Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma

Medical Oncology

Volumn 29, Issue 3, 2012, Pages 1699-1706

  Hui, Marco K C ^a   Lai, Kenneth K Y ^a   Chan, Kwok Wah ^a   Luk, John M ^b   Lee, Nikki P ^a   Chung, Yvonne ^a   Cheung, Leo C ^a   Srivastava, Gopesh ^a   Tsao, Sai Wah ^a   Tang, Johnny C ^c   Law, Simon ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Esophageal squamous cell carcinoma; Median survival after surgery; Overexpression; Phosphorylated RON; Poor prognostic marker

Indexed keywords

GLYCOPROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; RON PROTEIN; UNCLASSIFIED DRUG;

AGED; ARTICLE; CANCER CELL CULTURE; CANCER PROGNOSIS; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; EPITHELIUM CELL; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS RESECTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; UPREGULATION;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; ESOPHAGEAL NEOPLASMS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; PHOSPHORYLATION; PROGNOSIS; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84872819521     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-011-0112-9     Document Type: Article

References (36)

1. Jemal A, et al. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90.
2. Anderson LL, Lad TE. Autopsy findings in squamous-cell carcinoma of the esophagus. Cancer. 1982;50(8):1587-90.
3. Wang MH, et al. Identification of the RON gene product as the receptor for the human macrophage stimulating protein. Science. 1994;266(5182):117-9.
4. Iwama A, Yamaguchi N, Suda T. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J. 1996;15(21):5866-75.
5. Peace BE, et al. Point mutations and overexpression of RON induce transformation, tumor formation, and metastasis. Oncogene. 2001;20(43):6142-51.
6. Wang MH, et al. Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes. Exp Cell Res. 1996;226(1):39-46.
7. Thomas RM, et al. The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression. Cancer Res. 2007;67(13):6075-82.
8. Hsu PY, et al. Collaboration of RON and epidermal growth factor receptor in human bladder carcinogenesis. J Urol. 2006;176(5): 2262-7.
9. Wang MH, Kurtz AL, Chen Y. Identification of a novel splicing product of the RON receptor tyrosine kinase in human colorectal carcinoma cells. Carcinogenesis. 2000;21(8):1507-12.
10. Okino T, et al. Presence of RON receptor tyrosine kinase and its splicing variant in malignant and non-malignant human colonic mucosa. Int J Oncol. 1999;15(4):709-14.
11. Cheng HL, et al. Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder. Br J Cancer. 2005;92(10):1906-14.
12. Camp ER, et al. Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target. Cancer. 2007;109(6):1030-9.
13. Cheung LC, et al. Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of Chinese origin. Cancer Genet Cytogenet. 2007;178(1):17-25.
14. Hu YC, et al. Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines. Cancer Genet Cytogenet. 2002;135(2):120-7.
15. Tang JC, et al. Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line SLMT-1 of Chinese origin. Cancer Genet Cytogenet. 2001;124(1):36-41.
16. Hu Y, et al. Establishment and characterization of HKESC-1, a new cancer cell line from human esophageal squamous cell carcinoma. Cancer Genet Cytogenet. 2000;118(2):112-20.
17. Zhang H, et al. Cytogenetic aberrations in immortalization of esophageal epithelial cells. Cancer Genet Cytogenet. 2006; 165(1):25-35.
18. Zhang H, et al. Papillomavirus type 16 E6/E7 and human telomerase reverse transcriptase in esophageal cell immortalization and early transformation. Cancer Lett. 2007;245(1-2):184-94.
19. Lee NP, et al. Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma. Proteomics. 2008;8(10):2136-49.
20. Lee NP, et al. Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma. Int J Cancer. 2010;127(4):968-76.
21. Lee NP, et al. Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease. FEBS Lett. 2006;580(3):923-31.
22. Lee NP, et al. Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma. J Proteome Res. 2009;8(3):1293-303.
23. Liu LX, et al. Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 2009; 50(5):1453-63.
24. Chung Y, et al. Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma. Ann Surg Oncol. 2007;14(11):3260-7.
25. Wang MH, et al. Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells. J Pathol. 2007; 213(4):402-11.
26. Nakai K, Horton P. PSORT a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem Sci. 1999;24(1):34-6.
27. Lee WY, et al. Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients. Clin Cancer Res Off J Am Assoc Cancer Res. 2005;11(6):2222-8.
28. Rampino T, et al. The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma. Am J Surg Pathol. 2003;27(6): 779-85.
29. Kaku N, et al. Characterization of nuclear import of the domainspecific androgen receptor in association with the importin alpha/beta and Ran-guanosine 50-triphosphate systems. Endocrinology. 2008;149(8):3960-9.
30. Schlessinger J, Lemmon MA. Nuclear signaling by receptor tyrosine kinases: the first robin of spring. Cell. 2006;127(1):45-8.
31. Lin SY, et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol. 2001; 3(9):802-8.
32. Pozner-Moulis S, Pappas DJ, Rimm DL. Met, the hepatocyte growth factor receptor, localizes to the nucleus in cells at low density. Cancer Res. 2006;66(16):7976-82.
33. Ni CY, et al. Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science. 2001;294(5549):2179-81.
34. Lee HJ, et al. Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem. 2002;277(8):6318-23.
35. Lange A, et al. Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem. 2007; 282(8):5101-5.
36. Chen YQ, et al. Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines. Exp Cell Res. 2000;261(1):229-38.