Estrogen-induced retinal endothelial cell proliferation: Possible involvement of pigment epithelium-derived factor and phosphoinositide 3-kinase/mitogen-activated protein kinase pathways

Journal of Ocular Pharmacology and Therapeutics

Volumn 29, Issue 1, 2013, Pages 27-32

  Parvathaneni, Kalpana ^a   Grigsby, Jeffery G ^a   Betts, Brandi S ^a   Tsin, Andrew T ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PIGMENT EPITHELIUM DERIVED FACTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RETINA; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; ESTROGEN RECEPTOR BETA; EYE PROTEINS; MACACA MULATTA; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTORS; PHOSPHATIDYLINOSITOL 3-KINASES; POLYMERASE CHAIN REACTION; RETINAL VESSELS; RNA, MESSENGER; SERPINS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84872858590     PISSN: 10807683     EISSN: 15577732     Source Type: Journal    
DOI: 10.1089/jop.2011.0252     Document Type: Article

References (26)

1. Yan, Q., Vernon, R.B., Hendrickson, A.E., and Sage, E.H. Primary culture and characterization of microvascular endothelial cells from Macaca monkey retina. Invest. Ophthalmol. Vis. Sci. 37:2185-2194, 1996
2. Elayappan, B., Ravinarayannan, H., Sardar Pasha, S.P., Lee, K.J., and Gurunathan, S. PEDF inhibits VEGF- And EPOinduced angiogenesis in retinal endothelial cells through interruption of PI3K/Akt phosphorylation. Angiogenesis. 12:313-324, 2009
3. Takenaka, K., Yamagishi, S., Jinnouchi, Y., Nakamura, K., Matsui, T., and Imaizumi, T. Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells. Life Sci. 77:3231-3241, 2005
4. Gao, G., Li, Y., Zhang, D., Gee, S., Crosson, C., and Ma, J. Unbalanced expression of VEGF and PEDF in ischemiainduced retinal neovascularization. FEBS Lett. 489:270-276, 2001
5. Love, R.R., and Philips, J. Oophorectomy for breast cancer: History revisited. J. Natl. Cancer Inst. 94:1433-1434, 2002
6. Beatson, G.T. On the treatment of inoperable cases of carcinoma of the mamma: Suggestions for a new method of treatment with illustrative cases. Lancet. 1896:104-107, 1896
7. Lacassagne, A. Hormonal pathogenesis of adenocarcinoma of the breast. Am. J. Cancer. 27:217-225, 1936
8. Grigsby, J.G., Allen, D.M., Culbert, R., et al. The Role of Sex Hormones in Diabetic Retinopathy. Rijeka: InTech, 2011
9. Simoncini, T., Mannella, P., Fornari, L., Caruso, A., Varone, G., and Genazzani, A.R. Genomic and non-genomic effects of estrogens on endothelial cells. Steroids. 69:537-542, 2004
10. Miller, J.H., Jr., Gates, R.E., Ong, D.E., and King, L.E., Jr. A miniature molecular-sieving column assay for cytoplasmic vitamin A-binding proteins. Anal. Biochem. 139:104-114, 1984
11. Kumar, V., Green, S., Stack, G., Berry, M., Jin, J.R., and Chambon, P. Functional domains of the human estrogen receptor. Cell. 51:941-951, 1987
12. Wu, W.X., Ma, X.H., Smith, G.C., and Nathanielsz, P.W. Differential distribution of ERalpha and ERbeta mRNA in intrauterine tissues of the pregnant rhesus monkey. Am. J. Physiol. Cell Physiol. 278:C190-C198, 2000
13. Levin, E.R. Integration of the extranuclear and nuclear actions of estrogen. Mol. Endocrinol. 19:1951-1959, 2005
14. Zivadinovic, D., Gametchu, B., and Watson, C.S. Membrane estrogen receptor-Alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation responses. Breast Cancer Res. 7:R101-R112, 2005
15. Lu, Q., Pallas, D.C., Surks, H.K., Baur, W.E., Mendelsohn, M.E., and Karas, R.H. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. Proc. Natl. Acad. Sci. U S A. 101:17126-17131, 2004
16. Kato, S., Endoh, H., Masuhiro, Y., et al. Activation of the estrogen receptor through phosphorylation by mitogenactivated protein kinase. Science. 270:1491-1494, 1995
17. Atanaskova, N., Keshamouni, V.G., Krueger, J.S., Schwartz, J.A., Miller, F., and Reddy, K.B. MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. Oncogene. 21:4000-4008, 2002
18. Cheung, L.W., Au, S.C., Cheung, A.N., et al. Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells. Endocrinology. 147:4179-4191, 2006
19. Grigsby, J.G., Parvathaneni, K., Almanza, M.A., et al. Effects of tamoxifen versus raloxifene on retinal capillary endothelial cell proliferation. J. Ocul. Pharmacol. Ther. 27:225-233, 2011
20. Guo, R.X., Wei, L.H., Tu, Z., et al. 17 Beta-estradiol activates PI3K/Akt signaling pathway by estrogen receptor (ER)-dependent and ER-independent mechanisms in endometrial cancer cells. J. Steroid Biochem. 99:9-18, 2006
21. Critchley, H.O.D., Brenner, R.M., Henderson, T.A., et al. Estrogen receptor beta, but not estrogen receptor alpha, is present in the vascular endothelium of the human and nonhuman primate endometrium. J. Clin. Endocr. Metab. 86: 1370-1378, 2001
22. Noma, H., Funatsu, H., Mimura, T., Harino, S., Eguchi, S., and Hori, S. Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema. Graefes Arch. Clin. Exp. Ophthalmol. 248:1559-1565, 2010
23. Yang, L.W., Zhang, J.X., Zeng, L., et al. Vascular endothelial growth factor gene therapy with intramuscular injections of plasmid DNA enhances the survival of random pattern flaps in a rat model. Br. J. Plast. Surg. 58:339-347, 2005
24. Guan, M., Yam, H.F., Su, B., et al. Loss of pigment epithelium derived factor expression in glioma progression. J. Clin. Pathol. 56:277-282, 2003
25. Bratton, M.R., Duong, B.N., Elliott, S., et al. Regulation of ERalpha-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: Implications for breast cancer cell survival. Int. J. Oncol. 37:541-550, 2010
26. Schiff, R., Massarweh, S.A., Shou, J., Bharwani, L., Mohsin, S.K., and Osborne, C.K. Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clin. Cancer Res. 10(1 Pt 2):331S-336S, 2004