메뉴 건너뛰기




Volumn 50, Issue 11, 2012, Pages 1893-1902

Exhaled breath analysis for early cancer detection: Principle and progress in direct mass spectrometry techniques

Author keywords

Cancer; Direct sampling mass spectrometry; Exhaled breath; Proton transfer reaction mass spectrometry; Selected ion flow tube mass spectrometry; Volatile biomarker

Indexed keywords

ACETONE; TUMOR MARKER; VOLATILE ORGANIC COMPOUND;

EID: 84872942545     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2012-0208     Document Type: Review
Times cited : (17)

References (75)
  • 4
    • 57349099521 scopus 로고    scopus 로고
    • Are we finally winning the war on cancer ?
    • Cutler DM. Are we finally winning the war on cancer ? J Econ Perspect 2008;22:3 - 26.
    • (2008) J Econ Perspect , vol.22 , pp. 3-26
    • Cutler, D.M.1
  • 5
    • 33847788491 scopus 로고    scopus 로고
    • Breath analysis: The approach towards clinical applications
    • Amann A, Spanel P, Smith D. Breath analysis: the approach towards clinical applications. Mini Rev Med Chem 2007;7: 115 - 29.
    • (2007) Mini Rev Med Chem , vol.7 , pp. 115-129
    • Amann, A.1    Spanel, P.2    Smith, D.3
  • 6
    • 50349095278 scopus 로고    scopus 로고
    • Analysis of volatile organic compounds in the exhaled breath for the diagnosis of lung cancer
    • Mazzone PJ. Analysis of volatile organic compounds in the exhaled breath for the diagnosis of lung cancer. J Thorac Oncol 2008;3:774 - 80.
    • (2008) J Thorac Oncol , vol.3 , pp. 774-780
    • Mazzone, P.J.1
  • 7
    • 0041519192 scopus 로고    scopus 로고
    • Application of solid-phase microextraction and gas chromatography mass spectrometry to the determination of volatile organic compounds in end-exhaled breath samples
    • Prado C, Marin P, Periago JF. Application of solid-phase microextraction and gas chromatography mass spectrometry to the determination of volatile organic compounds in end-exhaled breath samples. J Chromatogr A 2003;1011:125 - 34.
    • (2003) J Chromatogr A , vol.1011 , pp. 125-134
    • Prado, C.1    Marin, P.2    Periago, J.F.3
  • 8
    • 0032566663 scopus 로고    scopus 로고
    • Method for analysis of exhaled air by microwave energy desorption coupled with gas chromatography-flame ionization detection-mass spectrometry
    • Mueller W, Schubert J, Benzing A, Geiger K. Method for analysis of exhaled air by microwave energy desorption coupled with gas chromatography-flame ionization detection-mass spectrometry. J Chromatogr B Biomed Sci Appl 1998;716:27 - 38.
    • (1998) J Chromatogr B Biomed Sci Appl , vol.716 , pp. 27-38
    • Mueller, W.1    Schubert, J.2    Benzing, A.3    Geiger, K.4
  • 9
    • 39449112689 scopus 로고    scopus 로고
    • Detection of biomarker in breath: A step towards non-invasive diabetes monitoring
    • Chakraborty S, Banerjee D, Ray I, Sen A. Detection of biomarker in breath: a step towards non-invasive diabetes monitoring. Curr Sci 2008;94:237 - 42.
    • (2008) Curr Sci , vol.94 , pp. 237-242
    • Chakraborty, S.1    Banerjee, D.2    Ray, I.3    Sen, A.4
  • 10
    • 0034912589 scopus 로고    scopus 로고
    • Human breath isoprene and its relation to blood cholesterol levels: New measurements and modeling
    • Karl T, Prazeller P, Mayr D, Jordan A, Rieder J, Fall R, et al. Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling. J App Physiol 2001;91:762 - 70.
    • (2001) J App Physiol , vol.91 , pp. 762-770
    • Karl, T.1    Prazeller, P.2    Mayr, D.3    Jordan, A.4    Rieder, J.5    Fall, R.6
  • 11
    • 17444399677 scopus 로고    scopus 로고
    • Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis
    • Smith D, Špan ěl P. Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. Mass Spectrom Rev 2005;24:661 - 700.
