Ferulic acid induces mammalian target of rapamycin inactivation in cultured mammalian cells

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 1, 2013, Pages 120-124

  Bian, Zehua ^a   Furuya, Norihiko ^a   Zheng, Dong Mei ^a   Trejo, Juan Alejandro Oliva ^a   Tada, Norihiro ^a   Ezaki, Junji ^a,b   Ueno, Takashi ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Autophagy; Ferulic acid; Mammalian target of rapamycin; Microtubule associated protein IA IB light chain 3; Ribosomal S6; S6 kinase

Indexed keywords

CARBON 14; FERULIC ACID; GREEN FLUORESCENT PROTEIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1A LIGHT CHAIN 3; MICROTUBULE ASSOCIATED PROTEIN 1B LIGHT CHAIN 3; PROTEIN S6; RAPAMYCIN; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGY; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME INACTIVATION; ENZYME INHIBITION; HELA CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; LIVER CELL; MAMMAL CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; CELLS, CULTURED; COUMARIC ACIDS; HELA CELLS; HEPATOCYTES; HUMANS; MICE; MICE, INBRED C57BL; RIBOSOMAL PROTEIN S6 KINASES; TOR SERINE-THREONINE KINASES;

EID: 84872741367     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00695     Document Type: Article

References (23)

1. Rechner AR, Spencer JP, Kuhnle G, Hahn U, Rice-Evans CA. Novel biomarkers of the metabolism of caffeic acid derivatives in vivo. Free Radic. Biol. Med., 30, 1213-1222 (2001).
2. Kanski J, Aksenova M, Stoyanova A, Butterfield DA. Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. J. Nutr. Biochem., 13, 273-281 (2002).
3. Khanduja KL, Avti PK, Kumar S, Mittal N, Sohi KK, Pathak CM. Anti-apoptotic activity of caffeic acid, ellagic acid and ferulic acid in normal human peripheral blood mononuclear cells: a Bcl-2 independent mechanism. Biochim. Biophys. Acta, 1760, 283-289 (2006).
4. Ma ZC, Hong Q, Wang YG, Tan HL, Xiao CR, Liang QD, Zhang BL, Gao Y. Ferulic acid protects human umbilical vein endothelial cells from radiation induced oxidative stress by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways. Biol. Pharm. Bull., 33, 29-34 (2010).
5. Yan JJ, Cho JY, Kim HS, Kim KL, Jung JS, Huh SO, Suh HW, Kim YH, Song DK. Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid. Br. J. Pharmacol., 133, 89-96 (2001).
6. Jin Y, Yan EZ, Fan Y, Zong ZH, Qi ZM, Li Z. Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus. Acta Pharmacol. Sin., 26, 943-951 (2005).
7. Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell, 147, 728-741 (2011).
8. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685 (1970).
9. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A., 76, 4350-4354 (1979).
10. Ueno T, Sato W, Horie Y, Komatsu M, Tanida I, Yoshida M, Ohshima S, Mak TW, Watanabe S, Kominami E. Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation. Autophagy, 4, 692-700 (2008).
11. Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC Jr, Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature, 371, 762-767 (1994).
12. Pullen N, Thomas G. The modular phosphorylation and activation of p70s6k. FEBS Lett., 410, 78-82 (1997).
13. Ganley IG, Lam H, Wang J, Ding X, Chen S, Jiang X. ULK1. ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J. Biol. Chem., 284, 12297-12305 (2009).
14. Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell, 20, 1992-2003 (2009).
15. Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell, 20, 1981-1991 (2009).
16. Scapagnini G, Butterfield DA, Colombrita C, Sultana R, Pascale A, Calabrese V. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid. Redox Signal., 6, 811-818 (2004).
17. Kimura S, Fujita N, Noda T, Yoshimori T. Monitoring autophagy in mammalian cultured cells through the dynamics of LC3. Methods Enzymol., 452, 1-12 (2009).
18. Kanski J, Aksenova M, Stoyanova A, Butterfield DA. Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. J. Nutr. Biochem., 13, 273-281 (2002).
19. Khanduja KL, Avti PK, Kumar S, Mittal N, Sohi KK, Pathak CM. Anti-apoptotic activity of caffeic acid, ellagic acid and ferulic acid in normal human peripheral blood mononuclear cells: a Bcl-2 independent mechanism. Biochim. Biophys. Acta, 1760, 283-289 (2006).
20. Ma ZC, Hong Q, Wang YG, Tan HL, Xiao CR, Liang QD, Cai SH, Gao Y. Ferulic acid attenuates adhesion molecule expression in gamma-radiated human umbilical vascular endothelial cells. Biol. Pharm. Bull., 33, 752-758 (2010).
21. Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R. Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ., 15, 1318-1329 (2008).
22. Shinojima N, Yokoyama T, Kondo Y, Kondo S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy, 3, 635-637 (2007).
23. Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, Huang C, Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy, 7, 966-978 (2011).