Therapeutic effects of valproate combined with lithium carbonate on mptp-induced parkinsonism in mice: Possible mediation through enhanced autophagy

International Journal of Neuroscience

Volumn 123, Issue 2, 2012, Pages 73-79

  Li, Xue Zhong ^a   Chen, Xiao Peng ^a   Zhao, Kun ^a   Bai, Long Mei ^a   Zhang, Hong ^a   Zhou, Xiao Ping ^a  

^a AFFILIATED PEOPLE S HOSPITAL OF JIANGSU UNIVERSITY   (China)

Author keywords

Autophagy; Lithium carbonate; Parkinson's disease; Valproate

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; BIOLOGICAL MARKER; LITHIUM CARBONATE; MICROTUBULE ASSOCIATED PROTEIN; NEUROTRANSMITTER; TYROSINE 3 MONOOXYGENASE; VALPROATE CALCIUM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PARKINSONISM; PROTEIN EXPRESSION; SUBSTANTIA NIGRA; WESTERN BLOTTING;

EID: 84872740046     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2012.729234     Document Type: Article

References (24)

1. Lauterbach EC, Fontenelle LF, Teixeira AL. The neuroprotective disease-Modifying potential of psychotropics in Parkinson's disease. Parkinsons Dis. 2012. doi: 10.1155/2012/753548.
2. Castro AA, Ghisoni K, Latini A, Quevedo J, Tasca CI, Prediger RD. Lithium and valproate prevent olfactory discrimination and short-Term memory impairments in the intranasal 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) rat model of Parkinson's disease. Behav Brain Res. 2012;229: 208-15.
3. Hicks CW, Pandya MM, Itin I, Fernandez HH. Valproate for the treatment of medication-induced impulse-Control disorders in three patients with Parkinson's disease. Parkinsonism Relat Disord. 2011;17:379-81.
4. Kidd SK, Schneider JS. Protection of dopaminergic cells from MPP+-Mediated toxicity by histone deacetylase inhibition. Brain Res. 2010;1354:172-8.
5. Pizzasegola C, Caron I, Daleno C, Ronchi A, Minoia C, Carr̀i MT, Bendotti C. Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice. Amyotroph Lateral Scler. 2009;10:221-8.
6. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004;304:1500-2. (Pubitemid 38720930)
7. Xilouri M, Stefanis L. Autophagic pathways in Parkinson disease and related disorders. Expert Rev Mol Med. 2011;13:e8. doi: Http://dx.doi.org/10. 1017/S1462399411001803
8. Martin AP, Park MA, Mitchell C, Walker T, Rahmani M, Thorburn A, Häussinger D, Reinehr R, Grant S, Dent P. BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. Mol Pharmacol. 2009;76:327-41.
9. Scheibye-Knudsen M, RamamoorthyM, Sykora P,Maynard S, Lin PC, Minor RK, Wilson DM 3rd, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA. Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med. 2012;209:855-69.
10. Choi CH, Lee BH, Ahn SG, Oh SH. Proteasome inhibitioninduced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β. Biochem Biophys Res Commun. 2012;418:759-64.
11. Wan G, Zhaorigetu S, Liu Z, Kaini R, Jiang Z, Hu CA. Apolipoprotein L1, a Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death. J Biol Chem. 2008;283(31):21540-9.
12. Fleming SM, Salcedo J, Hutson CB, Rockenstein E,Masliah E, Levine MS, Chesselet MF. Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype α-Synuclein. Neuroscience. 2006;142(4):1245-53. (Pubitemid 44636058)
13. Chen YP, Qian JJ, Liu CF, Chen YX, Li HD. Behavioral study of influence of aging and MPTP neurotoxin on motor function of C57BL mouse. Laboratory Animal and Comparative Medicine. 2007;2:86-9.
14. Monti B,Gatta V, Piretti F, Raffaelli SS, Virgili M, Contestabile A. Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: Involvement of alpha-Synuclein. Neurotox Res. 2010;17:130-41.
15. Chen PS, Peng GS, Li G, Yang S, Wu X, Wang CC, Wilson B, Lu RB, Gean PW, Chuang DM, Hong JS. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry. 2006;11:1116-25. (Pubitemid 44867481)
16. Peng GS, Li G, Tzeng NS, Chen PS, Chuang DM, Hsu YD, Yang S, Hong JS. Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: Role of microglia. Brain Res Mol Brain Res. 2005;134:162-9. (Pubitemid 40403648)
17. Moore DJ, West AB, Dawson VL, Dawson TM. Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci. 2005;28:57-87. (Pubitemid 41098899)
18. Song DD, Shults CW, Sisk A, Rockenstein E, Masliah E. Enhanced substantia nigra mitochondrial pathology in humann [alpha]-Synuclein transgenic mice after treatment with MPTP. Exp Neurol. 2004;186:158-72. (Pubitemid 38333191)
19. Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J, Mouatt-Prigent A, Ruberg M, Hirsch EC, Agid Y. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol. 1997;12:25-31. (Pubitemid 27106916)
20. Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem. 2003;278:25009-13. (Pubitemid 37548663)
21. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science. 2000;290:1717-21. (Pubitemid 32004796)
22. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Oxidative damage linked to neurodegeneration by selective alpha-Synuclein nitration in synucleinopathy lesions. Science. 2000;290:985-9.
23. Mizushima N, Sugita H, Yoshimori T, Ohsumi Y A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem. 1998;273:33889-92. (Pubitemid 29008848)
24. Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. J Biol Chem. 2000;275:19831-8. C (Pubitemid 30441585)