메뉴 건너뛰기




Volumn 48, Issue 1, 2013, Pages 1-12

Treatment of chronic hepatitis C virus infection in Japan: Update on therapy and guidelines

Author keywords

Anemia; Antiviral resistance; Dose reduction; Telaprevir; Triple therapy

Indexed keywords

ANTIVIRUS AGENT; ASUNAPREVIR; DACLATASVIR; GS 9256; MK 0608; MP 424; PEGINTERFERON; PLACEBO; RIBAVIRIN; TEGOBUVIR; TELAPREVIR; UNCLASSIFIED DRUG;

EID: 84872500351     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0714-9     Document Type: Review
Times cited : (39)

References (55)
  • 1
    • 0028131241 scopus 로고
    • Genetic heterogeneity of hepatitis C virus
    • 7814244 1:STN:280:DyaK2M7htlKktg%3D%3D
    • Okamoto H, Mishiro S. Genetic heterogeneity of hepatitis C virus. Intervirology. 1994;37:68-76.
    • (1994) Intervirology , vol.37 , pp. 68-76
    • Okamoto, H.1    Mishiro, S.2
  • 2
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis C
    • 19207969 10.1111/j.1478-3231.2008.01934.x
    • Lavanchy D. The global burden of hepatitis C. Liver Int. 2009;29(Suppl 1):74-81.
    • (2009) Liver Int , vol.29 , Issue.SUPPL. 1 , pp. 74-81
    • Lavanchy, D.1
  • 3
    • 0037387851 scopus 로고    scopus 로고
    • Projecting future complications of chronic hepatitis C in the United States
    • 12682882 10.1053/jlts.2003.50073
    • Davis GL, Albright JE, Cook SF, Rosenberg DM. Projecting future complications of chronic hepatitis C in the United States. Liver Transpl. 2003;9:331-8.
    • (2003) Liver Transpl , vol.9 , pp. 331-338
    • Davis, G.L.1    Albright, J.E.2    Cook, S.F.3    Rosenberg, D.M.4
  • 4
    • 0028898609 scopus 로고
    • Epidemiology of hepatitis C in the West
    • 7597444 10.1055/s-2007-1007259 1:STN:280:DyaK2MzitVKjsg%3D%3D
    • Alter MJ. Epidemiology of hepatitis C in the West. Semin Liver Dis. 1995;15:5-14.
    • (1995) Semin Liver Dis , vol.15 , pp. 5-14
    • Alter, M.J.1
  • 5
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • 16122679 10.1016/S1473-3099(05)70216-4
    • Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;5:558-67.
    • (2005) Lancet Infect Dis , vol.5 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 6
    • 0036828783 scopus 로고    scopus 로고
    • Course and outcome of hepatitis C
    • 12407573 10.1002/hep.1840360704
    • Hoofnagle JH. Course and outcome of hepatitis C. Hepatology. 2002;36:S21-9.
    • (2002) Hepatology , vol.36
    • Hoofnagle, J.H.1
  • 7
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • 12407575 10.1002/hep.1840360706
    • Seeff LB. Natural history of chronic hepatitis C. Hepatology. 2002;36:S35-46.
    • (2002) Hepatology , vol.36
    • Seeff, L.B.1
  • 8
    • 78650766355 scopus 로고    scopus 로고
    • Hepatitis C virus: How genetic variability affects pathobiology of disease
    • 21199518 10.1111/j.1440-1746.2010.06550.x 1:CAS:528:DC%2BC3MXhslOkt74%3D
    • Chayama K, Hayes CN. Hepatitis C virus: how genetic variability affects pathobiology of disease. J Gastroenterol Hepatol. 2011;26:83-95.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 83-95
    • Chayama, K.1    Hayes, C.N.2
  • 9
    • 77954368880 scopus 로고    scopus 로고
    • Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan
    • 20156296 10.1111/j.1872-034X.2009.00634.x
    • Kumada H, Okanoue T, Onji M, et al. Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan. Hepatol Res. 2010;40:8-13.
    • (2010) Hepatol Res , vol.40 , pp. 8-13
    • Kumada, H.1    Okanoue, T.2    Onji, M.3
  • 10
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose
    • 14996676 1:CAS:528:DC%2BD2cXitlOktrg%3D
    • Hadziyannis SJ, Sette H Jr, Morgan TR, et al. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med. 2004;140:346-55.
