The Impact of Bevacizumab (Avastin) on Survival in Metastatic Solid Tumors - A Meta-Analysis and Systematic Review

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Amit, Limor ^a,b   Ben Aharon, Irit ^a,b   Vidal, Liat ^a,b   Leibovici, Leonard ^b,c   Stemmer, Salomon ^a,b  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c Medicine E Rabin Medical Center Beilinson Campus   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CISPLATIN; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; INFLIXIMAB; IRINOTECAN; OXALIPLATIN; PACLITAXEL; PREDNISONE;

ARTICLE; BLEEDING; BREAST CANCER; CANCER SURVIVAL; COLON CANCER; COMBINATION CHEMOTHERAPY; DIGESTIVE SYSTEM PERFORATION; DRUG EFFECT; DRUG EFFICACY; DRUG FATALITY; DRUG RESPONSE; HUMAN; HYPERTENSION; ISCHEMIA; KIDNEY CARCINOMA; LUNG HEMORRHAGE; LUNG NON SMALL CELL CANCER; MELANOMA; META ANALYSIS; METASTASIS; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PANCREAS CANCER; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL (TOPIC); SOLID TUMOR; STOMACH CANCER; SYSTEMATIC REVIEW; VENOUS THROMBOEMBOLISM;

ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; SURVIVAL ANALYSIS;

EID: 84872777792     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051780     Document Type: Article

References (59)

1. Eskens FA, Sleijfer S, (2008) the use of Bevacizumab in colorectal, lung, breast, renal and ovarian cancer. Where does it fit? European journal of cancer 33: 2350-2356.
2. Rosen LS, Ashurst HL, Chap L, (2010) targeting signal transduction pathways in metastatic breast cancer a comprehensive review. Oncologist 15: 216-235.
3. Weidner N, Folkman J, Pazza F, Bevilacqua P, Allred EN, et al. (1992) Tumor angiogenesis: a new significant and independent prognostic indicator in early stage breast carcinoma. J Natl Cancer Inst 84: 1875-1887.
4. Linderholm B, Grankvist K, Wilking N, Johansson M, Tavelin B, et al. (2000) Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment. J Clin Oncol 18: 1423-1431.
5. Kerbel RS, (2008) Tumor angiogenesis. N Engl J Med 358: 2039-49.
6. Brufsky A, (2010) Angiogenesis inhibition and metastatic breast cancer: cases and answers. Presentation.
7. Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, et al. (2004) Bevacizumab plus Irinotecan, Flouorouracil and Leucovorin for metastatic colorectal cancer. NEJM 350: 2335-2342.
8. Saltz LB, Clarke S, Diaz-Rubio S, Scheithauer W, Figer A, et al. (2008) Bevacizumab in combination with oxaliplatin based chemotherapy as first line therapy in metastatic colorectal cancer: a randomized phase III study. JCO 26 (12):: 2013-2019.
9. Kabbinavar F, Hurwitz H, Fehrenbacher L, Meropol NJ, Novotny WF, et al. (2003) Phase II randomized trial comparing Bevacizumab plus Fluorouracil(FU)/Leucovorin(LV) with FU/LV alone in patients with metastatic colorectal cancer. JCO 21 (1):: 60-65.
10. Kabbinavar FF, Schulz J, McCleod M, Patel T, Hamm JT, et al. (2005) addition of Bevacizumab to bolus Fluorouracil and Leucovorin in first line metastatic colorectal cancer: results of randomized phase II trial. JCO 23 (16):: 3697-3705.
11. Kabbinavar FF, Hambleton J, Mass RD, Hurwitz HI, Berqsland E, et al. (2005) combined analysis of efficacy: the addition of Bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. JCO 23: 3706-3712.
12. Giantonio BJ, Catalano PJ, Meropol NJ, O'Dwyer PJ, Mitchell EP, et al. (2007) Bevacizumab in combination with FOLFOX4 for previously treated metastatic colorectal cancer: results from ECOG E3200. JCO 25 (12):: 1539-1544.
