Pathway analysis of genome-wide association study on asthma

Human Immunology

Volumn 74, Issue 2, 2013, Pages 256-260

  Song, Gwan Gyu ^a   Lee, Young Ho ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HLA DR ANTIGEN; INTERLEUKIN 13; MEMBRANE RECEPTOR;

ADULT; ALLERGY; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE RESPONSE; EOSINOPHIL; FEMALE; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CODE; HUMAN; IDENTIFY CANDIDATE CAUSAL SINGLE NUCLEOTIDE POLYMORPHISM AND PATHWAY ANALYSIS; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TH1 CELL; TH2 CELL;

ADOLESCENT; ADULT; AGED; ASTHMA; CHILD; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HLA-DR ALPHA-CHAINS; HUMANS; INTERLEUKIN-13; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84872617774     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2012.11.003     Document Type: Article

References (19)

1. Arima M., Fukuda T., Prostaglandin D. T(H)2 inflammation in the pathogenesis of bronchial. Korean J Intern Med 2011, 26:8-18.
2. Li X., Howard T.D., Zheng S.L., Haselkorn T., Peters S.P., Meyers D.A., et al. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/ DQ regions. J Allergy Clin Immunol 2010, 125. 328-335 e311.
3. Johnson A.D., O'Donnell C.J. An open access database of genome-wide association results. BMC Med Genet 2009, 10:6.
4. Lee Y.H., Nath S.K. Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Genet 2005, 118:434-443.
5. Choi S.J., Rho Y.H., Ji J.D., Song G.G., Lee Y.H. Genome scan meta-analysis of rheumatoid arthritis. Rheumatology (Oxford) 2006, 45:166-170.
6. Yaspan BL, Veatch OJ, (2011) Strategies for pathway analysis from GWAS data. Curr Protoc Hum Genet Chapter 1:Unit1.20.
7. Elbers C.C., van Eijk K.R., Franke L., Mulder F., van der Schouw Y.T., Wijmenga C., et al. Using genome-wide pathway analysis to unravel the etiology of complex diseases. Genet Epidemiol 2009, 33:419-431.
8. Zhang K., Chang S., Cui S., Guo L., Zhang L., Wang J. ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res 2011, 39:W437-443.
9. Kanehisa M., Goto S., Furumichi M., Tanabe M., Hirakawa M. KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 2010, 38:D355-360.
10. Ashburner M., Ball C.A., Blake J.A., Botstein D., Butler H., Cherry J.M., et al. Gene ontology: tool for the unification of biology. The gene ontology consortium. Nat Genet 2000, 25:25-29.
11. Johnson A.D., Handsaker R.E., Pulit S.L., Nizzari M.M., O'Donnell C.J., de Bakker P.I. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 2008, 24:2938-2939.
12. Manolio T.A. Genomewide association studies and assessment of the risk of disease. N Engl J Med 2010, 363:166-176.
13. Hong M.G., Pawitan Y., Magnusson P.K., Prince J.A. Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Hum Genet 2009, 126:289-301.
14. Pedroso I, Breen G (2011) Gene set analysis and network analysis for genome-wide association studies. Cold Spring Harb Protoc 2011(9):pdb.top065581.
15. Fridley B.L., Biernacka J.M. Gene set analysis of SNP data: benefits, challenges, and future directions. Eur J Hum Genet 2011, 19:837-843.
16. Wang K., Li M., Bucan M. Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet 2007, 81:1278-1283.
17. Schwiebert L.M., Hughes A., Monos D.S., Ono S.J. HLA-DRA promoter polymorphism and diversity generation within the immune system. Hum Genet 1997, 99:801-805.
18. Brightling C.E., Saha S., Hollins F. Interleukin-13: prospects for new treatments. Clin Exp Allergy 2010, 40:42-49.
19. Konstantinidis A.K., Barton S.J., Sayers I., Yang I.A., Lordan J.L., Rorke S. Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. Eur Respir J 2007, 30:40-47.