Disposition of ketamine and norketamine in hair after a single dose

International Journal of Legal Medicine

Volumn 125, Issue 6, 2011, Pages 831-840

  Xiang, Ping ^a,b   Sun, Qiran ^a   Shen, Baohua ^a   Shen, Min ^a  

^a INSTITUTE OF FORENSIC SCIENCE   (China)

^b UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

Diffusion; Disposition; Ketamine .A single dose; Segmental hair analysis

Indexed keywords

ANESTHETIC AGENT; DRUG DERIVATIVE; KETAMINE; NORKETAMINE;

ADULT; ARTICLE; FEMALE; FORENSIC MEDICINE; HAIR; HUMAN; LIQUID CHROMATOGRAPHY; METABOLISM; ORAL DRUG ADMINISTRATION; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ADULT; ANESTHETICS, DISSOCIATIVE; CHROMATOGRAPHY, LIQUID; FEMALE; FORENSIC MEDICINE; HAIR; HUMANS; KETAMINE; TANDEM MASS SPECTROMETRY;

EID: 83155185520     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-010-0534-5     Document Type: Article

References (27)

1. Villain M, Chèze M, Tracqui A, Ludes B, Kintz P (2004) Windows of detection of zolpidem in urine and hair: application to two drug facilitated sexual assaults. Forensic Sci Int 143(2):157-161 (Pubitemid 38881443)
2. Goullé JP, Chèze M, Pépin G (2003) Determination of endogenous levels of GHB in human hair. Are there possibilities for the identification of GHB administration through hair analysis in cases of drug-facilitated sexual assault? J Anal Toxicol 27:574-580 (Pubitemid 37500379)
3. Frison G, Favretto D, Tedeschi L, Ferrara SD (2003) Detection of thiopental and pentobarbital in head and pubic hair in a case of drug-facilitated sexual assault. Forensic Sci Int 133(1):171-174 (Pubitemid 36555436)
4. Pepin G, Chèze M, Duffort G, Vayssette F (2002) Interest of hair and tandem mass spectrometry for chemical submission: about nine cases. Ann Toxicol Anal 14:395-406
5. Chèze M, Villain M, Pépin G (2004) Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimes. Forensic Sci Int 145(2-3):123-130
6. Kintz P, Cirimele V, Jamey C, Ludes B (2003) Testing for GHB in hair by GC/MS/MS after a single exposure: application to document sexual assault. J Forensic Sci 48(1):195-200 (Pubitemid 36084110)
7. Kintz P, Villain M, Chèze M, Pépin G (2005) Identification of alprazolam in hair in two cases of drug-facilitated incidents. Forensic Sci Int 153(2):222-226 (Pubitemid 41219678)
8. Juhascik MP, Negrusz A, Faugno D, Ledray L, Greene P, Lindner A, Haner B, Gaensslen RE (2007) An estimate of the proportion of drug-facilitation of sexual assault in four U.S. localities. J Forensic Sci 52(6):1396-1400 (Pubitemid 350243451)
9. Marc B (2008) Current clinical aspects of drug-facilitated sexual assaults in sexually abused victims examined in a forensic emergency unit. Ther Drug Monit 30(2):218-224
10. Schloegl H, Dresen S, Spaczynski K, Stoertzel M, Wurst FM, Weinmann W (2006) Stability of ethyl glucuronide in urine, postmortem tissue and blood samples. Int J Leg Med 120:83-88 (Pubitemid 43261242)
11. Pavlic M, Libiseller K, Grubwieser P, Schubert H, Rabl W (2007) Medicolegal aspects of tetrazepam metabolism. Int J Leg Med 121:169-174 (Pubitemid 46866570)
12. Musshoff F, Madea B (2007) New trends in hair analysis and scientific demands on validation and technical notes. Forensic Sci Int 165(2):204-215 (Pubitemid 46084889)
13. Kintz P (2007) Analytical and practical aspects of drug testing in hair. Taylor & Francis Group LLC, CRC Press, Boca Raton, FL
14. Henderson GL, Harkey MR, Zhou C, Jones RT, Jacob P (1998) Incorporation of isotopically labeled cocaine into human hair: race as a factor. J Anal Toxicol 22:156-165 (Pubitemid 28128964)
15. Xiang P, Sun QR, Shen BH, Chen P, Liu W, Shen M (2010) Segmental hair analysis using liquid chromatography-tandem mass spectrometry after a single dose of benzodiazepines. Forensic Sci Int. doi:10.1016/j.forsciint.2010.04.046
16. Xiang P, Shen M, Zhuo XY (2006) Hair analysis for ketamine and its metabolites. Forensic Sci Int 162(1):131-134 (Pubitemid 44374233)
17. Leong HS, Tan NL, Lui CP, Lee TK (2005) Evaluation of ketamine abuse using hair analysis: concentration trends in a Singapore population. J Anal Toxicol 29:314-318 (Pubitemid 41191699)
18. Wu YH, Lin KL, Chen SC, Chang YZ (2008) Integration of GC/ EI-MS and GC/NCI-MS for simultaneous quantitative determination of opiates, amphetamines, MDMA, ketamine, and metabolites in human hair. J Chromatogr B 870(2):192-202
19. Inagaki S, Makino H, Fukushima T, Min JZ, Toyo'oka T (2009) Rapid detection of ketamine and norketamine in rat hair using micropulverized extraction and ultra-performance liquid chromatography-electrospray ionization mass spectrometry. Biomed Chromatogr 23(12):1245-1250
20. Nielsen MK, Johansen SS, Dalsgaard PW, Linnet K (2010) Simultaneous screening and quantification of 52 common pharmaceuticals and drugs of abuse in hair using UPLC-TOF-MS. Forensic Sci Int 196(1-3):85-92
21. Tabernero MJ, Felli ML, Bermejo AM, Chiarotti M (2009) Determination of ketamine and amphetamines in hair by LC/ MS/MS. Anal Bioanal Chem 395(8):2547-2557
22. Harun N, Anderson RA, Cormack PA (2010) Analysis of ketamine and norketamine in hair samples using molecularly imprinted solidphase extraction (MISPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Anal Bioanal Chem 396(7):2449-2459
23. Peters F, Drummer O, Musshoff F (2007) Validation of new methods. Forensic Sci Int 165(2):216-224 (Pubitemid 46073540)
24. Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 75:3019-3030 (Pubitemid 36830428)
25. Dams R, Huestis MA (2003) Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation and biofluid. J Am Soc Mass Spectrom 14:1290-1294 (Pubitemid 37330133)
26. Taylor RJ (2005) Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin Biochem 38:328-334
27. Kintz P (2007) Bioanalytical procedures for detection of chemical agents in hair in the case of drug-facilitated crimes. Anal Bioanal Chem 388(7):1467-1474 (Pubitemid 47150873)