메뉴 건너뛰기




Volumn 34, Issue 10, 2013, Pages 2547-2564

The targeted co-delivery of DNA and doxorubicin to tumor cells via multifunctional PEI-PEG based nanoparticles

Author keywords

Co delivery; DNA; Double targeting; Doxorubicin; Multifunctional nanoscaled delivery system; Polyion complex micelle

Indexed keywords

CO-DELIVERY; DELIVERY SYSTEMS; DOUBLE TARGETING; DOXORUBICIN; POLYION COMPLEX MICELLES;

EID: 84872681375     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.12.038     Document Type: Article
Times cited : (165)

References (56)
  • 1
    • 84875052761 scopus 로고    scopus 로고
    • Emerging biotechnological strategies for non-viral antiangiogenic gene therapy
    • Liu C., Zhang N. Emerging biotechnological strategies for non-viral antiangiogenic gene therapy. Angiogenesis 2012, 15:521-542.
    • (2012) Angiogenesis , vol.15 , pp. 521-542
    • Liu, C.1    Zhang, N.2
  • 2
    • 33750552967 scopus 로고    scopus 로고
    • Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy
    • Pastorino F., Brignole C., Di Paolo D., Nico B., Pezzolo A., Marimpietri D., et al. Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy. Cancer Res 2006, 66:10073-10082.
    • (2006) Cancer Res , vol.66 , pp. 10073-10082
    • Pastorino, F.1    Brignole, C.2    Di Paolo, D.3    Nico, B.4    Pezzolo, A.5    Marimpietri, D.6
  • 3
    • 57749092182 scopus 로고    scopus 로고
    • Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
    • Ma J., Waxman D.J. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther 2008, 7:3670-3684.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3670-3684
    • Ma, J.1    Waxman, D.J.2
  • 4
    • 4444379133 scopus 로고    scopus 로고
    • Nanoparticle and targeted systems for cancer therapy
    • Brannon-Peppas L., Blanchette J.O. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 2004, 56:1649-1659.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1649-1659
    • Brannon-Peppas, L.1    Blanchette, J.O.2
  • 5
    • 10744223089 scopus 로고    scopus 로고
    • Electrochemo-gene therapy of cancer: intratumoral delivery of interleukin-12 gene and bleomycin synergistically induced therapeutic immunity and suppressed subcutaneous and metastatic melanomas in mice
    • Kishida T., Asada H., Itokawa Y., Yasutomi K., Shin-Ya M., Gojo S., et al. Electrochemo-gene therapy of cancer: intratumoral delivery of interleukin-12 gene and bleomycin synergistically induced therapeutic immunity and suppressed subcutaneous and metastatic melanomas in mice. Mol Ther 2003, 8:738-745.
    • (2003) Mol Ther , vol.8 , pp. 738-745
    • Kishida, T.1    Asada, H.2    Itokawa, Y.3    Yasutomi, K.4    Shin-Ya, M.5    Gojo, S.6
  • 6
    • 3042773832 scopus 로고    scopus 로고
    • Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model
    • Janat-Amsbury M.M., Yockman J.W., Lee M., Kern S., Furgeson D.Y., Bikram M., et al. Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model. Mol Ther 2004, 9:829-836.
    • (2004) Mol Ther , vol.9 , pp. 829-836
    • Janat-Amsbury, M.M.1    Yockman, J.W.2    Lee, M.3    Kern, S.4    Furgeson, D.Y.5    Bikram, M.6
  • 7
    • 33749983751 scopus 로고    scopus 로고
    • Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer
    • Wang Y., Gao S., Ye W.H., Yoon H.S., Yang Y.Y. Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer. Nat Mater 2006, 5:791-796.
    • (2006) Nat Mater , vol.5 , pp. 791-796
    • Wang, Y.1    Gao, S.2    Ye, W.H.3    Yoon, H.S.4    Yang, Y.Y.5
  • 8
    • 78649315943 scopus 로고    scopus 로고
    • To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    • Danhier F., Feron O., Preat V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release 2010, 148:135-146.
