Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: A novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazoles

Drug Metabolism and Disposition

Volumn 41, Issue 2, 2013, Pages 508-517

  Yue, Qin ^a   Mulder, Teresa ^a   Rudewicz, Patrick J ^a   Solon, Eric ^c   Budha, Nageshwar ^b   Ware, Joseph A ^b   Lyssikatos, Joseph ^a   Hop, Cornelis E C A ^a   Wong, Harvey ^a   Khojasteh, S Cyrus ^a  

^a GENENTECH INC   (United States)

^b MEDIMMUNE   (United States)

^c QPS LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 CYCLOHEXYL 2 [2 (METHYLAMINO)PROPANAMIDO]ACETYL] N (4 PHENYL 1,2,3 THIADIAZOL 5 YL)PYRROLIDINE 2 CARBOXAMIDE; 1 AMINOBENZOTRIAZOLE; 4 PHENYL 5 AMINO 1,2,3 THIADIAZOLE; CARBON 14; DRUG METABOLITE; GDC 0152; HIPPURIC ACID; PEPTIDOMIMETIC AGENT; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG FECES LEVEL; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG OXIDATION; DRUG SULFATION; DRUG TRANSFORMATION; DRUG URINE LEVEL; EXPIRED AIR; FEMALE; ISOTOPE LABELING; LIVER CELL; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TISSUE DISTRIBUTION;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; AUTORADIOGRAPHY; BILE; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CYCLOHEXANES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FECES; FEMALE; HALF-LIFE; HEPATOCYTES; HIPPURATES; HYDROLYSIS; INJECTIONS, INTRAVENOUS; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; METABOLIC CLEARANCE RATE; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PYRROLES; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; TRIAZOLES;

RATTUS;

EID: 84872711833     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.047019     Document Type: Article

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