RNA interference-mediated silencing of VEGF and bFGF suppresses endostatin secretion in pancreatic carcinoma cells

Oncology Letters

Volumn 5, Issue 3, 2013, Pages 1031-1035

  Yan, Changqing ^a   Wang, Chuan ^a   Dong, Mei ^b   Liu, Sanguang ^a   Qi, Cheng ^a   Zhao, Yupei ^c  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

BFGF; Endostatin; Pancreatic carcinoma; SiRNA; VEGF

Indexed keywords

ENDOSTATIN; FIBROBLAST GROWTH FACTOR 2; MESSENGER RNA; SMALL INTERFERING RNA; VASCULOTROPIN;

ARTICLE; CANCER GROWTH; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PANCREAS CARCINOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

EID: 84872689451     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1102     Document Type: Article

References (20)

1. Yan CQ, Zhao YP, Dai MH, et al: The relationship between the changes of proangiogenic factors serum concentrations and progression of pancreatic carcinoma patients. Zhonghua Wai Ke Za Zhi 45: 496-498, 2007 (In Chinese).
2. Dai MH, Yan CQ, Zhao YP and Song YM: Relationship between changes of serum concentrations of antiangiogenic factors and disease progression in patients of pancreatic carcinoma. Zhonghua Wai Ke Za Zhi 45: 1199-1201, 2007 (In Chinese).
3. Yan CQ and Zhao YP: Expression of angiogenic factors in pancreatic carcinoma cell and their significance. Zhonghua Wai Ke Za Zhi 47: 787-790, 2009 (In Chinese).
4. Yan CQ and Zhao YP: The significance of VEGF siRNA and bFGF siRNA in invasion and proliferation of pancreatic carcinoma cell. Zhonghua Wai Ke Za Zhi 48: 610-614, 2010 (In Chinese).
5. Sakurai T and Kudo M: Signaling pathways governing tumor angiogenesis. Oncology 81 (Suppl 1): 24-29, 2011.
6. Ohlund D, Ardnor B, Oman M, et al: Expression pattern and circulating levels of endostatin in patients with pancreas cancer. Int J Cancer 122: 2805-2810, 2008.
7. Wigmore SJ: Endostatin in the pancreas. Br J Cancer 92: 5-6, 2005.
8. Rahbari NN, Schmidt T, Falk CS, et al: Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer. BMC Cancer 11: 286, 2011.
9. Jain RK: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307: 58-62, 2005.
10. Eichholz A, Merchant S and Gaya AM: Anti-angiogenesis therapies: their potential in cancer management. Onco Targets Ther 3: 69-82, 2010.
11. Korc M: Pathways for aberrant angiogenesis in pancreatic cancer. Mol Cancer 2: 8, 2003.
12. Benckert C, Thelen A, Cramer T, et al: Impact of microvessel density on lymph node metastasis and survival after curative resection of pancreatic cancer. Surg Today 42: 169-176, 2012.
13. Brammer RD, Bramhall SR and Eggo MC: Endostatin expression in a pancreatic cell line is modulated by a TNFalpha-dependent elastase. Br J Cancer 93: 1024-1028, 2005.
14. Heljasvaara R, Nyberg P, Luostarinen J, et al: Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases. Exp Cell Res 307: 292-304, 2005.
15. Nilsson UW, Garvin S and Dabrosin C: MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells. Breast Cancer Res Treat 102: 253-261, 2007.
16. Zhong J, Gencay MM, Bubendorf L, et al: ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells. J Cell Physiol 207: 540-552, 2006.
17. Xie L, Duncan MB, Pahler J, et al: Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci USA 108: 9939-9944, 2011.
18. Albrecht I, Kopfstein L, Strittmatter K, et al: Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS One 5: e14109, 2010.
19. Pereira ER, Liao N, Neale GA and Hendershot LM: Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response. PLoS One 5: e12521, 2010.
20. Schuch G, Kisker O, Atala A and Soker S: Pancreatic tumor growth is regulated by the balance between positive and negative modulators of angiogenesis. Angiogenesis 5: 181-190, 2002.