    • (2010) J Control Release , vol.148 , pp. 135-146
    • Danhier, F.1    Feron, O.2    Preat, V.3
  • 9
    • 84855444531 scopus 로고    scopus 로고
    • A facile preparation of novel multifunctional vectors by non-covalent bonds for co-delivery of doxorubicin and gene
    • Ma M., Yuan Z.F., Chen X.J., Li F., Zhuo R.X. A facile preparation of novel multifunctional vectors by non-covalent bonds for co-delivery of doxorubicin and gene. Acta Biomater 2012, 8:599-607.
    • (2012) Acta Biomater , vol.8 , pp. 599-607
    • Ma, M.1    Yuan, Z.F.2    Chen, X.J.3    Li, F.4    Zhuo, R.X.5
  • 10
    • 79955137394 scopus 로고    scopus 로고
    • Cationic supramolecular nanoparticles for co-delivery of gene and anticancer drug
    • Hu Q.D., Fan H., Ping Y., Liang W.Q., Tang G.P., Li J. Cationic supramolecular nanoparticles for co-delivery of gene and anticancer drug. Chem Commun (Camb) 2011, 47:5572-5574.
    • (2011) Chem Commun (Camb) , vol.47 , pp. 5572-5574
    • Hu, Q.D.1    Fan, H.2    Ping, Y.3    Liang, W.Q.4    Tang, G.P.5    Li, J.6
  • 11
    • 81355161723 scopus 로고    scopus 로고
    • Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat
    • Cheng D., Cao N., Chen J., Yu X., Shuai X. Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat. Biomaterials 2012, 33:1170-1179.
    • (2012) Biomaterials , vol.33 , pp. 1170-1179
    • Cheng, D.1    Cao, N.2    Chen, J.3    Yu, X.4    Shuai, X.5
  • 12
    • 79959776093 scopus 로고    scopus 로고
    • Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin
    • Xiong X.B., Lavasanifar A. Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin. ACS Nano 2011, 5:5202-5213.
    • (2011) ACS Nano , vol.5 , pp. 5202-5213
    • Xiong, X.B.1    Lavasanifar, A.2
  • 13
    • 80052145802 scopus 로고    scopus 로고
    • Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug
    • Shim G., Han S.E., Yu Y.H., Lee S., Lee H.Y., Kim K., et al. Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug. J Control Release 2011, 155:60-66.
    • (2011) J Control Release , vol.155 , pp. 60-66
    • Shim, G.1    Han, S.E.2    Yu, Y.H.3    Lee, S.4    Lee, H.Y.5    Kim, K.6
  • 14
    • 70649115439 scopus 로고    scopus 로고
    • The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model
    • Xu Z., Zhang Z., Chen Y., Chen L., Lin L., Li Y. The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model. Biomaterials 2010, 31:916-922.
    • (2010) Biomaterials , vol.31 , pp. 916-922
    • Xu, Z.1    Zhang, Z.2    Chen, Y.3    Chen, L.4    Lin, L.5    Li, Y.6
  • 15
    • 81155131290 scopus 로고    scopus 로고
    • Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome
    • Sun X., Pang Z., Ye H., Qiu B., Guo L., Li J., et al. Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome. Biomaterials 2012, 33:916-924.
    • (2012) Biomaterials , vol.33 , pp. 916-924
    • Sun, X.1    Pang, Z.2    Ye, H.3    Qiu, B.4    Guo, L.5    Li, J.6
  • 16
    • 84859817562 scopus 로고    scopus 로고
    • Gene and doxorubicin co-delivery system for targeting therapy of glioma
    • Liu S., Guo Y., Huang R., Li J., Huang S., Kuang Y., et al. Gene and doxorubicin co-delivery system for targeting therapy of glioma. Biomaterials 2012, 33:4907-4916.
    • (2012) Biomaterials , vol.33 , pp. 4907-4916
    • Liu, S.1    Guo, Y.2    Huang, R.3    Li, J.4    Huang, S.5    Kuang, Y.6
  • 17
    • 68549109372 scopus 로고    scopus 로고
    • Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier
    • Kaneshiro T.L., Lu Z.R. Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier. Biomaterials 2009, 30:5660-5666.