    • (2005) Mass Spectrom Rev , vol.24 , pp. 661-700
    • Smith, D.1    Španěl, P.2
  • 12
    • 84860333217 scopus 로고    scopus 로고
    • Canine olfactory detection of cancer versus laboratory testing: Myth or opportunity ?
    • Lippi G, Cervellin G. Canine olfactory detection of cancer versus laboratory testing: myth or opportunity ? Clin Chem Lab Med 2012;50:435 - 9.
    • (2012) Clin Chem Lab Med , vol.50 , pp. 435-439
    • Lippi, G.1    Cervellin, G.2
  • 13
    • 84860469257 scopus 로고    scopus 로고
    • Cancer diagnosis: From dogs to DNA or from DNA to dogs ?
    • Melichar B, Plebani M. Cancer diagnosis: from dogs to DNA or from DNA to dogs ? Clin Chem Lab Med 2012;50:415 - 8.
    • (2012) Clin Chem Lab Med , vol.50 , pp. 415-418
    • Melichar, B.1    Plebani, M.2
  • 14
    • 4143053648 scopus 로고    scopus 로고
    • Diagnostic potential of breath analysis-focus on volatile organic compounds
    • Miekisch W, Schubert JK, Noeldge-Schomburg GE. Diagnostic potential of breath analysis-focus on volatile organic compounds. Clin Chim Acta 2004;347:25 - 39.
    • (2004) Clin Chim Acta , vol.347 , pp. 25-39
    • Miekisch, W.1    Schubert, J.K.2    Noeldge-Schomburg, G.E.3
  • 15
    • 0020693943 scopus 로고
    • The diagnostic potential of breath analysis
    • Manolis A. The diagnostic potential of breath analysis. Clin Chem 1983;29:5 - 15.
    • (1983) Clin Chem , vol.29 , pp. 5-15
    • Manolis, A.1
  • 17
    • 33646338915 scopus 로고    scopus 로고
    • Breath analysis: Potential for clinical diagnosis and exposure assessment
    • Cao W, Duan Y. Breath analysis: potential for clinical diagnosis and exposure assessment. Clin Chem 2006;52:800 - 11.
    • (2006) Clin Chem , vol.52 , pp. 800-811
    • Cao, W.1    Duan, Y.2
  • 18
    • 48949095332 scopus 로고    scopus 로고
    • Analysis of exhaled breath condensate in respiratory medicine: Methodological aspects and potential clinical applications
    • Montuschi P. Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications. Ther Adv Respir Dis 2007;1:5 - 23.
    • (2007) Ther Adv Respir Dis , vol.1 , pp. 5-23
    • Montuschi, P.1
  • 19
    • 78049284012 scopus 로고    scopus 로고
    • Breath analysis in asbestos-related disorders: A review of the literature and potential future applications
    • Chapman EA, Thomas PS, Yates DH. Breath analysis in asbestos-related disorders: a review of the literature and potential future applications. J Breath Res 2010;4:034001.
    • (2010) J Breath Res , vol.4 , pp. 034001
    • Chapman, E.A.1    Thomas, P.S.2    Yates, D.H.3
  • 20
    • 3042524939 scopus 로고    scopus 로고
    • Recent developments in biomarkers for the early detection of lung cancer: Perspectives based on publications 2003 to present
    • Chanin TD, Merrick DT, Franklin WA, Hirsch FR. Recent developments in biomarkers for the early detection of lung cancer: perspectives based on publications 2003 to present. Curr Opin Pulm Med 2004;10:242 - 7.
    • (2004) Curr Opin Pulm Med , vol.10 , pp. 242-247
    • Chanin, T.D.1    Merrick, D.T.2    Franklin, W.A.3    Hirsch, F.R.4
  • 21
    • 31944446186 scopus 로고    scopus 로고
    • Exhaled breath analysis: From occupational to respiratory medicine
    • Corradi M, Mutti A. Exhaled breath analysis: from occupational to respiratory medicine. Acta Biomed 2005;76:20 - 9.
    • (2005) Acta Biomed , vol.76 , pp. 20-29
    • Corradi, M.1    Mutti, A.2
  • 22
    • 18444383957 scopus 로고    scopus 로고
    • Potential applications of breath isoprene as a biomarker in modern medicine: A concise overview
    • Salerno-Kennedy R, Cashman KD. Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview. Wien Klin Wochenschr 2005;117:180 - 6.
