Resveratrol prevents global cerebral ischemiainduced decrease in lipid content

Neurological Research

Volumn 35, Issue 1, 2013, Pages 59-64

  Simão, Fabrício ^a   Matté, Aline ^a   Breier, Ana Carolina ^a   Kreutz, Fernando ^a   Trindade, Vera Maria Treis ^a   Netto, Carlos Alexandre ^a   Salbego, Christianne G ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cerebral ischemia; Cholesterol; Gangliosides; Phospholipids; Resveratrol

Indexed keywords

CHOLESTEROL; GANGLIOSIDE; PHOSPHOLIPID; RESVERATROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; HIPPOCAMPUS; LIPID COMPOSITION; LIPID METABOLISM; MALE; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; CHOLESTEROL; CHROMATOGRAPHY, THIN LAYER; DISEASE MODELS, ANIMAL; GANGLIOSIDOSES; LIPID METABOLISM DISORDERS; MALE; PHOSPHOLIPIDS; RATS; RATS, WISTAR; STILBENES;

EID: 84872570346     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132812Y.0000000116     Document Type: Article

References (29)

1. Agranoff BW, Hajra AH. Lipids. In: Siegel GJ, Agranoff BW, Albers RW, Molinoff PB, editors. Basic neurochemistry. New York: Raven Press; 1994. p. 97-116.
2. Yu RK, Nakatani Y, Yanagisawa M. The role of glycosphingolipid metabolism in the developing brain. J Lipid Res. 2009;50:440-5.
3. Ohvo-Rekilä H, Ramstedt B, Leppimäki P, Slotte JP. Cholesterol interactions with phospholipids in membranes. Prog Lipid Res. 2002;41:66-97.
4. Korade Z, Kenworthy AK. Lipid rafts, cholesterol, and the brain. Neuropharmacology. 2008;55:1265-73.
5. Ramirez MR, Muraro F, Zylbersztejn DS, Abel CR, Arteni NS, Lavinsky D, et al. Neonatal hypoxia-ischemia reduces ganglioside, phospholipid and cholesterol contents in the rat hippocampus. Neurosci Res. 2003;46:339-47.
6. Trindade VMT, Perry ML, Bernard EA. Gangliosides and sialoproteins in hypothalamus of normal, postnatal, and pre- andpostnatal protein undernourished rats. J Neurol Sci. 1992;107:93-7.
7. Stefanello FM, Kreutz F, Scherer EB, Breier AC, Vianna LP, Trindade VM, et al. Reduction of gangliosides, phospholipids and cholesterol content in cerebral cortex of rats caused by chronic hypermethioninemia. Int J Dev Neurosci. 2007;25:473-7.
8. Wenk MR. The emerging field of lipidomics. Nat Rev Drug Discov. 2005;4:594-610.
9. Harukuni I, Bhardwaj A. Mechanisms of brain injury after global cerebral ischemia. Neurol Clin. 2006;24:1-21.
10. de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005;49:405-30.
11. +, -ATPase activity induced by transient global cerebral ischemia in rats. J Nutr Biochem. 2011;22:921-8.
12. Simão F, Pagnussat AS, Seo JH, Navaratna D, Leung W, Lok J, et al. Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases. J Cereb Blood Flow Metab. 2012;32:884-95.
13. Simão F, Matté A, Pagnussat AS, Netto CA, Salbego CG. Resveratrol preconditioning modulates inflammatory response in the rat hippocampus following global cerebral ischemia. Neurochem Int. 2012;61:659-65.
14. Simão F, Matté A, Pagnussat AS, Netto CA, Salbego CG. Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways. Eur J Neurosci. 2012;36:2899-905.
15. Colin D, Limagne E, Jeanningros S, Jacquel A, Lizard G, Athias A, et al. Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells. Cancer Prev Res (Phila). 2011;4:1095-106.
16. Jannin B, Menzel M, Berlot JP, Delmas D, Lançon A, Latruffe N. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochem Pharmacol. 2004;68:1113-8.
17. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497-509.
18. Skoza L, Mohos S. Stable thiobarbituric acid chromophore with dimethyl sulphoxide. Application to sialic acid assay in analytical de-O-acetylation. Biochem J. 1976;159:457-62.
19. Nores GA, Mitzumari RK, Kremer DM. Chromatographic tank designed to obtain highly reproducible high-performance thin-layer chromatograms of gangliosides and neutral glycosphingolipds. J Chromatogr A. 1994;686:155-7.
20. Bergmeyer A. Cholesterol and esterified cholesterol. In: Bergmeyer HU, editor. Methods of enzymatic analysis, Vol. 4, ed. Weinheim: Verlag Chemie; 1954. p. 1890-3.
21. Feng L, Prestwich GD. Functional lipidomics. Boca Raton, FL: CRC Press/Taylor and Francis Group; 2006.
22. Edgar AD, Stroznajder J, Horrocks LA. Activation of ethanolamine phospholipase A2 in brain during ischemia. J Neurochem. 1982;39:1111-6.
23. +- ATPase. In: Glynn I, Ellory C, editors. The sodium pump. Cambridge: The Company of Biologists Ltd; 1985. p. 73-6.
24. Lehotsky J, Kaplan P, Matejovicova M, Murin R, Racay P, Raeymaekers L. Ion transport systems as targets of free radicals during ischemia reperfusion injury. Gen Physiol Biophys. 2002;21:31-7.
25. Molander-Melin M, Blennow K, Bogdanovic N, Dellheden B, Mansson JE, Fredman P. Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergentresistant membrane domains. J Neurochem. 2005;92:171-82.
26. + -ATPase, thick ascending limb. Am J Physiol Regul Integr Comp Physiol. 2007;292:1328-37.
27. Avrova NF, Victorov IV, Tyurin VA, Zakharova IO, Sokolova TV, Andreeva NA, et al. Inhibition of glutamate-induced intensification of free radical reactions by gangliosides: possible role in their protective effect in rat cerebellar granule cells and brain synaptosomes. Neurochem Res. 1998;23:945-52.
28. Tyurina YY, Tyurin VA, Avrova NF. Ganglioside GM1 protects cAMP 3-, 5-phosphodiesterase from inactivation caused by lipid-peroxidation in brain synaptosomes of rats. Mol Chem Neuropathol. 1993;19:205-17.
29. Phillis JW, O'Regan MH. GM1 ganglioside inhibits ischemic release of amino acid neurotransmitters from rat cortex. Neuroreport. 1995;6:2010-2.