    • (2004) Ann Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Sette, Jr.H.2    Morgan, T.R.3
  • 11
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • 11583749 10.1016/S0140-6736(01)06102-5 1:CAS:528:DC%2BD3MXntF2qtb8%3D
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358:958-65.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 12
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • 12324553 10.1056/NEJMoa020047 1:CAS:528:DC%2BD38Xnt12rtb0%3D
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 2002;347:975-82.
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 13
    • 84871817621 scopus 로고    scopus 로고
    • The relative efficacy of boceprevir and telaprevir in the treatment of HCV Genotype 1
    • doi: 10.1093/cid/cis880
    • Schmitz S, O'Leary A, Walsh C, Bergin C, Norris S. The relative efficacy of boceprevir and telaprevir in the treatment of HCV Genotype 1. Clin Infect Dis. 2012. doi: 10.1093/cid/cis880
    • (2012) Clin Infect Dis.
    • Schmitz, S.1    O'Leary, A.2    Walsh, C.3    Bergin, C.4    Norris, S.5
  • 14
    • 33644636312 scopus 로고    scopus 로고
    • Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease
    • 16495249 10.1128/AAC.50.3.899-909.2006 1:CAS:528:DC%2BD28XisFamt70%3D
    • Perni RB, Almquist SJ, Byrn RA, et al. Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease. Antimicrob Agents Chemother. 2006;50:899-909.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 899-909
    • Perni, R.B.1    Almquist, S.J.2    Byrn, R.A.3
  • 15
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • 12702807 10.1126/science.1082604 1:CAS:528:DC%2BD3sXjslGqtro%3D
    • Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science. 2003;300:1145-8.
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3
  • 16
    • 33749360242 scopus 로고    scopus 로고
    • Rapid decline of viral RNA in hepatitis C patients treated with VX-950: A phase Ib, placebo-controlled, randomized study
    • 17030169 10.1053/j.gastro.2006.07.013 1:CAS:528:DC%2BD28XhtFyru7fM
    • Reesink HW, Zeuzem S, Weegink CJ, et al. Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study. Gastroenterology. 2006;131:997-1002.
    • (2006) Gastroenterology , vol.131 , pp. 997-1002
    • Reesink, H.W.1    Zeuzem, S.2    Weegink, C.J.3
  • 17
    • 34247594930 scopus 로고    scopus 로고
    • Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    • 17484874 10.1053/j.gastro.2007.02.037 1:CAS:528:DC%2BD2sXmsVyms7s%3D
    • Sarrazin C, Kieffer TL, Bartels D, et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology. 2007;132:1767-77.
    • (2007) Gastroenterology , vol.132 , pp. 1767-1777
    • Sarrazin, C.1    Kieffer, T.L.2    Bartels, D.3
  • 18
    • 80052035379 scopus 로고    scopus 로고
    • Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo
    • 21626527 10.1002/hep.24460 1:CAS:528:DC%2BC3MXhtVOktrbO
    • Hiraga N, Imamura M, Abe H, et al. Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo. Hepatology. 2011;54:781-8.
    • (2011) Hepatology , vol.54 , pp. 781-788
    • Hiraga, N.1    Imamura, M.2    Abe, H.3
  • 19
    • 79960328806 scopus 로고    scopus 로고
    • Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients
    • 21556829 10.1007/s00535-011-0411-0 1:CAS:528:DC%2BC3MXoslWis7c%3D
    • Ozeki I, Akaike J, Karino Y, et al. Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients. J Gastroenterol. 2011;46:929-37.
    • (2011) J Gastroenterol , vol.46 , pp. 929-937
    • Ozeki, I.1    Akaike, J.2    Karino, Y.3
  • 20
    • 65449152185 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    • 19403902 10.1056/NEJMoa0806104 1:CAS:528:DC%2BD1MXlsVGmtrc%3D
    • McHutchison JG, Everson GT, Gordon SC, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med. 2009;360:1827-38.