    • (2005) Wien Klin Wochenschr , vol.117 , pp. 180-186
    • Salerno-Kennedy, R.1    Cashman, K.D.2
  • 23
    • 34247624670 scopus 로고    scopus 로고
    • The challenge of breath analysis for clinical diagnosis and therapeutic monitoring
    • Smith D, Špan ěl P. The challenge of breath analysis for clinical diagnosis and therapeutic monitoring. Analyst 2007;132:390 - 6.
    • (2007) Analyst , vol.132 , pp. 390-396
    • Smith, D.1    Španěl, P.2
  • 24
    • 80052767061 scopus 로고    scopus 로고
    • The great challenge for exhaled breath analysis: Embracing complexity, delivering simplicity
    • Dweik RA. The great challenge for exhaled breath analysis: embracing complexity, delivering simplicity. J Breath Res 2011;5:030201.
    • (2011) J Breath Res , vol.5 , pp. 030201
    • Dweik, R.A.1
  • 25
    • 33749016240 scopus 로고    scopus 로고
    • Current status of clinical breath analysis
    • Risby TH, Solga SF. Current status of clinical breath analysis. Appl Phys B 2006;85:421 - 6.
    • (2006) Appl Phys B , vol.85 , pp. 421-426
    • Risby, T.H.1    Solga, S.F.2
  • 26
    • 33847639202 scopus 로고    scopus 로고
    • Current status of methods and techniques for breath analysis
    • Cao W, Duan Y. Current status of methods and techniques for breath analysis. Crit Rev Anal Chem 2007;37:3 - 13.
    • (2007) Crit Rev Anal Chem , vol.37 , pp. 3-13
    • Cao, W.1    Duan, Y.2
  • 27
    • 79951561425 scopus 로고    scopus 로고
    • Breath ammonia analysis: Clinical application and measurement
    • Hibbard T, Killard A. Breath ammonia analysis: clinical application and measurement. Crit Rev Anal Chem 2011;41:21 - 35.
    • (2011) Crit Rev Anal Chem , vol.41 , pp. 21-35
    • Hibbard, T.1    Killard, A.2
  • 28
    • 59249090120 scopus 로고    scopus 로고
    • Analytical methods for breath investigation
    • Ligor T. Analytical methods for breath investigation. Crit Rev Anal Chem 2009;39:2 - 12.
    • (2009) Crit Rev Anal Chem , vol.39 , pp. 2-12
    • Ligor, T.1
  • 29
    • 12344256993 scopus 로고    scopus 로고
    • Breath analysis: Trends in techniques and clinical applications
    • Di Francesco F, Fuoco R, Trivella MG, Ceccarini A. Breath analysis: trends in techniques and clinical applications. Microchem J 2005;79:405 - 10.
    • (2005) Microchem J , vol.79 , pp. 405-410
    • Di Francesco, F.1    Fuoco, R.2    Trivella, M.G.3    Ceccarini, A.4
  • 30
    • 78650010018 scopus 로고    scopus 로고
    • Hyphenated and unconventional methods for searching volatile cancer biomarkers
    • Ulanowska A, Ligor T, Michel M, Buszewski B. Hyphenated and unconventional methods for searching volatile cancer biomarkers. Ecol Chem Eng S 2010;17:9 - 23.
    • (2010) Ecol Chem Eng S , vol.17 , pp. 9-23
    • Ulanowska, A.1    Ligor, T.2    Michel, M.3    Buszewski, B.4
  • 31
    • 0015131404 scopus 로고
    • Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography
    • Pauling L, Robinson AB, Teranishi R, Cary P. Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc Natl Acad Sci USA 1971;68:2374 - 6.
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 2374-2376
    • Pauling, L.1    Robinson, A.B.2    Teranishi, R.3    Cary, P.4
  • 32
    • 58049216343 scopus 로고    scopus 로고
    • Exhaled breath analysis: Novel approach for early detection of lung cancer
    • Chan HP, Lewis C, Thomas PS. Exhaled breath analysis: novel approach for early detection of lung cancer. Lung Cancer 2009;63:164 - 8.
    • (2009) Lung Cancer , vol.63 , pp. 164-168
    • Chan, H.P.1    Lewis, C.2    Thomas, P.S.3
  • 33
    • 0028277936 scopus 로고
    • The potential of the hydrocarbon breath test as a measure of lipid peroxidation
    • Kneepkens CM, Lepage G, Roy CC. The potential of the hydrocarbon breath test as a measure of lipid peroxidation. Free Radic Biol Med 1994;17:127 - 60.