    • (2009) Biomaterials , vol.30 , pp. 5660-5666
    • Kaneshiro, T.L.1    Lu, Z.R.2
  • 18
    • 78650134637 scopus 로고    scopus 로고
    • Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line
    • Meng H., Liong M., Xia T., Li Z., Ji Z., Zink J.I., et al. Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano 2010, 4:4539-4550.
    • (2010) ACS Nano , vol.4 , pp. 4539-4550
    • Meng, H.1    Liong, M.2    Xia, T.3    Li, Z.4    Ji, Z.5    Zink, J.I.6
  • 19
    • 84862815497 scopus 로고    scopus 로고
    • Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking
    • Li J.M., Wang Y.Y., Zhao M.X., Tan C.P., Li Y.Q., Le X.Y., et al. Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking. Biomaterials 2012, 33:2780-2790.
    • (2012) Biomaterials , vol.33 , pp. 2780-2790
    • Li, J.M.1    Wang, Y.Y.2    Zhao, M.X.3    Tan, C.P.4    Li, Y.Q.5    Le, X.Y.6
  • 20
    • 84865370343 scopus 로고    scopus 로고
    • Combination drug delivery approaches in metastatic breast cancer
    • Lee J.H., Nan A. Combination drug delivery approaches in metastatic breast cancer. J Drug Deliv 2012, 2012:915375.
    • (2012) J Drug Deliv , vol.2012 , pp. 915375
    • Lee, J.H.1    Nan, A.2
  • 21
    • 40649085520 scopus 로고    scopus 로고
    • An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection
    • Lo S.L., Wang S. An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection. Biomaterials 2008, 29:2408-2414.
    • (2008) Biomaterials , vol.29 , pp. 2408-2414
    • Lo, S.L.1    Wang, S.2
  • 23
    • 79959365312 scopus 로고    scopus 로고
    • Mechanisms of cellular uptake of cell-penetrating peptides
    • Madani F., Lindberg S., Langel U., Futaki S., Graslund A. Mechanisms of cellular uptake of cell-penetrating peptides. J Biophys 2011, 2011:414729.
    • (2011) J Biophys , vol.2011 , pp. 414729
    • Madani, F.1    Lindberg, S.2    Langel, U.3    Futaki, S.4    Graslund, A.5
  • 24
    • 79956015439 scopus 로고    scopus 로고
    • Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo
    • Andaloussi S.E., Lehto T., Mager I., Rosenthal-Aizman K., Oprea I.I., Simonson O.E., et al. Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo. Nucleic Acids Res 2011, 39:3972-3987.
    • (2011) Nucleic Acids Res , vol.39 , pp. 3972-3987
    • Andaloussi, S.E.1    Lehto, T.2    Mager, I.3    Rosenthal-Aizman, K.4    Oprea, I.I.5    Simonson, O.E.6
  • 25
    • 40549135373 scopus 로고    scopus 로고
    • A biodegradable pH-sensitive micelle system for targeting acidic solid tumors
    • Sethuraman V.A., Lee M.C., Bae Y.H. A biodegradable pH-sensitive micelle system for targeting acidic solid tumors. Pharm Res 2008, 25:657-666.
    • (2008) Pharm Res , vol.25 , pp. 657-666
    • Sethuraman, V.A.1    Lee, M.C.2    Bae, Y.H.3
  • 26
    • 56049093057 scopus 로고    scopus 로고
    • Cell-penetrating and cell-targeting peptides in drug delivery
    • Vives E., Schmidt J., Pelegrin A. Cell-penetrating and cell-targeting peptides in drug delivery. Biochim Biophys Acta 2008, 1786:126-138.
    • (2008) Biochim Biophys Acta , vol.1786 , pp. 126-138
    • Vives, E.1    Schmidt, J.2    Pelegrin, A.3
  • 27
    • 0034889507 scopus 로고    scopus 로고
    • Sulfonamide-containing polymers: a new class of pH-sensitive polymers and gels
    • Kang S.I., Na K., Bae Y.H. Sulfonamide-containing polymers: a new class of pH-sensitive polymers and gels. Macromol Symp 2001, 172:149-156.
