interferon alpha-2a/ribavirin after 3-day monotherapy in genotype 1 (GT1) HCV-infected treatmentnaive subjects: 12-week sustained virologic response
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18-22 April Abstract 1187
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Lawitz E, Poordad F, De Jesus E, et al. ABT-450/ritonavir (ABT-450/r) combined with pegylated interferon alpha-2a/ribavirin after 3-day monotherapy in genotype 1 (GT1) HCV-infected treatmentnaive subjects: 12-week sustained virologic response. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1187.
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(2012)
47th EASL Barcelona
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Lawitz, E.1
Poordad, F.2
De Jesus, E.3
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11
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78049527728
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Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
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Gane E, Roberts S, Stedman C, et al. Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 2010; 376:1467-75.
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(2010)
Lancet
, vol.376
, pp. 1467-1475
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Gane, E.1
Roberts, S.2
Stedman, C.3
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12
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84873031427
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Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype 1-infected patients
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18-22 April Abstract 1412
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Gane E, Pockros P, Zeuzem S, et al. Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype 1-infected patients. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1412.
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(2012)
47th EASL Barcelona
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Gane, E.1
Pockros, P.2
Zeuzem, S.3
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13
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84873049899
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ATOMIC: 97% RVR for PSI-7977 + PEG/RBV x 12 week regimen in HCV GT1: An end to response-guided therapy?
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Barcelona 18-22 April Abstract 1
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Kowdley K, Lawitz E, Crespo I, et al. ATOMIC: 97% RVR for PSI-7977 + PEG/RBV x 12 week regimen in HCV GT1: an end to response-guided therapy? In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1.
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(2012)
47th EASL
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Kowdley, K.1
Lawitz, E.2
Crespo, I.3
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14
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84873044907
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PSI-7977 PROTON and ELECTRON: 100% concordance of SVR4 with SVR24 in HCV GT1, GT2 & GT3
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18-22 April Abstract 7
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Lawitz E, Gane E, Stedman C, et al. PSI-7977 PROTON and ELECTRON: 100% concordance of SVR4 with SVR24 in HCV GT1, GT2 & GT3. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 7.
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(2012)
47th EASL, Barcelona
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Lawitz, E.1
Gane, E.2
Stedman, C.3
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15
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84855248040
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Once daily PSI-7977 plus RBV: Pegylated interferon-α not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3
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San Francisco, CA 4-8 November Abstract 34
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Gane E, Stedman C, Hyland R, et al. Once daily PSI-7977 plus RBV: pegylated interferon-α not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3. In: 62nd AASLD, San Francisco, CA, 4-8 November 2011. Abstract 34.
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(2011)
62nd AASLD
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Gane, E.1
Stedman, C.2
Hyland, R.3
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16
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84873041620
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ELECTRON: Once daily PSI-7977 plus RBV in HCV GT1/2/3
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18-22 April Abstract 1113
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Gane E, Stedman C, Hyland R, et al. ELECTRON: once daily PSI-7977 plus RBV in HCV GT1/2/3. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1113.
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(2012)
47th EASL Barcelona
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Gane, E.1
Stedman, C.2
Hyland, R.3
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17
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84872614959
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100% rapid virologic response for PSI-7977 + ribavirin in genotype 1 null responders (ELECTRON): Early viral decline similar to that observed in genotype 1 and genotypes 2/3 treatment-naive patients
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Seattle, WA 5-8 March Abstract 54LB
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Gane E, Stedman C, Anderson J, et al. 100% rapid virologic response for PSI-7977 + ribavirin in genotype 1 null responders (ELECTRON): early viral decline similar to that observed in genotype 1 and genotypes 2/3 treatment-naive patients. In: 19th CROI, Seattle, WA, 5-8 March 2012. Abstract 54LB.
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(2012)
19th CROI
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Gane, E.1
Stedman, C.2
Anderson, J.3
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18
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84873035108
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PSI-7977 400 mg QD safety and tolerability in the first 450 patients treated for 12 weeks
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18-22 April Abstract 1120
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Jacobson I, Lawitz E, Lalezari J, et al. PSI-7977 400 mg QD safety and tolerability in the first 450 patients treated for 12 weeks. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1120.