    • (1994) Free Radic Biol Med , vol.17 , pp. 127-160
    • Kneepkens, C.M.1    Lepage, G.2    Roy, C.C.3
  • 35
    • 0033526615 scopus 로고    scopus 로고
    • Volatile organic compounds in breath as markers of lung cancer: A cross-sectional study
    • Phillips M, Gleeson K, Hughes JM, Greenberg J, Cataneo RN, Baker L, et al. Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 1999;353:1930 - 3.
    • (1999) Lancet , vol.353 , pp. 1930-1933
    • Phillips, M.1    Gleeson, K.2    Hughes, J.M.3    Greenberg, J.4    Cataneo, R.N.5    Baker, L.6
  • 37
    • 0034653790 scopus 로고    scopus 로고
    • Breath alkanes as a marker of oxidative stress in different clinical conditions
    • Aghdassi E, Allard JP. Breath alkanes as a marker of oxidative stress in different clinical conditions. Free Radic Biol Med 2000;28:880 - 6.
    • (2000) Free Radic Biol Med , vol.28 , pp. 880-886
    • Aghdassi, E.1    Allard, J.P.2
  • 38
    • 0033801596 scopus 로고    scopus 로고
    • Effect of age on the breath methylated alkane contour, a display of apparent new markers of oxidative stress
    • Phillips M, Cataneo RN, Greenberg J, Gunawardena R, Naidu A, Rahbari-Oskoui F. Effect of age on the breath methylated alkane contour, a display of apparent new markers of oxidative stress. J Lab Clin Med 2000;136:243 - 9.
    • (2000) J Lab Clin Med , vol.136 , pp. 243-249
    • Phillips, M.1    Cataneo, R.N.2    Greenberg, J.3    Gunawardena, R.4    Naidu, A.5    Rahbari-Oskoui, F.6
  • 40
    • 26244435817 scopus 로고    scopus 로고
    • Exhaled volatile organic compounds in patients with non-small cell lung cancer: Cross sectional and nested short-term follow-up study
    • Poli D, Carbognani P, Corradi M, Goldoni M, Acampa O, Balbi B, et al. Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study. Respir Res 2005;6:71.
    • (2005) Respir Res , vol.6 , pp. 71
    • Poli, D.1    Carbognani, P.2    Corradi, M.3    Goldoni, M.4    Acampa, O.5    Balbi, B.6
  • 41
    • 1042276529 scopus 로고    scopus 로고
    • Pathways and control of ketone body metabolism: On the fringe of lipid biochemistry
    • Fukao T, Lopaschuk GD, Mitchell GA. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Prost Leuk Ess Fat Ac 2004;70:243 - 51.
    • (2004) Prost Leuk Ess Fat Ac , vol.70 , pp. 243-251
    • Fukao, T.1    Lopaschuk, G.D.2    Mitchell, G.A.3
  • 42
    • 0030298211 scopus 로고    scopus 로고
    • Concentrating breath samples using liquid nitrogen: A reliable method for the simultaneous determination of ethane and pentane
    • Knutson MD, Viteri FE. Concentrating breath samples using liquid nitrogen: a reliable method for the simultaneous determination of ethane and pentane. Anal Biochem 1996;242:129 - 35.
    • (1996) Anal Biochem , vol.242 , pp. 129-135
    • Knutson, M.D.1    Viteri, F.E.2
  • 43
    • 0031568680 scopus 로고    scopus 로고
    • Solid-phase microextraction for the analysis of human breath
    • Grote C, Pawliszyn J. Solid-phase microextraction for the analysis of human breath. Anal Chem 1997;69:587 - 96.
    • (1997) Anal Chem , vol.69 , pp. 587-596
    • Grote, C.1    Pawliszyn, J.2
  • 44
    • 84860448274 scopus 로고    scopus 로고
    • Investigation of lung cancer biomarkers by hyphenated separation techniques and chemometrics
    • Buszewski B, Ulanowska A, Kowalkowski T, Cieśliński K. Investigation of lung cancer biomarkers by hyphenated separation techniques and chemometrics. Clin Chem Lab Med 2012;50:573 - 81.