    • (2001) Macromol Symp , vol.172 , pp. 149-156
    • Kang, S.I.1    Na, K.2    Bae, Y.H.3
  • 28
    • 56949105019 scopus 로고    scopus 로고
    • Recent progress in tumor pH targeting nanotechnology
    • Lee E.S., Gao Z., Bae Y.H. Recent progress in tumor pH targeting nanotechnology. J Control Release 2008, 132:164-170.
    • (2008) J Control Release , vol.132 , pp. 164-170
    • Lee, E.S.1    Gao, Z.2    Bae, Y.H.3
  • 29
    • 31544441899 scopus 로고    scopus 로고
    • PH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study
    • Sethuraman V.A., Na K., Bae Y.H. pH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study. Biomacromolecules 2006, 7:64-70.
    • (2006) Biomacromolecules , vol.7 , pp. 64-70
    • Sethuraman, V.A.1    Na, K.2    Bae, Y.H.3
  • 30
    • 34147191991 scopus 로고    scopus 로고
    • Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo
    • Yamashita M., Kajiyama H., Terauchi M., Shibata K., Ino K., Nawa A., et al. Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo. Int J Cancer 2007, 120:2243-2250.
    • (2007) Int J Cancer , vol.120 , pp. 2243-2250
    • Yamashita, M.1    Kajiyama, H.2    Terauchi, M.3    Shibata, K.4    Ino, K.5    Nawa, A.6
  • 31
    • 0028053036 scopus 로고
    • Expression of aminopeptidase-n (CD 13) in normal tissues and malignant neoplasms of epithelial and lymphoid origin
    • Dixon J., Kaklamanis L., Turley H., Hickson I.D., Leek R.D., Harris A.L., et al. Expression of aminopeptidase-n (CD 13) in normal tissues and malignant neoplasms of epithelial and lymphoid origin. J Clin Pathol 1994, 47:43-47.
    • (1994) J Clin Pathol , vol.47 , pp. 43-47
    • Dixon, J.1    Kaklamanis, L.2    Turley, H.3    Hickson, I.D.4    Leek, R.D.5    Harris, A.L.6
  • 32
    • 82955172978 scopus 로고    scopus 로고
    • Tumor specific delivery and therapy by double-targeted nanostructured lipid carriers with anti-VEGFR-2 antibody
    • Liu D., Liu F., Liu Z., Wang L., Zhang N. Tumor specific delivery and therapy by double-targeted nanostructured lipid carriers with anti-VEGFR-2 antibody. Mol Pharm 2011, 8:2291-2301.
    • (2011) Mol Pharm , vol.8 , pp. 2291-2301
    • Liu, D.1    Liu, F.2    Liu, Z.3    Wang, L.4    Zhang, N.5
  • 33
    • 77953651230 scopus 로고    scopus 로고
    • Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier
    • Son S., Singha K., Kim W.J. Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier. Biomaterials 2010, 31:6344-6354.
    • (2010) Biomaterials , vol.31 , pp. 6344-6354
    • Son, S.1    Singha, K.2    Kim, W.J.3
  • 34
    • 84861207701 scopus 로고    scopus 로고
    • CNGR conjugated poly(lactic acid)-poly(ethylene glycol) nanoparticles for targeted gene delivery
    • Liu C., Yu W., Chen Z., Zhang J., Zhang N. cNGR conjugated poly(lactic acid)-poly(ethylene glycol) nanoparticles for targeted gene delivery. J Control Release 2011, 152(Suppl. 1):e155-e157.
    • (2011) J Control Release , vol.152 , Issue.SUPPL. 1
    • Liu, C.1    Yu, W.2    Chen, Z.3    Zhang, J.4    Zhang, N.5
  • 35
    • 83355162386 scopus 로고    scopus 로고
    • The brain targeting mechanism of angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles
    • Xin H., Sha X., Jiang X., Chen L., Law K., Gu J., et al. The brain targeting mechanism of angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles. Biomaterials 2012, 33:1673-1681.
