Lessons from epidemiologic research about risk factors, modifiers, and progression of late onset Alzheimer's disease in New York City at Columbia University Medical Center

Journal of Alzheimer's Disease

Volumn 33, Issue SUPPL. 1, 2013, Pages

  Devanand, Devangere ^a,b   Lee, Joseph ^a,c,d   Luchsinger, Jose ^a,d   Manly, Jennifer ^a,c   Marder, Karen ^a   Mayeux, Richard ^a,c,d   Scarmeas, Nikolaos ^a,c   Schupf, Nicole ^a,c,d   Stern, Yaakov ^a,c  

^a New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Department of Epidemiology   (United States)

^d Mailman School of Public Health   (United States)

Author keywords

Alzheimer's disease; cognitive reserve; conversion; diet; epidemiology; genes; mild cognitive impairment; predictors; progression; risk factors

Indexed keywords

PROTEIN; SORL1 PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; CONCEPTUAL FRAMEWORK; DEMENTIA; DISEASE COURSE; FOOD INTAKE; HEREDITY; HUMAN; MEDITERRANEAN DIET; MILD COGNITIVE IMPAIRMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL ACTIVITY; PREDICTOR VARIABLE; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

EID: 84872519264     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-129041     Document Type: Review

References (21)

1. Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA (2006) Mediterranean diet and risk for Alzheimer's disease. Ann Neurol 59, 912-921
2. Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA (2009) Mediterranean diet and mild cognitive impairment. Arch Neurol 66, 216-225
3. Scarmeas N, Stern Y, Mayeux R, Luchsinger JA (2006) Mediterranean diet, Alzheimer disease, and vascular mediation. Arch Neurol 63, 1709-1717
4. Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, Stern Y (2009) Physical activity, diet, and risk of Alzheimer disease. JAMA 302, 627-637
5. Scarmeas N, Albert SM, Manly JJ, Stern Y (2006) Education and rates of cognitive decline in incident Alzheimer's disease. J Neurol Neurosurg Psychiatry 77, 308-316
6. Helzner EP, Luchsinger JA, Scarmeas N, Cosentino S, Brickman AM, Glymour MM, Stern Y (2009) Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol 66, 343-348
7. Tabert MH,Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, Zamora D, Goodkind M, Bell K, Stern Y, Devanand DP (2006) Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Arch Gen Psychiatry 63, 916-924
8. Stern Y (2006) Cognitive reserve and Alzheimer disease. Alzheimer Dis Assoc Disord 20, S69-S74
9. Devanand DP, Pradhaban G, Liu X, Khandji A, De Santi S, Segal S, Rusinek H, Pelton GH, Honig LS, Mayeux R, Stern Y, Tabert MH, de Leon MJ (2007) Hippocampal and entorhinal atrophy in mild cognitive impairment: Prediction of Alzheimer disease. Neurology 68, 828-836
10. Lee JH, Cheng R, Schupf N, Manly J, Lantigua R, Stern Y, Rogaeva E, Wakutani Y, Farrer L, St George-Hyslop P, Mayeux R (2007) The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch Neurol 64, 501-506
11. Amatniek JC, Hauser WA, DelCastillo-Castaneda C, Jacobs DM, Marder K, Bell K, Albert M, Brandt J, Stern Y (2006) Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia 47, 867-872
12. Scarmeas N, Luchsinger JA, Mayeux R, Stern Y (2007) Mediterranean diet and Alzheimer disease mortality. Neurology 69, 1084-1093
13. Tang M-X, Maestre G, Tsai W-Y (1996) Relative risk of Alzheimer's disease and age-At-onset base of APOE genotypes among elderly among elderly African Americans, Caucasians and Hispanics in NewYork City. Am J Hum Genet 58, 554-574
14. Reitz C, Tang MX, Schupf N, Manly JJ, Mayeux R, Luchsinger JA (2010) Association of higher levels of highdensity lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease. Arch Neurol 67, 1491-1497
15. Scarmeas N, Luchsinger JA, Stern Y, Gu Y, He J, Decarli C, Brown T, Brickman AM (2011) Mediterranean diet and magnetic resonance imaging-Assessed cerebrovascular disease. Ann Neurol 69, 257-268
16. - (2010) NIH Consensus Development Conference Statement on Preventing Alzheimer's Disease and Cognitive Decline. NIH Consensus and State-of-The-Art Statements, 27, http://consensus.nih.gov/2010/docs/alz/ALZ Final Statement. pdf
17. Lee JH, Cheng R, Honig LS, Vonsattel JP, Clark L, Mayeux R (2008) Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease. Neurology 70, 887-889
18. Meng Y, Lee JH, Cheng R, St George-Hyslop P, Mayeux R, Farrer LA (2007) Association between SORL1 and Alzheimer's disease in a genome-wide study. Neuroreport 18, 1761-1764
19. Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, Riemenschneider M, Owen M, Harold D, Hollingworth P, Cellini E, Sorbi S, Nacmias B, Takeda M, Pericak-Vance MA, Haines JL, Younkin S, Williams J, van Broeckhoven C, Farrer LA, St George-Hyslop PH, Mayeux R (2011) Meta-Analysis of the association between variants in SORL1 and Alzheimer disease. Arch Neurol 68, 99-106
20. Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C,WakutaniY, Cupples LA, CuencoKT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P (2007) The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39, 168-177
21. Lee JH, Shibata N, Cheng R, Mayeux R (2008) Possible association between SORL1 and Alzheimer disease? Reanalysing the data of Shibata et al. Dement Geriatr Cogn Disord 26, 482