    • (2012) Clin Chem Lab Med , vol.50 , pp. 573-581
    • Buszewski, B.1    Ulanowska, A.2    Kowalkowski, T.3    Cieśliński, K.4
  • 45
    • 34948849853 scopus 로고    scopus 로고
    • Real-time continuous monitoring methods for airborne VOCs
    • Badjagbo K, Moore S, SauvéS. Real-time continuous monitoring methods for airborne VOCs. Trends Analyt Chem 2007;26:931 - 40.
    • (2007) Trends Analyt Chem , vol.26 , pp. 931-940
    • Badjagbo, K.1    Moore, S.2    Sauvé, S.3
  • 47
    • 0032382401 scopus 로고    scopus 로고
    • Proton-transfer-reaction mass spectrometry (PTR - MS): On-line monitoring of volatile organic compounds at pptv levels
    • Lindinger W, Hansel A, Jordan A. Proton-transfer-reaction mass spectrometry (PTR - MS): on-line monitoring of volatile organic compounds at pptv levels. Chem Soc Rev 1998;27:347 - 75.
    • (1998) Chem Soc Rev , vol.27 , pp. 347-375
    • Lindinger, W.1    Hansel, A.2    Jordan, A.3
  • 48
    • 10044271359 scopus 로고    scopus 로고
    • Online monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS) medical applications, food control and environmental research
    • Lindinger W, Hansel A, Jordan A. Online monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS) medical applications, food control and environmental research. Int J Mass Spectrom Ion Process 1998;173:191 - 241.
    • (1998) Int J Mass Spectrom Ion Process , vol.173 , pp. 191-241
    • Lindinger, W.1    Hansel, A.2    Jordan, A.3
  • 50
    • 79960607496 scopus 로고    scopus 로고
    • Direct, rapid quantitative analyses of BVOCs using SIFT-MS and PTR-MS obviating sample collection
    • Smith D, Špan ěl P. Direct, rapid quantitative analyses of BVOCs using SIFT-MS and PTR-MS obviating sample collection. Trends Analyt Chem 2011;30:945 - 59.
    • (2011) Trends Analyt Chem , vol.30 , pp. 945-959
    • Smith, D.1    Španěl, P.2
  • 51
    • 84872899484 scopus 로고    scopus 로고
    • Accessed 25 March, 2012
    • National Institute of Standards and Technology. NIST Gas-phase ion energetics data. Available at: http://webbook.nist.gov/chemistry. Accessed 25 March, 2012.
    • NIST Gas-phase Ion Energetics Data
  • 52
    • 0037437569 scopus 로고    scopus 로고
    • Sensitivity and specificity of atmospheric trace gas detection by proton-transfer-reaction mass spectrometry
    • de Gouw J, Warneke C, Karl T, Eerdekens G, van der Veen C, Fall R. Sensitivity and specificity of atmospheric trace gas detection by proton-transfer-reaction mass spectrometry. Int J Mass Spectrom 2003;223 - 224:365 - 82.
    • (2003) Int J Mass Spectrom , vol.223-224 , pp. 365-382
    • De Gouw, J.1    Warneke, C.2    Karl, T.3    Eerdekens, G.4    Van Der Veen, C.5    Fall, R.6
  • 53
    • 67849109786 scopus 로고    scopus 로고
    • An online ultra-high sensitivity Proton-transfer-reaction mass-spectrometer combined with switchable reagent ion capability (PTR + SRI - MS)
    • Jordan A, Haidacher S, Hanel G, Hartungen E, Herbig J, Märk L, et al. An online ultra-high sensitivity Proton-transfer-reaction mass-spectrometer combined with switchable reagent ion capability (PTR + SRI - MS). Int J Mass Spectrom 2009;286:32 - 8.
    • (2009) Int J Mass Spectrom , vol.286 , pp. 32-38
    • Jordan, A.1    Haidacher, S.2    Hanel, G.3    Hartungen, E.4    Herbig, J.5    Märk, L.6
  • 54
    • 70249107428 scopus 로고    scopus 로고
    • A high resolution and high sensitivity proton-transferreaction time-of-flight mass spectrometer (PTR-TOF-MS)
    • Jordan A, Haidacher S, Hanel G, Hartungen E, Märk L, Seehauser H, et al. A high resolution and high sensitivity proton-transferreaction time-of-flight mass spectrometer (PTR-TOF-MS). Int J Mass Spectrom 2009;286:122 - 8.