    • (2009) N Engl J Med , vol.360 , pp. 1827-1838
    • McHutchison, J.G.1    Everson, G.T.2    Gordon, S.C.3
  • 21
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • 19403903 10.1056/NEJMoa0807650 1:CAS:528:DC%2BD1MXlsVSlurg%3D
    • Hezode C, Forestier N, Dusheiko G, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med. 2009;360:1839-50.
    • (2009) N Engl J Med , vol.360 , pp. 1839-1850
    • Hezode, C.1    Forestier, N.2    Dusheiko, G.3
  • 22
    • 77950817619 scopus 로고    scopus 로고
    • Telaprevir for previously treated chronic HCV infection
    • 20375406 10.1056/NEJMoa0908014 1:CAS:528:DC%2BC3cXksVyntrg%3D
    • McHutchison JG, Manns MP, Muir AJ, et al. Telaprevir for previously treated chronic HCV infection. N Engl J Med. 2010;362:1292-303.
    • (2010) N Engl J Med , vol.362 , pp. 1292-1303
    • McHutchison, J.G.1    Manns, M.P.2    Muir, A.J.3
  • 23
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • 21696307 10.1056/NEJMoa1012912 1:CAS:528:DC%2BC3MXotVCku7Y%3D
    • Jacobson IM, McHutchison JG, Dusheiko G, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med. 2011;364:2405-16.
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 24
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • 21696308 10.1056/NEJMoa1013086 1:CAS:528:DC%2BC3MXotVCrsrg%3D
    • Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. New Engl J Med. 2011;364:2417-28.
    • (2011) New Engl J Med , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 25
    • 84857368831 scopus 로고    scopus 로고
    • UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patients
    • 22296568 10.1111/j.1365-2036.2012.04992.x 1:CAS:528:DC%2BC38XlsVWis7o%3D
    • Ramachandran P, Fraser A, Agarwal K, et al. UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patients. Aliment Pharmacol Ther. 2012;35:647-62.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 647-662
    • Ramachandran, P.1    Fraser, A.2    Agarwal, K.3
  • 26
    • 79957963815 scopus 로고    scopus 로고
    • IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C
    • 21628662 10.1093/infdis/jir210 1:CAS:528:DC%2BC3MXntF2gt7k%3D
    • Chayama K, Hayes CN, Abe H, et al. IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C. J Infect Dis. 2011;204:84-93.
    • (2011) J Infect Dis , vol.204 , pp. 84-93
    • Chayama, K.1    Hayes, C.N.2    Abe, H.3
  • 27
    • 84874467035 scopus 로고    scopus 로고
    • Response guided telaprevir therapy in prior relapsers?: The role of bridging data from treatment-naive and experienced subjects
    • doi: 10.1002/hep.25764
    • Liu J, Jadhav PR, Amur S, et al. Response guided telaprevir therapy in prior relapsers?: the role of bridging data from treatment-naive and experienced subjects. Hepatol. 2012. doi: 10.1002/hep.25764
    • (2012) Hepatol.
    • Liu, J.1    Jadhav, P.R.2    Amur, S.3
  • 28
    • 83555163652 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan
    • 21827730 10.1016/j.jhep.2011.07.016 1:CAS:528:DC%2BC3MXhs1GhsbbM
    • Kumada H, Toyota J, Okanoue T, Chayama K, Tsubouchi H, Hayashi N. Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan. J Hepatol. 2012;56:78-84.
    • (2012) J Hepatol , vol.56 , pp. 78-84
    • Kumada, H.1    Toyota, J.2    Okanoue, T.3    Chayama, K.4    Tsubouchi, H.5    Hayashi, N.6
  • 29
    • 78649892926 scopus 로고    scopus 로고
    • Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C
    • 21040273 10.1111/j.1872-034X.2010.00726.x 1:CAS:528:DC%2BC3MXhtFOru7k%3D
    • Chayama K, Hayes CN, Yoshioka K, et al. Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C. Hepatol Res. 2010;40:1155-67.
    • (2010) Hepatol Res , vol.40 , pp. 1155-1167
    • Chayama, K.1    Hayes, C.N.2    Yoshioka, K.3
  • 30
    • 24944439884 scopus 로고    scopus 로고
    • National prevention of hepatocellular carcinoma in Japan based on epidemiology of hepatitis C virus infection in the general population
    • 16166783 10.1159/000087257
    • Yoshizawa H, Tanaka J, Miyakawa Y. National prevention of hepatocellular carcinoma in Japan based on epidemiology of hepatitis C virus infection in the general population. Intervirology. 2006;49:7-17.
