Phenotypic analysis of monocyte-derived dendritic cells loaded with tumor antigen with heat-shock cognate protein-70

Anticancer Research

Volumn 32, Issue 11, 2012, Pages 4897-4904

  Ito, Shinichiro ^a   Nagata, Yasuhiro ^b   Susumu, Seiya ^a   Yoneda, Akira ^a   Matsuo, Mitsutoshi ^c   Yui, Katsuyuki ^a   Udono, Heiichiro ^d   Eguchi, Susumu ^a   Kanematsu, Takashi ^a,e  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^c Nagasaki Memorial Hospital   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e Nagasaki Municipal Hospital   (Japan)

Author keywords

Dendritic cell; Hsc 70; IL 6; NY ESO 1; Phenotypic analysis

Indexed keywords

CANCER VACCINE; CD14 ANTIGEN; DENDRITIC CELL VACCINE; ESO P157 165 ANTIGEN; HEAT SHOCK COGNATE PROTEIN 70; HYBRID PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR ANTIBODY; RECEPTOR ANTIBODY; T6 ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DENDRITIC CELL; FETAL CALF SERUM; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; MONOCYTE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; TUMOR IMMUNITY;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, NEOPLASM; CANCER VACCINES; CROSS-PRIMING; DENDRITIC CELLS; FLOW CYTOMETRY; HSC70 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; PHENOTYPE;