    • (2009) Int J Mass Spectrom , vol.286 , pp. 122-128
    • Jordan, A.1    Haidacher, S.2    Hanel, G.3    Hartungen, E.4    Märk, L.5    Seehauser, H.6
  • 55
    • 77952880920 scopus 로고    scopus 로고
    • High resolution PTR-TOF: Quantification and formula confirmation of VOC in real time
    • Graus M, Müller M, Hansel A. High resolution PTR-TOF: quantification and formula confirmation of VOC in real time. J Am Soc Mass Spectrom 2010;21:1037 - 44.
    • (2010) J Am Soc Mass Spectrom , vol.21 , pp. 1037-1044
    • Graus, M.1    Müller, M.2    Hansel, A.3
  • 57
    • 0029760904 scopus 로고    scopus 로고
    • The novel selected-ion flow tube approach to trace gas analysis of air and breath
    • Smith D, Španěl P. The novel selected-ion flow tube approach to trace gas analysis of air and breath. Rapid Commun Mass Spectrom 1996;10:1183 - 98.
    • (1996) Rapid Commun Mass Spectrom , vol.10 , pp. 1183-1198
    • Smith, D.1    Španěl, P.2
  • 58
    • 79951844780 scopus 로고    scopus 로고
    • Progress in SIFT-MS: Breath analysis and other applications
    • Špan ěl P, Smith D. Progress in SIFT-MS: breath analysis and other applications. Mass Spectrom Rev 2011;30:236 - 67.
    • (2011) Mass Spectrom Rev , vol.30 , pp. 236-267
    • Španěl, P.1    Smith, D.2
  • 59
    • 0030293710 scopus 로고    scopus 로고
    • Selected ion flow tube: A technique for quantitative trace gas analysis of air and breath
    • Špan ěl P, Smith D. Selected ion flow tube: a technique for quantitative trace gas analysis of air and breath. Med Biol Eng Comput 1996;34:409 - 19.
    • (1996) Med Biol Eng Comput , vol.34 , pp. 409-419
    • Španěl, P.1    Smith, D.2
  • 60
    • 0035868531 scopus 로고    scopus 로고
    • Analysis of volatile organic compounds: Possible applications in metabolic disorders and cancer screening
    • Rieder J, Lirk P, Ebenbichler C, Gruber G, Prazeller P, Lindinger W, et al. Analysis of volatile organic compounds: possible applications in metabolic disorders and cancer screening. Wien Klin Wochenschr 2001;113:181 - 5.
    • (2001) Wien Klin Wochenschr , vol.113 , pp. 181-185
    • Rieder, J.1    Lirk, P.2    Ebenbichler, C.3    Gruber, G.4    Prazeller, P.5    Lindinger, W.6
  • 63
    • 34247866471 scopus 로고    scopus 로고
    • An offline breath sampling and analysis method suitable for large screening studies
    • Steeghs MM, Cristescu SM, Munnik P, Zanen P, Harren FJ. An offline breath sampling and analysis method suitable for large screening studies. Physiol Meas 2007;28:503 - 14.
    • (2007) Physiol Meas , vol.28 , pp. 503-514
    • Steeghs, M.M.1    Cristescu, S.M.2    Munnik, P.3    Zanen, P.4    Harren, F.J.5
  • 65
    • 33744929369 scopus 로고    scopus 로고
    • A longitudinal study methanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS
    • Turner C, Špan ěl P, Smith D. A longitudinal study methanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS. Physiol Meas 2006;27: 637 - 48.
    • (2006) Physiol Meas , vol.27 , pp. 637-648
    • Turner, C.1    Španěl, P.2    Smith, D.3
  • 66
    • 29144508524 scopus 로고    scopus 로고
    • A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry
    • Turner C, Špan ěl P, Smith D. A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry. Rapid Commun Mass Spectrom 2006;20:61 - 8.
    • (2006) Rapid Commun Mass Spectrom , vol.20 , pp. 61-68
    • Turner, C.1    Španěl, P.2    Smith, D.3
  • 67
    • 84974678877 scopus 로고    scopus 로고
    • The concentration distributions of some metabolites in the exhaled breath of young adults
    • Španěl P, Dryahina K, Smith D. The concentration distributions of some metabolites in the exhaled breath of young adults. J Breath Res 2007;1:026001.