    • (2006) Intervirology , vol.49 , pp. 7-17
    • Yoshizawa, H.1    Tanaka, J.2    Miyakawa, Y.3
  • 31
    • 84855860896 scopus 로고    scopus 로고
    • Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C
    • 22239511 10.1111/j.1365-2893.2011.01528.x 1:STN:280: DC%2BC383jtlymtg%3D%3D
    • Hayashi N, Okanoue T, Tsubouchi H, Toyota J, Chayama K, Kumada H. Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C. J Viral Hepat. 2012;19:e134-42.
    • (2012) J Viral Hepat , vol.19
    • Hayashi, N.1    Okanoue, T.2    Tsubouchi, H.3    Toyota, J.4    Chayama, K.5    Kumada, H.6
  • 32
    • 84855829643 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and resistant variants of telaprevir alone for 12 weeks in hepatitis C virus genotype 1b infection
    • 22239508 10.1111/j.1365-2893.2011.01514.x 1:STN:280: DC%2BC387ktFaktQ%3D%3D
    • Yamada I, Suzuki F, Kamiya N, et al. Safety, pharmacokinetics and resistant variants of telaprevir alone for 12 weeks in hepatitis C virus genotype 1b infection. J Viral Hepat. 2012;19:e112-9.
    • (2012) J Viral Hepat , vol.19
    • Yamada, I.1    Suzuki, F.2    Kamiya, N.3
  • 33
    • 84873448620 scopus 로고    scopus 로고
    • Virological response and safety of 24-week telaprevir alone in Japanese patients infected with hepatitis C virus subtype 1b
    • Toyota J, Ozeki I, Karino Y, et al. Virological response and safety of 24-week telaprevir alone in Japanese patients infected with hepatitis C virus subtype 1b. J Viral Hepat. 2012.
    • (2012) J Viral Hepat
    • Toyota, J.1    Ozeki, I.2    Karino, Y.3
  • 34
    • 67349254235 scopus 로고    scopus 로고
    • Poor response to pegylated interferon and ribavirin in older women infected with hepatitis C virus of genotype 1b in high viral loads
    • 18958621 10.1007/s10620-008-0500-y 1:CAS:528:DC%2BD1MXlsFKrtLY%3D
    • Sezaki H, Suzuki F, Kawamura Y, et al. Poor response to pegylated interferon and ribavirin in older women infected with hepatitis C virus of genotype 1b in high viral loads. Dig Dis Sci. 2009;54:1317-24.
    • (2009) Dig Dis Sci , vol.54 , pp. 1317-1324
    • Sezaki, H.1    Suzuki, F.2    Kawamura, Y.3
  • 35
    • 79958830099 scopus 로고    scopus 로고
    • Hepatitis C virus resistance to protease inhibitors
    • 21284949 10.1016/j.jhep.2011.01.011 1:CAS:528:DC%2BC3MXnslehtL0%3D
    • Halfon P, Locarnini S. Hepatitis C virus resistance to protease inhibitors. J Hepatol. 2011;55:192-206.
    • (2011) J Hepatol , vol.55 , pp. 192-206
    • Halfon, P.1    Locarnini, S.2
  • 36
    • 34548758435 scopus 로고    scopus 로고
    • Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
    • 17680654 10.1002/hep.21781 1:CAS:528:DC%2BD2sXhtFWhsr%2FL
    • Kieffer TL, Sarrazin C, Miller JS, et al. Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology. 2007;46:631-9.
    • (2007) Hepatology , vol.46 , pp. 631-639
    • Kieffer, T.L.1    Sarrazin, C.2    Miller, J.S.3
  • 37
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients
    • 19026009 10.1002/hep.22549
    • Kuntzen T, Timm J, Berical A, et al. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients. Hepatology. 2008;48:1769-78.
    • (2008) Hepatology , vol.48 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3
  • 38
    • 30044432484 scopus 로고    scopus 로고
    • American Gastroenterological Association technical review on the management of hepatitis C
    • (quiz 214-7)
    • Dienstag JL, McHutchison JG. American Gastroenterological Association technical review on the management of hepatitis C. Gastroenterology. 2006;130:231-64 (quiz 214-7).