    • (2012) Biomaterials , vol.33 , pp. 1673-1681
    • Xin, H.1    Sha, X.2    Jiang, X.3    Chen, L.4    Law, K.5    Gu, J.6
  • 36
    • 43049123443 scopus 로고    scopus 로고
    • Cysteine 155 plays an important role in the assembly of Mycobacterium tuberculosis FtsZ
    • Jaiswal R., Panda D. Cysteine 155 plays an important role in the assembly of Mycobacterium tuberculosis FtsZ. Protein Sci 2008, 17:846-854.
    • (2008) Protein Sci , vol.17 , pp. 846-854
    • Jaiswal, R.1    Panda, D.2
  • 37
    • 34548119853 scopus 로고    scopus 로고
    • Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy
    • Lai P.S., Lou P.J., Peng C.L., Pai C.L., Yen W.N., Huang M.Y., et al. Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. J Control Release 2007, 122:39-46.
    • (2007) J Control Release , vol.122 , pp. 39-46
    • Lai, P.S.1    Lou, P.J.2    Peng, C.L.3    Pai, C.L.4    Yen, W.N.5    Huang, M.Y.6
  • 38
    • 0035816157 scopus 로고    scopus 로고
    • Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes
    • Rihova B., Etrych T., Pechar M., Jelinkova M., Stastny M., Hovorka O., et al. Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes. J Control Release 2001, 74:225-232.
    • (2001) J Control Release , vol.74 , pp. 225-232
    • Rihova, B.1    Etrych, T.2    Pechar, M.3    Jelinkova, M.4    Stastny, M.5    Hovorka, O.6
  • 39
    • 34247863385 scopus 로고    scopus 로고
    • An improved method for covalently conjugating morpholino oligomers to antitumor antibodies
    • He J., Liu G., Dou S., Gupta S., Rusckowski M., Hnatowich D. An improved method for covalently conjugating morpholino oligomers to antitumor antibodies. Bioconjug Chem 2007, 18:983-988.
    • (2007) Bioconjug Chem , vol.18 , pp. 983-988
    • He, J.1    Liu, G.2    Dou, S.3    Gupta, S.4    Rusckowski, M.5    Hnatowich, D.6
  • 41
    • 1842830012 scopus 로고    scopus 로고
    • Efficient strategies for the conjugation of oligonucleotides to antibodies enabling highly sensitive protein detection
    • Kozlov I.A., Melnyk P.C., Stromsborg K.E., Chee M.S., Barker D.L., Zhao C. Efficient strategies for the conjugation of oligonucleotides to antibodies enabling highly sensitive protein detection. Biopolymers 2004, 73:621-630.
    • (2004) Biopolymers , vol.73 , pp. 621-630
    • Kozlov, I.A.1    Melnyk, P.C.2    Stromsborg, K.E.3    Chee, M.S.4    Barker, D.L.5    Zhao, C.6
  • 42
    • 77953666878 scopus 로고    scopus 로고
    • Multilayer nanoparticles with a magnetite core and a polycation inner shell as pH-responsive carriers for drug delivery
    • Guo M., Yan Y., Liu X., Yan H., Liu K., Zhang H., et al. Multilayer nanoparticles with a magnetite core and a polycation inner shell as pH-responsive carriers for drug delivery. Nanoscale 2010, 2:434-441.
    • (2010) Nanoscale , vol.2 , pp. 434-441
    • Guo, M.1    Yan, Y.2    Liu, X.3    Yan, H.4    Liu, K.5    Zhang, H.6
  • 43
    • 49749152440 scopus 로고    scopus 로고
    • Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo
    • Intra J., Salem A.K. Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. J Control Release 2008, 130:129-138.
    • (2008) J Control Release , vol.130 , pp. 129-138
    • Intra, J.1    Salem, A.K.2
  • 44
    • 19744372388 scopus 로고    scopus 로고
    • Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis
    • Akinc A., Thomas M., Klibanov A.M., Langer R. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 2005, 7:657-663.