13. Tebbutt NC, Wilson K, Gebski BJ, Cummins MM, Zannino D, et al. (2010) Capecitabine, Bevacizumab and Mitomycin in first line treatment of metastatic colorectal cancer: results of the Australian gastrointestinal trials group randomized phase III MAX study. JCO 28 (19):: 3191-3198.
14. Wagner AD, Arnold D, Grothey AA, Haerting J, Unverzaqt S, et al. (2009) anti-angiogenic therapies for metastatic colorectal cancer (review). The Cochrane database (3).
15. Gridelli C, Maione P, Rossi A, De Marinis F, (2007) The role of Bevacizumab in the treatment of NSCLC: current indications and future developments. The oncologist 12: 1183-1193.
16. Reck M, Von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, et al. (2009) Phase III trial of Cisplatin plus Gemcitabine with either placebo or bevacizumab as first line therapy for non-squamous NSCLC: AVAiL. JCO 27 (8):: 1227-1234.
17. Reck M, Von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, et al. (2010) overall survival with cisplatin-gemcitabina and Bevacizumab or placebo as first line therapy for non squamous NSCLC: results from a randomized phase III trial (AVAiL). Ann of oncology 21: 1804-1809.
18. Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, et al. (2006) Paclitaxel-Carboplatin alone or with Bevacizumab for NSCLC. NEJM 355: 2542-2550.
19. Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, et al. (2004) Randomized phase II trial comparing Bevacizumab plus Carboplatin and Paclitaxel with Carboplatin and Paclitaxel alone in previously untreated locally advanced or metastatic NSCLC. JCO 22 (11):: 2184-2191.
20. Herbst RS, O'Neill VJ, Fehrenbacher L, Belani CP, Bonomi PD, et al. (2007) phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or Erlotinib compared with chemotherapy alone for treatment of recurrent or refractory NSCLC. JCO 25 (30):: 4743-4750.
21. Scagliotti GV, Parikh P, Von Pawel J, Biesma B, Vansteenkiste J, et al. (2008) phase III study comparing Cisplatin plus Gemcitabine with Cisplatin plus Pemetrexed in chemotherapy-naïve patients with advanced NSCLC. JCO 26 (21):: 3543-3551.
22. Miller KD, Chap LI, Holmes FA, Cobleigh MA, Marcom PK, et al. (2005) Randomized phase III trial of Capecitabine compared with Bevacizumab plus Capecitabine in patient with previously treated metastatic breast cancer. JCO 23: 792-799.
23. Miller K, Wang M, Gralow J, Dickler M, Cobleigh M, et al. (2007) Paclitaxel with Bevacizumab versus Paclitaxel alone in metastatic breast cancer. NEJM 357: 2666-2676.
24. Gray R, Bhattacharya S, Boden C, Miller K, Comis RL, et al. (2009) Independent review of E2100: a phase III trial of Bevacizumab plus Paclitaxel versus Paclitaxel in women with metastatic breast cancer. JCO 27: 4966-4972.
25. Robert NJ, Dieras V, Glaspy J, Brufsky A, Bondarenko I, et al. (2009) RIBBON-1: randomized, double blind, placebo controlled phase III trial of chemotherapy with or without Bevacizumab for first line treatment of HER2 negative locally recurrent or metastatic breast cancer. ASCO presentation. JCO 27: 15sabst 1005.
26. Robert A, (2009) clinical benefit and time to response in RIBBON-1 a randomized, double blind, phase III trial of chemotherapy with or without Bevacizumab for first line treatment of HER2 negative locally recuurent or metastatic breast cancer. SABCS 2009.
27. Robert NJ, Dieras V, Glaspy J, Brufsky A, Bondarenko I, et al. (2011) RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative, Locally Recurrent or Metastatic Breast Cancer. JCO 29 (10):: 1252-1260.