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(2012)
47th EASL Barcelona
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Jacobson, I.1
Lawitz, E.2
Lalezari, J.3
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19
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84873024272
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The effect of hepatic impairment on the pharmacokinetics and antiviral activity of PSI-7977 in hepatitis C infected subjects treated for seven days
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18-22 April Abstract 1130
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Lawitz E, Rodriguez-Torres M, Cornpropst M, et al. The effect of hepatic impairment on the pharmacokinetics and antiviral activity of PSI-7977 in hepatitis C infected subjects treated for seven days. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1130.
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(2012)
47th EASL Barcelona
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Lawitz, E.1
Rodriguez-Torres, M.2
Cornpropst, M.3
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20
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84873021592
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Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), +/-ribavirin, in treatment-naive patients with chronic HCV GT1,2, or 3
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Barcelona 18-22 April Abstract 1422
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Sulkowski M, Gardiner D, Lawitz E, et al. Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), +/-ribavirin, in treatment-naive patients with chronic HCV GT1, 2, or 3. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1422.
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(2012)
47th EASL
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Sulkowski, M.1
Gardiner, D.2
Lawitz, E.3
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21
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84873040430
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SVR4 and SVR12 with an interferon-free regimen of BI-201335 and BI-207127 ± ribavirin in treatment-naïve patients with genotype 1 HCV infection: Interim results of SOUND-C2
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18-22 April Abstract 101
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Zuzem S, Soriano V, Asselah T, et al. SVR4 and SVR12 with an interferon-free regimen of BI-201335 and BI-207127 ± ribavirin in treatment-naïve patients with genotype 1 HCV infection: interim results of SOUND-C2. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 101.
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(2012)
47th EASL Barcelona
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Zuzem, S.1
Soriano, V.2
Asselah, T.3
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22
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84873052818
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The efficacy and safety of the interferon-free combination of BI-201335 and BI-207127 in genotype 1 HCV patients with cirrhosis-interim analysis from SOUND-C2
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18-22 April Abstract 1420
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Soriano V, Gane E, Angus P, et al. The efficacy and safety of the interferon-free combination of BI-201335 and BI-207127 in genotype 1 HCV patients with cirrhosis-interim analysis from SOUND-C2. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1420.
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(2012)
47th EASL Barcelona
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Soriano, V.1
Gane, E.2
Angus, P.3
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23
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84873027228
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Characterization of HCV variants in genotype 1 treatment-naive patients administered the combination of TVR and VX-222 in DUAL arms of ZENITH study
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18-22 April Abstract 1184
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Zhang E, Tigges A, Jiang M, et al. Characterization of HCV variants in genotype 1 treatment-naive patients administered the combination of TVR and VX-222 in DUAL arms of ZENITH study. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1184.
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(2012)
47th EASL Barcelona
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Zhang, E.1
Tigges, A.2
Jiang, M.3
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24
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84873035089
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ABT-072 or ABT-333 combined with pegylated interferon/ribavirin after 3-day monotherapy in HCV genotype 1 (GT1)-infected treatment-naive subjects: 12-week sustained virologic response (SVR12)
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Barcelona 18-22 April Abstract 1206
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Poordad F, Lawitz E, De Jesus E, et al. ABT-072 or ABT-333 combined with pegylated interferon/ribavirin after 3-day monotherapy in HCV genotype 1 (GT1)-infected treatment-naive subjects: 12-week sustained virologic response (SVR12). In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1206.
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(2012)
47th EASL
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Poordad, F.1
Lawitz, E.2
De Jesus, E.3
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25
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84873032562
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1. A 12-week interferon-free regimen of ABT-450/r, ABT-072, and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects
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Barcelona 18-22 April Abstract 13
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Lawitz E, Poordad F, Kowdley K, et al. 1. A 12-week interferon-free regimen of ABT-450/r, ABT-072, and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 13.
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(2012)
47th EASL
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Lawitz, E.1
Poordad, F.2
Kowdley, K.3
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26
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84873019512
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12-week interferon-free regimen of ABT-450/r + ABT-333 + ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders
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18-22 April Abstract 21
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Poordad F, Lawitz E, Kowdley K, et al. 12-week interferon-free regimen of ABT-450/r + ABT-333 + ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 21.
