NDRG2 down-regulation and CD24 up-regulation promote tumor aggravation and poor survival in patients with gallbladder carcinoma

Medical Oncology

Volumn 29, Issue 3, 2012, Pages 1879-1885

  Song, Shi Peng ^a   Zhang, Sheng Bin ^a   Liu, Rui ^a   Yao, Li ^b   Hao, Yu Qin ^a   Liao, Ming Mei ^c   Zhang, Yang De ^c   Li, Zhe Hai ^a  

^a INNER MONGOLIA MEDICAL COLLEGE   (China)

^b CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

CD24; Immunohistochemistry; NDRG2; Primary gallbladder carcinoma; Prognosis

Indexed keywords

CD24 ANTIGEN; N MYC DOWNSTREAM REGULATED GENE 2 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER SIZE; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; FEMALE; GALLBLADDER CARCINOMA; GENDER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SURVIVAL RATE; SURVIVAL TIME; UPREGULATION;

ANTIGENS, CD24; CARCINOMA; DOWN-REGULATION; FEMALE; GALLBLADDER NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84872761542     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-011-0110-y     Document Type: Article

References (23)

1. Shimizu H, Kimura F, Yoshidome H, et al. Aggressive surgical approach for stage IV gallbladder carcinoma based on Japanese Society of Biliary Surgery classification. Jpn Hepatobiliary Pancreat Surg. 2007;14:358-65.
2. Varga M, Obrist P, Schneeberger S, et al. Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival. Clin Cancer Res. 2004;10:3131-6.
3. Misra S, Chaturvedi A, Misra NC, et al. Carcinoma of the gallbladder. Lancet Oncol. 2003;4:167-76.
4. Batmunkh E, Shimada M, Morine Y, et al. Expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) in patients with the gallbladder carcinoma. Int J Clin Oncol. 2010;15:59-64.
5. Deng Y, Yao L, Chau L, et al. N-Myc downstreamregulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Int J Cancer. 2003;106:342-7.
6. Kim YJ, Yoon SY, Kim JT, et al. NDRG2 expression decreases with tumor stages and regulates TCF/beta-catenin signaling in human colon carcinoma. Carcinogenesis. 2009;30:598-605.
7. Piepoli A, Cotugno R, Merla G, et al. Promoter methylation correlates with reduced NDRG2 expression in advanced colon tumour. BMC Med Genomics. 2009;2:11.
8. Kim A, Kim MJ, Yang Y, et al. Suppression of NF-kappaB activity by NDRG2 expression attenuates the invasive potential of highly malignant tumor cells. Carcinogenesis. 2009;30:927-36.
9. Riener MO, Vogetseder A, Pestalozzi BC, et al. Cell adhesion molecules P-cadherin and CD24 are markers for carcinoma and dysplasia in the biliary tract. Hum Pathol. 2010;41:1558-65.
10. Yin BB, Wu SJ, Zong HJ, et al. Preliminary screening and identification of stem cell-like sphere clones in a gallbladder cancer cell line GBC-SD. J Zhejiang Univ Sci B. 2011;12: 256-63.
11. Choi YL, Lee SH, Kwon GY, et al. Overexpression of CD24: association with invasiveness in urothelial carcinoma of the bladder. Arch Pathol Lab Med. 2007;131:275-81.
12. Senner V, Sturm A, Baur I, et al. CD24 promotes invasion of glioma cells in vivo. J Neuropathol Exp Neurol. 1999;58: 795-802.
13. Keeratichamroen S, Leelawat K, Thongtawee T, et al. Expression of CD24 in cholangiocarcinoma cells is associated with disease progression and reduced patient survival. Int J Oncol. 2011;39: 873-81.
14. Diaz-Gallo LM, Medrano LM, Gómez-García M, et al. Analysis of the influence of two CD24 genetic variants in Crohn's disease and ulcerative colitis. Hum Immunol. 2011;72:969-72.
15. Overdevest JB, Thomas S, Kristiansen G, et al. CD24 offers a therapeutic target for control of bladder cancer metastasis based on a requirement for lung colonization. Cancer Res. 2011;71: 3802-11.
16. Lim SC, Oh SH. The role of CD24 in various human epithelial neoplasias. Pathol Res Pract. 2005;201:479-86.
17. Liu B, Zhang Y, Liao M, et al. Clinicopathologic and prognostic significance of CD24 in gallbladder carcinoma. Pathol Oncol Res. 2011;17:45-50.
18. Zheng J, Liu Q, Li Y, et al. NDRG2 expression regulates CD24 and metastatic potential of breast cancer cells. Asian Pac J Cancer Prev. 2010;11:1817-21.
19. Zheng J, Li Y, Yang J, et al. NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression. BMC Cancer. 2011;251:1-9.
20. Hamilton SR, Alatonen LA. World Health Organization classification of tumours. Pathology and genetics of tumors of the digestive system. Lyon: IARC Press; 2004.
21. Greene FL, Page DL, Fleming ID. AJCC cancer staging manual. 6th ed. New York: Springer; 2002.
22. Ma J, Jin H, Wang H, et al. Expression of NDRG2 in clear cell renal cell carcinoma. Biol Pharm Bull. 2008;31:1316-20.
23. Zhao H, Zhang J, Lu J, et al. Reduced expression of N-Myc downstream-regulated gene 2 in human thyroid cancer. BMC Cancer. 2008;8:303.