    • (2005) J Gene Med , vol.7 , pp. 657-663
    • Akinc, A.1    Thomas, M.2    Klibanov, A.M.3    Langer, R.4
  • 45
    • 85047685275 scopus 로고    scopus 로고
    • A pH-sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate
    • Lu D., Wen X., Liang J., Gu Z., Zhang X., Fan Y. A pH-sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate. J Biomed Mater Res B Appl Biomater 2009, 89:177-183.
    • (2009) J Biomed Mater Res B Appl Biomater , vol.89 , pp. 177-183
    • Lu, D.1    Wen, X.2    Liang, J.3    Gu, Z.4    Zhang, X.5    Fan, Y.6
  • 46
    • 84863301782 scopus 로고    scopus 로고
    • Charge shielding effects on gene delivery of polyethylenimine/DNA complexes: PEGylation and phospholipid coating
    • Luo X., Feng M., Pan S., Wen Y., Zhang W., Wu C. Charge shielding effects on gene delivery of polyethylenimine/DNA complexes: PEGylation and phospholipid coating. J Mater Sci Mater Med 2012, 23:1685-1695.
    • (2012) J Mater Sci Mater Med , vol.23 , pp. 1685-1695
    • Luo, X.1    Feng, M.2    Pan, S.3    Wen, Y.4    Zhang, W.5    Wu, C.6
  • 48
    • 41549123975 scopus 로고    scopus 로고
    • Nanoparticles for drug delivery: the need for precision in reporting particle size parameters
    • Gaumet M., Vargas A., Gurny R., Delie F. Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. Eur J Pharm Biopharm 2008, 69:1-9.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 1-9
    • Gaumet, M.1    Vargas, A.2    Gurny, R.3    Delie, F.4
  • 50
    • 0026469991 scopus 로고
    • Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer
    • Rettig W.J., Garin-Chesa P., Healey J.H., Su S.L., Jaffe E.A., Old L.J. Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. Proc Natl Acad Sci U S A 1992, 89:10832-10836.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10832-10836
    • Rettig, W.J.1    Garin-Chesa, P.2    Healey, J.H.3    Su, S.L.4    Jaffe, E.A.5    Old, L.J.6
  • 52
    • 70350736726 scopus 로고    scopus 로고
    • Proliferating and quiescent human umbilical vein endothelial cells (HUVECs): a potential in vitro model to evaluate contrast agents for molecular imaging of angiogenesis
    • Vag T., Schramm T., Kaiser W.A., Hilger I. Proliferating and quiescent human umbilical vein endothelial cells (HUVECs): a potential in vitro model to evaluate contrast agents for molecular imaging of angiogenesis. Contrast Media Mol Imaging 2009, 4:192-198.
    • (2009) Contrast Media Mol Imaging , vol.4 , pp. 192-198
    • Vag, T.1    Schramm, T.2    Kaiser, W.A.3    Hilger, I.4
  • 53
    • 77951697920 scopus 로고    scopus 로고
    • Regulation of endothelial permeability via paracellular and transcellular transport pathways
    • Komarova Y., Malik A.B. Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu Rev Physiol 2010, 72:463-493.
    • (2010) Annu Rev Physiol , vol.72 , pp. 463-493
    • Komarova, Y.1    Malik, A.B.2
  • 54
    • 0035963903 scopus 로고    scopus 로고
    • Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo
    • Schnitzer J.E. Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo. Adv Drug Deliv Rev 2001, 49:265-280.
    • (2001) Adv Drug Deliv Rev , vol.49 , pp. 265-280
    • Schnitzer, J.E.1
  • 55
    • 0037422066 scopus 로고    scopus 로고
    • Regulated portals of entry into the cell
    • Conner S.D., Schmid S.L. Regulated portals of entry into the cell. Nature 2003, 422:37-44.
    • (2003) Nature , vol.422 , pp. 37-44
    • Conner, S.D.1    Schmid, S.L.2
  • 56
    • 0036341207 scopus 로고    scopus 로고
    • Signal transduction and endocytosis: close encounters of many kinds
    • Sorkin A., Von Zastrow M. Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol 2002, 3:600-614.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 600-614
    • Sorkin, A.1    Von Zastrow, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.