28. Miles DW, Chan A, Dirix LY, Cortes J, Pivot X, et al. (2010) Phase III study of Bevacizumab plus Docetaxel campared with placebo plus docetaxel for the first line treatment of human epidermal growth factor receptor-2-negative metastatic breast cancer. JCO 28 (20):: 3239-3247.
29. Brufsky A, (2009) RIBBON-2: a randomized, double blind, placebo controlled phase III evaluating the efficacy and safety of Bevacizumab in combination with chemotherapy for second line treatment of HER2 negative metastatic breast cancer. SABCS.
30. Brufsky A, Rivera RR, Hurvitz AA, Bonderenko IN, Smirnov V, et al. (2010) progression free survival in patient subgroups in RIBBON-2, a phase III trial of chemotherapy plus or minus Bevacizumab for second line treatment of HER2 negative locally recurrent or metastatic breast cancer. ASCO presentation. JCO 28: 15s: abstr 1021.
31. Brufsky AM, Hurvitz SA, Perez EA, Yamamoto A, Valero V, et al. (2012) final overall survival (OS) and safety analyses of RIBBO-2 a randomized phase III trial of Bevacizumab versus placebo combined with second line chemotherapy in HER2 negative Bevacizumab naïve metastatic breats cancer. ASCO presentation. JCO 30 suppl 27: abstr 100.
32. O'Shaughnessy J, Miles D, Gray RJ, Perez EA, Diaras V, et al. (2010) A meta-analysis of overall survival data from three randomized trials of Bevacizumab and first line chemotherapy as treatment for patients with metastatic breast cancer. ASCO JCO 28:15s: abstr 1005.
33. Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, et al. (2003) A randomized trial of Bevacizumab an anti-vascular endothelial growth factor antibody for metastatic renal cancer. NEJM 349 (5):: 427-434.
34. Rini BL, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, et al. (2010) phase III trial of Bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma final results of CALGB 90206. JCO 28: 1-7.
35. Rini BL, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, et al. (2008) Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALBG 90206. JCO 26 (33):: 5422-5428.
36. Escudier B, Pluzanka A, Koralewski P, Ravaud A, Bracarda S, et al. (2007) Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomized double blind phase III trial. Lancet 370: 2103-2111.
37. Escudier B, Bellmunt J, Negrier S, Bajetta E, Melichar B, et al. (2010) phase III trial of Bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. JCO 28 (13):: 2144-2150.
38. Van Cutsem E, Vervenne WL, Bennouna J, Humblet Y, Gill S, et al. (2009) Phase III Trial of Bevacizumab in Combination With Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer. JCO 27 (13):: 2231-2237.
39. Kindler HL, Niedzwiecki D, Hollis D, Sutherland S, Schraq D, et al. (2010) Gemcitabine plus Bevacizumab Compared with Gemcitabine plus Placebo in Patients with Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303). JCO 28 (22):: 3617-3622.
40. Shah MA, Ramanathan RK, Ilson DH, Levnor A, D'Adamo D, et al. (2006) Multicenter Phase II Study of Irinotecan, Cisplatin, and Bevacizumab in Patients With Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma. JCO 24: 5201-5206.
41. Atsushi O, Shah MA, Van Cutsem E, Rha SY, Sawaki A, et al. (2011) Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study. JCO 29: 3968-3976.
42. Kelly WK, Halabi S, Carducci M, George D, Mahoney JF, et al. (2012) A randomized, double-blind, placebo-controlled phase III trial comparing docetaxel, prednisone, and placebo with docetaxel, prednisone, and bevacizumab in men with metastatic castration-resistant prostate cancer (mCRPC): Survival results of CALGB 90401. JCO 30 (13):: 1534-1540.
43. Kim KB, Sosman JA, Fruehauf JP, Linette GP, Markovic SN, et al. (2012) BEAM: a randomized phase II study evaluating the activity of Bevacizumab in combination with Carboplatinum plus Paclitaxel in patients with previously untreated advanced Melanoma. JCO 30 (1):: 34-41.
