Hepatic copper concentrations in labrador retrievers with and without chronic hepatitis: 72 cases (1980-2010)

Journal of the American Veterinary Medical Association

Volumn 242, Issue 3, 2013, Pages 372-380

  Johnston, Andrea N ^a   Center, Sharon A ^a   Mcdonough, Sean P ^a   Wakshlag, Joseph J ^a   Warner, Karen L ^a  

^a Animal Health Diagnostic Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84872704331     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.242.3.372     Document Type: Article

References (50)

1. Thornburg L P. A perspective on copper and liver disease in the dog. J Vet Diagn Invest 2000;12:101-110.
2. Thornburg L P. Histomorphological and immunohistochemical studies of chronic active hepatitis in Doberman Pinschers. Vet Pathol 1998;35:380-385.
3. Thornburg L P, Rottinghaus G, Dennis G, et al. The relationship between hepatic copper content and morphologic changes in the liver of West Highland White Terriers. Vet Pathol 1996;33:656-661.
4. Crawford MA, Schall WD, Jensen RK, et al. Chronic active hepatitis in 26 Doberman Pinschers. J Am Vet Med Assoc 1985;187:1343-1350.
5. Haywood S, Rutgers HC, Christian MK. Hepatitis and copper accumulation in Skye Terriers. Vet Pathol 1988;25:408-414.
6. Hoffmann G, van den Ingh TS, Bode P, et al. Copper-associated chronic hepatitis in Labrador Retrievers. J Ve t Intern Med 2006;20:856-861.
7. Smedley R, Mullaney T, Rumbeiha W. Copper-associated hepatitis in Labrador Retrievers. Vet Pathol 2009;46:484-490.
8. van de Sluis BJA, Breen M, Nanji M, et al. Genetic mapping of the copper toxicosis locus in Bedlington Terriers to dog chromosome 10, in a region syntenic to human chromosome region 2p13-p16. Hum Mol Genet 1999;8:501-507.
9. Shih JL, Keating JH, Freeman LM, et al. Chronic hepatitis in Labrador Retrievers: clinical presentation and prognostic factors. J Vet Intern Med 2007;21:33-39.
10. Coronado VA, Damaraju D, Kohijoki R, et al. New haplotypes in the Bedlington Terrier indicate complexity in copper toxicosis. Mamm Genome 2003;14:483-491.
11. Sarkar B, Roberts EA. The puzzle posed by COMMD1, a newly discovered protein binding Cu(II). Metallomics 2011;3:20-27.
12. Boal AK, Rosenzweig AC. Structural biology of copper trafficking. Chem Rev 2009;109:4760-4779.
13. Flinn FB, Vonglahn WC. A chemical and pathologic study of the effects of copper on the liver. J Exp Med 1929;49:5-20.
14. Twedt DC, Sternlieb I, Gilbertson SR. Clinical, morphologic, and chemical studies on copper toxicosis of Bedlington Terriers. J Am Vet Med Assoc 1979;175:269-275.
15. Su LC, Ravanshad S, Owen CA Jr, et al. A comparison of copperloading disease in Bedlington Terriers and Wilson's disease in humans. Am J Physiol 1982;243:G226-G230.
16. Thornburg L P, Crawford SJ. Liver disease in West Highland White Terriers (lett). Vet Rec 1986;118:110.
17. Beck A. The copper content of the liver and blood of some vertebrates. Aust J Zool 1956;4:1-18.
18. Czarnecki-Maulden G, Rudnick R, Chausow D. Copper bioavailability and requirement in the dog: comparison of copper oxide and copper sulfate. FASEB J 1993;7:A305.
19. Association of American Feed Control Officials. Official publication. Oxford, Ind: Association of Feed Control Officials, 1997.
20. Cole TL, Center SA, Flood SN, et al. Diagnostic comparison of needle and wedge biopsy specimens of the liver in dogs and cats. J Am Vet Med Assoc 2002;220:1483-1490.
21. Crawford AR, Lin X-Z, Crawford JM. The normal adult human liver biopsy: a quantitative reference standard. Hepatology 1998;28:323-331.
22. Collorado G, Guido M, Sonzogni A, et al. Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease. J Hepatol 2003;39:239-244.
23. Cholongitas E, Senzolo M, Standish R, et al. A systematic review of the quality of liver biopsy specimens. Am J Clin Pathol 2006;125:710-721.
24. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-699.
25. Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1:431-435.
26. Johnston AN, Centr SA, McDonough S P, et al. Influence of biopsy specimen size, tissue fixation, and assay variation on copper, iron, and zinc concentrations in canine livers. Am J Vet Res 2009;70:1502-1511.
27. Linder MC. Introduction and overview of copper as an element. In: Linder MC, ed. Biochemistry of copper. New York: Plenum Press, 1991;1-15.
28. Vonk WI, Wijmenga C, van de Sluis B. Relevance of animal models for understanding mammalian copper homeostasis. Am J Clin Nutr 2008;88:840S-845S.
29. Montaser A, Tetreault C, Linder M. Comparison of copper binding components in dog serum with those in other species. Proc Soc Exp Biol Med 1992;200:321-329.
30. Henry RB, Liu J, Choudhuri S, et al. Species variation in hepatic metallothionein. Toxicol Lett 1994;74:23-33.
31. Milne DB. Copper intake and assessment of copper status. Am J Clin Nutr 1998;67(suppl 5):1041S-1045S.
32. Scheinberg IH, Sternlieb I. Wilson's disease. Annu Rev Med 1965;16:119-134.
33. Portman BC, Thompson RJ, Roberts EA, et al. Disorder of copper metabolism. In: MacSween RNM, Burt AD, Portmann B, et al, eds. MacSween's pathology of the liver. 5th ed. London: Elsevier Churchill Livingstone, 2006;249-256.
34. Miyamura H, Nakanuma Y, Kono N. Survey of copper granules in liver biopsy specimens from various liver abnormalities other than Wilson's disease and biliary diseases. Gastroenterol Jpn 1988;23:633-638.
35. Goldfischer S, Popper H, Sternlieb I. The significance of variations in the distribution of copper in liver disease. Am J Pathol 1980;99:715-730.
36. Azumi N. Copper and liver injury-experimental studies on the dogs with biliary obstruction and copper loading. Hokkaido Igaku Zasshi 1982;57:331-349.
37. Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321.
38. Faa G, Nurchi V, Demelia L, et al. Uneven hepatic copper distribution in Wilson's disease. J Hepatol 1995;22:303-308.
39. Fuentealba IC, Aburto EM. Animal models of copper-associated liver disease. Comp Hepatol 2003;2:5.
40. Ammerman CB, Miller SM. Biological availability of minor mineral ions: a review. J Anim Sci 1972;35:681-694.
41. Baker DH. Cupric oxide should not be used as a copper supplement for either animals or humans. J Nutr 1999;129:2278-2279.
42. Kastenmayer P, Czarnecki-Maulden GL, King W. Mineral and trace element absorption from dry dog food by dogs, determined using stable isotopes. J Nutr 2002;132(suppl 2):1670S-1672S.
43. Cromwell GL, Stahly TS, Monegue HJ. Effects of source and level of copper on performance and liver copper stores in weanling pigs. J Anim Sci 1989;67:2996-3002.
44. Clark T W, Xin Z, Hemken RW, et al. A comparison of copper sulfate and copper oxide as copper sources for the mature ruminant. J Dairy Sci 1993;76(suppl 1):318.
45. Ledoux DR, Miles RD, Ammerman CB, et al. Interaction of dietary nutrient concentration and supplemental copper on chick performance and tissue copper concentrations. Poult Sci 1987;66:1379-1384.
46. Fascetti AJ, Rogers QR, Morris JG. Dietary copper influences reproduction in cats. J Nutr 2000;130:1287-1290.
47. National Research Council. Minerals. In: Beitz DC, ed. Nutrient requirements of dogs and cats. Washington, DC: National Academies Press, 2006;145-192.
48. Stowe HD, Lawler D F, Kealy RD. Antioxidant status of pair-fed Labrador Retrievers is affected by diet restriction and aging. J Nutr 2006;136:1844-1848.
49. Association of American Feed Control Officials. Official publication. West Lafayette, Ind: Association of American Feed Control Officials, 2001.
50. World Health Organization. Copper. In: Trace elements in human nutrition and health. Geneva: World Health Organization, 1996;123-143.