    • (2006) Gastroenterology , vol.130 , pp. 231-264
    • Dienstag, J.L.1    McHutchison, J.G.2
  • 39
    • 33846593397 scopus 로고    scopus 로고
    • Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: Amino acid substitutions in the core region and low-density lipoprotein cholesterol levels
    • 17126448 10.1016/j.jhep.2006.09.019 1:CAS:528:DC%2BD2sXhtlCmtLs%3D
    • Akuta N, Suzuki F, Kawamura Y, et al. Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: amino acid substitutions in the core region and low-density lipoprotein cholesterol levels. J Hepatol. 2007;46:403-10.
    • (2007) J Hepatol , vol.46 , pp. 403-410
    • Akuta, N.1    Suzuki, F.2    Kawamura, Y.3
  • 40
    • 15744381704 scopus 로고    scopus 로고
    • Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients
    • 15765399 10.1053/j.gastro.2004.12.049
    • Romero-Gómez M, Del Mar Viloria M, Andrade R, et al. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology. 2005;128:636-41.
    • (2005) Gastroenterology , vol.128 , pp. 636-641
    • Romero-Gómez, M.1    Del Mar Viloria, M.2    Andrade, R.3
  • 41
    • 0029908438 scopus 로고    scopus 로고
    • Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histology
    • 8903367 10.1002/hep.510240505 1:STN:280:DyaK2s%2FmtVegsA%3D%3D
    • Zeuzem S, Franke A, Lee JH, Herrmann G, Ruster B, Roth WK. Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histology. Hepatology. 1996;24:1003-9.
    • (1996) Hepatology , vol.24 , pp. 1003-1009
    • Zeuzem, S.1    Franke, A.2    Lee, J.H.3    Herrmann, G.4    Ruster, B.5    Roth, W.K.6
  • 42
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • 19684573 10.1038/nature08309 1:CAS:528:DC%2BD1MXpvFCrtbw%3D
    • Ge DL, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009;461:399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.L.1    Fellay, J.2    Thompson, A.J.3
  • 43
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet. 2009; 41:1100-4.
    • (2009) Nat Genet. , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 44
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • 19759533 10.1038/nature08463 1:CAS:528:DC%2BD1MXhtFentb%2FJ
    • Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461:798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3
  • 45
    • 22344457187 scopus 로고    scopus 로고
    • Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy
    • 16024941 10.1159/000086064 1:CAS:528:DC%2BD2MXmt1Gntbs%3D
    • Akuta N, Suzuki F, Sezaki H, et al. Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy. Intervirology. 2005;48:372-80.
    • (2005) Intervirology , vol.48 , pp. 372-380
    • Akuta, N.1    Suzuki, F.2    Sezaki, H.3
  • 46
    • 0029161576 scopus 로고
    • Comparison of full-length sequences of interferon-sensitive and resistant hepatitis-C virus 1b - Sensitivity to interferon is conferred by amino-acid substitutions in the NS5A region
    • 7542279 10.1172/JCI118025 1:CAS:528:DyaK2MXmslyqsro%3D
    • Enomoto N, Sakuma I, Asahina Y, et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis-C virus 1b - sensitivity to interferon is conferred by amino-acid substitutions in the NS5A region. J Clin Invest. 1995;96:224-30.
    • (1995) J Clin Invest , vol.96 , pp. 224-230
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3
  • 47
    • 84860997721 scopus 로고    scopus 로고
    • Determinants of response to triple therapy of telaprevir, peginterferon, and ribavirin in previous non-responders infected with HCV genotype 1
    • 22585728 10.1002/jmv.23262 1:CAS:528:DC%2BC38XmvFegurs%3D
    • Akuta N, Suzuki F, Seko Y, et al. Determinants of response to triple therapy of telaprevir, peginterferon, and ribavirin in previous non-responders infected with HCV genotype 1. J Med Virol. 2012;84:1097-105.