44. Scartozzi M, Galizia E, Chiorrini S, Giampierri R, Berardi R, et al. (2009) arterial HTN correlates with clinical outcome in colorectal patients treated with first line Bevacizumab. Annals of oncology 20 (2):: 227-230.
45. Bono P, Elfving H, Utriainen T, Osterlund P, Saarto T, et al. (2009) HTN and clinical benefit of Bevacizumab in the treatment of advanced renal cell carcinoma. Annals of oncology 20 (2):: 393-394.
46. Dahlberg SE, Sandler AB, Brahmer JR, Schiller JH, Johnson DH, et al. (2010) clinical course of advanced non small cell lung cancer in patients experiencing HTN during treatment with Bevacizumab in combination with carboplatin and paclitaxel in ECOG 4599. JCO 28 (6):: 949-954.
47. Schneider BP, Wang M, Radovich M, Sledge GW, Badve S, et al. (2008) association of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 genetic polymorphisms with outcome in a trial of paclitaxel compared with Paclitaxel plus Bevacizumab in advanced breast cancer: ECOG 2100. JCO 26 (28):: 4672-4678.
48. Chan A, Miles DW, Pivot X, (2010) Bevacizumab in combination with taxanes for the first line treatment of breast cancer annals of oncology. 21 (12):: 2305-2315.
49. Golfinopoulos V, Salanti G, Pavilidis N, Ioannidis JP, (2007) survival and disease progression benefits with treatment regimens for advanced colorectal cancer: a meta-analysis. The lancet oncol 8: 898-911.
50. Welch S, Spithoff K, Rumble RB, Maroun J, (2010) Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: a systematic review. Annal of oncology 21 (6):: 1152-1162.
51. Loupakis F, Bria E, Vaccaro V, Cuppone F, Millela M, et al. (2010) magnitude of benefit of the addition of Bevacizumab to first line chemotherapy for metastatic colorectal cancer: meta-analysis of randomized clinical trials. journal of experimental & clinical cancer research 29: 58.
52. Ocaña A, Amir E, Vera F, Eisenhauer EA, Tannock IF, et al. (2011) Addition of Bevacizumab to Chemotherapy for Treatment of Solid Tumors: Similar Results But Different Conclusions. JCO 29 (3):: 254-256.
53. Broglio KR, Berry DA, (2009) detecting an overall survival benefit that is derived from progression free survival. JNCI 101: 1642-1649.
54. Ranpura V, Hapani S, Wu S, (2011) Treatment-Related Mortality With Bevacizumab in Cancer Patients A Meta-analysis. JAMA 305 (5):: 487-494.
55. Hurwitz HI, Saltz LB, Van Cutsem E, Cassidy J, Weidenmann J, et al. (2011) Venous Thromboembolic Events With Chemotherapy Plus Bevacizumab: A Pooled Analysis of Patients in Randomized Phase II and III Studies. JCO 29 (13):: 1757-1764.
56. Vredenburgh JJ, Desjardins A, Herndon JE 2nd, Marcello J, Reardon DA, et al. (2007) Bevacizumab plus Irinotecan in recurrent glioblastoma multiforme. JCO 25: 4722-4729.
57. Bear HD, Tang G, Rastoqi P, Geyer CE Jr, Robidoux A, et al. (2012) Bevacizumab added to neoadjuvant chemotherapy forbreast cancer. NEJM 2012:366: 310-320.
58. Von Minckwitz G, Eidtmann H, Rezai M, Fasching PA, Tesch H, et al. (2012) Neoadjuvant chemotherapy and Bevacizumab for HER2 negative breast cancer. NEJM 366: 299-309.
59. Zhu J, Sharma DB, Gray SW, Chen AB, Weeks JC, et al. (2012) Carboplatin and Paclitaxel with vs without Bevacizumab in older patients with advanced non small cell lung cancer. JAMA 307 (15):: 1593-1601.