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(2012)
47th EASL Barcelona
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Poordad, F.1
Lawitz, E.2
Kowdley, K.3
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27
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84873045160
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Dual oral therapy with the NS5A inhibitor daclatasvir (BMS-790052) and NS3 protease inhibitor asunaprevir (BMS-650032) in HCV genotype 1b-infected null responders or ineligible/intolerant to peginterferon
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18-22 April Abstract 14
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Suzuki F, Ikeda K, Toyota J, et al. Dual oral therapy with the NS5A inhibitor daclatasvir (BMS-790052) and NS3 protease inhibitor asunaprevir (BMS-650032) in HCV genotype 1b-infected null responders or ineligible/ intolerant to peginterferon. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 14.
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(2012)
47th EASL Barcelona
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Suzuki, F.1
Ikeda, K.2
Toyota, J.3
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28
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84873047572
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High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: Interim results
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18-22 April Abstract 1421
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Sulkowski M, Rodriguez-Torres M, Lawitz E, et al. High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: interim results. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1421.
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(2012)
47th EASL Barcelona
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Sulkowski, M.1
Rodriguez-Torres, M.2
Lawitz, E.3
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29
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84873027365
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100% SVR in IL28B SNP rs12979860 C/C patients treated with 12 weeks of telaprevir, peginterferon and ribavirin in the PROVE2 trial
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Barcelona 18-22 April Abstract 1094
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Bronowicki J, Hezode C, Bergtsoon L, et al. 100% SVR in IL28B SNP rs12979860 C/C patients treated with 12 weeks of telaprevir, peginterferon and ribavirin in the PROVE2 trial. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1094.
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(2012)
47th EASL
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Bronowicki, J.1
Hezode, C.2
Bergtsoon, L.3
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30
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84873022900
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Pre-treatment IP-10 levels and IL28B genotype in prediction of SVR in prior treatment-experienced genotype 1 HCV patients treated with telaprevir/peginterferon/ribavirin in the REALIZE study
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18-22 April Abstract 1167
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Vijgen L, Talloen W, Scholliers A, et al. Pre-treatment IP-10 levels and IL28B genotype in prediction of SVR in prior treatment-experienced genotype 1 HCV patients treated with telaprevir/peginterferon/ribavirin in the REALIZE study. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1167.
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(2012)
47th EASL Barcelona
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Vijgen, L.1
Talloen, W.2
Scholliers, A.3
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31
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84873027096
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A comprehensive review of patterns of viral load decline in patients treated with telaprevir plus peginterferon and ribavirin
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18-22 April Abstract 1150
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Picchio G, De Meyer S, Dierynk I, et al. A comprehensive review of patterns of viral load decline in patients treated with telaprevir plus peginterferon and ribavirin. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1150.
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(2012)
47th EASL Barcelona
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Picchio, G.1
De Meyer, S.2
Dierynk, I.3
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32
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84873035565
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Dynamics of HCV quasiespecies during telaprevir treatment dissected using ultra-deep pyrosequencing: Treatment failure in 100% of genotype 1a patients
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18-22 April Abstract 56
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Pinson P, Trimoulet P, Papuchon J, et al. Dynamics of HCV quasiespecies during telaprevir treatment dissected using ultra-deep pyrosequencing: treatment failure in 100% of genotype 1a patients. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 56.
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(2012)
47th EASL Barcelona
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Pinson, P.1
Trimoulet, P.2
Papuchon, J.3
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33
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84873041815
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Futility rules in telaprevir combination therapy
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18-22 April Abstract 55
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Jacobson I, Bartels D, Gritz L, et al. Futility rules in telaprevir combination therapy. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 55.
