An imbalance between substance P and vasoactive intestinal polypeptide might contribute to the immunopathology of megaesophagus after Trypanosoma cruzi infection

Human Pathology

Volumn 44, Issue 2, 2013, Pages 269-276

  Nascimento, Rodolfo Duarte ^a   Martins, Patrícia Rocha ^a   De Souza Lisboa, André ^a   Adad, Sheila Jorge ^b   Morais Da Silveira, Alexandre Barcelos ^c   Reis, Débora D'Ávila ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

^c FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

Author keywords

Chagas megaesophagus; Denervation; Substance P; Vasoactive intestinal peptide

Indexed keywords

NEUROKININ 1 RECEPTOR; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; AGED; ARTICLE; CHAGAS DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ESOPHAGUS; FEMALE; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; MACROPHAGE; MALE; MAST CELL; MEGAESOPHAGUS; MORPHOMETRICS; NERVE FIBER; PROTEIN EXPRESSION; T LYMPHOCYTE; TRYPANOSOMA CRUZI;

ADULT; AGED; AGED, 80 AND OVER; CHAGAS DISEASE; ESOPHAGEAL ACHALASIA; ESOPHAGUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MYENTERIC PLEXUS; NEURONS; SUBSTANCE P; TRYPANOSOMA CRUZI; VASOACTIVE INTESTINAL PEPTIDE;

EID: 84872674601     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2012.05.020     Document Type: Article

References (30)

1. J.C. Dias Chagas disease: successes and challenges Cad Saude Publica 22 2006 2020 2021 (Pubitemid 44533489)
2. A. Prata Clinical and epidemiological aspects of Chagas disease Lancet Infect Dis 1 2001 92 100 (Pubitemid 33586044)
3. F. Koberle Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis Adv Parasitol 6 1968 63 116
4. S.J. Adad, D.C. Andrade, E.R. Lopes, and E. Chapadeiro Pathological anatomy of chagasic megaesophagus Rev Inst Med Trop Sao Paulo 33 1991 443 450
5. A.B. da Silveira, R.M. Arantes, and A.R. Vago Comparative study of the presence of Trypanosoma cruzi kDNA, inflammation and denervation in chagasic patients with and without megaesophagus Parasitology 131 2005 627 634 (Pubitemid 41577936)
6. D. d'Avila Reis, E.M. Lemos, and G.C. Silva Phenotypic characterization of the inflammatory cells in chagasic megaoesophagus Trans R Soc Trop Med Hyg 95 2001 177 178 (Pubitemid 34947381)
7. Y.Y. Wan, and R.A. Flavell The roles for cytokines in the generation and maintenance of regulatory T cells Immunol Rev 212 2006 114 130 (Pubitemid 44116704)
8. M. Delgado, and D. Ganea Anti-inflammatory neuropeptides: a new class of endogenous immunoregulatory agents Brain Behav Immun 22 2008 1146 1151
9. Y. Wang, Y. Mei, S. Bao, and L. Xu Vasoactive intestinal polypeptide enhances oral tolerance by regulating both cellular and humoral immune responses Clin Exp Immunol 148 2007 178 187 (Pubitemid 46364990)
10. W.I. Khan, and J.E. Ghia Gut hormones: emerging role in immune activation and inflammation Clin Exp Immunol 161 2010 19 27
11. L. Souza-Moreira, J. Campos-Salinas, M. Caro, and E. Gonzales-Rey Neuropeptides as pleiotropic modulations of the immune response Neuroendocrinology 94 2011 89 100
12. S.G. Smalley, P.A. Barrow, and N. Foster Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease Clin Exp Immunol 157 2009 225 234
13. E. Gonzalez-Rey, N. Varela, A. Chorny, and M. Delgado Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulator Curr Pharm Des 13 2007 1113 1139 (Pubitemid 46744821)
14. H.W. Koon, and C. Pothoulakis Immunomodulatory properties of substance P: the gastrointestinal system as a model Ann N YAcad Sci 1088 2006 23 40 (Pubitemid 47092045)
15. M.A. Engel, C. Becker, P.W. Reeh, and M.F. Neurath Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut Inflamm Bowel Dis 17 2011 1030 1033
16. R.D. Nascimento, A. de Souza Lisboa, and R.T. Fujiwara Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagus Hum Pathol 41 2010 528 534
17. F. Koberle The causation and importance of nervous lesions in American trypanosomiasis Bull World Health Organ 42 1970 739 743
18. S. Aggestrup, R. Uddman, and S.L. Jesen Regulatory peptides in lower esophageal sphincter of pig and man Dig Dis Sci 31 1986 1350 1357
19. D.A. Wattchow, J.B. Furness, M. Costa, P.E. O'Brien, and M. Peacock Distributions of neuropeptides in the human esophagus Gastroenterology 93 1987 1363 1371 (Pubitemid 17167280)
20. C. Abad, C. Martinez, and M.G. Juarranz Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease Gastroenterology 124 2003 961 971 (Pubitemid 36389799)
21. + T cells J Leukoc Biol 75 2004 1122 1130 (Pubitemid 38720656)
22. D. Pozo, P. Anderson, and E. Gonzalez-Rey Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptide J Immunol 183 2009 4346 4359
23. A.B. da Silveira, F.F. de Araújo, and M.A. Freitas Characterization of the presence and distribution of Foxp3(+) cells in chagasic patients with and without megacolon Hum Immunol 70 2009 65 67
24. P. Anderson, and E. Gonzalez-Rey Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels Mol Cell Biol 30 2010 2537 2551
25. M.R. Saban, R. Saban, D. Bjorling, and M. Haak-Frendscho Involvement of leukotrienes, TNF-alpha and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration J Leukoc Biol 61 1997 445 451 (Pubitemid 27219838)
26. S. Dunzendorfer, C. Meierhofer, and C.J. Wiedermann Signaling in neuropeptide-induced migration of human eosinophils J Leukoc Biol 64 1998 828 834 (Pubitemid 28555398)
27. A. Metwali, A.M. Blum, L. Ferraris, J.S. Klein, C. Fiocchi, and J.V. Weinstock Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide J Neuroimmunol 52 1994 69 78 (Pubitemid 24182248)
28. M. Delgado, G.M. Jonakait, and D. Ganea Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit chemokine production in activated microglia Glia 39 2002 148 161 (Pubitemid 34817055)
29. M. Delgado, and D. Ganea Vasoactive intestinal peptide prevents activated microglia-induced neurodegeneration under inflammatory conditions: potential therapeutic role in brain trauma FASEB J 17 2003 1922 1924
30. I. Gutiérrez-Canãs, Y. Juarranz, and B. Santiago VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts Rheumatology 45 2006 527 532