Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ROS production and caspase activation in rat chondrocytes in vitro

Journal of Orthopaedic Research

Volumn 31, Issue 3, 2013, Pages 364-369

  Jiang, Liping ^a   Li, Longjie ^a   Geng, Chengyan ^a   Gong, Dezheng ^a   Jiang, Lijie ^b   Ishikawa, Nobuyuki ^c   Kajima, Koji ^c   Zhong, Laifu ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY   (China)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

apoptosis; caspase 3; mitochondrial membrane potential; monosodium iodoacetate; reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CYTOCHROME C; IODOACETIC ACID; MONOSODIUM IODOACETIC ACID; PROCASPASE 3; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; FEMUR HEAD; FLOW CYTOMETRY; FLUORESCENCE SPECTROSCOPY; IN VITRO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CARTILAGE, ARTICULAR; CASPASE 3; CELL SURVIVAL; CHONDROCYTES; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMUR HEAD; IODOACETATES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OSTEOARTHRITIS; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84872766500     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22250     Document Type: Article

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