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(2012)
47th EASL Barcelona
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Jacobson, I.1
Bartels, D.2
Gritz, L.3
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34
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84865753312
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Comparison of high ribavirin induction versus standard ribavirin dosing, plus peginterferon-α for the treatment of chronic hepatitis C in HIV-infected patients: The PERICO trial
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Labarga P, Barreiro P, da Silva A, et al. Comparison of high ribavirin induction versus standard ribavirin dosing, plus peginterferon-α for the treatment of chronic hepatitis C in HIV-infected patients: the PERICO trial. J Infect Dis 2012; 206:961-8.
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(2012)
J Infect Dis
, vol.206
, pp. 961-968
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Labarga, P.1
Barreiro, P.2
Da Silva, A.3
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35
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84873022733
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Ribavirin dose modification in treatment-naive and previously treated patients who received telaprevir combination treatment: No impact on sustained virologic response in phase 3 studies
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18-22 April Abstract 1162
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Sulkowski M, Roberts S, Afdhal N, et al. Ribavirin dose modification in treatment-naive and previously treated patients who received telaprevir combination treatment: no impact on sustained virologic response in phase 3 studies. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1162.
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(2012)
47th EASL Barcelona
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Sulkowski, M.1
Roberts, S.2
Afdhal, N.3
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36
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84873032679
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A randomized trial comparing ribavirin dose reduction versus erythropoietin for anemia management in previously untreated patients with chronic hepatitis C receiving boceprevir plus peginterferon/ribavirin
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18-22 April Abstract 1419
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Poordad F, Lawitz E, Reddy K, et al. A randomized trial comparing ribavirin dose reduction versus erythropoietin for anemia management in previously untreated patients with chronic hepatitis C receiving boceprevir plus peginterferon/ribavirin. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 1419.
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(2012)
47th EASL Barcelona
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Poordad, F.1
Lawitz, E.2
Reddy, K.3
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37
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45749088957
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Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?
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Soriano V, Zeuzem S, Zoulim F. Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses? J Antimicrob Chemother 2008; 62:1-4.
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(2008)
J Antimicrob Chemother
, vol.62
, pp. 1-4
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Soriano, V.1
Zeuzem, S.2
Zoulim, F.3
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38
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84873041815
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Futility rules in telaprevir combination treatment
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18-22 April Abstract 55
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Jacobson I, Bartels D, Gritz L, et al. Futility rules in telaprevir combination treatment. In: 47th EASL, Barcelona, 18-22 April 2012. Abstract 55.
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(2012)
47th EASL Barcelona
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Jacobson, I.1
Bartels, D.2
Gritz, L.3
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39
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84856304724
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Treatment failure with new hepatitis C drugs
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Soriano V, Vispo E, Poveda E, Labarga P, Barreiro P. Treatment failure with new hepatitis C drugs. Expert Opin Pharmacother 2012; 13:313-23.
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(2012)
Expert Opin Pharmacother
, vol.13
, pp. 313-323
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Soriano, V.1
Vispo, E.2
Poveda, E.3
Labarga, P.4
Barreiro, P.5
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40
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77950203857
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Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs)
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Kieffer T, Kwong A, Picchio G. Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs). J Antimicrob Chemother. 2010; 65:202-12.
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J Antimicrob Chemother
, vol.65
, pp. 202-212
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Kieffer, T.1
Kwong, A.2
Picchio, G.3
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41
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84862117053
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Differences in virological response to peginterferon-α plus ribavirin in HIV-positive patients coinfected with HCV subtypes 1a or 1b
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Rallón N, Pineda JA, Soriano V, et al. Differences in virological response to peginterferon-α plus ribavirin in HIV-positive patients coinfected with HCV subtypes 1a or 1b. J Acquir Immune Defic Syndr 2012; 60:117-23.
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J Acquir Immune Defic Syndr
, vol.60
, pp. 117-123
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Rallón, N.1
Pineda, J.A.2
Soriano, V.3
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42
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84865195864
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Different impact of IL28B polymorphisms on response to peginterferon plus ribavirin in HIVpositive patients infected with HCV subtypes 1a or 1b
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Vispo E, Rallon N, Labarga P, et al. Different impact of IL28B polymorphisms on response to peginterferon plus ribavirin in HIVpositive patients infected with HCV subtypes 1a or 1b. J Clin Virol 2012; 55:58-61.
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J Clin Virol
, vol.55
, pp. 58-61
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