Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 20823-20829

  Stieglitz, Benjamin ^a   Haire, Lesley F ^a   Dikic, Ivan ^b   Rittinger, Katrin ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHAIN ASSEMBLIES; COILED COIL; FUNCTIONAL APPLICATIONS; INTERACTION MODULES; LIGAND RECOGNITION; N-TERMINALS; PLECKSTRIN HOMOLOGY; PROTEIN INTERACTION; PROTEIN-INTERACTION MODULES; SELF-ASSOCIATIONS; SIGNALING PATHWAYS; UBIQUITIN; UBIQUITIN LIGASES; UBIQUITIN-LIKE; ZINC FINGER DOMAINS;

ASSOCIATION REACTIONS; DIMERIZATION; PROTEINS; RHODIUM COMPOUNDS; SURFACE PROPERTIES;

SCAFFOLDS (BIOLOGY);

SHANK ASSOCIATED RH DOMAIN INTERACTING PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; HUMAN; IMMUNOREGULATION; LIGAND BINDING; PLECKSTRIN HOMOLOGY SUPERFOLD; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS;

BLOOD PROTEINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; NERVE TISSUE PROTEINS; PHOSPHOPROTEINS; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN-PROTEIN LIGASES; ZINC FINGERS;

EID: 84862285768     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.359547     Document Type: Article

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