Role of AKT isotypes in breast cancer

Journal of Pathology

Volumn 229, Issue 3, 2013, Pages

  Badve, Sunil ^a   Nakshatri, Harikrishna ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN; ISOENZYME; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE B BETA; SERINE; THREONINE; UNCLASSIFIED DRUG;

BREAST CANCER; CANCER INVASION; CELL PROLIFERATION; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; ESTROGEN RECEPTOR NEGATIVE BREAST CANCER; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; HUMAN; LETTER; METASTASIS POTENTIAL; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROTEIN PHOSPHORYLATION; TISSUE LEVEL;

BREAST NEOPLASMS; DISEASE PROGRESSION; FEMALE; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84872955296     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4137     Document Type: Letter

References (5)

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3. Kirkegaard T, Witton CJ, McGlynn LM, et al,. AKT activation predicts outcome in breast cancer patients treated with tamoxifen. J Pathol 2005; 207: 139-146. (Pubitemid 41404144)
4. Liu H, Radisky DC, Nelson CM, et al,. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci USA 2006; 103: 4134-4139.
5. Meric-Bernstam F, Akcakanat A, Chen H, et al,. PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors. Clin Cancer Res 2012; 18: 1777-1789.