EID: 84872656703     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Caballero OL and Chen YT: Cancer/testis (CT) antigens: potential targets for immunotherapy. Cancer Sci 100: 2014-2021, 2009.
2. Jager E, Stockert E, Zidianakis Z, Chen YT, Karbach J, Jager D, Arand M, Ritter G, Old LJ and Knuth A: Humoral immune responses of cancer patients against Cancer-Testis antigen NY-ESO- 1: correlation with clinical events. Int J Cancer 84: 506-510, 1999.
3. Scanlan MJ, Gure AO, Jungbluth AA, Old LJ and Chen YT: Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol Rev 188 : 22-32, 2002.
4. Gnjatic S, Nishikawa H, Jungbluth AA, Gure AO, Ritter G, Jager E, Knuth A, Chen YT and Old LJ: NY-ESO-1: review of an immunogenic tumor antigen. Adv Cancer Res 95: 1-30, 2006.
5. Jager E, Nagata Y, Gnjatic S, Wada H, Stockert E, Karbach J, Dunbar PR, Lee SY, Jungbluth A, Jager D, Arand M, Ritter G, Cerundolo V, Dupont B, Chen YT, Old LJ and Knuth A: Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses. Proc Natl Acad Sci USA 97 : 4760-4765, 2000.
6. + T-cell responses after vaccination with NY-ESO-1 peptide, CpG 7909 and Montanide ISA-51: association with survival. Int J Cancer 126: 909-918, 2010.
7. Old LJ: Cancer vaccines: an overview. Cancer Immun 8 Suppl 1: 1-4, 2008.
8. Banchereau J and Steinman RM: Dendritic cells and the control of immunity. Nature 392: 245-252, 1998.
9. Mellman I and Steinman RM: Dendritic cells: specialized and regulated antigen processing machines. Cell 106: 255-258, 2001.
10. Albert ML, Sauter B and Bhardwaj N: Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392: 86-89, 1998.
11. Liu WM, Dennis JL, Fowler DW and Dalgleish AG: The gene expression profile of unstimulated dendritic cells can be used as a predictor of function. Int J Cancer 130: 979-990, 2011.
12. Kawabata R, Wada H, Isobe M, Saika T, Sato S, Uenaka A, Miyata H, Yasuda T, Doki Y, Noguchi Y, Kumon H, Tsuji K, Iwatsuki K, Shiku H, Ritter G, Murphy R, Hoffman E, Old LJ, Monden M and Nakayama E: Antibody response against NY-ESO- 1 in CHP-NY-ESO-1 vaccinated patients. Int J Cancer 120: 2178-2184, 2007.
13. + T-cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors. Cancer Sci 99: 1008-1015, 2008.
14. Udono H, Saito T, Ogawa M and Yui Y: Hsp-antigen fusion and their use for immunization. Methods 32: 21-24, 2004.
15. Susumu S, Nagata Y, Ito S, Matsuo M, Valmori D, Yui K, Udono H and Kanematsu T: Cross-presentation of NY-ESO-1 cytotoxic T lymphocyte epitope fused to human heat shock cognate protein 70 by dendritic cells. Cancer Sci 99: 107-112, 2008.
16. Udono H, Yamano T, Kawabata Y, Ueda M and Yui K: Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat-shock cognate protein 70. Int Immunol 13 : 1233-1242, 2001.
17. Gnjatic S, Nagata Y, Jager E, Stockert E, Shankara S, Roberts BL, Mazzara GP, Lee SY, Dunbar PR, Dupont B, Cerundolo V, Ritter G, Chen YT, Knuth A and Old LJ: Strategy for monitoring T-cell responses to NY-ESO-1 in patients with any HLA class I allele. Proc Natl Acad Sci USA 97: 10917-10922, 2000.
18. Jager E, Chen YT, Drijfhout JW, Karbach J, Ringhoffer M, Jager D, Arand M, Wada H, Noguchi Y, Stockert E, Old LJ and Knuth A: Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med 187: 265-270, 1998.
19. Freudenthal PS and Steinman RM: The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc Natl Acad Sci USA 87: 7698-7702, 1990.
20. O'Doherty U, Steinman RM, Peng M, Cameron PU, Gezelter S, Kopeloff I, Swiggard WJ, Pope M and Bhardwaj N: Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med 178: 1067-1076, 1993.
21. Chomarat P, Banchereau J, Davoust J and Palucka AK: IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol 1 : 510-514, 2000.
22. + T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses. Proc Natl Acad Sci USA 100: 8862-8867, 2003.
23. Fourie AM, Sambrook JF and Gething MJ: Common and divergent peptide binding specificities of hsp70 molecular chaperones. J Biol Chem 269: 30470-30478, 1994.
24. Srivastava PK, Udono H, Blachere NE and Li Z: Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 39: 93-98, 1994.
25. Suto R and Srivastava PK: A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269 : 1585-1588, 1995.
26. Blachere NE, Li Z, Chandawarkar RY, Suto R, Jaikaria NS, Basu S, Udono H and Srivastava PK: Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med 186: 1315-1322, 1997.
27. Gong J, Zhang Y, Durfee J, Weng D, Liu C, Koido S, Song B, Apostolopoulos V and Calderwood SK: A heat shock protein 70- based vaccine with enhanced immunogenicity for clinical use. J Immunol 184: 488-496, 2010.
28. Ohno S, Takano F, Ohta Y, Kyo S, Myojo S, Dohi S, Sugiyama H, Ohta T and Inoue M: Frequency of myeloid dendritic cells can predict the efficacy of Wilms' tumor 1 peptide vaccination. Anticancer Res 31 : 2447-2452, 2011.
29. Sallusto F and Lanzavecchia A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179: 1109-1118, 1994.
30. Becker S, Warren MK and Haskill S: Colony-stimulating factor-induced monocyte survival and differentiation into macrophages in serum-free cultures. J Immunol 139: 3703-3709, 1987.
31. Hikino H, Kasono K, Kanzaki M, Kai T, Konishi F and Kawakami M: Granulocyte/macrophage colony-stimulating factor and interleukin-4-induced dendritic cells. Anticancer Res 24: 1609-1615, 2004.
32. Shinozaki Y, Wang S, Miyazaki Y, Miyazaki K, Yamada H, Yoshikai Y, Hara H and Yoshida H: Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity. Int J Cancer 124: 1372-1378, 2009.
33. Ekkens MJ, Shedlock DJ, Jung E, Troy A, Pearce EL, Shen H and Pearce EJ: Th1 and Th2 cells help CD8 T-cell responses. Infect Immun 75: 2291-2296, 2007.
34. Rissoan MC, Soumelis V, Kadowaki N, Grouard G, Briere F, de Waal Malefyt R and Liu YJ: Reciprocal control of T helper cell and dendritic cell differentiation. Science 283: 1183-1186, 1999.
35. Sen D, Forrest L, Kepler TB, Parker I and Cahalan MD: Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. Proc Natl Acad Sci USA 107 : 8334-8339, 2010.
36. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, Antonenko S and Liu YJ: The nature of the principal type 1 interferon-producing cells in human blood. Science 284 : 1835-1837, 1999.
37. Lebre MC and Tak PP: Dendritic cell subsets: their roles in rheumatoid arthritis. Acta Reumatol Port 33: 35-45, 2008.
38. Liu YJ: Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106 : 259-262, 2001.
39. Cernadas M, Lu J, Watts G and Brenner MB: CD1a expression defines an interleukin-12 producing population of human dendritic cells. Clin Exp Immunol 155 : 523-533, 2009.
40. Mohamadzadeh M, Berard F, Essert G, Chalouni C, Pulendran B, Davoust J, Bridges G, Palucka AK and Banchereau J: Interleukin 15 skews monocyte differentiation into dendritic cells with features of Langerhans cells. J Exp Med 194: 1013-1020, 2001.
41. Wertel I, Bednarek W, Stachowicz N, Rogala E, Nowicka A and Kotarski J: Phenotype of dendritic cells generated from peripheral blood monocytes of patients with ovarian cancer. Transplant Proc 42 : 3301-3305, 2010.
42. Hildenbrand B, Lorenzen D, Sauer B, Hertkorn C, Freudenberg MA, Peters JH, Nesselhut T, Unger C and Azemar M: IFN-γ enhances T(H)1 polarisation of monocyte-derived dendritic cells matured with clinical-grade cytokines using serum-free conditions. Anticancer Res 28: 1467-1476, 2008.
43. Mitani H, Katayama N, Araki H, Ohishi K, Kobayashi K, Suzuki H, Nishii K, Masuya M, Yasukawa K, Minami N and Shiku H: Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells. Br J Haematol 109 : 288-295, 2000.