Influence of bear bile on rat hepatocarcinoma induced by diethylnitrosamine

Yaoxue Xuebao

Volumn 47, Issue 11, 2012, Pages 1483-1488

  Zhou, Jian Yin ^a,b   Yin, Zhen Yu ^a,b   Wang, Sheng Yu ^a   Yan, Jiang Hua ^a   Zhao, Yi Lin ^a,b   Wu, Duan ^a,b   Liu, Zheng Jin ^a   Zhang, Sheng ^a,b   Wang, Xiao Min ^a,b  

^a XIAMEN UNIVERSITY   (China)

^b Digestive Disease Center of Xiamen City   (China)

Author keywords

Bear bile; Diethylnitrosamine hepatocarcinoma

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BEAR BILE POWDER; BILIRUBIN; CYCLINE; DIETHYLNITROSAMINE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; NONHUMAN; RAT;

ACTINS; ALANINE TRANSAMINASE; ANIMALS; ANTINEOPLASTIC AGENTS; ASPARTATE AMINOTRANSFERASES; BILE; BILIRUBIN; BODY WEIGHT; CARCINOMA, HEPATOCELLULAR; DIETHYLNITROSAMINE; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; POWDERS; PROLIFERATING CELL NUCLEAR ANTIGEN; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; URSIDAE;

EID: 84872531657     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Sun HF, Hou HL, Lu P, et al. Isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis[J]. PLoS One, 2012, 7: e36808. doi: 10.1371/joumal.pone.0036808.
2. Ling J, Wang X. The synergistic antitumor effects of berberine α-hydroxy-β-decanoylethyl sulfonate with hydroxycamptothecine and its effect on topoisomerase [J]. Acta Pharm Sin 2012, 46: 390-394.
3. Huang XY, Wang L, Huang ZL, et al. Herbal compound extract 'Songyou Yin' inhibits tumor growth and prolongs survival in nude mice bearing human hepatocellular carcinoma xenograft with high metastatic potential [J]. J Cancer Res Clin Oncol, 2009, 135: 1245-1255.
4. Jin Y, Moon YS, Choi IJ, et al. Effects of bears bile on the expression of tumor cell p53 protein [J]. Chin J lntegr Tradit West Med 2006, 26: 86-88.
5. Kang JH, Zhang WQ, Song W, et al. Apoptosis mechanism of human cholangiocarcinoma cells induced by bile extract from crocodile [J]. AppI Biochem Biotechnol, 2012, 166: 942-951.
6. Alberts DS, Martinez ME, Hess LM, et al. Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence [J]. J Nat Cancer lnst, 2005, 97: 846-853.
7. Choi YH, Im EO, Suh H, et al. Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells [J]. Cancer Lett, 2003; 199: 157-167.
8. Zhou CS, Yin ZY, Zhao WX, et al. Study of bear bile on immunologic feature of hepatic stellate cells in vivo [J]. China J Tradit Chin Med Pharm 2011, 26: 2251-2254.
9. Luo YQ, Wu MC, Chen H, et al. Gene expression of HGF and its receptor in experimental hepatomas [J]. NatI Med J China, 1996, 76: 822-825.
10. Yang M, Chen Q. Expression and significances of resistance protein P-gp and Topo-II in B cell non-hodgkin lymphoma [J]. China Pharm, 2012, 23: 1684-1687.
11. Zhang ZM, Wang Q Chen C, et al. Pathologic and morphologic study on modified DEN-induced hepatocarcinoma model in rats [J]. Acta Acad Med Mu Tert 2007, 29: 1164-1167.
12. Feng Y, Siu K, Wang N, et al. Bear bile: dilemma of traditional medicinal use and animal protection [J]. J Ethnobio Ethnomed, 2009, 5: 2.
13. Park Y, chae KJ, KimYB, et al. Apoptosis and proliferation in hepatocarcinogenesis related to cirrhoisis [J]. Cancer, 2001, 92: 2733-2738.
14. Bian W, Mu HL, Liu SG et al. The expression and significance of proliferating cell nuclear antigen in cholangioncarcinom [J]. Chin J Exp Sur 2010, 7: 873-875.
15. Shen U, Zhang HX, Zhang ZJ, et al. Detection of HBV, PCNA and GST-pi in hepatocellular carcinoma and chronic liver diseases [J]. World J Gastroenterol, 2003, 9: 459-462.
16. Zheng MH, Tian XD, Li H, et al. Expression of PCNA and the count of AgNOR in squamous cell carcinoma of larynx and hypopharynx [J]. J Clin Otorhinolaryngol 2002, 16: 653-655.
17. Ping J, Gao AM, Xu D. Therapeutic effect of indole-3-carbinol on pigserum-induced hepatic fibrosis in rats [J]. Acta Pharm Sin 2011, 46: 915-921.
18. Amann T, Bataille F, Spruss T, et al. Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma [J]. Cancer Sci, 2009, 100: 646-653.
19. Knolle PA, Gerken G. Local control of the immune response in the liver [J]. Immunol Rev, 2000, 174: 21-34.