Protective effect of paeonia anomala extracts and constituents against tert-butylhydroperoxide-induced oxidative stress in HepG2 cells

Planta Medica

Volumn 79, Issue 2, 2013, Pages 116-122

  Oidovsambuu, Sarangerel ^a,b   Kim, Chulyoung ^c   Kang, Kyungsu ^a   Dulamjav, Batsuren ^d   Jigjidsuren, Tunsag ^d   Nho, Chuwon ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Hanyang University   (South Korea)

^d Institute of Chemistry and Chemical Technology   (Mongolia)

Author keywords

antioxidants; fruits; Paeonia anomala L.; Paeoniaceae; tert butylhydroperoxide

Indexed keywords

2 HYDROXYL 6 METHOXY 4 O ( 6' O ALPHA LEVO ARABINOFURANOSYL BETA DEXTRO GLUCOPYRANOSYL)ACETOPHENONE; 3,3' DI O METHYL 4 O ( 3'' O GALLOYL BETA DEXTRO GLUCOPYRANOSYL)ELLAGIC ACID; ACETOPHENONE DERIVATIVE; DNA; ELLAGIC ACID; FISCHEROSIDE B; GALLIC ACID DERIVATIVE; GALLIC ACID ETHYL ESTER; GALLIC ACID METHYL ESTER; GLUTATHIONE; PAEONIA ANOMALA EXTRACT; PLANT EXTRACT; PLANT GLYCOSIDE; PLANT MEDICINAL PRODUCT; QUERCETIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; SCAVENGER; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL STRAIN HEPG2; CELL VIABILITY; CHEMICAL COMPOSITION; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG SYNTHESIS; FRUIT; GENOTOXICITY; HUMAN; HUMAN CELL; MEDICINAL PLANT; OXIDATIVE STRESS; PAEONIA; PAEONIA ANOMALA; PLANT ROOT; SCAVENGING SYSTEM;

ANTIOXIDANTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; FRUIT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEP G2 CELLS; HUMANS; LIPID PEROXIDATION; LIVER NEOPLASMS; MALONDIALDEHYDE; OXIDATIVE STRESS; PAEONIA; PLANT EXTRACTS; PLANT ROOTS; QUERCETIN; REACTIVE OXYGEN SPECIES; TERT-BUTYLHYDROPEROXIDE;

PAEONIA ANOMALA; PAEONIACEAE;

EID: 84872685610     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328062     Document Type: Article

References (24)