    • (2012) J Med Virol , vol.84 , pp. 1097-1105
    • Akuta, N.1    Suzuki, F.2    Seko, Y.3
  • 48
    • 84855245619 scopus 로고    scopus 로고
    • Phase III results in genotype 1 naive patients: Predictors of response with boceprevir and telaprevir combined with pegylated interferon and ribavirin
    • 22212570 10.1111/j.1478-3231.2011.02709.x 1:CAS:528:DC%2BC38XjtFKhsbw%3D
    • Kwo PY. Phase III results in genotype 1 naive patients: predictors of response with boceprevir and telaprevir combined with pegylated interferon and ribavirin. Liver Int. 2012;32(Suppl 1):39-43.
    • (2012) Liver Int , vol.32 , Issue.SUPPL. 1 , pp. 39-43
    • Kwo, P.Y.1
  • 49
    • 80755159054 scopus 로고    scopus 로고
    • Discovery and development of telaprevir: An NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus
    • 22068541 10.1038/nbt.2020 1:CAS:528:DC%2BC3MXhsVCntLvJ
    • Kwong AD, Kauffman RS, Hurter P, Mueller P. Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus. Nat Biotechnol. 2011;29:993-1003.
    • (2011) Nat Biotechnol , vol.29 , pp. 993-1003
    • Kwong, A.D.1    Kauffman, R.S.2    Hurter, P.3    Mueller, P.4
  • 50
    • 79954911259 scopus 로고    scopus 로고
    • Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice
    • 21145818 10.1016/j.jhep.2010.08.033 1:CAS:528:DC%2BC3MXkvFGhurk%3D
    • Ohara E, Hiraga N, Imamura M, et al. Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice. J Hepatol. 2011;54:872-8.
    • (2011) J Hepatol , vol.54 , pp. 872-878
    • Ohara, E.1    Hiraga, N.2    Imamura, M.3
  • 51
    • 84856159009 scopus 로고    scopus 로고
    • Preliminary study of two antiviral agents for hepatitis C genotype 1
    • 22256805 10.1056/NEJMoa1104430 1:CAS:528:DC%2BC38Xht1yltrw%3D
    • Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med. 2012;366:216-24.
    • (2012) N Engl J Med , vol.366 , pp. 216-224
    • Lok, A.S.1    Gardiner, D.F.2    Lawitz, E.3
  • 52
    • 84857395452 scopus 로고    scopus 로고
    • Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders
    • 21987462 10.1002/hep.24724 1:CAS:528:DC%2BC38Xislaiu7s%3D
    • Chayama K, Takahashi S, Toyota J, et al. Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders. Hepatology. 2012;55:742-8.
    • (2012) Hepatology , vol.55 , pp. 742-748
    • Chayama, K.1    Takahashi, S.2    Toyota, J.3
  • 53
    • 84867402086 scopus 로고    scopus 로고
    • Dual oral therapy with the NS5A inhibitor daclatasvir (BMS-790052) and NS3 protease inhibitor asunaprevir (BMS-650032) in HCV genotype 1b-infected null responders or ineligible/intolerant to peginterferon
    • Barcelona Abstract 14
    • Suzuki F, Ikeda K, Toyota J, et al. Dual oral therapy with the NS5A inhibitor daclatasvir (BMS-790052) and NS3 protease inhibitor asunaprevir (BMS-650032) in HCV genotype 1b-infected null responders or ineligible/ intolerant to peginterferon. In: 47th annual meeting of the European Association for the study of the liver (EASL 2012). Barcelona, 2012; Abstract 14.
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver (EASL 2012)
    • Suzuki, F.1    Ikeda, K.2    Toyota, J.3
  • 54
    • 84857415002 scopus 로고    scopus 로고
    • The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C
    • 22006408 10.1002/hep.24744 1:CAS:528:DC%2BC38Xislahs78%3D
    • Zeuzem S, Buggisch P, Agarwal K, et al. The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C. Hepatology. 2012;55:749-58.
    • (2012) Hepatology , vol.55 , pp. 749-758
    • Zeuzem, S.1    Buggisch, P.2    Agarwal, K.3
  • 55
    • 80052826527 scopus 로고    scopus 로고
    • Response-guided telaprevir combination treatment for hepatitis C virus infection
    • Sherman KE, Flamm SL, Afdhal NH, et al. Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med. 2011;365:1014-24.
    • (2011) N Engl J Med. , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.