Antiepileptic drugs and bone metabolism in children: Data from 128 patients

Journal of Child Neurology

Volumn 28, Issue 2, 2013, Pages 176-183

  Borusiak, Peter ^a   Langer, Thorsten ^a   Heruth, Marion ^b   Karenfort, Michael ^c   Bettendorf, Ulrich ^d   Jenke, Andreas Cw ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b HELIOS Hospital Borna   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d KiPraHi ^*  (Germany)

Author keywords

antiepileptic drugs; epilepsy; osteopenia; osteoporosis; vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; ANTICONVULSIVE AGENT; CALCIUM; CARBAMAZEPINE; ETIRACETAM; LAMOTRIGINE; OXCARBAZEPINE; PARATHYROID HORMONE; PHOSPHORUS; SULTIAME; TOPIRAMATE; VALPROIC ACID;

ADOLESCENT; ANTICONVULSANT THERAPY; ARTICLE; BONE METABOLISM; CALCIUM INTAKE; CHILD; CHILDHOOD DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EPILEPSY; FEMALE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; HUMAN; HYPOCALCEMIA; HYPOPHOSPHATEMIA; MAJOR CLINICAL STUDY; MALE; MIXED SEIZURE; MONOTHERAPY; MULTICENTER STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SYMPTOMATIC EPILEPSY;

ADOLESCENT; ANALYSIS OF VARIANCE; ANTHROPOMETRY; ANTICONVULSANTS; BONE AND BONES; CALCIUM; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; EPILEPSY; FEMALE; HUMANS; HYPOCALCEMIA; HYPOPHOSPHATEMIA; INFANT; MALE; RETROSPECTIVE STUDIES; VITAMIN D DEFICIENCY;

EID: 84872876428     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073812443005     Document Type: Article

References (29)

1. Dent CE, Richens A, Rowe DJ, Stamp TC. Osteomalacia with long-term anticonvulsant therapy in epilepsy. Br Med J. 1970 ; 4: 69-72
2. Farhat G, Yamout B, Mikati MA, et al. Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology. 2002 ; 58: 1348-1353
3. Petty SJ, Paton LM, O'Brien TJ, et al. Effect of antiepileptic medication on bone mineral measures. Neurology. 2005 ; 65: 1358-1365
4. Ensrud KE, Walczak TS, Blackwell TL, et al. Antiepileptic drug use and rates of hip bone loss in older men: a prospective study. Neurology. 2008 ; 71: 723-730
5. Feldkamp J, Becker A, Witte OW, et al. Long-term anticonvulsant therapy leads to low bone mineral density - evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells. Exp Clin Endocrinol Diabetes. 2000 ; 108: 37-43
6. Fitzpatrick LA. Pathophysiology of bone loss in patients receiving anticonvulsant therapy. Epilepsy Behav. 2004 ; 5: 3-15
7. Bacher M, Kurth C. Steinhoff BJ. 25-Hydroxyvitamin-D-Spiegel bei antikonvulsiver Dauermedikation. Z Epileptol. 2011 ; 24: 40-44
8. Kafali G, Erselcan T, Tanzer F. Effect of antiepileptic drugs on bone mineral density in children between ages 6 and 12 years. Clin Pediatr. (Phila). 1999 ; 38: 93-98
9. Erbayat Altay E, Serdaroglu A, Tumer L, et al. Evaluation of bone mineral metabolism in children receiving carbamazepine and valproic acid. J Pediatr Endocrinol Metab. 2000 ; 13: 933-999
10. Sheth RD, Binkley N, Hermann BP. Progressive bone deficit in epilepsy. Neurology. 2008 ; 70: 170-176
11. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989 ; 30: 389-399
12. DortschyRSchaffrath RosarioAScheidt-NaveC. Bevölkerungsbezogene Verteilungswerte ausgewählter Laborparameter aus der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS). Robert Koch-Institut, Berlin 2009. Available at: http://www.kiggs.de/experten/downloads/dokumente/ KiGGS-Laborparameter[1].pdf. Accessed December 15, 2011.
13. Elliot ME, Binkley N. Evaluation and measurement of bone mass. Epilepsy Behav. 2004 ; 5: 16-23
14. Desai KB, Ribbans WJ, Taylor GJ. Incidence of five common fracture types in an institutional epileptic population. Injury. 1996 ; 27: 97-100
15. Gniatkowska-Nowakowska A. Fractures in epilepsy children. Seizure. 2010 ; 19: 324-325
16. Chung S, Ahn C. Effects of anti-epileptic drug therapy on bone mineral density in ambulatory epileptic children. Brain Dev. 1994 ; 16: 382-385
17. Akin R, Okutan V, Sarrici Ü, et al. Evaluation of bone mineral density in children receiving antiepileptic drugs. Pediatr Neurol. 1998 ; 19: 129-131
18. Guo CY, Ronen GM, Atkinson SA. Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. Epilepsia. 2001 ; 42: 1141-1147
19. Ecevit C, Aydoǧan A, Kavakli T, Altinöz S. Effect of carbamazepine and valproate on bone mineral density. Pediatr Neurol. 2004 ; 31: 279-282
20. Oner N, Kaya M, Karasalihoǧlu S, et al. Bone mineral metabolism changes in epileptic children receiving valproic acid. J Paediatr Child Health. 2004 ; 40: 470-473
21. Sheth RD, Wesolowski CA, Jacob JC, et al. Effect of carbamazepine and valproate on bone mineral density. J Pediatr. 1995 ; 127: 256-262
22. Rieger-Wettengl G, Tutlewski B, Stabrey A, et al. Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine. Pediatrics. 2001 ; 108: E107
23. Tekgul H, Serdaroglu G, Huseyinov A, Gökben S. Bone mineral status in pediatric outpatients on antiepileptic drug monotherapy. J Child Neurol. 2006 ; 21: 411-414
24. Gissel T, Poulsen CS, Vestergaard P. Adverse effects of antiepileptic drugs on bone mineral density in children. Expert Opin Drug Saf. 2007 ; 6: 267-278
25. Nicolaidou P, Georgouli H, Kotsalis H, et al. Effects of anticonvulsant therapy on vitamin D status in children: prospective monitoring study. J Child Neurol. 2006 ; 21: 205-209
26. Rauchenzauner M, Griesmacher A, Tatarczyk T, et al. Chronic antiepileptic monotherapy, bone metabolism, and body composition in non-institutionalized children. Dev Med Child Neurol. 2010 ; 52: 283-288
27. Mintzer S, Boppana P, Toguri J, DeSantis A. Vitamin D levels and bone turnover in epilepsy patients taking carbamazepine or oxcarbazepine. Epilepsia. 2006 ; 47: 510-515
28. Pack AM, Morrell MJ, Marcus R, et al. Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. Ann Neurol. 2005 ; 57: 252-257
29. Coppola G, Fortunato D, Auricchio G, et al. Bone mineral density in children, adolescents, and young adults with epilepsy. Epilepsia. 2009 ; 50: 2140-2146