    • (2007) J Breath Res , vol.1 , pp. 026001
    • Španěl, P.1    Dryahina, K.2    Smith, D.3
  • 68
    • 84974678877 scopus 로고    scopus 로고
    • Acetone, ammonia and hydrogen cyanide in exhaled breath of several volunteers aged 4 - 83 years
    • Španěl P, Dryahina K, Smith D. Acetone, ammonia and hydrogen cyanide in exhaled breath of several volunteers aged 4 - 83 years. J Breath Res 2007;1:011001.
    • (2007) J Breath Res , vol.1 , pp. 011001
    • Španěl, P.1    Dryahina, K.2    Smith, D.3
  • 69
    • 77950614220 scopus 로고    scopus 로고
    • Advantages of breath testing for the early diagnosis of lung cancer
    • Smith D, Španěl P. Advantages of breath testing for the early diagnosis of lung cancer. Expert Rev Mol Diagn 2010;10:255 - 7.
    • (2010) Expert Rev Mol Diagn , vol.10 , pp. 255-257
    • Smith, D.1    Španěl, P.2
  • 70
    • 0032766142 scopus 로고    scopus 로고
    • Analysis of formaldehyde in the headspace of urine from bladder and prostate cancer patients using selected ion flow tube mass spectrometry
    • Španěl P, Smith D, Holland TA, Al Singary W, Elder JB. Analysis of formaldehyde in the headspace of urine from bladder and prostate cancer patients using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom 1999;13:1354 - 9.
    • (1999) Rapid Commun Mass Spectrom , vol.13 , pp. 1354-1359
    • Španěl, P.1    Smith, D.2    Holland, T.A.3    Al Singary, W.4    Elder, J.B.5
  • 71
    • 0037261382 scopus 로고    scopus 로고
    • Quantification of acetaldehyde released by lung cancer cells in vitro using selected ion flow tube mass spectrometry
    • Smith D, Wang TS, Sule-Suso J, Špan ěl P, El Haj A. Quantification of acetaldehyde released by lung cancer cells in vitro using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom 2003;17:845 - 50.
    • (2003) Rapid Commun Mass Spectrom , vol.17 , pp. 845-850
    • Smith, D.1    Wang, T.S.2    Sule-Suso, J.3    Španěl, P.4    El Haj, A.5
  • 72
    • 72449172575 scopus 로고    scopus 로고
    • Quantification of acetaldehyde and carbon dioxide in the headspace of malignant and non-malignant lung cells in vitro by SIFT-MS
    • Sulé-Suso J, Pysanenko A, Španěl P, Smith D. Quantification of acetaldehyde and carbon dioxide in the headspace of malignant and non-malignant lung cells in vitro by SIFT-MS. Analyst 2009;134:2419 - 25.
    • (2009) Analyst , vol.134 , pp. 2419-2425
    • Sulé-Suso, J.1    Pysanenko, A.2    Španěl, P.3    Smith, D.4
  • 73
    • 62349121500 scopus 로고    scopus 로고
    • Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS
    • Španěl P, Smith D. Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS. J Breath Res 2008;2:046003.
    • (2008) J Breath Res , vol.2 , pp. 046003
    • Španěl, P.1    Smith, D.2
  • 74
    • 59349111610 scopus 로고    scopus 로고
    • Sub-parts per billion detection of trace volatile chemicals in human breath using selected ion flow tube mass spectrometry
    • Ross BM. Sub-parts per billion detection of trace volatile chemicals in human breath using selected ion flow tube mass spectrometry. BMC Res Notes 2008;1:41.
    • (2008) BMC Res Notes , vol.1 , pp. 41
    • Ross, B.M.1
  • 75
    • 79960964023 scopus 로고    scopus 로고
    • On-line, real time monitoring of exhaled trace gases by SIFT-MS in the perioperative setting: A feasibility study
    • Boshier PR, Cushnir JR, Mistry V, Knaggs A, Španěl P, Smith D, et al. On-line, real time monitoring of exhaled trace gases by SIFT-MS in the perioperative setting: a feasibility study. Analyst 2011;136:3233 - 7.
    • (2011) Analyst , vol.136 , pp. 3233-3237
    • Boshier, P.R.1    Cushnir, J.R.2    Mistry, V.3    Knaggs, A.4    Španěl, P.5    Smith, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.