Detection of ketamine and its metabolites in human hair using an integrated nanoflow liquid chromatography column and electrospray emitter fritted with a single porous 10μm bead

Journal of Chromatography A

Volumn 1277, Issue , 2013, Pages 1-6

  Parkin, Mark C ^a   Longmoore, Alana M ^a   Turfus, Sophie C ^a   Braithwaite, Robin A ^a   Cowan, David A ^a   Elliott, Simon ^b   Kicman, Andrew T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Inverness Medical Innovations   (United States)

Author keywords

Hair analysis; Ketamine; Nano electrospray; Nanoflow liquid chromatography

Indexed keywords

ACID DIGESTION; BAND-BROADENING; DEHYDRONORKETAMINE; DRUG ADMINISTRATION; ELECTROSPRAY EMITTER; FUSED SILICA CAPILLARY COLUMNS; HAIR ANALYSIS; HUMAN HAIR; KETAMINE; LC-MS/MS; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; NANO-ELECTROSPRAY; NANO-ESI; NANOFLOWS; NORKETAMINE; ORAL DOSE; PHASE I; POLYMERIC BEADS; SOLID-PHASE EXTRACTION;

BALL MILLS; BIOMOLECULES; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; POLYMERS; SINTERING;

AMINES;

DEHYDRONORKETAMINE; DRUG METABOLITE; KETAMINE; METHANOL; NORKETAMINE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HAIR LEVEL; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HAIR ANALYSIS; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; NANOFLOW LIQUID CHROMATOGRAPHY; NORMAL HUMAN; POROSITY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VOLUNTEER;

CHROMATOGRAPHY, LIQUID; FORENSIC TOXICOLOGY; HAIR; HUMANS; KETAMINE; PARTICLE SIZE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84872681213     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.12.019     Document Type: Article

References (32)

1. de Oliveira C.D.R., Roehsig M., de Almeida R.M., Rocha W.L., Yonamine M. Curr. Pharm. Anal. 2007, 3:95.
2. Bosker W.M., Huestis M.A. Clin. Chem. 2009, 55:1910.
3. Kintz P., Villain M., Cirimele V. Ther. Drug Monit. 2006, 28:442.
4. Martins L.F., Yegles M., Thieme D., Wennig R. Forensic Sci. Int. 2008, 176:38.
5. Tanaka S., Lio R., Chinaka S., Takayama N., Hayakawa K. Biomed. Chromatogr. 2002, 16:390.
6. Uematsu T., Miyazawa N., Okazaki O., Nakashima M. J. Pharm. Sci. 1992, 81:45.
7. Harkey M.R. Forensic Sci. Int. 1993, 63:9.
8. Nakahara Y., Kikura R. Arch. Toxicol. 1994, 68:54.
9. Nakahara Y., Shimamine M., Takahashi K. J. Anal. Toxicol. 1992, 16:253.
10. Banning T.P., Heard C.M. Int. J. Pharm. 2002, 235:219.
11. Pragst F., Balikova M.A. Clin. Chim. Acta 2006, 370:17.
12. Wada M., Ikeda R., Kuroda N., Nakashima K. Anal. Bioanal. Chem. 2010, 397:1039.
13. Coufal P., Cihak M., Suchankova J., Tesarova E., Bosakova Z., Stulik K. J. Chromatogr. A 2002, 946:99.
14. Cutillas P.R. Curr. Nanosci. 2005, 1:65.
15. Kennedy R.T., Jorgenson J.W. Anal. Chem. 1989, 61:1128.
16. Novotny M. Anal. Chem. 1988, 60:A500.
17. Ling B.L., Baeyens W., Dewaele C. J. Microcolumn Sep. 1992, 4:17.
18. Wilm M., Mann M. Anal. Chem. 1996, 68:1.
19. Wilm M.S., Mann M. Int. J. Mass Spectrom. 1994, 136:167.
20. Haskins W.E., Wang Z.Q., Watson C.J., Rostand R.R., Witowski S.R., Powell D.H., Kennedy R.T. Anal. Chem. 2001, 73:5005.
21. Tan F., Chen S.O., Zhang Y.J., Cai Y., Qian X.H. Proteomics 2010, 10:1724.
22. Kang D., Nam H., Kim Y.S., Moon M.H. J. Chromatogr. A 2005, 1070:193.
23. Zhang B., Bergstrom E.T., Goodall D.M., Myers P. Anal. Chem. 2007, 79:9229.
24. Valaskovic G.A., Kelleher N.L., Little D.P., Aaserud D.J., Mclafferty F.W. Anal. Chem. 1995, 67:3802.
25. Tabernero M.J., Felli M.L., Bermejo A.M., Chiarotti M. Anal. Bioanal. Chem. 2009, 395:2547.
26. Tsim K.W.K., Zhu K.Y., Leung K.W., Ting A.K.L., Wong Z.C.F., Fu Q., Ng W.Y.Y., Choi R.C.Y., Dong T.T.X., Wang T.J., Lau D.T.W. Forensic Sci. Int. 2011, 208:53.
27. Xiang P., Sun Q., Shen B., Shen M. Int. J. Legal Med. 2011, 125:831.
28. Wu Y.H., Lin K.L., Chen S.C., Chang Y.Z. J. Chromatogr. B 2008, 870:192.
29. Wu Y.H., Lin K.L., Chen S.C., Chang Y.Z. Rapid Commun. Mass Spectrom. 2008, 22:887.
30. Kim J.Y., In M.K., Kim J.H. Rapid Commun. Mass Spectrom. 2006, 20:3159.
31. Wang W.L., Cone E.J. Forensic Sci. Int. 1995, 70:39.
32. Scheidweiler K.B., Huestis M.A. Anal. Chem. 2004, 76:4358.