1. Ligaa U., Davaasuren B., Ninjil N. Medicinal plants of Mongolia used in Western and Eastern medicine. Moscow Rosselhozakademii: 2009; 208
2. Li Xian L. SH, Pu J. X., Huang S. X., Sun H. D. Chemical constituents from Paeonia anomala subsp. veitchii (Paeoniaceae). Acta Bot Yunn: 2007; 29 259 262
3. Zapesochnaya G. G., Kurkin V. A., Avdeeva E. V., Popov D. M., Kolpakova M. V. A chemical study of the roots of Paeonia anomala. Khimiya Prirodnykh Soedinenii: 1992; 1 55 59
4. Volodya T., Tserenbaljir D., Lkhamjav T. Mongolian medicinal plants. Ulaanbaatar Admon: 2008; 334 336
5. Kohen R., Nyska A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol: 2002; 30 620 650 (Pubitemid 36018731)
6. Valko M., Leibfritz D., Moncol J., Cronin M. T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol: 2007; 39 44 84 (Pubitemid 44566469)
7. Alia M., Ramos S., Mateos R., Granado-Serrano A. B., Bravo L., Goya L. Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert -butyl hydroperoxide. Toxicol Appl Pharmacol: 2006; 212 110 118
8. Taffe B. G., Takahashi N., Kensler T. W., Mason R. P. Generation of free radicals from organic hydroperoxide tumor promoters in isolated mouse keratinocytes. Formation of alkyl and alkoxyl radicals from tert -butyl hydroperoxide and cumene hydroperoxide. J Biol Chem: 1987; 262 12143 12149
9. Alia M., Ramos S., Mateos R., Bravo L., Goya L. Response of the antioxidant defense system to tert -butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2). J Biochem Mol Toxicol: 2005; 19 119 128 (Pubitemid 40571692)
10. Pan M. H., Ho C. T. Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev: 2008; 37 2558 2574
11. Duan W. J., Yang J. Y., Chen L. X., Zhang L. J., Jiang Z. H., Cai X. D., Zhang X., Qiu F. Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. J Nat Prod: 2009; 72 1579 1584
12. Kang K., Jho E. H., Lee H. J., Oidovsambuu S., Yun J. H., Kim C. Y., Yoo J. H., Kim Y. J., Kim J. H., Ahn S. Y., Nho C. W. Youngia denticulata protects against oxidative damage induced by tert -butylhydroperoxide in HepG2 cells. J Med Food: 2011; 14 1198 1207
13. Pfundstein B., El Desouky S. K., Hull W. E., Haubner R., Erben G., Owen R. W. Polyphenolic compounds in the fruits of Egyptian medicinal plants (Terminalia bellerica, Terminalia chebula and Terminalia horrida): characterization, quantitation and determination of antioxidant capacities. Phytochemistry: 2010; 71 1132 1148
14. Washida K., Yamagaki T., Iwashita T., Nomoto K. Two new galloylated monoterpene glycosides, 4- O -galloylalbiflorin and 4- O -galloylpaeoniflorin, from the roots of Paeonia lactiflora (Paeoniae radix) grown and processed in Nara prefecture, Japan. Chem Pharm Bull (Tokyo): 2009; 57 1150 1152
15. Kurashima K., Fujii M., Ida Y., Akita H. Enzymatic β -glycosidation of primary alcohols. J Mol Catal B Enzym: 2003; 26 87 98
16. Lopez G., Nugier-Chauvin C., Remond C., ODonohue M. Investigation of the specificity of an α -L-arabinofuranosidase using C-2 and C-5 modified α -L-arabinofuranosides. Carbohydr Res: 2007; 342 2202 2211 (Pubitemid 47313398)
17. He C. N., Peng Y., Zhang Y. C., Xu L. J., Gu J., Xiao P. G. Phytochemical and biological studies of Paeoniaceae. Chem Biodivers: 2010; 7 805 838
18. Shon Y. H., Nam K. S. Protective effect of moutan cortex extract on acetaminophen-induced hepatotoxicity in mice. J Ethnopharmacol: 2004; 90 415 419
19. Su J., Zhang P., Zhang J. J., Qi X. M., Wu Y. G., Shen J. J. Effects of total glucosides of paeony on oxidative stress in the kidney from diabetic rats. Phytomedicine: 2010; 17 254 260
20. Wang H., Wei W., Wang N. P., Wu C. Y., Yan S. X., Yue L., Zhang L. L., Xu S. Y. Effects of total glucosides of peony on immunological hepatic fibrosis in rats. World J Gastroenterol: 2005; 11 2124 2129 (Pubitemid 40542656)
21. Wu Y. G., Ren K. J., Liang C., Yuan L. M., Qi X. M., Dong J., Shen J. J., Lin S. Y. Renoprotective effect of total glucosides of paeony (TGP) and its mechanism in experimental diabetes. J Pharmacol Sci: 2009; 109 78 87
22. Hayes J. D., Mclellan L. I. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res: 1999; 31 273 300 (Pubitemid 29452854)
23. Ramos A. A., Lima C. F., Pereira M. L., Fernandes-Ferreira M., Pereira-Wilson C. Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay. Toxicol Lett: 2008; 177 66 73
24. Fairbairn D. W., Olive P. L., Oneill K. L. The comet assay - a comprehensive review. Mutat Res: 1995; 339 37 59